USP/UBP Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7134 IU1

IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT.

Selective USP14, IC50: 4.7 μM
S7130 PR-619

PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM.

Pan USP47, EC50: 8.87 μM; USP28, EC50: 6.24 μM; USP20, EC50: 5.10 μM; USP15, EC50: 8.23 μM; USP8, EC50: 4.90 μM; USP7, EC50: 6.86 μM; USP5, EC50: 8.61 μM; USP4, EC50: 3.93 μM; USP2 core, EC50: 7.20 μM
S7132 P5091 (P005091)

P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.

Pan USP28, EC50: >100 μM; USP21, EC50: >100 μM; USP20, EC50: >100 μM; USP15, EC50: >100 μM; USP8c, EC50: >100 μM; USP5, EC50: >100 μM; USP2c, EC50: >100 μM; USP7, EC50: 4.2 μM
S7133 P22077

P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.

Pan USP28, EC50: >50 μM; USP20, EC50: >50 μM; USP15, EC50: >50 μM; USP8, EC50: >50 μM; USP5, EC50: >50 μM; USP4, EC50: >50 μM; USP2 core, EC50: >50 μM; USP47, EC50: 8.74 μM; USP7, EC50: 8.6 μM
S4920 b-AP15

b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.

Pan