Molecular Weight(MW): 283.92
TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
Purity & Quality Control
Choose Selective DUB Inhibitors
|Description||TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.|
|Features||TCID demonstrates selectivity for UCH-L3 over UCH-L1 by over 100-fold.|
TCID is selective for UCH-L3 over UCH-L1 by over 100-fold.  NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect.  TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods. 
|In vitro||DMSO||23 mg/mL (81.0 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03296917||Completed||Drug: PrEP-001|Drug: G-004||Asthma||Hvivo|Prep Biopharm Limited||December 11 2015||Phase 2|
|NCT03220048||Completed||Drug: PrEP-001|Other: Placebo Comparator||Influenza A H3N2||Hvivo|Prep Biopharm Limited||September 16 2015||Phase 2|
|NCT02134431||Completed||Device: flexible sigmoidoscopy or colonoscopy with biopsies||Human Immunodeficiency Virus||University of California Los Angeles||May 2014||--|
|NCT01866306||Completed||Biological: RV16UB|Drug: LABA||Asthma||Merck Sharp & Dohme Corp.|U-BIOPRED Consortium||October 22 2013||Phase 1|
|NCT02795403||Completed||Other: blood draw of 150ml twice||Hepatitis C||Hospices Civils de Lyon||January 2011||Not Applicable|
|NCT01227421||Completed||Drug: Nitazoxanide|Drug: Placebo||Influenza||Romark Laboratories L.C.||December 2010||Phase 2|Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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