For research use only.

Catalog No.S7140

TCID Chemical Structure

Molecular Weight(MW): 283.92

TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.

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Biological Activity

Description TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
Features TCID demonstrates selectivity for UCH-L3 over UCH-L1 by over 100-fold.
UCH-L3 [1]
0.6 μM
In vitro

TCID is selective for UCH-L3 over UCH-L1 by over 100-fold. [1] NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect. [2] TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods. [3]


Solubility (25°C)

In vitro DMSO 23 mg/mL (81.0 mM)
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 283.92


CAS No. 30675-13-9
Storage powder
in solvent
Synonyms N/A
Smiles ClC1=C(Cl)C(=C2C(=O)CC(=O)C2=C1Cl)Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03296917 Completed Drug: PrEP-001|Drug: G-004 Asthma Hvivo|Prep Biopharm Limited December 11 2015 Phase 2
NCT02134431 Completed Device: flexible sigmoidoscopy or colonoscopy with biopsies Human Immunodeficiency Virus University of California Los Angeles May 2014 --
NCT01866306 Completed Biological: RV16UB|Drug: LABA Asthma Merck Sharp & Dohme Corp.|U-BIOPRED Consortium October 22 2013 Phase 1
NCT02795403 Completed Other: blood draw of 150ml twice Hepatitis C Hospices Civils de Lyon January 2011 Not Applicable
NCT01227421 Completed Drug: Nitazoxanide|Drug: Placebo Influenza Romark Laboratories L.C. December 2010 Phase 2|Phase 3

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DUB Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID