UCH Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7135 LDN-57444

LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.

Selective UCH-L3, IC50: 25 μM; UCH-L1, Ki: 0.4 μM; UCH-L1, IC50: 0.88 μM
S7140 TCID

TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.

Selective UCH-L3, IC50: 0.6 μM
S4920 b-AP15

b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.

Pan UCHL5, IC50: 2.1 μM
S7130 PR-619

PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.

Pan UCH-L5, EC50: 9.26 μM; UCH-L3, EC50: 2.95 μM; UCH-L1, EC50: 12.8 μM