CK1 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6734 PF-670462

PF-670462 is a potent and selective inhibitor of CK1ε and CK1δ with IC50 value of 90 nM and 13 nM, respectively.

Selective CK1δ, IC50: 13 nM; CK1ε, IC50: 90 nM
S0350 CK1-IN-1

CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.

Selective CK1δ, IC50: 15 nM; CK1ε, IC50: 16 nM
S2249 PF 4800567

PF 4800567 is a novel and potent inhibitor of casein kinase 1 epsilon (IC50=32 nM) with greater than 20-fold selectivity over casein kinase 1 delta(IC50=711 nM).

Selective casein kinase 1 delta, IC50: 711 nM; casein kinase 1 epsilon, IC50: 32 nM
S6544 SR-3029

SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 values of 44 and 260 nM for CK1δ and CK1ε, respectively.

Selective CK1δ, IC50: 44 nM; CK1ε, IC50: 260 nM
S7642 D 4476

D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.

Selective CK1 from Schizosaccharomyces pombe, IC50: 200 nM; CK1δ, IC50: 300 nM
S2805 LY364947

LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.

Selective CK1δ, IC50: 0.22 μM
S6578 Longdaysin

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

Selective CKIδ, IC50: 8.8 μM; CKIα, IC50: 5.6 μM
S8237 IC261

IC261 (SU-5607) is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM.

Selective CK1, IC50: 16 μM
S5265 TBB

TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.

Pan CK1, Ki: 47 μM