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5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside Casein Kinase inhibitor

Name: 5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside
Brand: Selleck Chemicals
SKU: E2914
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E2914

5,6-Dichlorobenzimidazole riboside(DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs. It trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells.

Chemical Structure

Molecular Weight: 319.14

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: E291401 DMSO]64 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.73%

99.73

Related Targets	P450 (e.g. CYP17) Dehydrogenase PDE phosphatase PPAR HSP (HSP90) Vitamin Transferase Carbohydrate Metabolism Mitochondrial Metabolism Serine/threonin kinase Lipoxygenase Phospholipase (e.g. PLA) Retinoid Receptor DPP ACE Peroxidases Amino Acids and Derivatives Fatty Acid Synthase FXR HMG-CoA Reductase Carbonic Anhydrase Lipase Decarboxylase DHFR IDO/TDO Hydroxylase PCSK9 OXPHOS ROR
Related Products	Silmitasertib (CX-4945) Silmitasertib (CX-4945) sodium salt D 4476 TBB IC261 (E/Z)-GO289 TTP 22 Longdaysin PF 4800567 Ellagic Acid hydrate 7-Hydroxy-4-methyl-8-nitrocoumarin BTX-A51 SR-3029 DEG-77 DEG-35 CKI-7 SSTC3 BMS-986397 PF-05251749（CK1-IN-2） Casein Kinase 2β Antibody [K14H23] CK1-IN-1 PF-670462 DMAT Hematein TA-01

Chemical Information, Storage & Stability

Molecular Weight	319.14	Formula	C₁₂H₁₂Cl₂N₂O₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	53-85-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Solubility

In vitro
Batch:

DMSO : 64 mg/mL (200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	Casein Kinase 2 ^[1]
References	[1] https://pubmed.ncbi.nlm.nih.gov/2803263/ [2] https://pubmed.ncbi.nlm.nih.gov/10523857/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05051605	Recruiting	Liver Transplant	Ain Shams University	September 15 2021	--
NCT05040854	Recruiting	Inflammatory Bowel Diseases	Centro Hospitalar Tondela-Viseu	July 1 2021	--
NCT03861962	Not yet recruiting	Organ Transplantation	Assistance Publique - Hôpitaux de Paris	May 2019	--
NCT03506035	Unknown status	Rheumatoid Arthritis	Corporacion Parc Tauli	September 1 2018	--
NCT05284929	Unknown status	Pemphigus\|Bullous Pemphigoid\|Stevens-Johnson Syndrome\|Toxic Epidermal Necrolyses	Sechenov University\|Pirogov Russian National Research Medical University	May 17 2017	--
NCT05342948	Completed	Recurrent Pregnancy Loss	Aalborg University Hospital	January 1 2016	--

Tech Support

Handling Instructions

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