IC261

For research use only.

Catalog No.S8237 Synonyms: SU-5607

3 publications

IC261 Chemical Structure

CAS No. 186611-52-9

IC261 (SU-5607) is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM.

Selleck's IC261 has been cited by 3 publications

Purity & Quality Control

Choose Selective Casein Kinase Inhibitors

Biological Activity

Description IC261 (SU-5607) is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM.
Targets
CK1 [4]
()
16 μM
In vitro

IC261 leads to a p53-dependent arrest of the cells with a DNA content of 4 N. It can produce effects on cell cycle progression that are indistinguishable from an established spindle poison and are dependent on the p53 status of the cells[1].

In vivo Intrathecal injection of a CK1 inhibitor IC261 attenuates neuropathic pain behaviors. CK1 inhibitors are found to be effective in reducing spinal excitatory response elicited by the presynaptic electrical stimulation only in neuropathic mice[2]. Targeting CK1 isoforms by IC261 influences both pancreatic tumour cell growth and apoptosis sensitivity in vitro and the growth of induced tumours in vivo[3].

Protocol

Cell Research:

[1]

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  • Cell lines: MEFs
  • Concentrations: 1 μM
  • Incubation Time: 12 h, 24 h, 48 h
  • Method:

    Cultures of MEFs of di€erent genotypes (p53+/+, p53+/-, p53-/-) are treated with the inhibitor IC261 in the low micromolar range (1 μM). After 12, 24, 48 hours exposure, the effects of IC261 on cell cycle distribution are measured by flow cytometry.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male C57BL/6J mice
  • Dosages: 0.1-1 nmol
  • Administration: intrathecal administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 62 mg/mL (199.14 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 311.33
Formula

C18H17NO4

CAS No. 186611-52-9
Storage powder
in solvent
Synonyms SU-5607
Smiles COC1=CC(=C(C(=C1)OC)C=C2C3=CC=CC=C3NC2=O)OC

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID