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HC-7366 Serine/threonin kinase modulator

Name: HC-7366
Brand: Selleck Chemicals
SKU: E1975
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1975

HC-7366, is a First-in-Human modulator of General controlled nonderepressible 2 (GCN2) that activates GCN2. It demonstrates anti-metastatic efficacy, reducing lung metastases and exhibits anti-tumor activity.

Chemical Structure

Molecular Weight: 508.89

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Quality Control

Batch: E197501 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.38%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

99.38

Related Targets	CDK HSP PD-1/PD-L1 ROCK Wee1 DNA/RNA Synthesis Microtubule Associated Ras KRas Aurora Kinase
Other Serine/threonin kinase Inhibitors	WNK463 SRPIN340 GCN2iB SPHINX31 Benzamidine HCl BAY-1816032 BioE-1115 GAK inhibitor 49 ML281 DCLK1-IN-1

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (196.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (9.83mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.800mg/ml (1.57mM)	Taking the 1 mL working solution as an example, add 50 μL of 16 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	508.89	Formula	C₂₀H₁₅ClF₂N₆O₄S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2803470-63-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC₅₀/Ki	GCN2
References	[1] https://jitc.bmj.com/content/10/Suppl_2/A1378

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-10)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06285890	RECRUITING	Acute Myeloid Leukemia	M.D. Anderson Cancer Center	2024-05-20	PHASE1
NCT07401875	RECRUITING	Phase 1b; HC-7366; SHARK; Kidney Cancer	M.D. Anderson Cancer Center	2026-03-24	PHASE1
NCT06234605	RECRUITING	Renal Cell Carcinoma	HiberCell, Inc.	2024-04-29	PHASE1
NCT05121948	TERMINATED	Squamous Cell Carcinoma of Head and Neck; Colo-rectal Cancer; Non Small Cell Lung Cancer; Transitional Cell Carcinoma of the Bladder; Other Solid Tumors; Clear Cell Renal Cell Carcinoma	HiberCell, Inc.	2022-02-23	PHASE1

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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