Home Metabolism -Cell Cycle Serine/threonin kinase STK Selective Inhibitors

STK Selective Inhibitors

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S0431	ML281	ML281 is a potent and selective inhibitor of Serine/threonine kinase 33 (STK33) with IC50 of 0.014 μM. ML281 is selectively toxic to KRAS-dependent cancer cell lines.	Selective	STK33, IC50: 0.014 μM
S7083	Ceritinib	Ceritinib is a potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays. Ceritinib (LDK378) also inhibits IGF-1R, InsR, STK22D and FLT3 with IC50 of 8 nM, 7 nM, 23 nM and 60 nM, respectively. Phase 3.	Selective	STK22D, IC50: 23 nM
S4967	Ceritinib dihydrochloride	Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and STK22D with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity.	Selective	STK22D, IC50: 23 nM
S8864	ZT-12-037-01	ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM.	Selective	STK19, IC50: 23.96 nM; STK19 (D89N), IC50: 27.94 nM