Molecular Weight(MW): 342.61
A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
Cited by 1 publication
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|Description||A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.|
In 1321N1 cells stably expressing rat P2X7 receptors, A-438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM. A-438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM.
|In vivo||Intraperitoneal injection of A-438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A-438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A-438079 partially but signiﬁcantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A-438079 reduces nociceptive behaviour scores in the HC model. A-438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A-438079 (100 and 300 μmol/kg, i.p.) signiﬁcantly raises withdrawal thresh-olds in both the SNL and CCI models.|
|In vitro||DMSO||61 mg/mL (178.04 mM)|
|Water||61 mg/mL (178.04 mM)|
|Ethanol||20 mg/mL warmed (58.37 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
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