A-438079 HCl

Catalog No.S7705

A-438079 HCl Chemical Structure

Molecular Weight(MW): 342.61

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

Size Price Stock Quantity  
USD 97 In stock
USD 277 In stock
USD 677 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective P2 Receptor Inhibitors

Biological Activity

Description A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
Targets
P2X7 [1]
(in 1321N1 cells)
6.9(pIC50)
In vitro

In 1321N1 cells stably expressing rat P2X7 receptors, A-438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM. A-438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 cells MUTGeY5kfGmxbjDhd5NigQ>? M3n3SGFvfGGpb37pd5Qh[WO2aY\peJkh[XRiaIXtZY4hemWlb33ibY5idnRiUELYO{Bz\WOncITvdkBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZoVvgm:7bHLlcppwcWNiQWTQMYlv\HWlZXSgZ4Ft[2m3bTDwdo9lfWO2aX;uJIJ6KE[OSWDSJIF{e2G7LDDJR|UxRTBwMUKzNFMh|ryP MV:yNVU{PjR|NR?=
human 1321N1 cells M{DLRWZ2dmO2aX;uJIF{e2G7 MVLBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHAzYDdicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJIh2dWGwIEGzNlFPOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINidGOrdX2g[ox2gCCkeTDGUGlRWixiSVO1NF0xNjF{NUi5JO69VQ>? MkPxNVY4PTlzMEi=
human THP1 cells NFHvNXJHfW6ldHnvckBie3OjeR?= NWTDRY54SW62YXfvcol{fCCjY4Tpeol1gSCjdDDQNng4KHKnY3XweI9zKGmwIHj1cYFvKFSKUEGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCEelHUVE1qdmS3Y3XkJIV1cGmmaYXtJJVxfGGtZTygTWM2OD1yLkGyOVg6KM7:TR?= NVj4co1POTlzOUG1PFU>
HEK cells NEfYXpZHfW6ldHnvckBie3OjeR?= NWX3NoxNSWO2aY\peJkh[XRicnH0JHAzYDdicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGhGUyClZXzsd{Bie3Onc4Pl[EBieyCnZn\lZ5Qhd25iQorBWHAucW6mdXPl[EBmfGirZHn1cUB2eHSja3WsJGlEPTB;MD6zNVYzOyEQvF2= MWGxPVE6OTV6NR?=

... Click to View More Cell Line Experimental Data

In vivo Intraperitoneal injection of A-438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A-438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg).[2] A-438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores.[3] Pretreatment with A-438079 reduces nociceptive behaviour scores in the HC model.[4] A-438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A-438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models.[1]

Protocol

Animal Research:[3]
+ Expand
  • Animal Models: Sprague-Dawley male rats
  • Formulation: Saline
  • Dosages: 30 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 61 mg/mL (178.04 mM)
Water 61 mg/mL (178.04 mM)
Ethanol 20 mg/mL warmed (58.37 mM)
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 342.61
Formula

C13H10Cl3N5

CAS No. 899431-18-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

P2 Receptor Signaling Pathway Map

Related P2 Receptor Products0

Tags: buy A-438079 HCl | A-438079 HCl supplier | purchase A-438079 HCl | A-438079 HCl cost | A-438079 HCl manufacturer | order A-438079 HCl | A-438079 HCl distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID