A-438079 HCl

For research use only.

Catalog No.S7705

7 publications

A-438079 HCl Chemical Structure

CAS No. 899431-18-6

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

Selleck's A-438079 HCl has been cited by 7 publications

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Biological Activity

Description A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
P2X7 [1]
(in 1321N1 cells)
In vitro

In 1321N1 cells stably expressing rat P2X7 receptors, A-438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM. A-438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 cells NFzVdHNHfW6ldHnvckBie3OjeR?= MWDBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJJJm[2:vYnnuZY51KFB{WEegdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHLlcppwgWykZX76c4lkKEGWUD3pcoR2[2WmIHPhcINqfW1icILv[JVkfGmxbjDifUBHVEmSUjDhd5NigSxiSVO1NF0xNjF{M{CzJO69VQ>? NUPhUYpPOjF3M{[0N|U>
human 1321N1 cells NF;rcJlHfW6ldHnvckBie3OjeR?= M3HPUWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiaIXtZY4hWDK[NzDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hcHWvYX6gNVMzOU5zIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2GuY3n1cUBndHW6IHL5JGZNUVCULDDJR|UxRTBwMUK1PFkh|ryP M{\VTlE3PzV7MUC4
human THP1 cells NFfkVJlHfW6ldHnvckBie3OjeR?= MV3BcpRi\2:waYP0JIFkfGm4aYT5JIF1KFB{WEegdoVk\XC2b4KgbY4hcHWvYX6gWGhROSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGJ7SVSSLXnu[JVk\WRiZYTobYRqfW1idYD0ZYtmNCCLQ{WwQVAvOTJ3OEmg{txO MlHrNVkyQTF3OEW=

... Click to View More Cell Line Experimental Data

In vivo Intraperitoneal injection of A-438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A-438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg).[2] A-438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores.[3] Pretreatment with A-438079 reduces nociceptive behaviour scores in the HC model.[4] A-438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A-438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models.[1]


Animal Research:[3]
- Collapse
  • Animal Models: Sprague-Dawley male rats
  • Dosages: 30 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 61 mg/mL (178.04 mM)
Water 61 mg/mL (178.04 mM)
Ethanol 20 mg/mL warmed (58.37 mM)
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 342.61


CAS No. 899431-18-6
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID