Home Neuronal Signaling P2 Receptor inhibitor Ticlopidine HCl

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Ticlopidine HCl P2 Receptor inhibitor

Cat.No.S1984

Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.
Ticlopidine HCl P2 Receptor inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 300.25

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Quality Control

Batch: Purity: 99.99%
99.99

Solubility

In vitro
Batch:

Water : 4 mg/mL

DMSO : 1 mg/mL (3.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1 mg/mL

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 300.25 Formula

C14H14ClNS.HCl

 Storage (From the date of receipt)
CAS No. 53885-35-1 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl.Cl

Mechanism of Action

Targets/IC50/Ki
P2 receptor
~2 μM
In vitro
Ticlopidine HCl is an antiplatelet drug in the thienopyridine family. This compound inhibits platelet aggregation by altering the function of platelet membranes by blocking ADP receptors. This prevents the conformational change of glycoprotein IIb/IIIa which allows platelet binding to fibrinogen. It inhibits platelet aggregation and prostaglandin synthesis from endogenous substrate through activating basal and PGE1-stimulated activity of the cyclase, preventing PGE2-induced depression of the cyclase activity and thus increasing platelet c-AMP level.
In vivo
Ticlopidine HCl inhibits platelet aggregation with IC50 of ~2 μM in men. This compound, when orally administered to rats, results in activation of basal and prostaglandin E1 (PGE1)-stimulated adenylate cylase activity through increase in affinity of the cyclase in platelet membrane to PGE1, although it failed to affect adenosine- or sodium fluoride-stimulated activity of the enzyme.
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