For research use only.
Catalog No.S1258 Synonyms: CS-747, LY640315
Molecular Weight(MW): 373.44
Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.
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|Description||Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.|
Prasugrel is a novel orally active thienopyridine with faster, higher and more reliable inhibition of platelet aggregation than clopidogrel reflecting its metabolism in vivo to an active metabolite with selective P2Y(12) antagonistic activity. 
|In vivo||Prasugrel shows platelet inhibition that was 8.2 times more potent than clopidogrel in WT mice.  Prasugrel (3 and 10 mg/kg) dose-relatedly and significantly reduces thrombus-mediated cerebral infarction 24 hours after the irradiation in rat models of cerebral and peripheral arterial occlusive diseases. Prasugrel (0.3-3 mg/kg) reduces incidence, total area, and total number of cerebral infarcts in a dose-related manner 24 hours after the vascular injury in an embolic infarction rats model. Prasugrel (0.03-3 mg/kg/day) administered from the day before the lauric acid injection for 11 successive days inhibits the progression of the disease in a dose-related manner in rats with lauric acid-induced peripheral arterial occlusive diseases.  Prasugrel administrated in dogs (0.03-0.3 mg/kg/day) and monkeys (0.1 and 0.3 mg/kg/day) once a day for 14 days results in potent, dose-related and cumulative inhibition of ADP-induced platelet aggregation. Prasugrel (0.1-1 mg/kg/day, p.o.) significantly prolongs the time to arterial occlusion and increases the duration of arterial patency in a rat model of electrically-induced arterial thrombosis. |
|In vitro||DMSO||30 mg/mL (80.33 mM)|
|Ethanol||7 mg/mL (18.74 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02302508||Withdrawn||Drug: Clopidogrel Prasugrel Ticagrelor||Diabetes||Centre hospitalier de l''Université de Montréal (CHUM)|Centre de Recherche du Centre Hospitalier de l''Université de Montréal||September 1 2019||Phase 4|
|NCT03016611||Unknown status||Drug: Chewing Ticagrelor LD|Drug: Chewing Prasugrel LD||Acute Coronary Syndrome|STEMI||Sheba Medical Center||February 2017||Phase 4|
|NCT03054207||Terminated||Drug: Clopidogrel 300Mg Tablet|Drug: Prasugrel 60Mg||Hiv||Jules Desmeules|University Hospital Geneva||June 2015||Phase 1|
|NCT02376283||Completed||Drug: Prasugrel|Drug: Clopidogrel|Drug: ticagrelor||Heart Attack||The Royal Wolverhampton Hospitals NHS Trust||March 9 2015||Phase 4|
|NCT02271022||Completed||Other: Non-Interventional Study||Acute Coronary Syndromes||AstraZeneca||February 17 2015||--|
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