For research use only.

Catalog No.S1258 Synonyms: CS-747, LY640315

2 publications

Prasugrel Chemical Structure

CAS No. 150322-43-3

Prasugrel (CS-747, LY640315) is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.

Selleck's Prasugrel has been cited by 2 publications

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Biological Activity

Description Prasugrel (CS-747, LY640315) is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.
P2Y12 receptor [1]
In vitro

Prasugrel is a novel orally active thienopyridine with faster, higher and more reliable inhibition of platelet aggregation than clopidogrel reflecting its metabolism in vivo to an active metabolite with selective P2Y(12) antagonistic activity. [1]

Methods Test Index PMID
Western blot
p-VEGDFR2 / VEGFR2 / p-STAT3 / STAT3 / p-p65 / p65 / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 28383032     

The cells were treated with tivozanib for 48 h then whole cell lysates were prepared and resolved by SDS PAGE. Samples were blotted for the phospho-form and re-probed for the respective total form of VEGFR2, STAT3, NF-κB p65, AKT and ERK1/2. β-actin was used as the loading control. The concentrations of tivozanib were 5, 10 and 20 μM. The blots are representative of three independent experiments with similar results.

In vivo Prasugrel shows platelet inhibition that was 8.2 times more potent than clopidogrel in WT mice. [1] Prasugrel (3 and 10 mg/kg) dose-relatedly and significantly reduces thrombus-mediated cerebral infarction 24 hours after the irradiation in rat models of cerebral and peripheral arterial occlusive diseases. Prasugrel (0.3-3 mg/kg) reduces incidence, total area, and total number of cerebral infarcts in a dose-related manner 24 hours after the vascular injury in an embolic infarction rats model. Prasugrel (0.03-3 mg/kg/day) administered from the day before the lauric acid injection for 11 successive days inhibits the progression of the disease in a dose-related manner in rats with lauric acid-induced peripheral arterial occlusive diseases. [2] Prasugrel administrated in dogs (0.03-0.3 mg/kg/day) and monkeys (0.1 and 0.3 mg/kg/day) once a day for 14 days results in potent, dose-related and cumulative inhibition of ADP-induced platelet aggregation. Prasugrel (0.1-1 mg/kg/day, p.o.) significantly prolongs the time to arterial occlusion and increases the duration of arterial patency in a rat model of electrically-induced arterial thrombosis. [3]


Solubility (25°C)

In vitro DMSO 30 mg/mL (80.33 mM)
Ethanol 7 mg/mL (18.74 mM)
Water Insoluble

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Chemical Information

Molecular Weight 373.44


CAS No. 150322-43-3
Storage powder
in solvent
Synonyms CS-747, LY640315
Smiles CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04471870 Recruiting -- Acute Coronary Syndrome Chiesi Farmaceutici S.p.A. October 23 2020 --
NCT02302508 Withdrawn Drug: Clopidogrel Prasugrel Ticagrelor Diabetes Centre hospitalier de l''Université de Montréal (CHUM)|Centre de Recherche du Centre Hospitalier de l''Université de Montréal September 1 2019 Phase 4
NCT03016611 Unknown status Drug: Chewing Ticagrelor LD|Drug: Chewing Prasugrel LD Acute Coronary Syndrome|STEMI Sheba Medical Center February 2017 Phase 4
NCT03054207 Terminated Drug: Clopidogrel 300Mg Tablet|Drug: Prasugrel 60Mg Hiv Jules Desmeules|University Hospital Geneva June 2015 Phase 1

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P2 Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID