Home Metabolism FXR agonist LY2562175

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LY2562175 FXR agonist

Cat.No.S0403

LY2562175 is a potent and selective agonist of FXR. This compound promotes transcriptional activation of human FXR in a cell-based cotransfection assay with EC50 of 193 nM.
LY2562175 FXR agonist Chemical Structure

Chemical Structure

Molecular Weight: 540.44

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Quality Control

Batch: S040301 DMSO]100 mg/mL]false]Ethanol]1.5 mg/mL]false]Water]Insoluble]false Purity: 99.75%
99.75

Chemical Information, Storage & Stability

Molecular Weight 540.44 Formula

C28H27Cl2N3O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1103500-20-4 -- Storage of Stock Solutions

Synonyms N/A Smiles CN1C=C(C2=C1C=C(C=C2)N3CCC(CC3)OCC4=C(ON=C4C5=C(C=CC=C5Cl)Cl)C6CC6)C(=O)O

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (185.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1.5 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
human FXR [1]
(cell-based cotransfection assay)
193 nM(EC50)
References

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