VX-702

Catalog No.S6005

VX-702 Chemical Structure

Molecular Weight(MW): 404.3

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.

Size Price Stock Quantity  
In DMSO USD 64 In stock
USD 70 In stock
USD 110 In stock
USD 370 In stock
USD 670 In stock
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3 Customer Reviews

  • J Invest Dermatol, 2018, 138(6):1380-1390. VX-702 purchased from Selleck.

    Reduction of IL-10 expression due to p38 inhibition is observed also in CpG-stimulated B cells and using VX-702. B cells were pre-treated with 10 uM of VX-702 for 1 h and stimulated with LPS or CpG for 24 or 48 h. Bar graphs indicate mean (±SEM) IL-10 concentrations at 48 h from n = 4 (LPS) and n = 3 (CpG) experiments. Significant differences against the no inhibitor condition were calculated using a paired Student's t-test and indicated as follows: *p < 0.05, ***p < 0.001.

    Mol Immunol 2014 62(2), 266-76. VX-702 purchased from Selleck.

  •  Bone marrow derived macrophages were pre-treated with the indicated concentrations of VX702 for 1h prior to LPS treatment (100 ng/ml).  TNF-a production was analyzed 24h later.

    Lee lay hoon from National University of Singapore. VX-702 purchased from Selleck.

Purity & Quality Control

Choose Selective p38 MAPK Inhibitors

Biological Activity

Description VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.
Features Highly selective, orally active inhibitor of p38 MAPK.
Targets
p38α [1]
(Cell-free assay)
4 nM-20 nM
In vitro

Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies. [1] VX-702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HOP-62 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYrJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC14MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFE2PDNizszN NWnrSY9ZW0GQR1XS
human NCI-H720 cell NYDEVlI2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xOTZ6MjFOwG0> MUXTRW5ITVJ?
JVM-2 cell M4PmUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3jGVGlvcGmkaYTpc44hd2ZiaIXtZY4hUl[PLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA5OyEQvF2= MVTTRW5ITVJ?
human NCI-H69 cell NXrMfGlTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIm0UnBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB7OUSxJO69VQ>? MUPTRW5ITVJ?
human BV-173 cell M2fweWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGDxbnBKdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTF|OE[g{txO MX;TRW5ITVJ?
human KU812 cell NVvu[HRXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXTNfnB[UW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTJ2OEig{txO NEPKfIVUSU6JRWK=
human DU-145 cell MoL3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGrCRWVKdmirYnn0bY9vKG:oIHj1cYFvKESXLUG0OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTR3NUSg{txO NWnLS4RoW0GQR1XS
KARPAS-45 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjpTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF2OEK2JO69VQ>? M2TyNHNCVkeHUh?=
human AGS cell Mm\hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnvVTY5pcWKrdHnvckBw\iCqdX3hckBCT1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkG1NlUyKM7:TR?= M371WHNCVkeHUh?=
human MOLT-13 cell NYDVSZFvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnHnTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPTl6MTFOwG0> NEPtfIVUSU6JRWK=
human NCI-H209 cell Ml2wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmnPTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTd3ODFOwG0> MUfTRW5ITVJ?
human CTV-1 cell NHu4TpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXHWdncyUW6qaXLpeIlwdiCxZjDoeY1idiCFVG[tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTh|OEmg{txO NU\KW2hsW0GQR1XS
LU-139 cell NH2yN4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHLr[|dKdmirYnn0bY9vKG:oIHj1cYFvKEyXLUGzPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTl2M{Wg{txO Mn2yV2FPT0WU
ML-2 cell MnTHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHXidJJKdmirYnn0bY9vKG:oIHj1cYFvKE2OLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlIzPjZzIN88US=> MmXNV2FPT0WU
human K5 cell NWjxWHhPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIflUIlKdmirYnn0bY9vKG:oIHj1cYFvKEt3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yNlkyPyEQvF2= M4rKbnNCVkeHUh?=
human SBC-1 cell M1j2[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYDJcohq[mm2aX;uJI9nKGi3bXHuJHNDSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yN|YzKM7:TR?= M2HmWHNCVkeHUh?=
human COR-L88 cell NGPaSGtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM{PDhizszN MXzTRW5ITVJ?
human KY821 cell MmrOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1LSVmlvcGmkaYTpc44hd2ZiaIXtZY4hU1l6MkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM6PjB|IN88US=> MUTTRW5ITVJ?
human HCC2218 cell NV3wNldNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYj0RXc3UW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OyNlE5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC52OUeyPEDPxE1? MU\TRW5ITVJ?
human ECC10 cell NWW4T|VRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{m3WmlvcGmkaYTpc44hd2ZiaIXtZY4hTUOFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY2Ozh7IN88US=> M2LDWHNCVkeHUh?=
human EW-3 cell MmjPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M33HUWlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOlY3OTFizszN MnTzV2FPT0WU
human EW-18 cell NWLuO2psT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYPNdJM6UW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzR4N{mg{txO NGT5NpNUSU6JRWK=
human UACC-257 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYftSIlDUW6qaXLpeIlwdiCxZjDoeY1idiCXQVPDMVI2PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMkCzNlYh|ryP MkjkV2FPT0WU
human G-361 cell MnK5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnHPTY5pcWKrdHnvckBw\iCqdX3hckBINTN4MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFk2OTlizszN NVLleIp4W0GQR1XS
human HMV-II cell NYLyNWRYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo\VTY5pcWKrdHnvckBw\iCqdX3hckBJVVZvSVmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc4OTh2IN88US=> NELZSnJUSU6JRWK=
human DEL cell NWT6R|VqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NY\2bGx4UW6qaXLpeIlwdiCxZjDoeY1idiCGRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIxPzB2IN88US=> NVHucXg5W0GQR1XS
human IGROV-1 cell NYm0cZdpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3XHOGlvcGmkaYTpc44hd2ZiaIXtZY4hUUeUT2[tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDNzOEig{txO NY\5Oo5LW0GQR1XS
human SK-OV-3 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU:YLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYyPjl5IN88US=> MYPTRW5ITVJ?
human LAMA-84 cell NIT3T4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkfQTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44OTJ6NDFOwG0> Ml72V2FPT0WU
human NCI-H510A cell M{LVUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUjoZpZ3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUyOEFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmyOVI3KM7:TR?= MmLSV2FPT0WU
human CP66-MEL cell NVz3S4V6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3LUXGlvcGmkaYTpc44hd2ZiaIXtZY4hS1B4Nj3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjl|NUW5JO69VQ>? MUnTRW5ITVJ?
human HAL-01 cell Mo\yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXLCSI5nUW6qaXLpeIlwdiCxZjDoeY1idiCKQVytNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ5OUG4JO69VQ>? NX:3eGJDW0GQR1XS
human RS4-11 cell  MlHkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHTkfIpKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPzB3N{Og{txO MXrTRW5ITVJ?
human RPMI-8226 cell M3\wSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1fuXmlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24NlI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy56MkO3OkDPxE1? MnTXV2FPT0WU
human NCI-H82 cell M4q3VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFjONmFKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Njh7M{C1JO69VQ>? NH3lRWhUSU6JRWK=
human NY cells M3zEO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGi3bXHuJG5[KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5{N{[zO{DPxE1? MUfTRW5ITVJ?
human MDA-MB-361 cell MnPOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{fXe2lvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVM3OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNEOxOVgh|ryP NWnJNI9pW0GQR1XS
human MOLT-4 cell M1vPO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGm0eVZKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvQTlzOUOg{txO NG\scndUSU6JRWK=
human DU-4475 cell NVr0N5NpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2[5UGlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvNES3OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvODV3NkWg{txO M33ZWXNCVkeHUh?=
human ESS-1 cell NXT1[|A3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\CVnZKdmirYnn0bY9vKG:oIHj1cYFvKEWVUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4zQTF5OTFOwG0> MUHTRW5ITVJ?
human NCI-H1299 cell M{fNN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUK5PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPTNyM{Og{txO M4S0WnNCVkeHUh?=
human COLO-684 cell NIPxdo9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9vNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU42QDF4NTFOwG0> MV\TRW5ITVJ?
human MV-4-11 cell NGPoelRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXLJcohq[mm2aX;uJI9nKGi3bXHuJG1XNTRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlcyOTl7IN88US=> M3\TO3NCVkeHUh?=
human D-542MG cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1rJbmlvcGmkaYTpc44hd2ZiaIXtZY4hTC13NELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvOzl{N{Kg{txO MknBV2FPT0WU
human A4-Fuk cell Mn7mS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYHJcohq[mm2aX;uJI9nKGi3bXHuJGE1NU[3azDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uOFM3PjJizszN M2jhVXNCVkeHUh?=
human HL-60 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkC2TY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOVIzOTJizszN Mof3V2FPT0WU
human NCI-H526 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVzyV2N5UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNUm4NFEh|ryP M1e0UHNCVkeHUh?=
human L-363 cell NUPK[HZNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXvPO|NoUW6qaXLpeIlwdiCxZjDoeY1idiCOLUO2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPzl{NUKg{txO NUW3VGljW0GQR1XS
human A388 cell NWe3WGZ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVjQVFExUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{45ODN6NDFOwG0> MnnoV2FPT0WU
human MS-1 NIH2OnZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mo\MTY5pcWKrdHnvckBw\iCqdX3hckBOWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64N|Q3PSEQvF2= MYrTRW5ITVJ?
human JAR cell NVLRVnlWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVfJcohq[mm2aX;uJI9nKGi3bXHuJGpCWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwOES5NlMh|ryP NXH3dldRW0GQR1XS
human TI-73 cell NF:zOI9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4XZRWlvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA3OjJizszN NH7tZ2pUSU6JRWK=
human CTB-1 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3rYRmlvcGmkaYTpc44hd2ZiaIXtZY4hS1SELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlE4QDJ3IN88US=> MojJV2FPT0WU
human SK-NEP-1 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlTNTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QRWCtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjNyM{ig{txO MkDZV2FPT0WU
human HT-29 cell NVnrZpVJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGhVNTJ7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuPVEyOSEQvF2= MX3TRW5ITVJ?
human NCI-H1092 cell NXzaNIh5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlTiTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGwPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC5|MUig{txO M1fxNnNCVkeHUh?=
human KMOE-2 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkDpTY5pcWKrdHnvckBw\iCqdX3hckBMVU:HLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE43OTd6IN88US=> NFHpZ5pUSU6JRWK=
human EM-2 cell NI[3[FJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWfJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNT6yPFQyKM7:TR?= MlLwV2FPT0WU
human RT-112 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYjONGVxUW6qaXLpeIlwdiCxZjDoeY1idiCUVD2xNVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS5|OUi0JO69VQ>? NYO3U5FKW0GQR1XS
human DB cell MlPpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWGxbnoxUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1Mlg2OTNizszN M3L6enNCVkeHUh?=
human NCI-H1770 cell M3jLXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH65VGRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7 M{\ESHNCVkeHUh?=
human CAL-54 cell M4XvSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MknETY5pcWKrdHnvckBw\iCqdX3hckBESUxvNUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOk44OyEQvF2= M3PsR3NCVkeHUh?=
human NB14 cell NWrpXVZUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYmxTmpDUW6qaXLpeIlwdiCxZjDoeY1idiCQQkG0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvPjN7NTFOwG0> NVL2bWhlW0GQR1XS
human RPMI-7951 cell Ml7qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnLrTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUe5OVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQS5zN{izJO69VQ>? MkL0V2FPT0WU
human T47D cell NETHXXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWjSXZR{UW6qaXLpeIlwdiCxZjDoeY1idiCWNEfEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOjJ2MzFOwG0> M2XHc3NCVkeHUh?=
human A549 cell M3zSVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{HOPGlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlI5OTFizszN NG\IT3BUSU6JRWK=
human A2780 cell M{HLdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIjI[JhKdmirYnn0bY9vKG:oIHj1cYFvKEF{N{iwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvQDJ{NTFOwG0> M2LGSHNCVkeHUh?=
human SK-MEL-24 cell NH;qbJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{jXfmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXMMVI1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzNwMEOxNUDPxE1? MWXTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. [2] VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score. [3] VX-702 selectively inhibits activation of p38 MAPK after ischemia with no effects on ERKs and JNKs. The MI/AAR ratio is significantly reduced in the 50 mg/kg group compared with the 5 mg/kg and vehicle groups.[4]

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (200.34 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.3
Formula

C19H12F4N4O2

CAS No. 745833-23-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00395577 Completed Rheumatoid Arthritis Vertex Pharmaceuticals Incorporated November 2006 Phase 2
NCT00205478 Completed Rheumatoid Arthritis Vertex Pharmaceuticals Incorporated June 2005 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID