VX-702

Catalog No.S6005

VX-702 Chemical Structure

Molecular Weight(MW): 404.3

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.

Size Price Stock Quantity  
In DMSO USD 64 In stock
USD 70 In stock
USD 110 In stock
USD 370 In stock
USD 670 In stock
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Cited by 15 Publications

3 Customer Reviews

  • Reduction of IL-10 expression due to p38 inhibition is observed also in CpG-stimulated B cells and using VX-702. B cells were pre-treated with 10 uM of VX-702 for 1 h and stimulated with LPS or CpG for 24 or 48 h. Bar graphs indicate mean (±SEM) IL-10 concentrations at 48 h from n = 4 (LPS) and n = 3 (CpG) experiments. Significant differences against the no inhibitor condition were calculated using a paired Student's t-test and indicated as follows: *p < 0.05, ***p < 0.001.

    Mol Immunol 2014 62(2), 266-76. VX-702 purchased from Selleck.

  •  Bone marrow derived macrophages were pre-treated with the indicated concentrations of VX702 for 1h prior to LPS treatment (100 ng/ml).  TNF-a production was analyzed 24h later.

    Lee lay hoon from National University of Singapore. VX-702 purchased from Selleck.

  • J Invest Dermatol, 2018, 138(6):1380-1390. VX-702 purchased from Selleck.

Purity & Quality Control

Choose Selective p38 MAPK Inhibitors

Biological Activity

Description VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.
Features Highly selective, orally active inhibitor of p38 MAPK.
Targets
p38α [1]
(Cell-free assay)
4 nM-20 nM
In vitro

Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies. [1] VX-702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HOP-62 cell NWDmSGVNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC14MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFE2PDNizszN MXzTRW5ITVJ?
human NCI-H720 cell NIPiWYtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV7QeHpOUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFczOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEG2PFIh|ryP Mln2V2FPT0WU
JVM-2 cell NXvVS5pwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV2yXHhkUW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODh|IN88US=> M1n0WXNCVkeHUh?=
human NCI-H69 cell NYPVXWd4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnr5TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xQTl2MTFOwG0> MXfTRW5ITVJ?
human BV-173 cell MmPvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIm0WXhKdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTF|OE[g{txO M4PjbHNCVkeHUh?=
human KU812 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVjhTIg3UW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTJ2OEig{txO NIP3RVJUSU6JRWK=
human DU-145 cell Ml\MS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk\zTY5pcWKrdHnvckBw\iCqdX3hckBFXS1zNEWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE1PTV2IN88US=> MX;TRW5ITVJ?
KARPAS-45 cell MmLvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{Tyd2lvcGmkaYTpc44hd2ZiaIXtZY4hU0GUUFHTMVQ2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zNEiyOkDPxE1? NF;yNXRUSU6JRWK=
human AGS cell NVfBV4w6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{HGXWlvcGmkaYTpc44hd2ZiaIXtZY4hSUeVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xOVI2OSEQvF2= MVjTRW5ITVJ?
human MOLT-13 cell NYTXWXFkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGHEb2RKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF3OUixJO69VQ>? MY\TRW5ITVJ?
human NCI-H209 cell Mm[1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkC5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPzV6IN88US=> NETGdlNUSU6JRWK=
human CTV-1 cell M1XTTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGNVXi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xPFM5QSEQvF2= M3XJNnNCVkeHUh?=
LU-139 cell M1K5VGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlnMTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE6PDN3IN88US=> M2LFUHNCVkeHUh?=
ML-2 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHTlfZFKdmirYnn0bY9vKG:oIHj1cYFvKE2OLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlIzPjZzIN88US=> NILjSWpUSU6JRWK=
human K5 cell NGO5THVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHTmSWZKdmirYnn0bY9vKG:oIHj1cYFvKEt3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yNlkyPyEQvF2= NGHrdVBUSU6JRWK=
human SBC-1 cell NGjKVodIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXHJcohq[mm2aX;uJI9nKGi3bXHuJHNDSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yN|YzKM7:TR?= NWO2UY5WW0GQR1XS
human COR-L88 cell NEC0ZVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mnm2TY5pcWKrdHnvckBw\iCqdX3hckBEV1JvTEi4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{OzR6IN88US=> NIHLenBUSU6JRWK=
human KY821 cell M{nuUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYS2SnAyUW6qaXLpeIlwdiCxZjDoeY1idiCNWUiyNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzl4MEOg{txO MX\TRW5ITVJ?
human HCC2218 cell Mk[zS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M13jdmlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMkKxPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPDl5Mkig{txO NXzuelBuW0GQR1XS
human ECC10 cell NX3xcIZVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4W5NGlvcGmkaYTpc44hd2ZiaIXtZY4hTUOFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY2Ozh7IN88US=> MVXTRW5ITVJ?
human EW-3 cell NH;aeIFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX\pdlNGUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43PjZzMTFOwG0> M3G2XHNCVkeHUh?=
human EW-18 cell Mk\LS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH3xUJZKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44PDZ5OTFOwG0> NECxcVlUSU6JRWK=
human UACC-257 cell NWmxU4NrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4PUeWlvcGmkaYTpc44hd2ZiaIXtZY4hXUGFQz2yOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJyM{K2JO69VQ>? MYLTRW5ITVJ?
human G-361 cell MnHaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml[xTY5pcWKrdHnvckBw\iCqdX3hckBINTN4MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFk2OTlizszN NYLIUGtlW0GQR1XS
human HMV-II cell MlnWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkDUTY5pcWKrdHnvckBw\iCqdX3hckBJVVZvSVmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc4OTh2IN88US=> MoHPV2FPT0WU
human DEL cell M4HHeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mo\aTY5pcWKrdHnvckBw\iCqdX3hckBFTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkKwO|A1KM7:TR?= M2PS[3NCVkeHUh?=
human IGROV-1 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn7NTY5pcWKrdHnvckBw\iCqdX3hckBKT1KRVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OzF6ODFOwG0> M2jEVHNCVkeHUh?=
human SK-OV-3 cell NYXoOYY2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmjBTY5pcWKrdHnvckBw\iCqdX3hckBUUy2RVj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43OTZ7NzFOwG0> M3LBO3NCVkeHUh?=
human LAMA-84 cell NVLlN3A3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVPJPVFPUW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55MUK4OEDPxE1? MU\TRW5ITVJ?
human NCI-H510A cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XxVGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NVBCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi57MkWyOkDPxE1? MXjTRW5ITVJ?
human CP66-MEL cell Mo\XS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkjBTY5pcWKrdHnvckBw\iCqdX3hckBEWDZ4LV3FUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQTN3NUmg{txO M4TUWnNCVkeHUh?=
human HAL-01 cell NFPONY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH;0OpVKdmirYnn0bY9vKG:oIHj1cYFvKEiDTD2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOjd7MUig{txO MWnTRW5ITVJ?
human RS4-11 cell  M4Plb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4TVfGlvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44ODV5MzFOwG0> NYPTSFZXW0GQR1XS
human RPMI-8226 cell NF\VVXBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3XpT2lvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24NlI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy56MkO3OkDPxE1? MlH1V2FPT0WU
human NCI-H82 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M37ZOWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvQDl|MEWg{txO MnnqV2FPT0WU
human NY cells M37JfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3HtOGlvcGmkaYTpc44hd2ZiaIXtZY4hVlliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkK3OlM4KM7:TR?= NF;qR29USU6JRWK=
human MDA-MB-361 cell NXzOOnRxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmXkTY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtN|YyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC52M{G1PEDPxE1? NWLxPXJoW0GQR1XS
human MOLT-4 cell MmWzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXjyOGJrUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Njl7MUmzJO69VQ>? MVnTRW5ITVJ?
human DU-4475 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlnPTY5pcWKrdHnvckBw\iCqdX3hckBFXS12NEe1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4xPTV4NTFOwG0> MojCV2FPT0WU
human ESS-1 cell NEfuZmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{DsOWlvcGmkaYTpc44hd2ZiaIXtZY4hTVOVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI6OTd7IN88US=> NVK0ZmZvW0GQR1XS
human NCI-H1299 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4\p[WlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNlk6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS53M{CzN{DPxE1? NFrH[WdUSU6JRWK=
human COLO-684 cell NHLlPY5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mlv0TY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLU[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPThzNkWg{txO MmLoV2FPT0WU
human MV-4-11 cell NYHy[W9vT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3NTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44OTF7OTFOwG0> NIHTfYdUSU6JRWK=
human D-542MG cell MoSyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1GzUGlvcGmkaYTpc44hd2ZiaIXtZY4hTC13NELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvOzl{N{Kg{txO NUnmR4xjW0GQR1XS
human A4-Fuk cell NGG1WlRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml\mTY5pcWKrdHnvckBw\iCqdX3hckBCPC2IdXugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlQ{PjZ{IN88US=> M165bHNCVkeHUh?=
human HL-60 cell NHHoZZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz61NlIyOiEQvF2= NVSwOpYyW0GQR1XS
human NCI-H526 cell NF[4bmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{LneGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjV7OECxJO69VQ>? NVzZOFB4W0GQR1XS
human L-363 cell NYXMdnBiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{DjW2lvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Mlc6OjV{IN88US=> MmHOV2FPT0WU
human A388 cell NFjLZ2NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXXJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkiwN|g1KM7:TR?= MUnTRW5ITVJ?
human MS-1 MkDIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrtTY5pcWKrdHnvckBw\iCqdX3hckBOWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64N|Q3PSEQvF2= NH\ReHdUSU6JRWK=
human JAR cell NIG1SGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmHBTY5pcWKrdHnvckBw\iCqdX3hckBLSVJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15Lki0PVI{KM7:TR?= MmjIV2FPT0WU
human TI-73 cell MmezS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1nPUmlvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA3OjJizszN MVLTRW5ITVJ?
human CTB-1 cell NFS0bWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVLLc4FnUW6qaXLpeIlwdiCxZjDoeY1idiCFVFKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvOTd6MkWg{txO NV\uT3h7W0GQR1XS
human SK-NEP-1 cell NUfST4pyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU6HUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOzB|ODFOwG0> M{XveXNCVkeHUh?=
human HT-29 cell MlvLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn[xTY5pcWKrdHnvckBw\iCqdX3hckBJXC1{OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlkyOTFizszN MkXIV2FPT0WU
human NCI-H1092 cell NUfyZ|RLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF3tbYxKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVA6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF2LkOxPEDPxE1? NFrNWI5USU6JRWK=
human KMOE-2 cell M1XGOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1jveWlvcGmkaYTpc44hd2ZiaIXtZY4hU02RRT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPjF5ODFOwG0> MnOyV2FPT0WU
human EM-2 cell M3PXZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUPzVZE6UW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvOjh2MTFOwG0> MYDTRW5ITVJ?
human RT-112 cell M3jRR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHXPc2xKdmirYnn0bY9vKG:oIHj1cYFvKFKWLUGxNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjN7OESg{txO MUDTRW5ITVJ?
human DB cell M{jUXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoP6TY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF3Lki1NVMh|ryP NXrFflJjW0GQR1XS
human NCI-H1770 cell NFfRd3RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEPLR|JKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7 M1vHTHNCVkeHUh?=
human CAL-54 cell NIqyOItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MULJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG2Mlc{KM7:TR?= MVXTRW5ITVJ?
human NB14 cell MlrMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3nyNWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG3MlY{QTVizszN MlviV2FPT0WU
human RPMI-7951 cell M{LYfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkX5TY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUe5OVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQS5zN{izJO69VQ>? M1HwbHNCVkeHUh?=
human T47D cell NV\ZfFdOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIe2[JBKdmirYnn0bY9vKG:oIHj1cYFvKFR2N1SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU4zOjR|IN88US=> NHfwN|FUSU6JRWK=
human A549 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3nBU2lvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlI5OTFizszN MYHTRW5ITVJ?
human A2780 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{jufGlvcGmkaYTpc44hd2ZiaIXtZY4hSTJ5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU45OjJ3IN88US=> MmrpV2FPT0WU
human SK-MEL-24 cell M{nXOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmTZTY5pcWKrdHnvckBw\iCqdX3hckBUUy2PRVytNlQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oy5yM{GxJO69VQ>? NU\WUm1tW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. [2] VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score. [3] VX-702 selectively inhibits activation of p38 MAPK after ischemia with no effects on ERKs and JNKs. The MI/AAR ratio is significantly reduced in the 50 mg/kg group compared with the 5 mg/kg and vehicle groups.[4]

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (200.34 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.3
Formula

C19H12F4N4O2

CAS No. 745833-23-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID