VX-702

For research use only.

Catalog No.S6005

28 publications

VX-702 Chemical Structure

CAS No. 745833-23-2

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.

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Selleck's VX-702 has been cited by 28 publications

Purity & Quality Control

Choose Selective p38 MAPK Inhibitors

Biological Activity

Description VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.
Features Highly selective, orally active inhibitor of p38 MAPK.
Targets
p38α [1]
(Cell-free assay)
4 nM-20 nM
In vitro

Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies. [1] VX-702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HOP-62 cell M1TxXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XDVmlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xOTV2MzFOwG0> NGTRS3ZUSU6JRWK=
human NCI-H720 cell NVH4foVHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xOTZ6MjFOwG0> MXvTRW5ITVJ?
JVM-2 cell NF3iRpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M17oPGlvcGmkaYTpc44hd2ZiaIXtZY4hUl[PLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA5OyEQvF2= NUnNWFYzW0GQR1XS
human NCI-H69 cell M33F[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnfOTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xQTl2MTFOwG0> NYnDVo5CW0GQR1XS
human BV-173 cell NFfvSYZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYTEbnpFUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjFzM{i2JO69VQ>? MWnTRW5ITVJ?
human KU812 cell MmLZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M37PXmlvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlEzPDh6IN88US=> M1O3fHNCVkeHUh?=
human DU-145 cell NXfEe5VPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUnJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTF2NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVQ2PTRizszN Mnj2V2FPT0WU
KARPAS-45 cell NXrwcIFyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGtCWlCDUz20OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTR6Mk[g{txO M3jhWnNCVkeHUh?=
human AGS cell NWPkfnRPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlvqTY5pcWKrdHnvckBw\iCqdX3hckBCT1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkG1NlUyKM7:TR?= MWfTRW5ITVJ?
human MOLT-13 cell M{HSU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEPMO3ZKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF3OUixJO69VQ>? NXPGUnYxW0GQR1XS
human NCI-H209 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFT3OINKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zN{W4JO69VQ>? MlHQV2FPT0WU
human CTV-1 cell Mm\vS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mnz0TY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVg{QDlizszN M2e2UnNCVkeHUh?=
LU-139 cell M3jrW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlTKTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE6PDN3IN88US=> NUf4c4VkW0GQR1XS
ML-2 cell M3zCXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnL4TY5pcWKrdHnvckBw\iCqdX3hckBOVC1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yNlY3OSEQvF2= NVvBV492W0GQR1XS
human K5 cell MofCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGs2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5{MkmxO{DPxE1? MYfTRW5ITVJ?
human SBC-1 cell NU\HUIh6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEe1RoxKdmirYnn0bY9vKG:oIHj1cYFvKFOEQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOzZ{IN88US=> NEjIRoxUSU6JRWK=
human COR-L88 cell MlK2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3fvOWlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVy4PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzN2ODFOwG0> M2TadnNCVkeHUh?=
human KY821 cell M{nhUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV3oZ45vUW6qaXLpeIlwdiCxZjDoeY1idiCNWUiyNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzl4MEOg{txO Mnj5V2FPT0WU
human HCC2218 cell NEf2UW5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn:5TY5pcWKrdHnvckBw\iCqdX3hckBJS0N{MkG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE41QTd{ODFOwG0> MXrTRW5ITVJ?
human ECC10 cell Mn\pS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXHyPWtTUW6qaXLpeIlwdiCxZjDoeY1idiCHQ1OxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjV|OEmg{txO NXLjeVVMW0GQR1XS
human EW-3 cell NUDpU|VIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFnGU2lKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY3PjFzIN88US=> NFfjfnVUSU6JRWK=
human EW-18 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYfjfpRtUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzR4N{mg{txO NVS2bopsW0GQR1XS
human UACC-257 cell M1v6ZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkjhTY5pcWKrdHnvckBw\iCqdX3hckBWSUOFLUK1O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjB|Mk[g{txO MnLWV2FPT0WU
human G-361 cell M1;0T2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF\hc2FKdmirYnn0bY9vKG:oIHj1cYFvKEdvM{[xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41QTVzOTFOwG0> M{\5c3NCVkeHUh?=
human HMV-II cell M4Wxb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2fTWGlvcGmkaYTpc44hd2ZiaIXtZY4hUE2YLVnJJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44PzF6NDFOwG0> NWG1NFE4W0GQR1XS
human DEL cell NHe1RVhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4G5fWlvcGmkaYTpc44hd2ZiaIXtZY4hTEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yNFcxPCEQvF2= NIe2fW9USU6JRWK=
human IGROV-1 cell MlTLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnK1TY5pcWKrdHnvckBw\iCqdX3hckBKT1KRVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OzF6ODFOwG0> NEn5SpVUSU6JRWK=
human SK-OV-3 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2noemlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvT2[tN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjF4OUeg{txO NEHCWWVUSU6JRWK=
human LAMA-84 cell NX\kb4dvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGTQfVhKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjdzMki0JO69VQ>? MUHTRW5ITVJ?
human NCI-H510A cell MoLBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoftTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWxNGEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjl{NUK2JO69VQ>? M37ZdnNCVkeHUh?=
human CP66-MEL cell MkHRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M17pUWlvcGmkaYTpc44hd2ZiaIXtZY4hS1B4Nj3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjl|NUW5JO69VQ>? MYDTRW5ITVJ?
human HAL-01 cell MkjIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWXJcohq[mm2aX;uJI9nKGi3bXHuJGhCVC1yMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlc6OThizszN MUXTRW5ITVJ?
human RS4-11 cell  NFXYWIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUfF[WlHUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjdyNUezJO69VQ>? MlrXV2FPT0WU
human RPMI-8226 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYjJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOEKyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvQDJ|N{[g{txO MYPTRW5ITVJ?
human NCI-H82 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIPOTldKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Njh7M{C1JO69VQ>? NGC4NY9USU6JRWK=
human NY cells M2f0eGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHJcohq[mm2aX;uJI9nKGi3bXHuJG5[KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5{N{[zO{DPxE1? MmPRV2FPT0WU
human MDA-MB-361 cell NYLXT5VIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF3RRpdKdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk0{PjFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkSzNVU5KM7:TR?= NV3oZWdRW0GQR1XS
human MOLT-4 cell NGrUR5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MljsTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlk6OTl|IN88US=> M4DiUHNCVkeHUh?=
human DU-4475 cell MlvYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjBXWhKdmirYnn0bY9vKG:oIHj1cYFvKESXLUS0O|Uh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjB3NU[1JO69VQ>? MVjTRW5ITVJ?
human ESS-1 cell NG\qToZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3fOVmlvcGmkaYTpc44hd2ZiaIXtZY4hTVOVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI6OTd7IN88US=> MXHTRW5ITVJ?
human NCI-H1299 cell MkPJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3XSNmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNlk6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS53M{CzN{DPxE1? MofGV2FPT0WU
human COLO-684 cell M3XsfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHLzcWVKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tOlg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS53OEG2OUDPxE1? NGToeHBUSU6JRWK=
human MV-4-11 cell M1HtWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWjlbYZDUW6qaXLpeIlwdiCxZjDoeY1idiCPVj20MVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS55MUG5PUDPxE1? MYLTRW5ITVJ?
human D-542MG cell MlXOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3;5b2lvcGmkaYTpc44hd2ZiaIXtZY4hTC13NELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvOzl{N{Kg{txO MmfuV2FPT0WU
human A4-Fuk cell M{n2W2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYjJcohq[mm2aX;uJI9nKGi3bXHuJGE1NU[3azDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uOFM3PjJizszN M1;tVHNCVkeHUh?=
human HL-60 cell M4\BPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXrCVpRUUW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPTJ{MUKg{txO Mln3V2FPT0WU
human NCI-H526 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{H1b2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjV7OECxJO69VQ>? MoTHV2FPT0WU
human L-363 cell NUO3[HQyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHHPVItKdmirYnn0bY9vKG:oIHj1cYFvKExvM{[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{44QTJ3MjFOwG0> M2PtZnNCVkeHUh?=
human A388 cell NFvmephIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFjOcphKdmirYnn0bY9vKG:oIHj1cYFvKEF|OEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlgxOzh2IN88US=> MlSyV2FPT0WU
human MS-1 NHf6W2lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{HLfGlvcGmkaYTpc44hd2ZiaIXtZY4hVVNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuPFM1PjVizszN M{XBVXNCVkeHUh?=
human JAR cell NEPB[ZFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXTUbms2UW6qaXLpeIlwdiCxZjDoeY1idiCMQWKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Mlg1QTJ|IN88US=> NIDae4RUSU6JRWK=
human TI-73 cell MkP3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIf1bnJKdmirYnn0bY9vKG:oIHj1cYFvKFSLLUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPjJ{IN88US=> NUK4WXhwW0GQR1XS
human CTB-1 cell NV3n[JZzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJGNVSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6xO|gzPSEQvF2= Mkj1V2FPT0WU
human SK-NEP-1 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4fCRmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS5|MEO4JO69VQ>? NHP5XVBUSU6JRWK=
human HT-29 cell M{iweGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFnBW5RKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUK5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQTFzMTFOwG0> Ml;BV2FPT0WU
human NCI-H1092 cell NFrUNYZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUC5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjNzODFOwG0> MV\TRW5ITVJ?
human KMOE-2 cell M1nmXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYLKXHN6UW6qaXLpeIlwdiCxZjDoeY1idiCNTV;FMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC54MUe4JO69VQ>? MWDTRW5ITVJ?
human EM-2 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4fsTmlvcGmkaYTpc44hd2ZiaIXtZY4hTU1vMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlI5PDFizszN MoP4V2FPT0WU
human RT-112 cell M4TTcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJHJVNTFzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlM6QDRizszN MWfTRW5ITVJ?
human DB cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwOEWxN{DPxE1? MkmxV2FPT0WU
human NCI-H1770 cell NXTn[pRoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NILwc3JKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7 Ml3EV2FPT0WU
human CAL-54 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF:3VnpKdmirYnn0bY9vKG:oIHj1cYFvKEODTD21OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3Njd|IN88US=> MVjTRW5ITVJ?
human NB14 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XaeGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG3MlY{QTVizszN NF;1[3JUSU6JRWK=
human RPMI-7951 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXixO3M5UW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVc6PTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zOT6xO|g{KM7:TR?= MnnEV2FPT0WU
human T47D cell NGjhO2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml7DTY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuNlI1OyEQvF2= MV\TRW5ITVJ?
human A549 cell NVvOepdTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M133NGlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlI5OTFizszN M1Xrc3NCVkeHUh?=
human A2780 cell MnjPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUDJcohq[mm2aX;uJI9nKGi3bXHuJGEzPzhyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuPFIzPSEQvF2= NYf1blR7W0GQR1XS
human SK-MEL-24 cell Ml[3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{G3OmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXMMVI1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzNwMEOxNUDPxE1? NFTlNppUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. [2] VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score. [3] VX-702 selectively inhibits activation of p38 MAPK after ischemia with no effects on ERKs and JNKs. The MI/AAR ratio is significantly reduced in the 50 mg/kg group compared with the 5 mg/kg and vehicle groups.[4]

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (200.34 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.3
Formula

C19H12F4N4O2

CAS No. 745833-23-2
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID