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VX-702

For research use only.

Catalog No.S6005

27 publications

VX-702 Chemical Structure

CAS No. 745833-23-2

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.

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Selleck's VX-702 has been cited by 27 publications

Purity & Quality Control

Choose Selective p38 MAPK Inhibitors

Biological Activity

Description VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.
Features Highly selective, orally active inhibitor of p38 MAPK.
Targets
p38α [1]
(Cell-free assay)
4 nM-20 nM
In vitro

Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies. [1] VX-702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HOP-62 cell NWOwS4dXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M13meWlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xOTV2MzFOwG0> MmfuV2FPT0WU
human NCI-H720 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnvmTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEeyNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODF4OEKg{txO MXTTRW5ITVJ?
JVM-2 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXfhfm5DUW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODh|IN88US=> Mk[wV2FPT0WU
human NCI-H69 cell NFHwcY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXPM[WFJUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yOUm0NUDPxE1? MnT6V2FPT0WU
human BV-173 cell M3nkZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{i5SWlvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yOTN6NjFOwG0> NFm0U29USU6JRWK=
human KU812 cell NFvz[2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MorMTY5pcWKrdHnvckBw\iCqdX3hckBMXThzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVI1QDhizszN NECzNFVUSU6JRWK=
human DU-145 cell NET4VWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2jYemlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvMUS1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPDV3NDFOwG0> Mom0V2FPT0WU
KARPAS-45 cell MnLGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHGwVoJKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMUS4NlYh|ryP NYXJZo96W0GQR1XS
human AGS cell NGHIVHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4CxbmlvcGmkaYTpc44hd2ZiaIXtZY4hSUeVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xOVI2OSEQvF2= NF7pTXhUSU6JRWK=
human MOLT-13 cell M1z1bWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1nDOWlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTV7OEGg{txO NGnyOXlUSU6JRWK=
human NCI-H209 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWTIdldoUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMUe1PEDPxE1? MVzTRW5ITVJ?
human CTV-1 cell M4fke2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTJcohq[mm2aX;uJI9nKGi3bXHuJGNVXi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xPFM5QSEQvF2= M1\TTnNCVkeHUh?=
LU-139 cell NIOyfWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2DadWlvcGmkaYTpc44hd2ZiaIXtZY4hVFVvMUO5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yQTR|NTFOwG0> NVLKOFNiW0GQR1XS
ML-2 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUfJcohq[mm2aX;uJI9nKGi3bXHuJG1NNTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkKyOlYyKM7:TR?= NVvxPYJzW0GQR1XS
human K5 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4rrWWlvcGmkaYTpc44hd2ZiaIXtZY4hUzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkKyPVE4KM7:TR?= MVrTRW5ITVJ?
human SBC-1 cell NFfXfnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmHKTY5pcWKrdHnvckBw\iCqdX3hckBUSkNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlM3OiEQvF2= NXracoNOW0GQR1XS
human COR-L88 cell M3rqeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3PCTmlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVy4PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzN2ODFOwG0> NYLBfmxWW0GQR1XS
human KY821 cell M{T5[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NY\ndFV7UW6qaXLpeIlwdiCxZjDoeY1idiCNWUiyNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzl4MEOg{txO MXTTRW5ITVJ?
human HCC2218 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkfkTY5pcWKrdHnvckBw\iCqdX3hckBJS0N{MkG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE41QTd{ODFOwG0> NGHlOVNUSU6JRWK=
human ECC10 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH7hNIpKdmirYnn0bY9vKG:oIHj1cYFvKEWFQ{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43PTN6OTFOwG0> M3;hfHNCVkeHUh?=
human EW-3 cell M37sPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUPJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLk[2OlEyKM7:TR?= M{\M[3NCVkeHUh?=
human EW-18 cell NYDVe3lYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUfJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD63OFY4QSEQvF2= NHHZcFRUSU6JRWK=
human UACC-257 cell M3jKO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfTTGk3UW6qaXLpeIlwdiCxZjDoeY1idiCXQVPDMVI2PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMkCzNlYh|ryP NUTHR4RtW0GQR1XS
human G-361 cell MlrPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUDYTYJ2UW6qaXLpeIlwdiCxZjDoeY1idiCJLUO2NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDl3MUmg{txO NIDiSHZUSU6JRWK=
human HMV-II cell NFPJXoJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUfZSo1QUW6qaXLpeIlwdiCxZjDoeY1idiCKTW[tTWkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd5MUi0JO69VQ>? NEjiWmJUSU6JRWK=
human DEL cell NVH5O25RT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn;yTY5pcWKrdHnvckBw\iCqdX3hckBFTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkKwO|A1KM7:TR?= NIn4foxUSU6JRWK=
human IGROV-1 cell M4jOUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXXyWoVbUW6qaXLpeIlwdiCxZjDoeY1idiCLR2LPWk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi52M{G4PEDPxE1? NFG3[W1USU6JRWK=
human SK-OV-3 cell M2jRd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWL6bWFjUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3PWk0{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54MU[5O{DPxE1? NYKzUIo3W0GQR1XS
human LAMA-84 cell MmrpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2XzUmlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzF{OESg{txO MV7TRW5ITVJ?
human NCI-H510A cell MkDqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF;v[IlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVExSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUK1NlYh|ryP NX\iTllqW0GQR1XS
human CP66-MEL cell NIjSW41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2jvTWlvcGmkaYTpc44hd2ZiaIXtZY4hS1B4Nj3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjl|NUW5JO69VQ>? M3rHdnNCVkeHUh?=
human HAL-01 cell NYXaVJloT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGhCVC1yMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlc6OThizszN M3;CTHNCVkeHUh?=
human RS4-11 cell  M3rqeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnq0TY5pcWKrdHnvckBw\iCqdX3hckBTWzRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlcxPTd|IN88US=> NWLyVZZiW0GQR1XS
human RPMI-8226 cell NEXt[5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnLmTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUiyNlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Njh{M{e2JO69VQ>? NWDP[YhHW0GQR1XS
human NCI-H82 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M121PGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvQDl|MEWg{txO MUPTRW5ITVJ?
human NY cells NWPQSVNkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFzoVJBKdmirYnn0bY9vKG:oIHj1cYFvKE6\IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yO|Y{PyEQvF2= NXX6NpdGW0GQR1XS
human MDA-MB-361 cell NWL2ZnJYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1i0XmlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVM3OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNEOxOVgh|ryP M3XDS3NCVkeHUh?=
human MOLT-4 cell NIP4d|FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NULGT41MUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Njl7MUmzJO69VQ>? NYe0UlVYW0GQR1XS
human DU-4475 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXLyW3g1UW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS5yNUW2OUDPxE1? M4m5O3NCVkeHUh?=
human ESS-1 cell NHi2bZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoPRTY5pcWKrdHnvckBw\iCqdX3hckBGW1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNlkyPzlizszN M2e2VXNCVkeHUh?=
human NCI-H1299 cell M1\5dmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEnrcG5KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVI6QSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNUOwN|Mh|ryP M2HBN3NCVkeHUh?=
human COLO-684 cell NVTJU5BjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWfBTnA2UW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVY5PCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNUixOlUh|ryP NGXvfYRUSU6JRWK=
human MV-4-11 cell M3\lW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlzoTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44OTF7OTFOwG0> NEm2dW5USU6JRWK=
human D-542MG cell MmixS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M17iUmlvcGmkaYTpc44hd2ZiaIXtZY4hTC13NELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvOzl{N{Kg{txO NWPMTVZ[W0GQR1XS
human A4-Fuk cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEnXcZNKdmirYnn0bY9vKG:oIHj1cYFvKEF2LV\1b{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPDN4NkKg{txO MUnTRW5ITVJ?
human HL-60 cell NVLUTWNOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvXXVBkUW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPTJ{MUKg{txO M1Tpe3NCVkeHUh?=
human NCI-H526 cell NYnwO5RzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3f3dWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjV7OECxJO69VQ>? NHnxNGpUSU6JRWK=
human L-363 cell M4q3Omdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkLaTY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuO|kzPTJizszN NFu1eoNUSU6JRWK=
human A388 cell M3TkTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUfZephnUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{45ODN6NDFOwG0> MmC0V2FPT0WU
human MS-1 MnvvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2D1OWlvcGmkaYTpc44hd2ZiaIXtZY4hVVNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuPFM1PjVizszN Mnn2V2FPT0WU
human JAR cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUPEPXFpUW6qaXLpeIlwdiCxZjDoeY1idiCMQWKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Mlg1QTJ|IN88US=> MUfTRW5ITVJ?
human TI-73 cell M{fFUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{HmU2lvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA3OjJizszN NHT3NHVUSU6JRWK=
human CTB-1 cell NX;SZoRST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHjWTJRKdmirYnn0bY9vKG:oIHj1cYFvKEOWQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4yPzh{NTFOwG0> M{i5XXNCVkeHUh?=
human SK-NEP-1 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkDXTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QRWCtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjNyM{ig{txO MXXTRW5ITVJ?
human HT-29 cell NXTzN3F1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFm4e21KdmirYnn0bY9vKG:oIHj1cYFvKEiWLUK5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQTFzMTFOwG0> M2C1NnNCVkeHUh?=
human NCI-H1092 cell Ml\6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUC5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjNzODFOwG0> MVvTRW5ITVJ?
human KMOE-2 cell Mn7xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJGtOV0VvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlYyPzhizszN NWXscoJ1W0GQR1XS
human EM-2 cell NVjrOoMzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVfJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNT6yPFQyKM7:TR?= MnLTV2FPT0WU
human RT-112 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;WTY5pcWKrdHnvckBw\iCqdX3hckBTXC1zMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4{QTh2IN88US=> NIrocGRUSU6JRWK=
human DB cell M4nwN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWLVVnRyUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1Mlg2OTNizszN NIXTbFVUSU6JRWK=
human NCI-H1770 cell NGfkSppIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHzmXmhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7 M1PuXXNCVkeHUh?=
human CAL-54 cell NHzZeZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{jPO2lvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUW0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvPzNizszN MXnTRW5ITVJ?
human NB14 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWPJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNz62N|k2KM7:TR?= NIHo[VVUSU6JRWK=
human RPMI-7951 cell M3vMTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXfr[mtHUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVc6PTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zOT6xO|g{KM7:TR?= MUjTRW5ITVJ?
human T47D cell MmDUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3XO[WlvcGmkaYTpc44hd2ZiaIXtZY4hXDR5RDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlIzPDNizszN M1W4T3NCVkeHUh?=
human A549 cell MmP5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXPJcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6yPFEyKM7:TR?= MlrrV2FPT0WU
human A2780 cell MmLzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYCwbnJYUW6qaXLpeIlwdiCxZjDoeY1idiCDMke4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIyNjh{MkWg{txO NFG2dppUSU6JRWK=
human SK-MEL-24 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWPWXIRtUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSWwuOjRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Mz6wN|EyKM7:TR?= MlL5V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. [2] VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score. [3] VX-702 selectively inhibits activation of p38 MAPK after ischemia with no effects on ERKs and JNKs. The MI/AAR ratio is significantly reduced in the 50 mg/kg group compared with the 5 mg/kg and vehicle groups.[4]

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (200.34 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.3
Formula

C19H12F4N4O2

CAS No. 745833-23-2
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

p38 MAPK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID