VX-702

Catalog No.S6005

VX-702 Chemical Structure

Molecular Weight(MW): 404.3

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.

Size Price Stock Quantity  
In DMSO USD 64 In stock
USD 70 In stock
USD 110 In stock
USD 370 In stock
USD 670 In stock
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Cited by 11 Publications

3 Customer Reviews

  • Reduction of IL-10 expression due to p38 inhibition is observed also in CpG-stimulated B cells and using VX-702. B cells were pre-treated with 10 uM of VX-702 for 1 h and stimulated with LPS or CpG for 24 or 48 h. Bar graphs indicate mean (±SEM) IL-10 concentrations at 48 h from n = 4 (LPS) and n = 3 (CpG) experiments. Significant differences against the no inhibitor condition were calculated using a paired Student's t-test and indicated as follows: *p < 0.05, ***p < 0.001.

    Mol Immunol 2014 62(2), 266-76. VX-702 purchased from Selleck.

     Bone marrow derived macrophages were pre-treated with the indicated concentrations of VX702 for 1h prior to LPS treatment (100 ng/ml).  TNF-a production was analyzed 24h later.

    Lee lay hoon from National University of Singapore. VX-702 purchased from Selleck.

  • J Invest Dermatol, 2018, 138(6):1380-1390. VX-702 purchased from Selleck.

Purity & Quality Control

Choose Selective p38 MAPK Inhibitors

Biological Activity

Description VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.
Features Highly selective, orally active inhibitor of p38 MAPK.
Targets
p38α [1]
(Cell-free assay)
4 nM-20 nM
In vitro

Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies. [1] VX-702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HOP-62 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4\6dmlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xOTV2MzFOwG0> NWDOPHJKW0GQR1XS
human NCI-H720 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xOTZ6MjFOwG0> M{\2UnNCVkeHUh?=
JVM-2 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wPFMh|ryP NU\tR|lFW0GQR1XS
human NCI-H69 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGfKZnBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB7OUSxJO69VQ>? MWjTRW5ITVJ?
human BV-173 cell MlTGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnnQTY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlEyOzh4IN88US=> MYLTRW5ITVJ?
human KU812 cell MoDRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3;YTGlvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlEzPDh6IN88US=> NGnl[41USU6JRWK=
human DU-145 cell MkL2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NET0ZmNKdmirYnn0bY9vKG:oIHj1cYFvKESXLUG0OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTR3NUSg{txO M3XZVnNCVkeHUh?=
KARPAS-45 cell NHzFem1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NI\CT2RKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMUS4NlYh|ryP NIC3ZWpUSU6JRWK=
human AGS cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIDYV2FKdmirYnn0bY9vKG:oIHj1cYFvKEGJUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVUzPTFizszN Mmj1V2FPT0WU
human MOLT-13 cell NWD1Z2J2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4K2c2lvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTV7OEGg{txO NELVdWdUSU6JRWK=
human NCI-H209 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2XCT2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF5NUig{txO NGnVfVhUSU6JRWK=
human CTV-1 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlfDTY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVg{QDlizszN NFuySI1USU6JRWK=
LU-139 cell M3;lWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlTLTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE6PDN3IN88US=> NInaT4hUSU6JRWK=
ML-2 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUW1VGlwUW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOjZ4MTFOwG0> MnPoV2FPT0WU
human K5 cell NUjHN|F3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4T5c2lvcGmkaYTpc44hd2ZiaIXtZY4hUzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkKyPVE4KM7:TR?= NWTWUFRtW0GQR1XS
human SBC-1 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NInaWWtKdmirYnn0bY9vKG:oIHj1cYFvKFOEQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOzZ{IN88US=> NGLpXmFUSU6JRWK=
human COR-L88 cell NH\0c41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnfsTY5pcWKrdHnvckBw\iCqdX3hckBEV1JvTEi4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{OzR6IN88US=> MUXTRW5ITVJ?
human KY821 cell NH65bJdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3f6SWlvcGmkaYTpc44hd2ZiaIXtZY4hU1l6MkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM6PjB|IN88US=> M17jRnNCVkeHUh?=
human HCC2218 cell NGW1PYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlXQTY5pcWKrdHnvckBw\iCqdX3hckBJS0N{MkG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE41QTd{ODFOwG0> MonTV2FPT0WU
human ECC10 cell MljpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGVESzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD62OVM5QSEQvF2= NHHwXJdUSU6JRWK=
human EW-3 cell NX7WbFFST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmjqTY5pcWKrdHnvckBw\iCqdX3hckBGXy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD62OlYyOSEQvF2= M17vSnNCVkeHUh?=
human EW-18 cell NH7NfnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3jVXWlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlc1Pjd7IN88US=> M1WyenNCVkeHUh?=
human UACC-257 cell NFPYVIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnPkTY5pcWKrdHnvckBw\iCqdX3hckBWSUOFLUK1O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjB|Mk[g{txO MVnTRW5ITVJ?
human G-361 cell MnLkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkLETY5pcWKrdHnvckBw\iCqdX3hckBINTN4MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFk2OTlizszN M4nJWXNCVkeHUh?=
human HMV-II cell NYPBdHNsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NG\neoVKdmirYnn0bY9vKG:oIHj1cYFvKEiPVj3JTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzdzOESg{txO NIj4Nm1USU6JRWK=
human DEL cell MlfpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYG0eYZKUW6qaXLpeIlwdiCxZjDoeY1idiCGRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIxPzB2IN88US=> MkXmV2FPT0WU
human IGROV-1 cell NEDDbXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGXnT3VKdmirYnn0bY9vKG:oIHj1cYFvKEmJUl;WMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjR|MUi4JO69VQ>? M1LCb3NCVkeHUh?=
human SK-OV-3 cell NILJPXZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHNMNU:YLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYyPjl5IN88US=> M{HFVXNCVkeHUh?=
human LAMA-84 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWKzWJk6UW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55MUK4OEDPxE1? MWHTRW5ITVJ?
human NCI-H510A cell NYX5fI4{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4LIWmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NVBCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi57MkWyOkDPxE1? NFewS45USU6JRWK=
human CP66-MEL cell MnGxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NESySndKdmirYnn0bY9vKG:oIHj1cYFvKEOSNk[tUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi57M{W1PUDPxE1? M2P4UHNCVkeHUh?=
human HAL-01 cell NITW[IRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHjaPXNKdmirYnn0bY9vKG:oIHj1cYFvKEiDTD2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOjd7MUig{txO NWPhS3NrW0GQR1XS
human RS4-11 cell  MkPtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuO|A2PzNizszN NUX0PJU2W0GQR1XS
human RPMI-8226 cell M2LUVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm\iTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUiyNlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Njh{M{e2JO69VQ>? NEP2eZVUSU6JRWK=
human NCI-H82 cell NYP3dFZST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHLTUVNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Njh7M{C1JO69VQ>? MoDWV2FPT0WU
human NY cells NHXIbXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF7Tc2ZKdmirYnn0bY9vKG:oIHj1cYFvKE6\IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yO|Y{PyEQvF2= NEm0N41USU6JRWK=
human MDA-MB-361 cell Mlm5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVrYV5NEUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOzZzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND60N|E2QCEQvF2= MlnCV2FPT0WU
human MOLT-4 cell NFLUboVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1L4OWlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE46QTF7MzFOwG0> MWrTRW5ITVJ?
human DU-4475 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTR2N{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlA2PTZ3IN88US=> MlPzV2FPT0WU
human ESS-1 cell MkXWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mmm1TY5pcWKrdHnvckBw\iCqdX3hckBGW1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNlkyPzlizszN M{m3PHNCVkeHUh?=
human NCI-H1299 cell NYHOepRMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWDnTZZ{UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFEzQTliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkWzNFM{KM7:TR?= Mnm1V2FPT0WU
human COLO-684 cell NVPOXHJ6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmrPTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLU[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPThzNkWg{txO NI\C[2pUSU6JRWK=
human MV-4-11 cell NWDUclFyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH6yfJlKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjdzMUm5JO69VQ>? NYjoPXFHW0GQR1XS
human D-542MG cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUW3bpJjUW6qaXLpeIlwdiCxZjDoeY1idiCGLUW0Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi5|OUK3NkDPxE1? NYPCVIxlW0GQR1XS
human A4-Fuk cell M3fJVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVGxdpNsUW6qaXLpeIlwdiCxZjDoeY1idiCDND3GeYsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjR|Nk[yJO69VQ>? MYLTRW5ITVJ?
human HL-60 cell MlnrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkHMTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOVIzOTJizszN M1S5cnNCVkeHUh?=
human NCI-H526 cell M3q3OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHK3dolKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py53OUiwNUDPxE1? MnXPV2FPT0WU
human L-363 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz63PVI2OiEQvF2= M{LFTHNCVkeHUh?=
human A388 cell MlnUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkiwN|g1KM7:TR?= MmLiV2FPT0WU
human MS-1 MljsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWj3WZBTUW6qaXLpeIlwdiCxZjDoeY1idiCPUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{45OzR4NTFOwG0> NFm4R5RUSU6JRWK=
human JAR cell NV:wXY9NT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWjJcohq[mm2aX;uJI9nKGi3bXHuJGpCWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwOES5NlMh|ryP NYi1O3BKW0GQR1XS
human TI-73 cell MljZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4jvOGlvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA3OjJizszN NGPUSGZUSU6JRWK=
human CTB-1 cell NVrVdWlJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFW4NIhKdmirYnn0bY9vKG:oIHj1cYFvKEOWQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4yPzh{NTFOwG0> M1r1OXNCVkeHUh?=
human SK-NEP-1 cell NWn6R|RKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlXkTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QRWCtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjNyM{ig{txO NH7JUFhUSU6JRWK=
human HT-29 cell MmHVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4rmbWlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{46OTFzIN88US=> MVXTRW5ITVJ?
human NCI-H1092 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUC5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjNzODFOwG0> M2GyeHNCVkeHUh?=
human KMOE-2 cell NXe1bI9VT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2S5[GlvcGmkaYTpc44hd2ZiaIXtZY4hU02RRT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPjF5ODFOwG0> NYjpRXZ1W0GQR1XS
human EM-2 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYLJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNT6yPFQyKM7:TR?= MnPIV2FPT0WU
human RT-112 cell M4POSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml\GTY5pcWKrdHnvckBw\iCqdX3hckBTXC1zMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4{QTh2IN88US=> NU\4dW8zW0GQR1XS
human DB cell NGe1T29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mk\VTY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF3Lki1NVMh|ryP MnfHV2FPT0WU
human NCI-H1770 cell M2ntZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYrMXIRvUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4PzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeR?= MUXTRW5ITVJ?
human CAL-54 cell NHfu[npIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGroOGJKdmirYnn0bY9vKG:oIHj1cYFvKEODTD21OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3Njd|IN88US=> NHTIVW9USU6JRWK=
human NB14 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1LISWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG3MlY{QTVizszN MXfTRW5ITVJ?
human RPMI-7951 cell NWfrbnd[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4\hRWlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST23PVUyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwMUe4N{DPxE1? MWHTRW5ITVJ?
human T47D cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUHXfHBqUW6qaXLpeIlwdiCxZjDoeY1idiCWNEfEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOjJ2MzFOwG0> NXjLcnhnW0GQR1XS
human A549 cell NUjuZlU3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYX0[IR{UW6qaXLpeIlwdiCxZjDoeY1idiCDNUS5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOjhzMTFOwG0> MmryV2FPT0WU
human A2780 cell NEGzW2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYDRe|JRUW6qaXLpeIlwdiCxZjDoeY1idiCDMke4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIyNjh{MkWg{txO NVq0SZBCW0GQR1XS
human SK-MEL-24 cell NGHie2hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2GxbmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXMMVI1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzNwMEOxNUDPxE1? NYPQeYpGW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. [2] VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score. [3] VX-702 selectively inhibits activation of p38 MAPK after ischemia with no effects on ERKs and JNKs. The MI/AAR ratio is significantly reduced in the 50 mg/kg group compared with the 5 mg/kg and vehicle groups.[4]

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (200.34 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.3
Formula

C19H12F4N4O2

CAS No. 745833-23-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID