VX-702

Catalog No.S6005

VX-702 Chemical Structure

Molecular Weight(MW): 404.3

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.

Size Price Stock Quantity  
In DMSO USD 64 In stock
USD 70 In stock
USD 110 In stock
USD 370 In stock
USD 670 In stock
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Cited by 10 Publications

3 Customer Reviews

  • Reduction of IL-10 expression due to p38 inhibition is observed also in CpG-stimulated B cells and using VX-702. B cells were pre-treated with 10 uM of VX-702 for 1 h and stimulated with LPS or CpG for 24 or 48 h. Bar graphs indicate mean (±SEM) IL-10 concentrations at 48 h from n = 4 (LPS) and n = 3 (CpG) experiments. Significant differences against the no inhibitor condition were calculated using a paired Student's t-test and indicated as follows: *p < 0.05, ***p < 0.001.

    Mol Immunol 2014 62(2), 266-76. VX-702 purchased from Selleck.

     Bone marrow derived macrophages were pre-treated with the indicated concentrations of VX702 for 1h prior to LPS treatment (100 ng/ml).  TNF-a production was analyzed 24h later.

    Lee lay hoon from National University of Singapore. VX-702 purchased from Selleck.

  • J Invest Dermatol, 2018, 138(6):1380-1390. VX-702 purchased from Selleck.

Purity & Quality Control

Choose Selective p38 MAPK Inhibitors

Biological Activity

Description VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.
Features Highly selective, orally active inhibitor of p38 MAPK.
Targets
p38α [1]
(Cell-free assay)
4 nM-20 nM
In vitro

Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies. [1] VX-702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HOP-62 cell M2mxWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\pe25KdmirYnn0bY9vKG:oIHj1cYFvKEiRUD22NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODF3NEOg{txO NEC2VndUSU6JRWK=
human NCI-H720 cell MmDMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV;vXIVmUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFczOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEG2PFIh|ryP M2DQd3NCVkeHUh?=
JVM-2 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVzJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wPFMh|ryP NH;DNnhUSU6JRWK=
human NCI-H69 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEK2fplKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB7OUSxJO69VQ>? NXvtNI1lW0GQR1XS
human BV-173 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXvpOZIxUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjFzM{i2JO69VQ>? MlK1V2FPT0WU
human KU812 cell MoXES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlXYTY5pcWKrdHnvckBw\iCqdX3hckBMXThzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVI1QDhizszN Mmm3V2FPT0WU
human DU-145 cell M2qyPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGH6TldKdmirYnn0bY9vKG:oIHj1cYFvKESXLUG0OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTR3NUSg{txO MkD5V2FPT0WU
KARPAS-45 cell NFHmVIFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4XxTWlvcGmkaYTpc44hd2ZiaIXtZY4hU0GUUFHTMVQ2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zNEiyOkDPxE1? NEfBVWpUSU6JRWK=
human AGS cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVe1SlF7UW6qaXLpeIlwdiCxZjDoeY1idiCDR2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE2OjVzIN88US=> M2TxUXNCVkeHUh?=
human MOLT-13 cell NIXUWnZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGTTbm5KdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF3OUixJO69VQ>? M4fNVnNCVkeHUh?=
human NCI-H209 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjVTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTd3ODFOwG0> M{DYO3NCVkeHUh?=
human CTV-1 cell M4exWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH:4VlBKdmirYnn0bY9vKG:oIHj1cYFvKEOWVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yQDN6OTFOwG0> NGDEdJVUSU6JRWK=
LU-139 cell NI\LRWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXnJcohq[mm2aX;uJI9nKGi3bXHuJGxWNTF|OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVk1OzVizszN NGP6V5RUSU6JRWK=
ML-2 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYfhTIpPUW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOjZ4MTFOwG0> NIXOOGVUSU6JRWK=
human K5 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\3TY5pcWKrdHnvckBw\iCqdX3hckBMPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMkK5NVch|ryP MmnFV2FPT0WU
human SBC-1 cell NV;6cIM6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2PtN2lvcGmkaYTpc44hd2ZiaIXtZY4hW0KFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI{PjJizszN M1Kx[3NCVkeHUh?=
human COR-L88 cell M1K5Nmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUDJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM{PDhizszN NIP4PG1USU6JRWK=
human KY821 cell M13r[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1[yWmlvcGmkaYTpc44hd2ZiaIXtZY4hU1l6MkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM6PjB|IN88US=> MkP6V2FPT0WU
human HCC2218 cell Mly0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHPkXppKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{KyNVgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjR7N{K4JO69VQ>? MlrNV2FPT0WU
human ECC10 cell MnrHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEPDfoNKdmirYnn0bY9vKG:oIHj1cYFvKEWFQ{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43PTN6OTFOwG0> MV;TRW5ITVJ?
human EW-3 cell NEG3NZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4\kdGlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOlY3OTFizszN NGjFTIpUSU6JRWK=
human EW-18 cell NIC1d5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrsT3hKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44PDZ5OTFOwG0> MnjVV2FPT0WU
human UACC-257 cell MkO3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3HRUGlvcGmkaYTpc44hd2ZiaIXtZY4hXUGFQz2yOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJyM{K2JO69VQ>? NFHOPGZUSU6JRWK=
human G-361 cell NIDJbldIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1[xPGlvcGmkaYTpc44hd2ZiaIXtZY4hTy1|NkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ6PTF7IN88US=> NX22W4M{W0GQR1XS
human HMV-II cell NHP2NGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{\Z[2lvcGmkaYTpc44hd2ZiaIXtZY4hUE2YLVnJJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44PzF6NDFOwG0> M3rFVHNCVkeHUh?=
human DEL cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUDlWI5FUW6qaXLpeIlwdiCxZjDoeY1idiCGRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIxPzB2IN88US=> MUDTRW5ITVJ?
human IGROV-1 cell NH3nT29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4O5[2lvcGmkaYTpc44hd2ZiaIXtZY4hUUeUT2[tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDNzOEig{txO NEDoWpRUSU6JRWK=
human SK-OV-3 cell NYDzOIQxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU:YLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYyPjl5IN88US=> MlfHV2FPT0WU
human LAMA-84 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2WxNWlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzF{OESg{txO Ml\jV2FPT0WU
human NCI-H510A cell MmjsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV\EWm5tUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUyOEFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmyOVI3KM7:TR?= MXXTRW5ITVJ?
human CP66-MEL cell NEG3NndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlnLTY5pcWKrdHnvckBw\iCqdX3hckBEWDZ4LV3FUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQTN3NUmg{txO MlPnV2FPT0WU
human HAL-01 cell NIrFNHpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnmwTY5pcWKrdHnvckBw\iCqdX3hckBJSUxvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI4QTF6IN88US=> M4fFenNCVkeHUh?=
human RS4-11 cell  NEPiTFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NViybnM5UW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjdyNUezJO69VQ>? M3PkeXNCVkeHUh?=
human RPMI-8226 cell MoXpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\Dd4JpUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVgzOjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkiyN|c3KM7:TR?= MoTqV2FPT0WU
human NCI-H82 cell NEfUbIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4\IcmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvQDl|MEWg{txO MkKzV2FPT0WU
human NY cells NHzmSoNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEOzTnNKdmirYnn0bY9vKG:oIHj1cYFvKE6\IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yO|Y{PyEQvF2= MYPTRW5ITVJ?
human MDA-MB-361 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2zOlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjR|MUW4JO69VQ>? NFzCempUSU6JRWK=
human MOLT-4 cell NWLSN|JHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mof4TY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlk6OTl|IN88US=> MnexV2FPT0WU
human DU-4475 cell M1nEcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4Kyd2lvcGmkaYTpc44hd2ZiaIXtZY4hTFVvNES3OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvODV3NkWg{txO NX\l[pBpW0GQR1XS
human ESS-1 cell NWP5NldTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEPQUWdKdmirYnn0bY9vKG:oIHj1cYFvKEWVUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4zQTF5OTFOwG0> NFS5Tm9USU6JRWK=
human NCI-H1299 cell NU\rVWp2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIrhdIdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVI6QSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNUOwN|Mh|ryP NFrSPZRUSU6JRWK=
human COLO-684 cell NF\tPGVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlPxTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLU[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPThzNkWg{txO NGq0bWdUSU6JRWK=
human MV-4-11 cell NFLDNIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{DBT2lvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzFzOUmg{txO NF7qfG9USU6JRWK=
human D-542MG cell M{\QV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HlSWlvcGmkaYTpc44hd2ZiaIXtZY4hTC13NELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvOzl{N{Kg{txO Mly0V2FPT0WU
human A4-Fuk cell NWXkW|ZWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3X5R2lvcGmkaYTpc44hd2ZiaIXtZY4hSTRvRoXrJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok41OzZ4MjFOwG0> MVXTRW5ITVJ?
human HL-60 cell Mmf3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4LITGlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlUzOjF{IN88US=> Mk\UV2FPT0WU
human NCI-H526 cell MoDNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml\HTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPTl6MEGg{txO MVHTRW5ITVJ?
human L-363 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz63PVI2OiEQvF2= NVfKXYFuW0GQR1XS
human A388 cell M1LI[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFr2So9KdmirYnn0bY9vKG:oIHj1cYFvKEF|OEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlgxOzh2IN88US=> M2HpSHNCVkeHUh?=
human MS-1 MnvkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml7LTY5pcWKrdHnvckBw\iCqdX3hckBOWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64N|Q3PSEQvF2= NF\5SVdUSU6JRWK=
human JAR cell NIPIWZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWjS[YhKUW6qaXLpeIlwdiCxZjDoeY1idiCMQWKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Mlg1QTJ|IN88US=> MoTpV2FPT0WU
human TI-73 cell NGGzW4xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVfJcVEyUW6qaXLpeIlwdiCxZjDoeY1idiCWST23N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvODZ{MjFOwG0> NVnBSJl1W0GQR1XS
human CTB-1 cell MoP2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3fDOWlvcGmkaYTpc44hd2ZiaIXtZY4hS1SELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlE4QDJ3IN88US=> MWPTRW5ITVJ?
human SK-NEP-1 cell MmHYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXTJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU6HUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOzB|ODFOwG0> NHTwPZBUSU6JRWK=
human HT-29 cell MmLZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M17kdmlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{46OTFzIN88US=> NYfpRVZxW0GQR1XS
human NCI-H1092 cell Ml7JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NW\DTo51UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFExQTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND6zNVgh|ryP MXXTRW5ITVJ?
human KMOE-2 cell MknHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MleyTY5pcWKrdHnvckBw\iCqdX3hckBMVU:HLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE43OTd6IN88US=> NFXk[oxUSU6JRWK=
human EM-2 cell NFPUTVZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{nzV2lvcGmkaYTpc44hd2ZiaIXtZY4hTU1vMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlI5PDFizszN MnTiV2FPT0WU
human RT-112 cell NEfuSYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV7a[HcyUW6qaXLpeIlwdiCxZjDoeY1idiCUVD2xNVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS5|OUi0JO69VQ>? NFLYZm5USU6JRWK=
human DB cell NWPDblY3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHO5OJNKdmirYnn0bY9vKG:oIHj1cYFvKESEIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuPFUyOyEQvF2= NX75cYNMW0GQR1XS
human NCI-H1770 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWHKdoNwUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4PzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeR?= NXvKZZNPW0GQR1XS
human CAL-54 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2PUZ2lvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUW0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvPzNizszN MYHTRW5ITVJ?
human NB14 cell MnXsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWDJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNz62N|k2KM7:TR?= M1rtRnNCVkeHUh?=
human RPMI-7951 cell NH\hUpJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH;JSplKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtO|k2OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF7LkG3PFMh|ryP M3jMS3NCVkeHUh?=
human T47D cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUfJcohq[mm2aX;uJI9nKGi3bXHuJHQ1P0RiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6yNlQ{KM7:TR?= NH7lfFNUSU6JRWK=
human A549 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmPxTY5pcWKrdHnvckBw\iCqdX3hckBCPTR7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuNlgyOSEQvF2= M2[wbnNCVkeHUh?=
human A2780 cell NFvyR5VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2DvZ2lvcGmkaYTpc44hd2ZiaIXtZY4hSTJ5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU45OjJ3IN88US=> MmP1V2FPT0WU
human SK-MEL-24 cell NH;TR4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHHQW25KdmirYnn0bY9vKG:oIHj1cYFvKFONLV3FUE0zPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN|LkCzNVEh|ryP MnPEV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. [2] VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score. [3] VX-702 selectively inhibits activation of p38 MAPK after ischemia with no effects on ERKs and JNKs. The MI/AAR ratio is significantly reduced in the 50 mg/kg group compared with the 5 mg/kg and vehicle groups.[4]

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (200.34 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.3
Formula

C19H12F4N4O2

CAS No. 745833-23-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00395577 Completed Rheumatoid Arthritis Vertex Pharmaceuticals Incorporated November 2006 Phase 2
NCT00395577 Completed Rheumatoid Arthritis Vertex Pharmaceuticals Incorporated November 2006 Phase 2
NCT00205478 Completed Rheumatoid Arthritis Vertex Pharmaceuticals Incorporated June 2005 Phase 2
NCT00205478 Completed Rheumatoid Arthritis Vertex Pharmaceuticals Incorporated June 2005 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

Related p38 MAPK Products4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID