Plerixafor (AMD3100) 8HCl
For research use only.
Catalog No.S3013 Synonyms: JM 3100 8HCl
CAS No. 155148-31-5
Plerixafor (AMD3100, JM 3100) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.
Selleck's Plerixafor (AMD3100) 8HCl has been cited by 28 publications
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|Description||Plerixafor (AMD3100, JM 3100) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.|
Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4.  Plerixafor also antagonizes SDF-1/CXCL12 ligand binding with an IC50 of 651 nM. Plerixafor inhibits SDF-1 mediated GTP-binding, SDF-1 mediated calcium flux and SDF-1 stimulated chemotaxis with IC50 of 27 nM, 572 nM and 51 nM, respectively. Plerixafor does not inhibit calcium flux against cells expressing CXCR3, CCR1, CCR2b, CCR4, CCR5 or CCR7 when stimulated with their cognate ligands, nor does Plerixafor inhibit receptor binding of LTB4. Plerixafor does not, on its own, induce a calcium flux in the CCRF–CEM cells, which express multiple GPCRs including CXCR4, CCR4 and CCR7. 
|In vivo||A single topical application of Plerixafor promotes wound healing in diabetic mice by increasing cytokine production, mobilizing bone marrow EPCs, and enhancing the activity of fibroblasts and monocytes/macrophages, thereby increasing both angiogenesis and vasculogenesis.  Cohorts of mice are administered with PBS, IGF1, PDGF, SCF, or VEGF for five consecutive days and Plerixafor on the 5th day. The number and size of the colonies are highest in IGF1 plus Plerixafor injected mice compared to PDGF, SCF and VEGF treated groups, in combination with Plerixafor. |
|In vitro||Water||100 mg/mL (125.87 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||JM 3100 8HCl|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04646603||Active not recruiting||Drug: MRG-001|Drug: Placebo||COVID-19||MedRegen LLC|ICON plc||January 28 2021||Phase 1|Phase 2|
|NCT03547830||Recruiting||Drug: Plerixafor|Drug: Gcsf||Chronic Granulomatous Disease||Federal Research Institute of Pediatric Hematology Oncology and Immunology||April 13 2019||Phase 2|
|NCT03653247||Recruiting||Biological: Plerixafor|Drug: Busulfan|Genetic: BIVV003||Sickle Cell Disease||Bioverativ a Sanofi company|Sanofi||March 6 2019||Phase 1|Phase 2|
|NCT03442673||Recruiting||Drug: Vinorelbine|Drug: Gemcitabine|Drug: G-CSF||Multiple Myeloma||University Hospital Inselspital Berne||September 17 2018||Phase 2|
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