WZ811

Catalog No.S2912

For research use only.

WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.

WZ811 Chemical Structure

CAS No. 55778-02-4

Selleck's WZ811 has been cited by 14 publications

Purity & Quality Control

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Biological Activity

Description WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.
Targets
CXCR4 [1]
0.3 nM(EC50)
In vitro

WZ811 is a highly potent competitive antagonist of CXCR4. WZ811 is effective in counteracting SDF-1 on cAMP reduction at doses as low as a few nanomoles. WZ811 blocks SDF-1-mediated invasion with EC50 of 5.2 nM. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 290.36
Formula

 

C18H18N4
 
CAS No. 55778-02-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=NC(=C1)NCC2=CC=C(C=C2)CNC3=CC=CC=N3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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