Catalog No.S7551 Synonyms: PPLGM, Piplartine

Piperlongumine Chemical Structure

Molecular Weight(MW): 317.34

Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.

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Cited by 7 Publications

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  • a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.

    Oncotarget, 2016, 7(35):56933-56943. Piperlongumine purchased from Selleck.

    MPC cells were treated with the indicated concentrations of PL at 21% and 1% O2 for 24 hours. Total cell lysates were subjected to Western blot with antibodies against cleaved PARP, cleaved caspase 3, and caspase 3. β-tubulin was used as a loading control. A representative image (n=3) is shown.

    Oncotarget, 2016, 7(26):40531-40545. Piperlongumine purchased from Selleck.

Purity & Quality Control

Choose Selective ROS Inhibitors

Biological Activity

Description Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
reactive oxygen species (ROS) [1] TrxR1 [5] CRM1 [6] PI3K/Akt/mTOR [7]
In vitro

Piperlongumine is a known ROS inducer which could induce pancreatic cancer cell death in cell culture[1] As a thromboxane A(2) receptor antagonist, Piperlongumine inhibits platelet aggregation. [2] Piperlongumine also promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MA9.3 cells NIjM[JhEgXSxdH;4bYNqfHliYYPzZZk> Mlm5OFghcA>? MlznR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWE6NjNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yJO69VQ>? NXrUN3hrOjV2NkS4PFc>
mouse RAW264.7 cells NHjqfmVHfW6ldHnvckBie3OjeR?= M{PwbGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDOU{Bxem:mdXP0bY9vNCCLQ{WwQVMh|ryP MoG1NlU1PTN6MEm=
PANC1 cells NE\ZbJREgXSxdH;4bYNqfHliYYPzZZk> M4jZOFI1KGh? NUL5bpdzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQhemWmdXP0bY9vKGG|c3H5MEBKSzVyPUOuNkDPxE1? MYqyOVMxPTdzOB?=
SK-MEL-2 cells NEjwSpBRem:uaX\ldoF1cW:wIHHzd4F6 NYHSVoJUPzJiaB?= NVPzUIR4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT{1OTUxvMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCHQ{WwQVQvOzlizszN M3Ts[lI2QDJ4M{m4
HaCaT cells M1LFPHBzd2yrZnXyZZRqd25iYYPzZZk> MXm3NkBp M{PKRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHHDZXQh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygSWM2OD12LkS2JO69VQ>? NEXkdJUzPTh{NkO5PC=>
ZR75-30 cells MlfxR5l1d3SxeHnjbZR6KGG|c3H5 MWe3NkBp M3TD[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHpTPzVvM{CgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF02Njh4IN88US=> M3uxPFI1QTN5MUi2
HCT116 cells NVLvdYdDS3m2b4TvfIlkcXS7IHHzd4F6 NGXIbYQ4OiCq MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME22MlA1KM7:TR?= MoDmNlQ6OzdzOE[=
A375 cells NXWwb|M2WHKxbHnm[ZJifGmxbjDhd5NigQ>? NYLU[2V[PzJiaB?= MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF|N{WgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiRVO1NF03NjF5IN88US=> NXH2eVZVOjV6Mk[zPVg>
MDA-MB-231 cells NFjrdJpEgXSxdH;4bYNqfHliYYPzZZk> MUS3NkBp MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:QC52NjFOwG0> MXeyOFk{PzF6Nh?=
A549 cells NIW3XHJRem:uaX\ldoF1cW:wIHHzd4F6 NUDwOId2PzJiaB?= M1K4dmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDFR|UxRTF{LkKg{txO NFHLc3MzPTh{NkO5PC=>
HFF1 cells NFex[4RRem:uaX\ldoF1cW:wIHHzd4F6 MlqxO|IhcA>? Mk\5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDISmYyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;MUOuNUDPxE1? NUHyZphwOjV6Mk[zPVg>
MCF10A cells MkjaVJJwdGmoZYLheIlwdiCjc4PhfS=> NIXlXI04OiCq MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkGwRUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDFR|UxRTF6LkGg{txO NV2yO21NOjV6Mk[zPVg>
WI38 cells NUHaNHdoS3m2b4TvfIlkcXS7IHHzd4F6 NEj5epg4OiCq M4P2R2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHdKOzhiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yOk44QCEQvF2= MYeyOFk{PzF6Nh?=
MRC5 cells MWXDfZRwfG:6aXPpeJkh[XO|YYm= NWTTO|ZpPzJiaB?= MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNVmM2KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;M{WuNFQh|ryP MUGyOFk{PzF6Nh?=

... Click to View More Cell Line Experimental Data

In vivo Piperlongumine (50 mg/kg i.p.) causes in vivo growth inhibition of tumor cells without leading to major changes in the biochemical, hematological and histopathological parameters. [4]


Cell Research:


+ Expand
  • Cell lines: MCF-7 and 786-O cells
  • Concentrations: ~10 μM
  • Incubation Time: 48 hours
  • Method:

    MCF-7 and 786-O cells are incubated with various PL concentrations for 48h. Cell proliferation is analysed by CellTiter Blue assay. Effective doses (ED) are calculated using XLift, Microsoft Excel add-in.

    (Only for Reference)
Animal Research:


+ Expand
  • Animal Models: Mice transplanted with sarcoma 180 tumors
  • Formulation: 4% DMSO
  • Dosages: ~50 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 16 mg/mL warmed (50.41 mM)
Ethanol 6 mg/mL warmed (18.9 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 317.34


CAS No. 20069-09-4
Storage powder
in solvent
Synonyms PPLGM, Piplartine

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID