CRM1

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CRM1 Products

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  • CRM1 Inhibitors (7)
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Catalog No. Product Name Information Product Use Citations Product Validations
S7125 KPT-185 KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
Oncotarget, 2020, 11(36):3371-3386
EMBO Rep, 2019, 20(11):e48150
Exp Cell Res, 2019, 10.1016/j.yexcr.2019.111505
S7251 KPT-276 KPT-276 is an orally bioavailable selective CRM1 inhibitor.
Elife, 2021, 10e67587
Front Oncol, 2020, 10:1424
Nat Commun, 2019, 10(1):3827
S7252 Selinexor (KPT-330) Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
Cell Rep, 2022, 38(10):110472
Cell Death Dis, 2022, 13(2):174
Neoplasia, 2022, 26:100776
S7551 Piperlongumine Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Nat Commun, 2022, 13(1):107
SLAS Discov, 2021, 24725552211020678
S7580New Leptomycin B Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
S7707 Verdinexor (KPT-335) Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.
Cell Rep, 2022, 38(10):110472
Ecotoxicol Environ Saf, 2021, 208:111668
Cancers (Basel), 2020, 12(11)E3335
S8397 Eltanexor (KPT-8602) Eltanexor (KPT-8602, ONO-7706,ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
J Hematol Oncol, 2021, 14(1):97
Cell Death Dis, 2021, 12(1):29
Oncol Rep, 2021, 46(2)170
S7125 KPT-185 KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
Oncotarget, 2020, 11(36):3371-3386
EMBO Rep, 2019, 20(11):e48150
Exp Cell Res, 2019, 10.1016/j.yexcr.2019.111505
S7251 KPT-276 KPT-276 is an orally bioavailable selective CRM1 inhibitor.
Elife, 2021, 10e67587
Front Oncol, 2020, 10:1424
Nat Commun, 2019, 10(1):3827
S7252 Selinexor (KPT-330) Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
Cell Rep, 2022, 38(10):110472
Cell Death Dis, 2022, 13(2):174
Neoplasia, 2022, 26:100776
S7551 Piperlongumine Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Nat Commun, 2022, 13(1):107
SLAS Discov, 2021, 24725552211020678
S7580New Leptomycin B Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
S7707 Verdinexor (KPT-335) Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.
Cell Rep, 2022, 38(10):110472
Ecotoxicol Environ Saf, 2021, 208:111668
Cancers (Basel), 2020, 12(11)E3335
S8397 Eltanexor (KPT-8602) Eltanexor (KPT-8602, ONO-7706,ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
J Hematol Oncol, 2021, 14(1):97
Cell Death Dis, 2021, 12(1):29
Oncol Rep, 2021, 46(2)170
S7580New Leptomycin B Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.