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CRM1 Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S7252 Selinexor (KPT-330) Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Leukemia, 2025, 39(1):75-86
Cancer Lett, 2025, 613:217501
S7551 Piperlongumine Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
Biochim Biophys Acta Mol Basis Dis, 2025, 1871(3):167687
Eur J Pharmacol, 2025, 997:177478
NPJ Aging, 2025, 11(1):6
S8397 Eltanexor (KPT-8602) Eltanexor (KPT-8602, ONO-7706，ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
J Transl Med, 2025, 23(1):62
Gastroenterology, 2024, S0016-5085(24)00062-3
Cells, 2024, 13(7)632
S7125 KPT-185 KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
Cell Chem Biol, 2022, S2451-9456(22)00275-6
Oncotarget, 2020, 11(36):3371-3386
EMBO Rep, 2019, 20(11):e48150
S7707 Verdinexor (KPT-335) Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.
J Transl Med, 2025, 23(1):62
J Biomed Sci, 2022, 29(1):44
Cell Rep, 2022, 38(10):110472
S7251 KPT-276 KPT-276 is an orally bioavailable selective CRM1 inhibitor.
Elife, 2021, 10e67587
Front Oncol, 2020, 10:1424
Nat Commun, 2019, 10(1):3827
S7580 Leptomycin B Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
Cells, 2024, 13(22)1855
Biochem Biophys Rep, 2024, 39:101793
bioRxiv, 2024, 2024.04.24.590854
S7252 Selinexor (KPT-330) Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Leukemia, 2025, 39(1):75-86
Cancer Lett, 2025, 613:217501
S7551 Piperlongumine Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
Biochim Biophys Acta Mol Basis Dis, 2025, 1871(3):167687
Eur J Pharmacol, 2025, 997:177478
NPJ Aging, 2025, 11(1):6
S8397 Eltanexor (KPT-8602) Eltanexor (KPT-8602, ONO-7706，ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
J Transl Med, 2025, 23(1):62
Gastroenterology, 2024, S0016-5085(24)00062-3
Cells, 2024, 13(7)632
S7125 KPT-185 KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
Cell Chem Biol, 2022, S2451-9456(22)00275-6
Oncotarget, 2020, 11(36):3371-3386
EMBO Rep, 2019, 20(11):e48150
S7707 Verdinexor (KPT-335) Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.
J Transl Med, 2025, 23(1):62
J Biomed Sci, 2022, 29(1):44
Cell Rep, 2022, 38(10):110472
S7251 KPT-276 KPT-276 is an orally bioavailable selective CRM1 inhibitor.
Elife, 2021, 10e67587
Front Oncol, 2020, 10:1424
Nat Commun, 2019, 10(1):3827
S7580 Leptomycin B Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
Cells, 2024, 13(22)1855
Biochem Biophys Rep, 2024, 39:101793
bioRxiv, 2024, 2024.04.24.590854

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