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Technical Data
| Formula | C17H14F2N2 |
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| Molecular Weight | 284.3 | CAS No. | 1139889-93-2 | |
| Solubility (25°C)* | In vitro | DMSO | 57 mg/mL (200.49 mM) | |
| Ethanol | 4 mg/mL (14.06 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Golgicide A is a potent and rapidly reversible GBF1 inhibitor. | |
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| In vitro | Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. [1] Golgicide A decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition, Golgicide A causes redistribution of NS5A and accumulation of infectious viral particles in J6/JFH1 cells. [2] |
Protocol (from reference)
References
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Customer Product Validation
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Data from [Data independently produced by , , J Biosci, 2017, 42(1):43-56]
Selleck's Golgicide A has been cited by 9 publications
| STING1 is essential for an RNA-virus triggered autophagy [ Autophagy, 2021, 1-13] | PubMed: 34338134 |
| The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction [ Front Cell Dev Biol, 2021, 9:706768] | PubMed: 34513838 |
| Autophagy induction via STING trafficking is a primordial function of the cGAS pathway [Gui X, et al Nature, 2019, 567(7747):262-266] | PubMed: 30842662 |
| Niclosamide Triggers Non-Canonical LC3 Lipidation [ Cells, 2019, 8(3)] | PubMed: 30875964 |
| Regulatory role of Golgi brefeldin A resistance factor-1 in amyloid precursor protein trafficking, cleavage and Aβ formation. [ J Cell Biochem, 2019, 120(9):15604-15615] | PubMed: 31111546 |
| Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression [Yan H J Nat Med, 2019, 10.1007/s11418-019-01287-7] | PubMed: 30758716 |
| Intracellular trafficking of begomoviruses in the midgut cells of their insect vector [ PLoS Pathog, 2018, 14(1):e1006866] | PubMed: 29370296 |
| CSFV proliferation is associated with GBF1 and Rab2 [Liang W J Biosci, 2017, 42(1):43-56] | PubMed: 28229964 |
| Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy [ Cell Death Dis, 2016, 7(8):e2330] | PubMed: 27512951 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.