For research use only.

Catalog No.S4097 Synonyms: NSC 92336

Dydrogesterone Chemical Structure

CAS No. 152-62-5

Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
progestogen Receptor [1]
In vitro

Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. [1]

In vivo Dydrogesterone abrogates stress-triggered increase of the abortion rate in mice. Dydrogesterone restores the percentage of CD8+ uterus cells back to levels seen in control mice. Dydrogesterone significantly lowers the relative number of TNF-α-producing uterine cells on days 7.5, 9.5, and even on 10.5 in mice. Dydrogesterone results in significantly higher percentages of pregnancy protective IL-4+ uterus cells beginning on gestation day 7.5 and, even more strikingly, maintained until day 10.5 in stressed mice. [2] Dydrogesterone abrogates the highly elevated abortion rate of the abortion rate in mice exposured to sound stress. Dydrogesterone increases levels of plasma PIBF in stressed mice, but does not affect progesterone levels. Dydrogesterone dramatically increases the percentage of IL-4 positive decidual immune cells in stressed mice. [3]


Solubility (25°C)

In vitro DMSO 63 mg/mL (201.63 mM)
Water Insoluble
Ethanol '63 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 312.45


CAS No. 152-62-5
Storage powder
in solvent
Synonyms NSC 92336
Smiles CC(=O)C1CCC2C1(CCC3C2C=CC4=CC(=O)CCC34C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04287205 Completed Drug: Dydrogesterone Endometriosis|Sexual Dysfunction Kanuni Sultan Suleyman Training and Research Hospital April 20 2019 Not Applicable
NCT02706470 Unknown status Drug: Cyclosporin A|Drug: Dydrogesterone Miscarriage Recurrent Fudan University May 2016 Phase 2|Phase 3
NCT01711216 Completed -- Irregular Menstrual Cycle Abbott August 2012 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Estrogen/progestogen Receptor Signaling Pathway Map

Related Estrogen/progestogen Receptor Products

Tags: buy Dydrogesterone | Dydrogesterone ic50 | Dydrogesterone price | Dydrogesterone cost | Dydrogesterone solubility dmso | Dydrogesterone purchase | Dydrogesterone manufacturer | Dydrogesterone research buy | Dydrogesterone order | Dydrogesterone mouse | Dydrogesterone chemical structure | Dydrogesterone mw | Dydrogesterone molecular weight | Dydrogesterone datasheet | Dydrogesterone supplier | Dydrogesterone in vitro | Dydrogesterone cell line | Dydrogesterone concentration | Dydrogesterone nmr
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID