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Dydrogesterone Estrogen/progestogen Receptor agonist

Name: Dydrogesterone
Brand: Selleck Chemicals
SKU: S4097
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4097

Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.

Chemical Structure

Molecular Weight: 312.45

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.99%

99.99

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Chemical Information, Storage & Stability

Molecular Weight	312.45	Formula	C₂₁H₂₈O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	152-62-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	NSC 92336			Smiles	CC(=O)C1CCC2C1(CCC3C2C=CC4=CC(=O)CCC34C)C

Solubility

In vitro
Batch:

DMSO : 62 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	progestogen Receptor ^[1]
In vitro	Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. ^[1]
In vivo	Dydrogesterone abrogates stress-triggered increase of the abortion rate in mice. This compound restores the percentage of CD8+ uterus cells back to levels seen in control mice. It significantly lowers the relative number of TNF-α-producing uterine cells on days 7.5, 9.5, and even on 10.5 in mice. This chemical results in significantly higher percentages of pregnancy protective IL-4+ uterus cells beginning on gestation day 7.5 and, even more strikingly, maintained until day 10.5 in stressed mice. ^[2] It abrogates the highly elevated abortion rate of the abortion rate in mice exposured to sound stress. This compound increases levels of plasma PIBF in stressed mice, but does not affect progesterone levels. It dramatically increases the percentage of IL-4 positive decidual immune cells in stressed mice. ^[3]
References	[1] https://pubmed.ncbi.nlm.nih.gov/16963030/ [2] https://pubmed.ncbi.nlm.nih.gov/15128769/ [3] https://pubmed.ncbi.nlm.nih.gov/14667986/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05186779	Terminated	Early Pregnancy Bleeding\|Recurrent Pregnancy Loss	Center for Epidemiology and Health Research Germany\|Abbott Products Operations AG	December 15 2021	--
NCT04287205	Completed	Endometriosis\|Sexual Dysfunction	Kanuni Sultan Suleyman Training and Research Hospital	April 20 2019	Not Applicable
NCT02706470	Unknown status	Miscarriage Recurrent	Fudan University	May 2016	Phase 2\|Phase 3
NCT01711216	Completed	Irregular Menstrual Cycle	Abbott	August 2012	--

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