Dydrogesterone

Synonyms: NSC 92336

Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.

Dydrogesterone Chemical Structure

Dydrogesterone Chemical Structure

CAS: 152-62-5

Purity & Quality Control

Batch: Purity: 99.99%
99.99

Dydrogesterone Related Products

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
Targets
progestogen Receptor [1]
In vitro
In vitro Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. [1]
In Vivo
In vivo Dydrogesterone abrogates stress-triggered increase of the abortion rate in mice. Dydrogesterone restores the percentage of CD8+ uterus cells back to levels seen in control mice. Dydrogesterone significantly lowers the relative number of TNF-α-producing uterine cells on days 7.5, 9.5, and even on 10.5 in mice. Dydrogesterone results in significantly higher percentages of pregnancy protective IL-4+ uterus cells beginning on gestation day 7.5 and, even more strikingly, maintained until day 10.5 in stressed mice. [2] Dydrogesterone abrogates the highly elevated abortion rate of the abortion rate in mice exposured to sound stress. Dydrogesterone increases levels of plasma PIBF in stressed mice, but does not affect progesterone levels. Dydrogesterone dramatically increases the percentage of IL-4 positive decidual immune cells in stressed mice. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05186779 Terminated
Early Pregnancy Bleeding|Recurrent Pregnancy Loss
Center for Epidemiology and Health Research Germany|Abbott Products Operations AG
December 15 2021 --
NCT04287205 Completed
Endometriosis|Sexual Dysfunction
Kanuni Sultan Suleyman Training and Research Hospital
April 20 2019 Not Applicable
NCT02706470 Unknown status
Miscarriage Recurrent
Fudan University
May 2016 Phase 2|Phase 3
NCT01711216 Completed
Irregular Menstrual Cycle
Abbott
August 2012 --

Chemical Information & Solubility

Molecular Weight 312.45 Formula

C21H28O2

CAS No. 152-62-5 SDF Download Dydrogesterone SDF
Smiles CC(=O)C1CCC2C1(CCC3C2C=CC4=CC(=O)CCC34C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (198.43 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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