Dydrogesterone

Catalog No.S4097 Synonyms: NSC 92336

For research use only.

Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.

Dydrogesterone Chemical Structure

CAS No. 152-62-5

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Biological Activity

Description Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
Targets
progestogen Receptor [1]
In vitro

Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. [1]

In vivo Dydrogesterone abrogates stress-triggered increase of the abortion rate in mice. Dydrogesterone restores the percentage of CD8+ uterus cells back to levels seen in control mice. Dydrogesterone significantly lowers the relative number of TNF-α-producing uterine cells on days 7.5, 9.5, and even on 10.5 in mice. Dydrogesterone results in significantly higher percentages of pregnancy protective IL-4+ uterus cells beginning on gestation day 7.5 and, even more strikingly, maintained until day 10.5 in stressed mice. [2] Dydrogesterone abrogates the highly elevated abortion rate of the abortion rate in mice exposured to sound stress. Dydrogesterone increases levels of plasma PIBF in stressed mice, but does not affect progesterone levels. Dydrogesterone dramatically increases the percentage of IL-4 positive decidual immune cells in stressed mice. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 312.45
Formula

C21H28O2

CAS No. 152-62-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)C1CCC2C1(CCC3C2C=CC4=CC(=O)CCC34C)C

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05186779 Recruiting Drug: Progestagen Early Pregnancy Bleeding|Recurrent Pregnancy Loss Center for Epidemiology and Health Research Germany|Abbott Products Operations AG December 15 2021 --
NCT04287205 Completed Drug: Dydrogesterone Endometriosis|Sexual Dysfunction Kanuni Sultan Suleyman Training and Research Hospital April 20 2019 Not Applicable
NCT02706470 Unknown status Drug: Cyclosporin A|Drug: Dydrogesterone Miscarriage Recurrent Fudan University May 2016 Phase 2|Phase 3
NCT01711216 Completed -- Irregular Menstrual Cycle Abbott August 2012 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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