Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Licochalcone A

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Licochalcone A Estrogen/progestogen Receptor agonist

Cat.No.S7828

Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.
Licochalcone A Estrogen/progestogen Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 338.4

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Quality Control

Batch: S782801 DMSO]67 mg/mL]false]Ethanol]67 mg/mL]false]Water]Insoluble]false Purity: 99.93%
99.93

Chemical Information, Storage & Stability

Molecular Weight 338.4 Formula

C21H22O4

 Storage (From the date of receipt)
CAS No. 58749-22-7 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O

Solubility

In vitro
Batch:

DMSO : 67 mg/mL (197.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 67 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vitro
Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. [1] This compound shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL. [3] In CT-26 colon cancer cells, it reduces the cell viability and DNA synthesis. [4] It also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis. [5]
In vivo
In mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, this compound (150 mg/kg, p.o.) results in > 65 and 85% reductions of parasite loads in the liver and the spleen, respectively. [2] In CT-26 cell-inoculated Balb/c mice, this chemical (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity. [4]
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/18484961/
  • [5] https://pubmed.ncbi.nlm.nih.gov/25981581/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04002024 Completed
Acne Vulgaris|Acne
Mahidol University|Beiersdorf
 June 1 2019 Not Applicable

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