Licochalcone A

Catalog No.S7828

Licochalcone A Chemical Structure

Molecular Weight(MW): 338.4

Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.

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Biological Activity

Description Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.
In vitro

Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. [1] Licochalcone A shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL. [3] In CT-26 colon cancer cells, Licochalcone A reduces the cell viability and DNA synthesis. [4] Licochalcone A also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis. [5]

In vivo In mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, licochalcone A (150 mg/kg, p.o.) results in > 65 and 85% reductions of parasite loads in the liver and the spleen, respectively. [2] In CT-26 cell-inoculated Balb/c mice, licochalcone A (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity. [4]

Protocol

Cell Research: [4]
+ Expand
  • Cell lines: CT-26 cells
  • Concentrations: ~20 μM
  • Incubation Time: 72 hours
  • Method: The viability of CT-26 mouse colon cancer cells is determined via a MTT assay. In brief, colon cancer cells are seeded onto each well of a 96-well plate with DMEM containing 10% FBS and cultured to adhere overnight. The cells are then treated with various concentrations of LCA in serum-free medium for 24 and 72 hr, respectively. Twenty microlitres of a MTT solution (5 mg/ml) is added to each well, and the cells are incubated for 4 hr at 37°. The medium is then removed, and 200 µL of dimethyl sulfoxide is added to each well. The absorbance is determined at 570 nm using a microplate reader.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: Mice infected with L. major
  • Formulation: Dissolved in 20 uL of 99% (v/v) ethanol and suspended in 1% carboxymethyl cellulose (CMC) solution.
  • Dosages: 5 mg/kg/day
  • Administration: i.p. or p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 67 mg/mL (197.99 mM)
Ethanol 67 mg/mL (197.99 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 338.4
Formula

C21H22O4

CAS No. 58749-22-7
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02173054 Completed Acne Mahidol University July 2014 Phase 3
NCT03292822 Not yet recruiting Squamous Cell Carcinoma Cairo University November 1 2017 Early Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID