Molecular Weight(MW): 338.4
Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.
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|Description||Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.|
Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells.  Licochalcone A shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL.  In CT-26 colon cancer cells, Licochalcone A reduces the cell viability and DNA synthesis.  Licochalcone A also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis. 
|In vivo||In mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, licochalcone A (150 mg/kg, p.o.) results in > 65 and 85% reductions of parasite loads in the liver and the spleen, respectively.  In CT-26 cell-inoculated Balb/c mice, licochalcone A (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity. |
|Cell Research: ||
-  Chen M, et al. Antimicrob Agents Chemother. 1993, 37(12), 2550-2556.
-  Chen M, et al. Antimicrob Agents Chemother. 1994, 38(6), 1339-1344.
-  Tsukiyama R, et al. Antimicrob Agents Chemother. 2002, 46(5), 1226-1230.
|In vitro||DMSO||67 mg/mL (197.99 mM)|
|Ethanol||67 mg/mL (197.99 mM)|
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