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Technical Data
| Formula | C21H28O2 |
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| Molecular Weight | 312.45 | CAS No. | 152-62-5 | |
| Solubility (25°C)* | In vitro | DMSO | 63 mg/mL (201.63 mM) | |
| Ethanol | 63 mg/mL (201.63 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. | |
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| In vitro | Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. [1] | |
| In vivo | Dydrogesterone abrogates stress-triggered increase of the abortion rate in mice. Dydrogesterone restores the percentage of CD8+ uterus cells back to levels seen in control mice. Dydrogesterone significantly lowers the relative number of TNF-α-producing uterine cells on days 7.5, 9.5, and even on 10.5 in mice. Dydrogesterone results in significantly higher percentages of pregnancy protective IL-4+ uterus cells beginning on gestation day 7.5 and, even more strikingly, maintained until day 10.5 in stressed mice. [2] Dydrogesterone abrogates the highly elevated abortion rate of the abortion rate in mice exposured to sound stress. Dydrogesterone increases levels of plasma PIBF in stressed mice, but does not affect progesterone levels. Dydrogesterone dramatically increases the percentage of IL-4 positive decidual immune cells in stressed mice. [3] |
Protocol (from reference)
References
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.