Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Cited by 43 Publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MWPLbY5ie2ViQYPzZZk> NXrITHhnUW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJGhqeyC2YXfn[YQhSi2UYX[gWlYxOEVibYX0ZY51KGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNiY3:t[ZhxemW|c3nu[{BETEN|NzDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCkaX;0bY56dGG2ZXStUWVMKHC{b4TlbY4heGixc4Doc5J6dGG2aX;uJIJ6KEGucHjhV4Nz\WWwIHHzd4F6KHerdHigTWM2OCCxZjCwMlAxODdizszN NIn5foEzPDlyME[3Ny=>
SK-MEL-28 MmLLT4lv[XOnIFHzd4F6 MXuxJIg> NGTLdoNKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN M{e0dlI1QTByNkez
HepG2 M{LiZmtqdmG|ZTDBd5NigQ>? MYfJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjByNDFOwG0> NUe0ZldjOjR7MEC2O|M>
COLO205 NYXIWJB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfLTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRMkC1JINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFch|ryP NHXIVnczPDlyME[3Ny=>
HepG2 NX7RTZQ4TnWwY4Tpc44hSXO|YYm= M13j[FQ2KG2rbh?= NWjZOnRGTE2VTx?= M4nheGlvcGmkaYTpc44hd2ZiQXzrOUBqdiCWR1[tZoV1[S2|dHnteYxifGWmIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFOvYXSyJJBpd3OyaH;yfYxifGmxbjD0doVifGWmIH\vdkA1PSCvaX7zJJBzcW:{IITvJHRITi2kZYThJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFYxKG2rboOgZpkhd2S7c4PlfUBjdG:2IIPjZY5v\XJiYX7hcJl{cXNid3n0bEBKSzVyIH;mJFMvPyEQvF2= NULwOVYzOjR7MEC2O|M>
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SK-MEL-28 NHPlWVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfKV4NGOTBizszN NXSzfVZ1PzJiaB?= M{XlVmROW09? MXvJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfC2mcnn2[Y4hW0tvTVXMMVI5KGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xPDNizszN Ml36NlM5PDRyM{i=
A375P-F11 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW4NVAh|ryP NWTNSppbPzJiaB?= MmPiSG1UVw>? MVnJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfC2mcnn2[Y4hSTN5NWCtSlEyKGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xPzFizszN M1fx[|I{QDR2MEO4
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NCI-H508 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PzW|ExKM7:TR?= NWDj[mFZPzJiaB?= NUfjTGpHTE2VTx?= NXGyRWNNUUN3ME2xNEDPxE1? NWjrc2hSOjN6NESwN|g>
MDA-MB-231 MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XueFExKM7:TR?= M3fmXFczKGh? MULEUXNQ NI[ydmpKSzVyPUGwJO69VQ>? MknzNlM5PDRyM{i=
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SW-837 M1LScmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL0NVAh|ryP M3m5ZVczKGh? M3j0[GROW09? NHXsRnpKSzVyPUGwJO69VQ>? NWS3eopiOjN6NESwN|g>
UMUC-3 NEnjWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfQNVAh|ryP NYLyUFB7PzJiaB?= NGfs[YZFVVOR MV3JR|UxRTFyIN88US=> MWeyN|g1PDB|OB?=
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SHP-77 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXGxNEDPxE1? M1fSTFczKGh? NULCfmVKTE2VTx?= MoXETWM2OD1zMDFOwG0> MWOyN|g1PDB|OB?=
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DLD-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInJW5oyOCEQvF2= MnLGO|IhcA>? NGnjfIFFVVOR NYG5V3A3UUN3ME2xNEDPxE1? NVjOVWxXOjN6NESwN|g>
HCT-116 M2rLPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7FNWMyOCEQvF2= MUC3NkBp MnXpSG1UVw>? MkOzTWM2OD1zMDFOwG0> NXXrbFF[OjN6NESwN|g>
NCI-H747 M{Cxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfHUI0yOCEQvF2= MXy3NkBp MYnEUXNQ MkDFTWM2OD1zMDFOwG0> NEPqTlUzOzh2NECzPC=>
T-84 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33xWlExKM7:TR?= M{H2b|czKGh? NWfMd4hYTE2VTx?= M4T3dWlEPTB;MUCg{txO NXrT[FZDOjN6NESwN|g>
NCI-H460 M2fjcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjIcoIyOCEQvF2= MUe3NkBp MnWySG1UVw>? NGD6TWlKSzVyPUGwJO69VQ>? NYfISpl6OjN6NESwN|g>
Calu-6 M{K0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXflcWVJOTBizszN NIfp[lA4OiCq NIrBdZNFVVOR M{KzNmlEPTB;MUCg{txO NUPIbYlDOjN6NESwN|g>
HCC-2998 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7UNmkyOCEQvF2= MnTGO|IhcA>? MVnEUXNQ M2XWR2lEPTB;MUCg{txO MkPJNlM5PDRyM{i=
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A427 MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXixNEDPxE1? NGK0dIo4OiCq MkPPSG1UVw>? MWrJR|UxRTFyIN88US=> MX2yN|g1PDB|OB?=
A431 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPxdXBMOTBizszN MYG3NkBp NVmzSGhPTE2VTx?= NX;LVpVVUUN3ME2xNEDPxE1? NFrXbI0zOzh2NECzPC=>
A2780 NXrze5FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj4OmI1OTBizszN MVG3NkBp MkLOSG1UVw>? NXiySXBDUUN3ME2xNEDPxE1? M1zBblI{QDR2MEO4
ARH-77 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljPNVAh|ryP MXu3NkBp MXPEUXNQ M{CxfGlEPTB;MUCg{txO NF7m[mwzOzh2NECzPC=>
Be(2)C MkXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW4NVAh|ryP MkmzO|IhcA>? NUXzRoxSTE2VTx?= Ml\CTWM2OD1zMDFOwG0> MnvUNlM5PDRyM{i=
BT-20 NUiwTJZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XqUFExKM7:TR?= M1XVcVczKGh? NFzDcHFFVVOR MYLJR|UxRTFyIN88US=> MXeyN|g1PDB|OB?=
BxPc3 M3;ve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVuxNEDPxE1? MkCyO|IhcA>? NGmxfFFFVVOR MX7JR|UxRTFyIN88US=> M1fZN|I{QDR2MEO4
C-4 I MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\6NVAh|ryP MVW3NkBp NGjLbGtFVVOR MnmwTWM2OD1zMDFOwG0> MXiyN|g1PDB|OB?=
C33A Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzwNVAh|ryP NUC2blZ[PzJiaB?= MnrUSG1UVw>? NWjqZld2UUN3ME2xNEDPxE1? M2r6UFI{QDR2MEO4
CAL-27 NYrv[FlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW[xNEDPxE1? NFHObmQ4OiCq MUnEUXNQ NX3jS3N{UUN3ME2xNEDPxE1? NIrn[mkzOzh2NECzPC=>
CAL-62 NUfaVINuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHONVAh|ryP MoW1O|IhcA>? NEfH[4pFVVOR NFewblNKSzVyPUGwJO69VQ>? NX3LRVk1OjN6NESwN|g>
Calu-3 NIPXWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fZeFExKM7:TR?= Mlz1O|IhcA>? NY[wUZZuTE2VTx?= M3;IZWlEPTB;MUCg{txO NVPGV4xjOjN6NESwN|g>
CaOV3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFviTmsyOCEQvF2= M13HclczKGh? NHWyTWFFVVOR MlvsTWM2OD1zMDFOwG0> NW\EPGEyOjN6NESwN|g>
CGTHW1 MlLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjBfmwyOCEQvF2= M4faeFczKGh? M4SzdGROW09? M2DmR2lEPTB;MUCg{txO MYWyN|g1PDB|OB?=
CHL-1 NH;YWXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljwNVAh|ryP M2nueVczKGh? NUjBbI9YTE2VTx?= MV7JR|UxRTFyIN88US=> M1XsVVI{QDR2MEO4
Colo320DM NHHVVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\4VFExKM7:TR?= NWj2WHJQPzJiaB?= NHnybVlFVVOR NV;LNI9QUUN3ME2xNEDPxE1? MV6yN|g1PDB|OB?=
Colo704 NXHIe2N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:xNEDPxE1? NYLwN2dRPzJiaB?= NVnxVFhRTE2VTx?= MkjGTWM2OD1zMDFOwG0> MWGyN|g1PDB|OB?=
COR-L23 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDZNVAh|ryP MnjsO|IhcA>? MVzEUXNQ NUO1ZpRUUUN3ME2xNEDPxE1? MXKyN|g1PDB|OB?=
CRO-AP2 NH\JNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmxNEDPxE1? NUnHXZc2PzJiaB?= MmDHSG1UVw>? NXXqVpV{UUN3ME2xNEDPxE1? MXSyN|g1PDB|OB?=
Daudi MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLVc4gyOCEQvF2= MmPwO|IhcA>? MnX0SG1UVw>? MkjZTWM2OD1zMDFOwG0> MlX6NlM5PDRyM{i=
DOTC 24510 M3fCTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTyNVAh|ryP NH;3UWI4OiCq NE\TUlFFVVOR M1vnSGlEPTB;MUCg{txO M4TQbFI{QDR2MEO4
DU-145 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DlelExKM7:TR?= MVS3NkBp MYrEUXNQ NX34eFl6UUN3ME2xNEDPxE1? Mn7YNlM5PDRyM{i=
EB-3 NUTFcXA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nMXVExKM7:TR?= M1\KelczKGh? MV;EUXNQ MYfJR|UxRTFyIN88US=> MYmyN|g1PDB|OB?=
EFM-19 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7aNVAh|ryP NFuyW5g4OiCq M3riXGROW09? M3XW[2lEPTB;MUCg{txO MlLRNlM5PDRyM{i=
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FaDu NFKxSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;nN|ExKM7:TR?= M2XvTFczKGh? MXXEUXNQ M37FV2lEPTB;MUCg{txO NXHySVNmOjN6NESwN|g>
G401 NXrIfYdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWixNEDPxE1? M1yxUFczKGh? MoTNSG1UVw>? NEXvemhKSzVyPUGwJO69VQ>? Ml3ENlM5PDRyM{i=
HCC-70 M3r1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVmxNEDPxE1? NIPJOI04OiCq NW\jZ|BWTE2VTx?= M4XBS2lEPTB;MUCg{txO NHjlN5UzOzh2NECzPC=>
HCC-1954 NHXOOoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln1NVAh|ryP MXS3NkBp MoHDSG1UVw>? MkPnTWM2OD1zMDFOwG0> MXWyN|g1PDB|OB?=
Hela NHrOcHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[zc|ExKM7:TR?= NIjoVGY4OiCq MUPEUXNQ MX;JR|UxRTFyIN88US=> MXWyN|g1PDB|OB?=
Hep3B MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m4PFExKM7:TR?= NU\oe4pSPzJiaB?= MWnEUXNQ MXHJR|UxRTFyIN88US=> NVj5blNLOjN6NESwN|g>
HMCB NXmzUpQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWCxNEDPxE1? MYC3NkBp MUXEUXNQ NWDSbZV[UUN3ME2xNEDPxE1? NXLu[IJXOjN6NESwN|g>
HN5 NUfobnRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jFcFExKM7:TR?= MkG0O|IhcA>? MXHEUXNQ M1nxO2lEPTB;MUCg{txO NH;uZ3QzOzh2NECzPC=>
HOS NXrzWmluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXuxNEDPxE1? NFrmcYM4OiCq MofXSG1UVw>? NFy2WHhKSzVyPUGwJO69VQ>? NXP4UmhOOjN6NESwN|g>
HPAF-II NXzaZ4xxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jzSFExKM7:TR?= MoPHO|IhcA>? NUf4TY1vTE2VTx?= NYrmephNUUN3ME2xNEDPxE1? MUWyN|g1PDB|OB?=
Hs746.T MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\UNVAh|ryP MWq3NkBp M{eyPWROW09? M3juXWlEPTB;MUCg{txO MmnyNlM5PDRyM{i=
HT NFTOT|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjLNVAh|ryP M{K1bFczKGh? NGDBTWRFVVOR NVn3V2JIUUN3ME2xNEDPxE1? NH7wR2ozOzh2NECzPC=>
HT-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYCxNEDPxE1? MoC5O|IhcA>? MVPEUXNQ NVXIbWRtUUN3ME2xNEDPxE1? NXvY[|dNOjN6NESwN|g>
HuNS-1 NWSzeZFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LiUlExKM7:TR?= Mn7kO|IhcA>? NHvIXolFVVOR M1zKXWlEPTB;MUCg{txO NInDe44zOzh2NECzPC=>
IGROV1 M1i0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnraNVAh|ryP NXnpUpRuPzJiaB?= M1;HZmROW09? MYDJR|UxRTFyIN88US=> M4mzcVI{QDR2MEO4
J82 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPufoIyOCEQvF2= NIS5[HE4OiCq MWrEUXNQ M3foNWlEPTB;MUCg{txO MnP1NlM5PDRyM{i=
JM1 NUfRSW5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWmxNEDPxE1? Ml3HO|IhcA>? M1;W[2ROW09? MnTpTWM2OD1zMDFOwG0> MYmyN|g1PDB|OB?=
Kato III NWTIZ2VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7PNVAh|ryP MUi3NkBp MmDoSG1UVw>? MV3JR|UxRTFyIN88US=> M2DsUFI{QDR2MEO4
KHOS-240S NEO1NFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXoWnIyOCEQvF2= MV:3NkBp NUfGcYJpTE2VTx?= MUnJR|UxRTFyIN88US=> NFnQU5EzOzh2NECzPC=>
KM-12 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:xNEDPxE1? MoLsO|IhcA>? MUnEUXNQ MV7JR|UxRTFyIN88US=> MlvpNlM5PDRyM{i=
KPL-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[xNEDPxE1? M2PMNFczKGh? NFHjb41FVVOR MonnTWM2OD1zMDFOwG0> NYTqPJU3OjN6NESwN|g>
KYSE-30 M1;rNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUG1VoVVOTBizszN MXG3NkBp MoriSG1UVw>? NF;2V4VKSzVyPUGwJO69VQ>? NFS5PIszOzh2NECzPC=>
LNCaP M13I[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYWxNEDPxE1? MWG3NkBp Mlz0SG1UVw>? NH7MOINKSzVyPUGwJO69VQ>? MnW5NlM5PDRyM{i=
MCF-7 NX7qNJB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DMblExKM7:TR?= NEfKRY44OiCq Ml;CSG1UVw>? NGrzc21KSzVyPUGwJO69VQ>? NGTLbFAzOzh2NECzPC=>
MC-IXC MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSxNEDPxE1? NIPMPYY4OiCq NVHzcm9RTE2VTx?= M3LrfGlEPTB;MUCg{txO MYWyN|g1PDB|OB?=
MDA-MB-175 VII MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHGNVAh|ryP MnizO|IhcA>? MX7EUXNQ NEDwNpNKSzVyPUGwJO69VQ>? MVmyN|g1PDB|OB?=
MDA-MB-468 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK0UWFxOTBizszN MYW3NkBp M{\mRWROW09? NEDjR3lKSzVyPUGwJO69VQ>? MoL6NlM5PDRyM{i=
MiaPaCa MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7DV5NGOTBizszN M2rTUVczKGh? M3jz[WROW09? NHztbpNKSzVyPUGwJO69VQ>? MonJNlM5PDRyM{i=
Molt-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrMe2wyOCEQvF2= MWW3NkBp MknRSG1UVw>? M4ntcmlEPTB;MUCg{txO M3jDdlI{QDR2MEO4
NCI-ADR/RES MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVOxNEDPxE1? M4jPblczKGh? NWHjfWxVTE2VTx?= MXvJR|UxRTFyIN88US=> MXeyN|g1PDB|OB?=
NCI-H69 M2DqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXWNVAh|ryP MX[3NkBp MYnEUXNQ NGDYZm9KSzVyPUGwJO69VQ>? NWPI[lRwOjN6NESwN|g>
NCI-H82 M1XIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULzWIdWOTBizszN MkS0O|IhcA>? MWDEUXNQ MmP2TWM2OD1zMDFOwG0> NVLOd2RtOjN6NESwN|g>
NCI-N87 NXX1VXJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXixNEDPxE1? MlPsO|IhcA>? MnzsSG1UVw>? MVnJR|UxRTFyIN88US=> MYOyN|g1PDB|OB?=
NCI-H146 MoXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P4eFExKM7:TR?= M3\veVczKGh? MmT2SG1UVw>? NVna[41nUUN3ME2xNEDPxE1? MmGwNlM5PDRyM{i=
NCI-H157 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:0NVAh|ryP M2LsVFczKGh? MUXEUXNQ NGnvXItKSzVyPUGwJO69VQ>? NGXwRZkzOzh2NECzPC=>
NCI-H187 NUXBT45MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fDWlExKM7:TR?= NGXGWow4OiCq MX\EUXNQ MV3JR|UxRTFyIN88US=> M3rmRlI{QDR2MEO4
NCI-H209 NIPsZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;SSFExKM7:TR?= MmjnO|IhcA>? M2DacmROW09? NHHZSWtKSzVyPUGwJO69VQ>? NHz4bmkzOzh2NECzPC=>
NCI-H226 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETwNosyOCEQvF2= MkfnO|IhcA>? NYKzWVltTE2VTx?= NFXydXJKSzVyPUGwJO69VQ>? MV[yN|g1PDB|OB?=
NCI-H292 M4XKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPYOZFqOTBizszN M37yNlczKGh? M3vrbWROW09? MoDxTWM2OD1zMDFOwG0> NGLtPVIzOzh2NECzPC=>
NCI-H322 NYDBcZIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPMc3R2OTBizszN MYW3NkBp MVXEUXNQ M{fX[mlEPTB;MUCg{txO MXmyN|g1PDB|OB?=
NCI-H358 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvKd4IyOCEQvF2= M1\WO|czKGh? M2LYUGROW09? MYTJR|UxRTFyIN88US=> MXSyN|g1PDB|OB?=
NCI-H520 M2T3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVOxNEDPxE1? MVq3NkBp NXTr[WVbTE2VTx?= M362[WlEPTB;MUCg{txO MX[yN|g1PDB|OB?=
NCI-H526 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFSwXJMyOCEQvF2= MnyyO|IhcA>? NX3VeJIzTE2VTx?= M{DzSmlEPTB;MUCg{txO MlLENlM5PDRyM{i=
NCI-H630 M2DyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LKT|ExKM7:TR?= M4q4dFczKGh? M3KzXWROW09? NH\6NXpKSzVyPUGwJO69VQ>? NIq5[YszOzh2NECzPC=>
NCI-H661 NXn1e5AxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[1NVAh|ryP NGrMTGQ4OiCq MmPjSG1UVw>? NEjOUo1KSzVyPUGwJO69VQ>? NWLYN5F4OjN6NESwN|g>
NCI-H716 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W1PVExKM7:TR?= NEnxcGI4OiCq MUjEUXNQ NWX3[pVFUUN3ME2xNEDPxE1? MYmyN|g1PDB|OB?=
NCI-H1563 NGO2VFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[zR|ExKM7:TR?= M2n4W|czKGh? MXXEUXNQ NELSSIFKSzVyPUGwJO69VQ>? MUeyN|g1PDB|OB?=
NCI-H1792 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUGxNEDPxE1? NITle5Q4OiCq NXjvTW5zTE2VTx?= NFixPG5KSzVyPUGwJO69VQ>? MlTqNlM5PDRyM{i=
NCI-H2030 MoXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jQUFExKM7:TR?= MVy3NkBp M2fJfWROW09? MWTJR|UxRTFyIN88US=> M3fCXVI{QDR2MEO4
NCI-H2052 NFvKeY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\vNVAh|ryP MWq3NkBp NH\5bHFFVVOR NV3ZbI5PUUN3ME2xNEDPxE1? Mnn2NlM5PDRyM{i=
NCI-H2122 NXi1[ZBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjXNVAh|ryP Ml3uO|IhcA>? MlrQSG1UVw>? MoTwTWM2OD1zMDFOwG0> MX[yN|g1PDB|OB?=
NCI-H2228 M1zIRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHwNVAh|ryP MWG3NkBp NYC1fWJ{TE2VTx?= MVvJR|UxRTFyIN88US=> MmDyNlM5PDRyM{i=
OE-19 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWxNEDPxE1? MXG3NkBp NYW0VZd[TE2VTx?= M3jqSWlEPTB;MUCg{txO M3rMfVI{QDR2MEO4
OE-21 M2jzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2exNVExKM7:TR?= NUT2TlB6PzJiaB?= MkjLSG1UVw>? NXfDe4NxUUN3ME2xNEDPxE1? MkfDNlM5PDRyM{i=
OE-33 NHTRUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vDZlExKM7:TR?= MkPjO|IhcA>? NHLCNJJFVVOR M2LrdmlEPTB;MUCg{txO NXLWVHVxOjN6NESwN|g>
OVCAR-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnRNVAh|ryP NYHyRWxWPzJiaB?= NXfoUGQ6TE2VTx?= MVPJR|UxRTFyIN88US=> MU[yN|g1PDB|OB?=
OVCAR-4 NHXYRXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVGxNEDPxE1? MWS3NkBp MWnEUXNQ MUPJR|UxRTFyIN88US=> NFPnZ2IzOzh2NECzPC=>
OVCAR-5 NEjPTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW4T4syOCEQvF2= MX23NkBp NYfRfFA2TE2VTx?= MUnJR|UxRTFyIN88US=> NULBbWg2OjN6NESwN|g>
P3HR-1 M{LMd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j3dFExKM7:TR?= NGPyO2o4OiCq MoK1SG1UVw>? NGTPO5hKSzVyPUGwJO69VQ>? MXKyN|g1PDB|OB?=
PC-3 M3S5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonYNVAh|ryP M1exPFczKGh? MkXWSG1UVw>? MXfJR|UxRTFyIN88US=> M2n2T|I{QDR2MEO4
Raji M3joUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkW4NVAh|ryP NILPe3g4OiCq M124W2ROW09? M37rNGlEPTB;MUCg{txO NUf6S2pDOjN6NESwN|g>
RD NITUfGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\5NFIyOCEQvF2= M4fub|czKGh? M{jZ[WROW09? NWTScY9VUUN3ME2xNEDPxE1? MoHuNlM5PDRyM{i=
RD-ES NUfGZZJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HNS|ExKM7:TR?= Mle1O|IhcA>? M4jYfGROW09? NGPRWHBKSzVyPUGwJO69VQ>? M4ewWlI{QDR2MEO4
RL M{fMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH5UWQyOTBizszN NYHZd41LPzJiaB?= MnnSSG1UVw>? NITscGJKSzVyPUGwJO69VQ>? MVKyN|g1PDB|OB?=
SaOS2 Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPWZZQyOCEQvF2= MXe3NkBp NF:4VGJFVVOR MX7JR|UxRTFyIN88US=> MojQNlM5PDRyM{i=
SCC-9 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjVWIxoOTBizszN MVG3NkBp M{jKcWROW09? MUjJR|UxRTFyIN88US=> NYLLeJhkOjN6NESwN|g>
SCC-12 MknhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrZNVAh|ryP NYHuRXYzPzJiaB?= MVjEUXNQ Mlm0TWM2OD1zMDFOwG0> MYCyN|g1PDB|OB?=
SCC-13 NF7zPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljhNVAh|ryP M4rjPFczKGh? NYfBTGtvTE2VTx?= Mm\DTWM2OD1zMDFOwG0> MlTMNlM5PDRyM{i=
SCC-15 Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:0NVAh|ryP M3jiT|czKGh? MVrEUXNQ NIP2N45KSzVyPUGwJO69VQ>? NES5NIQzOzh2NECzPC=>
SCC-25 NW\6XG4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV6xNEDPxE1? NVHzenpsPzJiaB?= M4jFPGROW09? MXTJR|UxRTFyIN88US=> Mlv0NlM5PDRyM{i=
SCLC-3 MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxNEDPxE1? M2D2TlczKGh? NF;Lb2tFVVOR NYjyXVdKUUN3ME2xNEDPxE1? Mnq3NlM5PDRyM{i=
SF-268 NUH5TIlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjFcIEyOCEQvF2= M{LVV|czKGh? NY\1dVlGTE2VTx?= M{PlSGlEPTB;MUCg{txO M3TIOlI{QDR2MEO4
SF-295 MmH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LLPFExKM7:TR?= MYO3NkBp MUfEUXNQ M{n5cmlEPTB;MUCg{txO MlHINlM5PDRyM{i=
SJRH30 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvBS3QyOCEQvF2= NYjqN5djPzJiaB?= MYTEUXNQ NWrvNIJ3UUN3ME2xNEDPxE1? NYXBW2VROjN6NESwN|g>
SK-BR-3 NGrXSIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3YNVAh|ryP MXm3NkBp MkfTSG1UVw>? NX7IfYxoUUN3ME2xNEDPxE1? M13mdlI{QDR2MEO4
SK-LMS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjqPFZjOTBizszN MlLpO|IhcA>? NVzYcG5DTE2VTx?= MnO5TWM2OD1zMDFOwG0> MXOyN|g1PDB|OB?=
SK-N-DZ Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYixNEDPxE1? NIjmOo04OiCq M2nTZmROW09? NIHjN3NKSzVyPUGwJO69VQ>? NWLHfJJZOjN6NESwN|g>
SK-N-F1 NUfENmF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK4NVAh|ryP MkPvO|IhcA>? M3joOWROW09? MlPCTWM2OD1zMDFOwG0> MWOyN|g1PDB|OB?=
SKOV-3 NX;UXotUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXzNVAh|ryP NVrZWGFTPzJiaB?= NWi5VIF4TE2VTx?= MVvJR|UxRTFyIN88US=> Mnu5NlM5PDRyM{i=
SK-UT-1 M2X6b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrD[GpHOTBizszN MUm3NkBp MVXEUXNQ NX7kcY1{UUN3ME2xNEDPxE1? NVLnSoFWOjN6NESwN|g>
SN12C NIX4UoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYSxNEDPxE1? NHH4PI84OiCq NE\OZZZFVVOR MnPJTWM2OD1zMDFOwG0> NV\uO5VuOjN6NESwN|g>
SNB-19 MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmxNEDPxE1? NF3CRmc4OiCq NVjZNXVJTE2VTx?= MWrJR|UxRTFyIN88US=> NE\lSWQzOzh2NECzPC=>
SNU-5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu0SnEyOCEQvF2= M{fWNlczKGh? NEnwOIpFVVOR NGHKRlBKSzVyPUGwJO69VQ>? M3O0flI{QDR2MEO4
SNU-16 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXKxNEDPxE1? NW[0WnFkPzJiaB?= NVjld3U1TE2VTx?= NGfBVYpKSzVyPUGwJO69VQ>? NFq0dVUzOzh2NECzPC=>
SNU-398 M1K3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7hR3dGOTBizszN M{nUZlczKGh? NW\XbXdsTE2VTx?= NFf4ZXBKSzVyPUGwJO69VQ>? M{nIZ|I{QDR2MEO4
SNU-449 NHTwZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXqNVAh|ryP MWW3NkBp M1KwV2ROW09? Mnn4TWM2OD1zMDFOwG0> Mlq3NlM5PDRyM{i=
SR Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT4UJE4OTBizszN MWG3NkBp NYHvU2hvTE2VTx?= NXXLUpBJUUN3ME2xNEDPxE1? M1;I[lI{QDR2MEO4
ST486 NF3BSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPRNVAh|ryP M1nqdVczKGh? M4TiOGROW09? MVXJR|UxRTFyIN88US=> NV7Hb3JFOjN6NESwN|g>
SW579 NFvtPFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon1NVAh|ryP NUX2bm1nPzJiaB?= NX;4[ZU1TE2VTx?= NGP6SHdKSzVyPUGwJO69VQ>? MWmyN|g1PDB|OB?=
SW684 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUOxNEDPxE1? MVS3NkBp NVPqZ44xTE2VTx?= MWXJR|UxRTFyIN88US=> NF7uUnAzOzh2NECzPC=>
SW-780 NGnDWGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWixNEDPxE1? MkLDO|IhcA>? NWm4TmRsTE2VTx?= MlTlTWM2OD1zMDFOwG0> NYjlelZYOjN6NESwN|g>
SW900 M2nOfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TzNFExKM7:TR?= NG\RWnI4OiCq NHHlZYdFVVOR NHzZS5hKSzVyPUGwJO69VQ>? NGXlTY4zOzh2NECzPC=>
SW1088 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XqOlExKM7:TR?= Mor0O|IhcA>? M4TsW2ROW09? M{P2WmlEPTB;MUCg{txO NF;GPGkzOzh2NECzPC=>
SW1463 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDKNVAh|ryP MlfGO|IhcA>? NUTMVJRPTE2VTx?= M4r3fmlEPTB;MUCg{txO MoHaNlM5PDRyM{i=
SW1990 NF7WdFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXqxNEDPxE1? MnK5O|IhcA>? MWTEUXNQ NXfyfmRDUUN3ME2xNEDPxE1? NW[3NoJCOjN6NESwN|g>
T47D NVO5d3I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL1TlU5OTBizszN MnXqO|IhcA>? MXTEUXNQ Mnu0TWM2OD1zMDFOwG0> MmXMNlM5PDRyM{i=
TE381.T MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37nSlExKM7:TR?= NYDxUmxwPzJiaB?= NFzkWnRFVVOR NYqxc5diUUN3ME2xNEDPxE1? M1Lle|I{QDR2MEO4
TK-10 M4DXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmxNEDPxE1? NWf2TJNrPzJiaB?= M{H4SWROW09? M3HrfmlEPTB;MUCg{txO M2\TVVI{QDR2MEO4
U2OS M37MTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mof6NVAh|ryP MV:3NkBp NWniUG9vTE2VTx?= MlziTWM2OD1zMDFOwG0> MWWyN|g1PDB|OB?=
U251 NFXnPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnQc|EyOCEQvF2= NWTjc3ZvPzJiaB?= NEDGdnRFVVOR MVzJR|UxRTFyIN88US=> MWmyN|g1PDB|OB?=
UACC-812 NXez[XhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\zdFExKM7:TR?= Mkj2O|IhcA>? M2HtfmROW09? NVLjd4hFUUN3ME2xNEDPxE1? NW\6PWwzOjN6NESwN|g>
YAPC Mlv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVyxNEDPxE1? NUfTbpp1PzJiaB?= M2LmRmROW09? NYLMbVRkUUN3ME2xNEDPxE1? M{j3S|I{QDR2MEO4
ZR-75-1 M1;MXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWSxNEDPxE1? MlrMO|IhcA>? M4XEcWROW09? M{n5TGlEPTB;MUCg{txO M2fBWlI{QDR2MEO4
A375 MX;GeY5kfGmxbjDhd5NigQ>? MWWxMlIh|ryP M{fCSFQhcA>? NF;FbIxFVVOR M3zq[mlvcGmkaYTpc44hd2ZicHjvd5Bpd3K7bHH0bY9vKG:oIF3FT{whTVKNLDDhcoQhWz[S MlPqNlI{QDl2N{G=
YUSIT1 MkLOSpVv[3Srb36gZZN{[Xl? NXHIXJhkTE2VTx?= NFz6Z2pz\WS3Y3XkJJNmdnOrdHn2bZR6KHerdHigTWM2OCB-IECuOUDPxE1? M3nlTVIzOzh7NEex
MeWo NVqyVXNwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7EUXNQ NELaV|FKSzVyIE2gPVg4KG6P NIfReGozPjBzOEWyOC=>
WiDr NVr1WmtQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn30SG1UVw>? NIrCN3lKSzVyIE2gO|Yhdk1? MYqyOlAyQDV{NB?=
Colo-205 MmW1SpVv[3Srb36gZZN{[Xl? MYqxJO69VQ>? M3myVVQh\A>? NYGxNnhITE2VTx?= MmW5TY5lfWOnZDDhJIhq\2iueTDjc41x[XKjYnzlJINwdXCjY4Tpc44heGinbn;0fZBm M2DOVVI2OzhzMUWy
RBW-1 M1vjdmZ2dmO2aX;uJIF{e2G7 NXTCO4M5OSEQvF2= NGX5WY1FVVOR NX3mVoZNVm9icnXkeYN1cW:wIH;mJG1mcyBzL{KgdIhwe3Cqb4L5cIF1cW:w NHfOUIQzPDh6NU[5NC=>
RBO-1 MXPGeY5kfGmxbjDhd5NigQ>? NGrnU3IyKM7:TR?= MlnNSG1UVw>? M1TOZ2lvcGmkaYTpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> M2C1c|I1QDh3Nkmw
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M257 NI\UNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnLNVAxKG6P NX[3OG8yPzJiaB?= MVzEc4V{KG6xdDDpcohq[mm2IIDyc4xq\mW{YYTpc44hd2ZiTUK1O{Bk\WyuIHjhdoJwfXKrbnege4lt\CC2eYDlJGJTSUZ? MkSyNlM{OTd2NE[=
LCP M4HIVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\mcIF3OTByIH7N M1[yTVczKGh? M{TUOmlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCOQ2CgZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMGKgcZV1[W62YYTpc44> Mlm2NlM{OTd2NE[=
WM266 NVjwOHd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDZbHFLOTByIH7N MkXoO|IhcA>? MX;Jcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhX01{Nk[gZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMVSgcZV1[W62YYTpc44> MVqyN|MyPzR2Nh?=
M257 M2XGdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX5O2FSOTByIH7N M{DteVczKGh? NFfjNVJFd2W|IH7veEBqdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= MV:yN|MyPzR2Nh?=
LCP NYnkVpV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW3NVAxKG6P Mk[0O|IhcA>? NG\LZm5KdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gUGNRKGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFBTKG23dHHueIF1cW:w NGXvNpczOzNzN{S0Oi=>
WM266 NXm1TVdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[xUmQyODBibl2= MX63NkBp MoXCTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFBFKG23dHHueIF1cW:w MnHZNlM{OTd2NE[=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
8 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03794297 Not yet recruiting BRAF NP_004324.2:p.V600X|Erdheim-Chester Disease National Cancer Institute (NCI) January 12 2020 Phase 2
NCT03794297 Not yet recruiting BRAF NP_004324.2:p.V600X|Erdheim-Chester Disease National Cancer Institute (NCI) January 12 2020 Phase 2
NCT03784014 Not yet recruiting Soft Tissue Sarcoma Institut National de la Santé Et de la Recherche Médicale France|Commissariat A L''energie Atomique|Institut Bergonié|Plateforme labellisée Inca – Institut Bergonié Bordeaux|Plateforme labellisée Inca – Hôpital Européen Georges Pompidou Paris|CIC-EC 1401/EUCLID March 2019 Phase 3
NCT03784014 Not yet recruiting Soft Tissue Sarcoma Institut National de la Santé Et de la Recherche Médicale France|Commissariat A L''energie Atomique|Institut Bergonié|Plateforme labellisée Inca – Institut Bergonié Bordeaux|Plateforme labellisée Inca – Hôpital Européen Georges Pompidou Paris|CIC-EC 1401/EUCLID March 2019 Phase 3
NCT03272464 Recruiting Melanoma Massachusetts General Hospital|Incyte Corporation November 30 2018 Phase 1
NCT03272464 Recruiting Melanoma Massachusetts General Hospital|Incyte Corporation November 30 2018 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID