Dabrafenib (GSK2118436)

For research use only.

Catalog No.S2807

145 publications

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Selleck's Dabrafenib (GSK2118436) has been cited by 145 publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MmizT4lv[XOnIFHzd4F6 MoHiTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFjpd{B1[WepZXSgRk1T[WZiVk[wNGUhdXW2YX70JIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMh[29vZYjwdoV{e2mwZzDDSGM{PyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBjcW:2aX75cIF1\WRvTVXLJJBzd3SnaX6gdIhwe3Cqb4L5cIF1cW:wIHL5JGFteGijU3Py[YVvKGG|c3H5JJdqfGhiSVO1NEBw\iByLkCwNFch|ryP M3XablI1QTByNkez
SK-MEL-28 NWDkeWE6U2mwYYPlJGF{e2G7 MWCxJIg> MYjJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP NEDGTY0zPDlyME[3Ny=>
HepG2 Mnn6T4lv[XOnIFHzd4F6 MYrJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjByNDFOwG0> M1PteFI1QTByNkez
COLO205 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomzTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRMkC1JINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFch|ryP NYW3U4RPOjR7MEC2O|M>
HepG2 NV\pUYZSTnWwY4Tpc44hSXO|YYm= NV\SPFNiPDVibXnu NYXpZ2lQTE2VTx?= NH7jeHRKdmirYnn0bY9vKG:oIFHsb|UhcW5iVFfGMYJmfGFvc4TpcZVt[XSnZDDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCVbXHkNkBxcG:|cHjvdplt[XSrb36geJJm[XSnZDDmc5IhPDVibXnud{BxemmxcjD0c{BVT0ZvYnX0ZUB{fGmvdXzheIlwdiCvZXHzeZJm\CCjZoTldkA3OCCvaX7zJIJ6KG:meYPz[Zkh[myxdDDzZ4FvdmW{IHHuZYx6e2m|IIfpeIghUUN3MDDv[kA{NjdizszN NX;Qe5VbOjR7MEC2O|M>
HFF MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUexNEDPxE1? NGewZpM4OiCq Mn;lSG1UVw>? Mn;3TY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKGi3bXHuJGhHTiClZXzsd{Bp[XKkb4Lpcochf2muZDD0fZBmKEJvUnHmJJdqfGhiSVO1NEBw\iB|IN88US=> M3XSSlI{QDR2MEO4
SK-MEL-28 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NISyRWQyOCEQvF2= NWnGS3Q{PzJiaB?= NV[2UHpzTE2VTx?= NEL2fJlKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iU1utUWVNNTJ6IHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yNEOg{txO MofoNlM5PDRyM{i=
A375P-F11 NIHrOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnDWVlWOTBizszN M1:3T|czKGh? M1e2ZmROW09? NYr2XXJFUW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSt[JJqfmWwIFGzO|VRNUZzMTDj[YxtKHC{b3zp[oVz[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEexJO69VQ>? MoeyNlM5PDRyM{i=
MALME-3M NXzzdZZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHoT294OTBizszN NXnQXWc5PzJiaB?= M3q1PGROW09? M4TFNGlEPTB;MTDuUS=> NEfPTpozOzh2NECzPC=>
UACC-62 M{LWcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C3eFExKM7:TR?= NIDYT5Q4OiCq NXK5c4c6TE2VTx?= NUX4NHdNUUN3ME2xJI5O NIq2PFkzOzh2NECzPC=>
C32TG MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr1Z2IyOCEQvF2= NVTR[nF3PzJiaB?= NYPBW2dxTE2VTx?= MVfJR|UxRTFibl2= MV:yN|g1PDB|OB?=
SK-MEL-1 M4XrU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjOZoxHOTBizszN NHzBdHE4OiCq MVHEUXNQ M2XqcmlEPTB;MjDuUS=> NG\TUFAzOzh2NECzPC=>
M14 MlfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXINVAh|ryP M1S2UFczKGh? NIrmSpRFVVOR MnLVTWM2OD1{IH7N NGrzN4czOzh2NECzPC=>
SK-MEL-28 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV2xNEDPxE1? M4ewbFczKGh? NFL4V3VFVVOR NEK0U2lKSzVyPUOgcm0> NXnF[YJpOjN6NESwN|g>
A375 NWnj[FZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK4OI9VOTBizszN NFjVPZY4OiCq MULEUXNQ MUTJR|UxRTRibl2= NFHMTVAzOzh2NECzPC=>
DU-4475 NIiyVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? MnvXO|IhcA>? NVzpPFVPTE2VTx?= NUXm[pAyUUN3ME21JI5O MWeyN|g1PDB|OB?=
UACC-257 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[5[G1zOTBizszN MnnJO|IhcA>? M1zsUWROW09? NUTYNHI6UUN3ME22JI5O NW\5T|c5OjN6NESwN|g>
Colo 205 NWXBPI9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWOxNEDPxE1? M{DvZlczKGh? NHfsbFRFVVOR NILzUpZKSzVyPUegcm0> MWKyN|g1PDB|OB?=
SK-MEL-3 MoTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUmxNEDPxE1? NHX5UGg4OiCq MmjKSG1UVw>? NHHxVpBKSzVyPUegcm0> NWfVZmdnOjN6NESwN|g>
SH-4 NIK3e|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H0OlExKM7:TR?= NILRSoE4OiCq M1nPZWROW09? MX\JR|UxRThibl2= NE\TPJkzOzh2NECzPC=>
A101D MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDoZ4huOTBizszN MYq3NkBp M{nUdWROW09? Mn;ZTWM2OD17IH7N MmjjNlM5PDRyM{i=
ES-2 M3;qZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT1NVAh|ryP NWrQeI9CPzJiaB?= MonkSG1UVw>? NHPNdplKSzVyPUWzJI5O NIqwWYszOzh2NECzPC=>
HT-29 M2rUOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnYPXBjOTBizszN M3;DNFczKGh? MX\EUXNQ NEX4VIpKSzVyPU[2JI5O NVf4eFZvOjN6NESwN|g>
SW1417 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG4dnl5OTBizszN MXi3NkBp M3\y[GROW09? NVq3ZnN2UUN3ME2xOVghdk1? M1i2NVI{QDR2MEO4
SW872 NHezcllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK1cXhVOTBizszN NHOzRZc4OiCq M1m3XWROW09? NFvvOG5KSzVyPUO3O{BvVQ>? NXywTmVYOjN6NESwN|g>
RKO NGGyTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjsNVAh|ryP MYq3NkBp MWDEUXNQ MXTJR|UxRTJwNUKyJO69VQ>? NH;sV2EzOzh2NECzPC=>
A673 M3vnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrwNVAh|ryP NHP6coQ4OiCq NEjKOVdFVVOR M3rFNGlEPTB;MUCg{txO MnrONlM5PDRyM{i=
GCT M2TLSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPVdo9yOTBizszN M2T3bFczKGh? MnXNSG1UVw>? NXSzSVNWUUN3ME2xNEDPxE1? MYSyN|g1PDB|OB?=
WM-115 M{HxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFywXooyOCEQvF2= Mmr2O|IhcA>? M1\sUGROW09? MVXJR|UxRTVibl2= MYeyN|g1PDB|OB?=
YUMAC NGjNcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnhXGxPOTBizszN MXq3NkBp NWL0ToNPTE2VTx?= Mmn3TWM2OD13IH7N MWSyN|g1PDB|OB?=
OV-90 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXmRmgyOCEQvF2= MYS3NkBp NVHnfJRnTE2VTx?= NInwdJVKSzVyPUK5JI5O MUWyN|g1PDB|OB?=
NCI-H508 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWCxNEDPxE1? MWe3NkBp MnfySG1UVw>? MoPETWM2OD1zMDFOwG0> Moi1NlM5PDRyM{i=
MDA-MB-231 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[xNEDPxE1? MkDIO|IhcA>? MnLYSG1UVw>? NFiwZYhKSzVyPUGwJO69VQ>? MUmyN|g1PDB|OB?=
SW756 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TDdFExKM7:TR?= NVK3WXF{PzJiaB?= MUDEUXNQ NImycpRKSzVyPUGwJO69VQ>? M4TQOlI{QDR2MEO4
SW-837 NFrPN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XtPFExKM7:TR?= NFW4U|Q4OiCq NInHfllFVVOR NYD6fpI3UUN3ME2xNEDPxE1? NIDodngzOzh2NECzPC=>
UMUC-3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jqO|ExKM7:TR?= M1v4PVczKGh? MluySG1UVw>? MnLiTWM2OD1zMDFOwG0> MX[yN|g1PDB|OB?=
LS-174T M4fzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzIWZMyOCEQvF2= NW\3NpZzPzJiaB?= MkT6SG1UVw>? MVXJR|UxRTFyIN88US=> M4TE[FI{QDR2MEO4
A549 M2O2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HRb|ExKM7:TR?= NITUZZc4OiCq M1PacmROW09? MXfJR|UxRTFyIN88US=> MVeyN|g1PDB|OB?=
SHP-77 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1njTVExKM7:TR?= M2\SR|czKGh? Mn\MSG1UVw>? NFT1V|RKSzVyPUGwJO69VQ>? MV:yN|g1PDB|OB?=
SW480 NGrGfJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nBN|ExKM7:TR?= NFr5WYQ4OiCq MXXEUXNQ MUfJR|UxRTFyIN88US=> NEnrcIozOzh2NECzPC=>
DLD-1 NGHJfXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUWxNEDPxE1? NI\CN5c4OiCq M1ntV2ROW09? M1LqNWlEPTB;MUCg{txO NELLXpEzOzh2NECzPC=>
HCT-116 NVywVJNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVyxXZpYOTBizszN NVq2R4lWPzJiaB?= MYfEUXNQ NHnacIdKSzVyPUGwJO69VQ>? Mn3HNlM5PDRyM{i=
NCI-H747 M1jod2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVGxNEDPxE1? NFrrUo04OiCq NGXneW5FVVOR MkjUTWM2OD1zMDFOwG0> MWeyN|g1PDB|OB?=
T-84 M{O0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXsc3IyOCEQvF2= MnPzO|IhcA>? MkewSG1UVw>? NF\VSnFKSzVyPUGwJO69VQ>? MnzCNlM5PDRyM{i=
NCI-H460 NXfyXGtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFraSVUyOCEQvF2= MkKyO|IhcA>? NHXV[2lFVVOR NIS3W4pKSzVyPUGwJO69VQ>? MXqyN|g1PDB|OB?=
Calu-6 M4r2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;JNVAh|ryP Ml3UO|IhcA>? NFnCU5ZFVVOR NYDmXlhVUUN3ME2xNEDPxE1? MWWyN|g1PDB|OB?=
HCC-2998 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXwSGcyOCEQvF2= M3ns[lczKGh? NXPYSINRTE2VTx?= MnLNTWM2OD1zMDFOwG0> MV2yN|g1PDB|OB?=
LS1034 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L2bVExKM7:TR?= NXLZZpk4PzJiaB?= Mlj0SG1UVw>? MUjJR|UxRTFyIN88US=> MVeyN|g1PDB|OB?=
CHP-212 MoPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;TbZkzOTBizszN MkPwO|IhcA>? M2fwcWROW09? MU\JR|UxRTFyIN88US=> NHrFPWgzOzh2NECzPC=>
SK-N-AS M{Sx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S4TVExKM7:TR?= MX63NkBp NXf2TJE6TE2VTx?= MY\JR|UxRTFyIN88US=> NXHBUZVlOjN6NESwN|g>
BFTC-905 NWTKSolJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHoSnMyOCEQvF2= NHy5eXA4OiCq NIjhbHJFVVOR MnvDTWM2OD1zMDFOwG0> NVX6VWNbOjN6NESwN|g>
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RPMI-8226 NW[5RmpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? M3TNSFczKGh? NEn5UFhFVVOR MW\JR|UxRTJ4MzDuUS=> MYGyN|g1PDB|OB?=
BC-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6xNEDPxE1? MUS3NkBp MVnEUXNQ MYHJR|UxRTJ5NzDuUS=> MV2yN|g1PDB|OB?=
ACHN MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorJNVAh|ryP MmqxO|IhcA>? Mo\ySG1UVw>? NF3tZZdKSzVyPUK5OEBvVQ>? M2nrOFI{QDR2MEO4
JRT3-T35 M2HKTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PMfVExKM7:TR?= MVO3NkBp NFL0[JlFVVOR MX3JR|UxRTJ7NTDuUS=> MmHINlM5PDRyM{i=
SK-MES-1 NGjTTFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjMW2FPOTBizszN MVO3NkBp NInNWJlFVVOR MXfJR|UxRTN{OTDuUS=> NUjQ[mJKOjN6NESwN|g>
CESS Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17PT|ExKM7:TR?= NEjrOIs4OiCq NYLmXG93TE2VTx?= MkHMTWM2OD12OUegcm0> MmDDNlM5PDRyM{i=
H4 NXrSUoRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT5NVAh|ryP MV63NkBp MlLrSG1UVw>? NFS2NZNKSzVyPU[xPUBvVQ>? M3PBOFI{QDR2MEO4
BC-1 M4\rOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTUNVAh|ryP NFnFWGY4OiCq NIroS3BFVVOR NHXDeWNKSzVyPUewOEBvVQ>? MlK3NlM5PDRyM{i=
DB NIrXSGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPrbIQyOCEQvF2= NUHvVIFXPzJiaB?= NVHHSXpQTE2VTx?= NYDKS3RjUUN3ME24O|Mhdk1? NWnNXYdGOjN6NESwN|g>
RPMI-6666 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDxNVAh|ryP MXi3NkBp NVLUU45MTE2VTx?= M2O0cGlEPTB;OUK4JI5O MX:yN|g1PDB|OB?=
MC/CAR MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PsTFExKM7:TR?= NVzvN285PzJiaB?= MYXEUXNQ MnvNTWM2OD1zLkCwNkDPxE1? MVGyN|g1PDB|OB?=
SNU-1 NYrIfWhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T5V|ExKM7:TR?= MmX6O|IhcA>? NWK0WYpbTE2VTx?= MXjJR|UxRTFwNUCxJO69VQ>? M{\Se|I{QDR2MEO4
CEM/C1 M2HmPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXpNVAh|ryP Mly5O|IhcA>? M1H4fWROW09? MXLJR|UxRTFwN{ezJO69VQ>? M3fX[FI{QDR2MEO4
GDM-1 NWT3T5NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTDZ|cyOCEQvF2= M1rGclczKGh? MWDEUXNQ NVfIN5k3UUN3ME2xMlk6PyEQvF2= MX[yN|g1PDB|OB?=
HT-1080 NIPvXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2wNVAh|ryP MVm3NkBp M3vGWGROW09? MkPCTWM2OD1{LkCwOEDPxE1? MkL2NlM5PDRyM{i=
HL-60 M{SwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVKxNEDPxE1? M1PYc|czKGh? MV;EUXNQ MU\JR|UxRTJwMUe4JO69VQ>? NU\wRo5VOjN6NESwN|g>
C3A NX\WSYxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT4SmF4OTBizszN NVvr[25iPzJiaB?= M{TsPWROW09? NELkcVFKSzVyPUWuOFE1KM7:TR?= NULoOGwzOjN6NESwN|g>
MES-SA NXvFe282T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLVTWFQOTBizszN NWHPNHpCPzJiaB?= M3XReGROW09? M2rES2lEPTB;Nj65PFkh|ryP MXGyN|g1PDB|OB?=
22Rv1 Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf2VoYyOCEQvF2= NIO1O2c4OiCq NIDSbWJFVVOR NFTKeZRKSzVyPUGwJO69VQ>? Ml\aNlM5PDRyM{i=
647-V MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4WzbVExKM7:TR?= MXK3NkBp MmfjSG1UVw>? M1LWOmlEPTB;MUCg{txO M4LRTFI{QDR2MEO4
786-O NUXjcohlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILZO2oyOCEQvF2= M3XvV|czKGh? MU\EUXNQ M3LUUGlEPTB;MUCg{txO NYnjdo5HOjN6NESwN|g>
A172 Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\vbVExKM7:TR?= NGrO[XQ4OiCq M1m1PGROW09? NVniUXA2UUN3ME2xNEDPxE1? NVTIeXU4OjN6NESwN|g>
A204 NY\iUm41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[4NVAh|ryP NV[xU5A4PzJiaB?= MUXEUXNQ MmHpTWM2OD1zMDFOwG0> NU[1PItCOjN6NESwN|g>
A427 MlzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37kclExKM7:TR?= MmDWO|IhcA>? NWfD[FE2TE2VTx?= NXvSOJV1UUN3ME2xNEDPxE1? MWOyN|g1PDB|OB?=
A431 NUnTOJZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TNclExKM7:TR?= M2DZcVczKGh? NIDFbHhFVVOR MnXsTWM2OD1zMDFOwG0> MWWyN|g1PDB|OB?=
A2780 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELoVW4yOCEQvF2= NUPtOmpuPzJiaB?= MnHkSG1UVw>? MnjwTWM2OD1zMDFOwG0> MWSyN|g1PDB|OB?=
ARH-77 NGqzNWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPJe4YyOCEQvF2= NIi3eZY4OiCq NEDxdW9FVVOR NXrMS21FUUN3ME2xNEDPxE1? MVKyN|g1PDB|OB?=
Be(2)C M3r4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL4ZYE{OTBizszN M4H2OVczKGh? NG\2O5hFVVOR NHHrZWJKSzVyPUGwJO69VQ>? MXyyN|g1PDB|OB?=
BT-20 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjEUJpQOTBizszN M3njNVczKGh? NWCzWWRlTE2VTx?= Mn3iTWM2OD1zMDFOwG0> MlS3NlM5PDRyM{i=
BxPc3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli4NVAh|ryP M3rKUVczKGh? MWjEUXNQ MnXETWM2OD1zMDFOwG0> MoDWNlM5PDRyM{i=
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C33A MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[xV|ExKM7:TR?= MVK3NkBp NFrk[XVFVVOR NEnxOJBKSzVyPUGwJO69VQ>? M3W5PVI{QDR2MEO4
CAL-27 Mn3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHZNVAh|ryP MofPO|IhcA>? Ml\SSG1UVw>? NIrIOGJKSzVyPUGwJO69VQ>? M4DFS|I{QDR2MEO4
CAL-62 MkjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf4NVAh|ryP MVe3NkBp MmnuSG1UVw>? MoHTTWM2OD1zMDFOwG0> NWj6Xm42OjN6NESwN|g>
Calu-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLFfYYyOCEQvF2= NHHSU|c4OiCq NYXrN45mTE2VTx?= M4\DemlEPTB;MUCg{txO MYiyN|g1PDB|OB?=
CaOV3 NIHrTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfoe5VzOTBizszN MlnUO|IhcA>? MnftSG1UVw>? M2DicmlEPTB;MUCg{txO M4XGfFI{QDR2MEO4
CGTHW1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3DNVAh|ryP M4C3ZlczKGh? NH21bndFVVOR NXrmfVlrUUN3ME2xNEDPxE1? NGPZ[3MzOzh2NECzPC=>
CHL-1 NHLXUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVOxNEDPxE1? NVPVVVVjPzJiaB?= MlfiSG1UVw>? M2P3eGlEPTB;MUCg{txO Mn3pNlM5PDRyM{i=
Colo320DM Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfFPXoyOCEQvF2= M1\NV|czKGh? NELCOlVFVVOR MWLJR|UxRTFyIN88US=> NH7Q[o8zOzh2NECzPC=>
Colo704 NWrLUHYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXOxNEDPxE1? MUW3NkBp MU\EUXNQ NXnn[od3UUN3ME2xNEDPxE1? NXT5SnhnOjN6NESwN|g>
COR-L23 MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLo[lc2OTBizszN M17FNlczKGh? NVzyNJNXTE2VTx?= NVvXdmV5UUN3ME2xNEDPxE1? MnPmNlM5PDRyM{i=
CRO-AP2 NYC4RY5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVmxNEDPxE1? MWW3NkBp NXWwNlliTE2VTx?= NYTC[oIyUUN3ME2xNEDPxE1? M37vZVI{QDR2MEO4
Daudi MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYixNEDPxE1? MkD5O|IhcA>? MYDEUXNQ M3GxZmlEPTB;MUCg{txO MYSyN|g1PDB|OB?=
DOTC 24510 NVewS|BET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmxNEDPxE1? M33NbVczKGh? NHH0N|hFVVOR MYnJR|UxRTFyIN88US=> M4LjV|I{QDR2MEO4
DU-145 MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXGxNEDPxE1? M2riZVczKGh? MnzESG1UVw>? MVjJR|UxRTFyIN88US=> NE[5NoszOzh2NECzPC=>
EB-3 NHrONlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjjV3JyOTBizszN MnTjO|IhcA>? NWLWdHo{TE2VTx?= MYDJR|UxRTFyIN88US=> M3HZOVI{QDR2MEO4
EFM-19 M3HJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUOxNEDPxE1? M3rsRlczKGh? NFzuWWpFVVOR NImyXJRKSzVyPUGwJO69VQ>? MWWyN|g1PDB|OB?=
EKVX NYfSTlZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofmNVAh|ryP M1jPcVczKGh? M3TTZWROW09? M3\hO2lEPTB;MUCg{txO NH2xTnYzOzh2NECzPC=>
FaDu MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXexNEDPxE1? NXnj[W5sPzJiaB?= MWjEUXNQ MlTnTWM2OD1zMDFOwG0> Mon3NlM5PDRyM{i=
G401 M{CzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;L[m8yOCEQvF2= NXy2R2xMPzJiaB?= M4rYOmROW09? M1;0WGlEPTB;MUCg{txO NFjCclEzOzh2NECzPC=>
HCC-70 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHX[mIyOCEQvF2= NGPSToc4OiCq NXzteVdbTE2VTx?= M{X5R2lEPTB;MUCg{txO NFHZOJkzOzh2NECzPC=>
HCC-1954 NIfq[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17XblExKM7:TR?= NVfvZnFKPzJiaB?= M1fGWGROW09? MlLOTWM2OD1zMDFOwG0> M1vpZ|I{QDR2MEO4
Hela MlrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m4ZVExKM7:TR?= NEHabGk4OiCq MVTEUXNQ M3P4XGlEPTB;MUCg{txO NFvQbHozOzh2NECzPC=>
Hep3B MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXmxNEDPxE1? M4TV[lczKGh? Mn3NSG1UVw>? M3\EVmlEPTB;MUCg{txO MnL5NlM5PDRyM{i=
HMCB MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6xNEDPxE1? MVe3NkBp NX7OeYVwTE2VTx?= MnfVTWM2OD1zMDFOwG0> MWOyN|g1PDB|OB?=
HN5 M3;Wb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHnR4gyOCEQvF2= M2K5O|czKGh? M2nYSWROW09? NIHnRZlKSzVyPUGwJO69VQ>? MXKyN|g1PDB|OB?=
HOS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHkN3VzOTBizszN MYS3NkBp NYrZend4TE2VTx?= M4\5UmlEPTB;MUCg{txO MYWyN|g1PDB|OB?=
HPAF-II NHnKenhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvKNVAh|ryP MWS3NkBp NUDsO3UyTE2VTx?= NFvWXHZKSzVyPUGwJO69VQ>? MUSyN|g1PDB|OB?=
Hs746.T M1rXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi5V25QOTBizszN NETPfpU4OiCq MnziSG1UVw>? M4fxPGlEPTB;MUCg{txO MYGyN|g1PDB|OB?=
HT NX\r[otHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XOcVExKM7:TR?= NHPBcIE4OiCq NXv0SllWTE2VTx?= MWfJR|UxRTFyIN88US=> MYOyN|g1PDB|OB?=
HT-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XSclExKM7:TR?= NUTjSZVmPzJiaB?= NXfSZYs1TE2VTx?= NYezeZdWUUN3ME2xNEDPxE1? M4XxNFI{QDR2MEO4
HuNS-1 NXrZcFl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlKwNVAh|ryP Mn3OO|IhcA>? NXnxW5BDTE2VTx?= M2P1VmlEPTB;MUCg{txO NF7iVnEzOzh2NECzPC=>
IGROV1 NY\vS|dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[yPJozOTBizszN M1;JSFczKGh? MmrYSG1UVw>? NEHiOYNKSzVyPUGwJO69VQ>? NY\tRphqOjN6NESwN|g>
J82 NYHUfIZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofzNVAh|ryP MU[3NkBp MW\EUXNQ MoTmTWM2OD1zMDFOwG0> NFzsc4EzOzh2NECzPC=>
JM1 M2j6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TVTFExKM7:TR?= NIPySY84OiCq Mk\0SG1UVw>? MYDJR|UxRTFyIN88US=> MlzHNlM5PDRyM{i=
Kato III NIjXRnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\ONVAh|ryP NHHidYU4OiCq NXjDRoZOTE2VTx?= MnvyTWM2OD1zMDFOwG0> M1\ielI{QDR2MEO4
KHOS-240S NV\pS41sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfPNVAh|ryP MYW3NkBp NWniVmZoTE2VTx?= M3\kfGlEPTB;MUCg{txO M3XyO|I{QDR2MEO4
KM-12 M37Dc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2myblExKM7:TR?= M4XtSFczKGh? NWHYVppVTE2VTx?= MWTJR|UxRTFyIN88US=> NGfl[ZQzOzh2NECzPC=>
KPL-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWOw[m4{OTBizszN MYO3NkBp Ml7ZSG1UVw>? NFTSUmZKSzVyPUGwJO69VQ>? Mo\VNlM5PDRyM{i=
KYSE-30 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PZW|ExKM7:TR?= NFHHeWw4OiCq MUfEUXNQ MYfJR|UxRTFyIN88US=> NY[0cFRsOjN6NESwN|g>
LNCaP Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnaT25{OTBizszN NX7rbIVVPzJiaB?= M3;ZU2ROW09? MkDITWM2OD1zMDFOwG0> NHzVOnEzOzh2NECzPC=>
MCF-7 M4jqU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTjUJQyOCEQvF2= Mni1O|IhcA>? MXfEUXNQ M2\Fd2lEPTB;MUCg{txO NFfzUIwzOzh2NECzPC=>
MC-IXC M3jFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYGxNEDPxE1? NXPYR4ZUPzJiaB?= MUHEUXNQ M1fMc2lEPTB;MUCg{txO MYGyN|g1PDB|OB?=
MDA-MB-175 VII MoPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUSxNEDPxE1? NFPzUJo4OiCq MX\EUXNQ NEL2bXhKSzVyPUGwJO69VQ>? NWHNOlNqOjN6NESwN|g>
MDA-MB-468 Mnn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV24dGg2OTBizszN NVTIell2PzJiaB?= Mn;aSG1UVw>? M4fzc2lEPTB;MUCg{txO NFj6bI8zOzh2NECzPC=>
MiaPaCa MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HIZVExKM7:TR?= M{PpfFczKGh? MmSySG1UVw>? MkDvTWM2OD1zMDFOwG0> MmHGNlM5PDRyM{i=
Molt-4 NEfCPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr6e|JNOTBizszN MkTsO|IhcA>? NFq4e3NFVVOR M1jpbmlEPTB;MUCg{txO MlHENlM5PDRyM{i=
NCI-ADR/RES NIPvS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\ReZkyOCEQvF2= M3zidVczKGh? MYfEUXNQ NGHCelFKSzVyPUGwJO69VQ>? NGnMNXMzOzh2NECzPC=>
NCI-H69 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\zWYgyOCEQvF2= NHG1XXE4OiCq NHrxcnlFVVOR M3jkeGlEPTB;MUCg{txO MmjGNlM5PDRyM{i=
NCI-H82 NYTwTYd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrzNVAh|ryP NF7IcFU4OiCq MoDjSG1UVw>? NH7vSYRKSzVyPUGwJO69VQ>? NHfkUXkzOzh2NECzPC=>
NCI-N87 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3sVngyOCEQvF2= NWWwb4kzPzJiaB?= NEjRTJNFVVOR M3X5N2lEPTB;MUCg{txO M{PqPVI{QDR2MEO4
NCI-H146 NHnTNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK2NVAh|ryP NIjSUpg4OiCq NVXXflVZTE2VTx?= NYLVUW1RUUN3ME2xNEDPxE1? MXuyN|g1PDB|OB?=
NCI-H157 M4PzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTGNVAh|ryP NV3idJBlPzJiaB?= M13SemROW09? MX\JR|UxRTFyIN88US=> MmfGNlM5PDRyM{i=
NCI-H187 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU[xNEDPxE1? NIr6UZM4OiCq Mke4SG1UVw>? M1fFW2lEPTB;MUCg{txO MWSyN|g1PDB|OB?=
NCI-H209 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M176O|ExKM7:TR?= MUS3NkBp M1qxbWROW09? Mo\pTWM2OD1zMDFOwG0> M3H3S|I{QDR2MEO4
NCI-H226 NHm5VFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\Fb5YyOCEQvF2= NWDUNoZsPzJiaB?= MUjEUXNQ MnOxTWM2OD1zMDFOwG0> NGHNXoMzOzh2NECzPC=>
NCI-H292 Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHWNVAh|ryP NYXz[nB1PzJiaB?= M4jVVGROW09? NFTkUoFKSzVyPUGwJO69VQ>? M4DN[|I{QDR2MEO4
NCI-H322 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHTPHYyOCEQvF2= NFL5boM4OiCq NWLCN4lqTE2VTx?= MVXJR|UxRTFyIN88US=> NXvpWXREOjN6NESwN|g>
NCI-H358 M2rofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGn4PXoyOCEQvF2= M1XaWlczKGh? MkfQSG1UVw>? NVfOU3JOUUN3ME2xNEDPxE1? NWTZSXlZOjN6NESwN|g>
NCI-H520 MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDsNVAh|ryP Mnu3O|IhcA>? M3vTfmROW09? NFzvTW1KSzVyPUGwJO69VQ>? NVu4OXY5OjN6NESwN|g>
NCI-H526 M1O1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7kN4gyOCEQvF2= NGe5[Fk4OiCq NV\ZfW5nTE2VTx?= MX3JR|UxRTFyIN88US=> M12yTFI{QDR2MEO4
NCI-H630 M1TpW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnKzNVAh|ryP NEHoXXk4OiCq MmjvSG1UVw>? NX\Qc41sUUN3ME2xNEDPxE1? MVmyN|g1PDB|OB?=
NCI-H661 NGjWepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? M4jCelczKGh? M4\OSmROW09? MmnDTWM2OD1zMDFOwG0> MlS3NlM5PDRyM{i=
NCI-H716 M2\Yfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrTNVAh|ryP NXzt[WI4PzJiaB?= NX3Qdo5LTE2VTx?= MWfJR|UxRTFyIN88US=> Mn[xNlM5PDRyM{i=
NCI-H1563 M{TFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\pZVExKM7:TR?= NE\HUlk4OiCq NVniOFlbTE2VTx?= MXPJR|UxRTFyIN88US=> MYOyN|g1PDB|OB?=
NCI-H1792 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn1Xos3OTBizszN M{LMdlczKGh? NEDyPIhFVVOR NYKzemh2UUN3ME2xNEDPxE1? MojaNlM5PDRyM{i=
NCI-H2030 M4XMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofTNVAh|ryP MX[3NkBp MV\EUXNQ MXzJR|UxRTFyIN88US=> NGX6eXczOzh2NECzPC=>
NCI-H2052 MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:2ZndKOTBizszN MWS3NkBp NUKxTYo5TE2VTx?= NXvMeYRlUUN3ME2xNEDPxE1? MVqyN|g1PDB|OB?=
NCI-H2122 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELVUHoyOCEQvF2= M4fIb|czKGh? Mn\PSG1UVw>? NV;jd201UUN3ME2xNEDPxE1? NUjjXIpkOjN6NESwN|g>
NCI-H2228 MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYKxNEDPxE1? M1HUZ|czKGh? NETCfpJFVVOR NVnrNlBZUUN3ME2xNEDPxE1? MUSyN|g1PDB|OB?=
OE-19 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYSxNEDPxE1? MXi3NkBp NEe1RmFFVVOR NUjoUpVbUUN3ME2xNEDPxE1? M4K2SFI{QDR2MEO4
OE-21 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDMOYg5OTBizszN MYi3NkBp NEHKTpNFVVOR NYnIWZJkUUN3ME2xNEDPxE1? NYqzSHN4OjN6NESwN|g>
OE-33 NVm3eYVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnrfW82OTBizszN MWm3NkBp NHTq[Y5FVVOR MXLJR|UxRTFyIN88US=> M{W3RlI{QDR2MEO4
OVCAR-3 NGPzcoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTiNVAh|ryP M3\pVVczKGh? NIfRSVRFVVOR NIHHdotKSzVyPUGwJO69VQ>? Mn[wNlM5PDRyM{i=
OVCAR-4 NHTkdXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTONVAh|ryP Ml\SO|IhcA>? MlHySG1UVw>? MVPJR|UxRTFyIN88US=> MWqyN|g1PDB|OB?=
OVCAR-5 M1\wdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHVNVAh|ryP MV[3NkBp M3rNb2ROW09? NVuzXGxPUUN3ME2xNEDPxE1? MljGNlM5PDRyM{i=
P3HR-1 MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3xeZQyOCEQvF2= MlvvO|IhcA>? M{DMW2ROW09? NYCyV4trUUN3ME2xNEDPxE1? M{TOWVI{QDR2MEO4
PC-3 NVfaeYExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\Q[Xc2OTBizszN MortO|IhcA>? NVHqUGJ3TE2VTx?= M2XKe2lEPTB;MUCg{txO NV\PdI9MOjN6NESwN|g>
Raji NELmO2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkmxNVAh|ryP M1rDOVczKGh? NFz5U4RFVVOR MnPGTWM2OD1zMDFOwG0> MUWyN|g1PDB|OB?=
RD MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D6XFExKM7:TR?= M2T1dlczKGh? M1;CXmROW09? Mo[yTWM2OD1zMDFOwG0> NEX6cmkzOzh2NECzPC=>
RD-ES NGTRNWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:xNEDPxE1? NH[xTnI4OiCq MnrBSG1UVw>? NUC4UpMxUUN3ME2xNEDPxE1? MWKyN|g1PDB|OB?=
RL M3PXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWKzepRmOTBizszN NXnTfoZzPzJiaB?= MUPEUXNQ Mn3ZTWM2OD1zMDFOwG0> MnzmNlM5PDRyM{i=
SaOS2 M3v5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDyUWEyOCEQvF2= NFfJO2o4OiCq NGLjclVFVVOR MV7JR|UxRTFyIN88US=> MlL4NlM5PDRyM{i=
SCC-9 MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jLR|ExKM7:TR?= MmfvO|IhcA>? M4XL[GROW09? MljzTWM2OD1zMDFOwG0> MljINlM5PDRyM{i=
SCC-12 M{m1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXMOVUyOCEQvF2= MV:3NkBp MojMSG1UVw>? NX3E[IdLUUN3ME2xNEDPxE1? MnzqNlM5PDRyM{i=
SCC-13 M{PlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle5NVAh|ryP M{TsUVczKGh? MnjKSG1UVw>? NG\iR4lKSzVyPUGwJO69VQ>? M1LKRVI{QDR2MEO4
SCC-15 M4DIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nkUVExKM7:TR?= NFjrVGE4OiCq M1z0bGROW09? Mn;VTWM2OD1zMDFOwG0> M1O2WlI{QDR2MEO4
SCC-25 Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHlOGhOOTBizszN M{LTNFczKGh? NIS5U|NFVVOR MoHITWM2OD1zMDFOwG0> NWPGe|E4OjN6NESwN|g>
SCLC-3 MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfQO5cyOCEQvF2= NV7mT|F5PzJiaB?= MmPFSG1UVw>? NHzIZo9KSzVyPUGwJO69VQ>? NX2wSlFyOjN6NESwN|g>
SF-268 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXmwOWwyOTBizszN M3PPNVczKGh? MljuSG1UVw>? NUXnOY9SUUN3ME2xNEDPxE1? MV:yN|g1PDB|OB?=
SF-295 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X6d|ExKM7:TR?= M2rLRVczKGh? NYLUdnVvTE2VTx?= MYXJR|UxRTFyIN88US=> NETybFkzOzh2NECzPC=>
SJRH30 MlfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHQTGtHOTBizszN MX[3NkBp NUmybIdLTE2VTx?= NXuxXYtqUUN3ME2xNEDPxE1? Mom3NlM5PDRyM{i=
SK-BR-3 MnvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUOxNEDPxE1? NVXSTXRtPzJiaB?= NIToUYNFVVOR MX;JR|UxRTFyIN88US=> MV2yN|g1PDB|OB?=
SK-LMS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr5PXEyOCEQvF2= NIDkSFI4OiCq Mn2zSG1UVw>? MkTJTWM2OD1zMDFOwG0> MljMNlM5PDRyM{i=
SK-N-DZ MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\jU4cyOCEQvF2= MWi3NkBp M4\N[GROW09? M{HNfGlEPTB;MUCg{txO MoLkNlM5PDRyM{i=
SK-N-F1 M{PJbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmxNEDPxE1? NE\nZWU4OiCq NFjaU2VFVVOR MoPQTWM2OD1zMDFOwG0> NH;kZ3AzOzh2NECzPC=>
SKOV-3 NHrrWGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTo[YhLOTBizszN MXy3NkBp NWn5UnAxTE2VTx?= NYPHdIh1UUN3ME2xNEDPxE1? M4rPNFI{QDR2MEO4
SK-UT-1 NGfFT|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXqxNEDPxE1? MoHXO|IhcA>? MWfEUXNQ NWDw[GlFUUN3ME2xNEDPxE1? Mk\QNlM5PDRyM{i=
SN12C NETWUXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUCxNEDPxE1? NHL2W284OiCq NU\PN4xCTE2VTx?= MYPJR|UxRTFyIN88US=> NVzjUI1POjN6NESwN|g>
SNB-19 NVnIT5lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPrd|ZWOTBizszN MVS3NkBp M4XUc2ROW09? MoTpTWM2OD1zMDFOwG0> NYXIcmg3OjN6NESwN|g>
SNU-5 MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWGxNEDPxE1? NWjT[IFXPzJiaB?= NGrpbVZFVVOR NGDtcHBKSzVyPUGwJO69VQ>? NGjTbFczOzh2NECzPC=>
SNU-16 NVW2[25ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV2xNEDPxE1? MkH3O|IhcA>? MYLEUXNQ NXrFXldSUUN3ME2xNEDPxE1? M{LwTVI{QDR2MEO4
SNU-398 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHVO4hOOTBizszN NV\KSJFYPzJiaB?= MWHEUXNQ MVPJR|UxRTFyIN88US=> MlH1NlM5PDRyM{i=
SNU-449 M1HXRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? MnqzO|IhcA>? M2nO[WROW09? NF\yXW9KSzVyPUGwJO69VQ>? MoXjNlM5PDRyM{i=
SR M{e4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHqTYJMOTBizszN MV23NkBp M3nzRmROW09? NGjwcldKSzVyPUGwJO69VQ>? NIn3UJUzOzh2NECzPC=>
ST486 NXPJdIZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\RWIMyOCEQvF2= NHy4XJE4OiCq NXjOWIFiTE2VTx?= NFrGXHZKSzVyPUGwJO69VQ>? MnzKNlM5PDRyM{i=
SW579 Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjaUnkyOCEQvF2= MonCO|IhcA>? NEXGcldFVVOR MYTJR|UxRTFyIN88US=> MlroNlM5PDRyM{i=
SW684 M2Pn[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOyNmgyOCEQvF2= NF2xXoQ4OiCq MYXEUXNQ M1;iVmlEPTB;MUCg{txO M2[wdFI{QDR2MEO4
SW-780 NUDsb|VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj1NVAh|ryP NITpV4Q4OiCq Mk\YSG1UVw>? MoT3TWM2OD1zMDFOwG0> NWXlTmM5OjN6NESwN|g>
SW900 M{DmeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfwNpp5OTBizszN NUPC[HNQPzJiaB?= NUL2eZdQTE2VTx?= NVHyZ481UUN3ME2xNEDPxE1? Mn3WNlM5PDRyM{i=
SW1088 NXTqOI9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nWS|ExKM7:TR?= NEDrUmM4OiCq MV3EUXNQ MWPJR|UxRTFyIN88US=> MoPhNlM5PDRyM{i=
SW1463 NHrySIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETHe5AyOCEQvF2= NULnR4tuPzJiaB?= NGq0WJVFVVOR MWLJR|UxRTFyIN88US=> NGn1VmQzOzh2NECzPC=>
SW1990 NUOx[oZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWOxNEDPxE1? M4j4bVczKGh? MVnEUXNQ NVTzWHh4UUN3ME2xNEDPxE1? M3jVdVI{QDR2MEO4
T47D MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S5RVExKM7:TR?= MWG3NkBp NITTV3dFVVOR MXnJR|UxRTFyIN88US=> M{Hhb|I{QDR2MEO4
TE381.T MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYWxNEDPxE1? M2TPUVczKGh? MmrzSG1UVw>? MWDJR|UxRTFyIN88US=> MYGyN|g1PDB|OB?=
TK-10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlSzNVAh|ryP NELOXpo4OiCq M4r1WWROW09? M{m2N2lEPTB;MUCg{txO NEizWZAzOzh2NECzPC=>
U2OS MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nVd|ExKM7:TR?= NU\ydJFKPzJiaB?= MWDEUXNQ MoC2TWM2OD1zMDFOwG0> NVy1RZFrOjN6NESwN|g>
U251 NVXI[5F2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LUcFExKM7:TR?= M1nrNVczKGh? NV3kZnF6TE2VTx?= M1zrXmlEPTB;MUCg{txO NEPqXoEzOzh2NECzPC=>
UACC-812 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXXNVAh|ryP MYm3NkBp MmPrSG1UVw>? M3LtWmlEPTB;MUCg{txO MYKyN|g1PDB|OB?=
YAPC M2jVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUmxNEDPxE1? M32xbVczKGh? Mk\ZSG1UVw>? MlfRTWM2OD1zMDFOwG0> NYXtWnkyOjN6NESwN|g>
ZR-75-1 NIPLWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zDUFExKM7:TR?= M2PQeVczKGh? MVnEUXNQ M1WzSGlEPTB;MUCg{txO MoW0NlM5PDRyM{i=
A375 NULZT2JvTnWwY4Tpc44h[XO|YYm= MXGxMlIh|ryP Mlf4OEBp MW\EUXNQ NVzXT|Y1UW6qaXLpeIlwdiCxZjDwbI9{eGixconsZZRqd25ib3[gUWVMNCCHUlusJIFv\CCVNmC= M{PBPFIzOzh7NEex
YUSIT1 MWrGeY5kfGmxbjDhd5NigQ>? NYnpWpV[TE2VTx?= NYLHXmZoemWmdXPl[EB{\W6|aYTpeol1gSC5aYToJGlEPTBiPjCwMlUh|ryP MXiyNlM5QTR5MR?=
MeWo NUPyRVQ6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTKZ4lFVVOR MWrJR|UxKD1iOUi3JI5O M4DxdlI3ODF6NUK0
WiDr MluxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NITVRoFFVVOR NX3kZWNvUUN3MDC9JFc3KG6P NHHpbpEzPjBzOEWyOC=>
Colo-205 M2OxeGZ2dmO2aX;uJIF{e2G7 NFn5U|cyKM7:TR?= MYW0JIQ> NWPPbGV6TE2VTx?= NXnNOoRQUW6mdXPl[EBiKGirZ3jsfUBkd22yYYLhZoxmKGOxbYDhZ5Rqd25icHjlco91gXCn NVz6Nm9jOjV|OEGxOVI>
RBW-1 M2PGTmZ2dmO2aX;uJIF{e2G7 NEjocFEyKM7:TR?= NICyUllFVVOR NEK2VWxPdyC{ZXT1Z5Rqd25ib3[gUYVsKDFxMjDwbI9{eGixconsZZRqd25? NXfyNGFSOjR6OEW2PVA>
RBO-1 NHuxPHRHfW6ldHnvckBie3OjeR?= NEfkfFMyKM7:TR?= MnnzSG1UVw>? M1TJcmlvcGmkaYTpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> NETmPXEzPDh6NU[5NC=>
RBO-2 M37mXmZ2dmO2aX;uJIF{e2G7 M3TGXlEh|ryP M2jzNmROW09? NEH6RXhKdmirYnn0bY9vKG:oIDDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? M4fVT|I1QDh3Nkmw
RBOW M3f2bWZ2dmO2aX;uJIF{e2G7 NFrKTIQyKM7:TR?= NYPYOFlrTE2VTx?= MlL3TY5pcWKrdHnvckBw\iBiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> Mn[xNlQ5QDV4OUC=
M257 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TCZlExOCCwTR?= Mom3O|IhcA>? MWjEc4V{KG6xdDDpcohq[mm2IIDyc4xq\mW{YYTpc44hd2ZiTUK1O{Bk\WyuIHjhdoJwfXKrbnege4lt\CC2eYDlJGJTSUZ? NHjidIgzOzNzN{S0Oi=>
LCP NGn5NFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTaNVAxKG6P NEjFOmY4OiCq NID1flJKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v MlXXNlM{OTd2NE[=
WM266 NUnITXYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7iOlNIOTByIH7N NH7zOWw4OiCq MnvwTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKFePMk[2JINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEHEJI12fGGwdHH0bY9v MnjENlM{OTd2NE[=
M257 Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vFXFExOCCwTR?= NInKUJE4OiCq NXnQWYk1TG:nczDuc5QhcW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG NE[3bXgzOzNzN{S0Oi=>
LCP NHLDZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j3XVExOCCwTR?= NVracFh5PzJiaB?= M3e1dmlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDMR3Ah[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNHIhdXW2YX70ZZRqd25? NXn0TFJ4OjN|MUe0OFY>
WM266 NEG4S4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HFVFExOCCwTR?= NYi0OlM6PzJiaB?= NYe5VGFDUW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJHdOOjZ4IHPlcIwhcGG{Yn;1dolv\yCEUlHGJHY3ODCGIH31eIFvfGG2aX;u MoGyNlM{OTd2NE[=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --
NCT03340506 Recruiting Drug: dabrafenib|Drug: trametinib Melanoma|Non Small Cell Lung Cancer|Solid Tumor|Rare Cancers|High Grade Glioma Novartis Pharmaceuticals|Novartis December 28 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID