Dabrafenib (GSK2118436)

For research use only.

Catalog No.S2807

152 publications

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Selleck's Dabrafenib (GSK2118436) has been cited by 152 publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NIrVWoJMcW6jc3WgRZN{[Xl? MWTJcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiSHnzJJRi\2enZDDCMXJi\iCYNkCwSUBufXSjboSg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIHnud4VkfCClZXzsd{Bkdy2neIDy[ZN{cW6pIFPER|M4KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJIJqd3SrbonsZZRm\C2PRVugdJJwfGWrbjDwbI9{eGixconsZZRqd25iYomgRYxxcGGVY4Ll[Y4h[XO|YYmge4l1cCCLQ{WwJI9nKDBwMECwO{DPxE1? NWPVbJZsOjR7MEC2O|M>
SK-MEL-28 Mn3mT4lv[XOnIFHzd4F6 MYSxJIg> MXLJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP NUfUSo5uOjR7MEC2O|M>
HepG2 NFvMNm9McW6jc3WgRZN{[Xl? M1;RXGlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? NV;iOlZ6OjR7MEC2O|M>
COLO205 NFfRemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33qN2lvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= MnPtNlQ6ODB4N{O=
HepG2 MXLGeY5kfGmxbjDBd5NigQ>? MkP0OFUhdWmw NFLwTVNFVVOR NFzVcWxKdmirYnn0bY9vKG:oIFHsb|UhcW5iVFfGMYJmfGFvc4TpcZVt[XSnZDDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCVbXHkNkBxcG:|cHjvdplt[XSrb36geJJm[XSnZDDmc5IhPDVibXnud{BxemmxcjD0c{BVT0ZvYnX0ZUB{fGmvdXzheIlwdiCvZXHzeZJm\CCjZoTldkA3OCCvaX7zJIJ6KG:meYPz[Zkh[myxdDDzZ4FvdmW{IHHuZYx6e2m|IIfpeIghUUN3MDDv[kA{NjdizszN NWHtZXgyOjR7MEC2O|M>
HFF Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTi[WEyOCEQvF2= NHXHe4k4OiCq NHjVV4ZFVVOR M3vVNWlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCqdX3hckBJTkZiY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCELWLh[kB4cXSqIFnDOVAhd2ZiMzFOwG0> MoPiNlM5PDRyM{i=
SK-MEL-28 MlK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK5UIpDOTBizszN NIrrWIQ4OiCq M1vu[GROW09? NHy1WlJKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iU1utUWVNNTJ6IHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yNEOg{txO NXrHcXZzOjN6NESwN|g>
A375P-F11 NELHWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj3doY6OTBizszN MWS3NkBp MXrEUXNQ MV3Jcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfC2mcnn2[Y4hSTN5NWCtSlEyKGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xPzFizszN M2XyTlI{QDR2MEO4
MALME-3M MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XTflExKM7:TR?= NWDjd3p5PzJiaB?= NUTLeFJrTE2VTx?= M2jtcGlEPTB;MTDuUS=> MkjLNlM5PDRyM{i=
UACC-62 NEXmdoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVG1NHZEOTBizszN NUjIUYxUPzJiaB?= NI\kXJlFVVOR NFvGeVVKSzVyPUGgcm0> M33QclI{QDR2MEO4
C32TG NFfqU4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnzOWl6OTBizszN MnnyO|IhcA>? NEO3[GFFVVOR NVLDdpZNUUN3ME2xJI5O NF7jRpozOzh2NECzPC=>
SK-MEL-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;kOVEyOCEQvF2= NU\XN3pIPzJiaB?= NH\IXJZFVVOR NUPqWZNRUUN3ME2yJI5O NEGyWVIzOzh2NECzPC=>
M14 NILXeI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HBSlExKM7:TR?= NWnyR4I4PzJiaB?= MWfEUXNQ MlTtTWM2OD1{IH7N NWPtdZB4OjN6NESwN|g>
SK-MEL-28 NYLuc2tFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKxNEDPxE1? NUjTcpk2PzJiaB?= MWTEUXNQ MUXJR|UxRTNibl2= NYSwfphCOjN6NESwN|g>
A375 M{\yU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HIcFExKM7:TR?= NVLOZog3PzJiaB?= MUHEUXNQ NVvUV4s3UUN3ME20JI5O Mm\ZNlM5PDRyM{i=
DU-4475 NXXXUnJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkOxNVAh|ryP NYLH[Jk3PzJiaB?= M4XUSGROW09? NFHu[FFKSzVyPUWgcm0> MVmyN|g1PDB|OB?=
UACC-257 M165emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnleolLOTBizszN MUi3NkBp MWrEUXNQ NHTPN5pKSzVyPU[gcm0> NXj1T2JTOjN6NESwN|g>
Colo 205 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LJVlExKM7:TR?= MX[3NkBp MofDSG1UVw>? NIfUNpFKSzVyPUegcm0> NEDXbWszOzh2NECzPC=>
SK-MEL-3 NYezPINlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3sZ|IyOCEQvF2= M4D6SFczKGh? NXG5XXE4TE2VTx?= NF\ISVdKSzVyPUegcm0> NXPvOW1HOjN6NESwN|g>
SH-4 M37RPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojGNVAh|ryP NFzVTGQ4OiCq M4rVdmROW09? NGnFc3BKSzVyPUigcm0> NHXQdFIzOzh2NECzPC=>
A101D NELqSnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvyNVAh|ryP NVXWcZlOPzJiaB?= NVGwd5I3TE2VTx?= NYrhfHpnUUN3ME25JI5O NX;NNI83OjN6NESwN|g>
ES-2 NIXhZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPVXVVtOTBizszN NIDrPW84OiCq MnLzSG1UVw>? Mn3XTWM2OD13MzDuUS=> MYWyN|g1PDB|OB?=
HT-29 NWfzN5ZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? MXS3NkBp MYfEUXNQ MYfJR|UxRTZ4IH7N MUmyN|g1PDB|OB?=
SW1417 NV7WeVc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXqxNEDPxE1? NUGxNYtRPzJiaB?= NF\MfIFFVVOR NESxU25KSzVyPUG1PEBvVQ>? MUGyN|g1PDB|OB?=
SW872 MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7q[oFpOTBizszN M1fXOVczKGh? M3;JN2ROW09? MYLJR|UxRTN5NzDuUS=> NGLoNHEzOzh2NECzPC=>
RKO M13tfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrENVAh|ryP MkHQO|IhcA>? NXL4Z|FZTE2VTx?= M{mycmlEPTB;Mj61NlIh|ryP MmPJNlM5PDRyM{i=
A673 NEL0fXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmxNEDPxE1? MlLrO|IhcA>? MXLEUXNQ NIPoc|ZKSzVyPUGwJO69VQ>? MnrwNlM5PDRyM{i=
GCT NIDZNI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET3[oUyOCEQvF2= M{LvcVczKGh? M3S4VmROW09? M{j1U2lEPTB;MUCg{txO M3PLZ|I{QDR2MEO4
WM-115 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\4VJIyOCEQvF2= M3LHXVczKGh? MoXVSG1UVw>? NF\GfIZKSzVyPUWgcm0> NWnJOXVXOjN6NESwN|g>
YUMAC MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjsN|AzOTBizszN MXK3NkBp M{LZPWROW09? MoP3TWM2OD13IH7N Mk\lNlM5PDRyM{i=
OV-90 MmHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33aSFExKM7:TR?= M4PmUlczKGh? Mlf6SG1UVw>? NFW3OY1KSzVyPUK5JI5O NFHvc3AzOzh2NECzPC=>
NCI-H508 NIDneItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVixNEDPxE1? MnnTO|IhcA>? NFvxUHJFVVOR MojDTWM2OD1zMDFOwG0> MXOyN|g1PDB|OB?=
MDA-MB-231 NVO2NmdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLGTGx1OTBizszN NIfGPWQ4OiCq NFH2c5FFVVOR MlLxTWM2OD1zMDFOwG0> M13BTFI{QDR2MEO4
SW756 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zSN|ExKM7:TR?= M3zqN|czKGh? MVzEUXNQ M2LPV2lEPTB;MUCg{txO M3PrWVI{QDR2MEO4
SW-837 NYDVZ|V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInOcIYyOCEQvF2= MVy3NkBp MlrFSG1UVw>? MkDRTWM2OD1zMDFOwG0> M{LwclI{QDR2MEO4
UMUC-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;1[FYyOCEQvF2= NF3abW44OiCq NIHsfnBFVVOR NYP0VVVKUUN3ME2xNEDPxE1? M2T5VFI{QDR2MEO4
LS-174T NXXNflQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TieFExKM7:TR?= Ml7UO|IhcA>? Ml75SG1UVw>? NFK1cG1KSzVyPUGwJO69VQ>? M{m5UlI{QDR2MEO4
A549 NF20UmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr1NVAh|ryP NHnEcI84OiCq MYHEUXNQ NFLFcXZKSzVyPUGwJO69VQ>? M1vrWFI{QDR2MEO4
SHP-77 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXmOWMyOCEQvF2= M{nCclczKGh? Mn;FSG1UVw>? M1q5OWlEPTB;MUCg{txO MYCyN|g1PDB|OB?=
SW480 NGrlVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[xNEDPxE1? MljHO|IhcA>? MlTFSG1UVw>? NYiwVZh[UUN3ME2xNEDPxE1? M{PoUVI{QDR2MEO4
DLD-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v3XlExKM7:TR?= MnvOO|IhcA>? MVPEUXNQ MVXJR|UxRTFyIN88US=> MnXlNlM5PDRyM{i=
HCT-116 NV;Yem1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSxNEDPxE1? MXi3NkBp M3TQVGROW09? M4TaNWlEPTB;MUCg{txO M3uyTFI{QDR2MEO4
NCI-H747 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\lNVAh|ryP MorVO|IhcA>? MkPTSG1UVw>? M2\qXmlEPTB;MUCg{txO NV7r[ItkOjN6NESwN|g>
T-84 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVqxNEDPxE1? MmnzO|IhcA>? MXjEUXNQ MWDJR|UxRTFyIN88US=> MUWyN|g1PDB|OB?=
NCI-H460 MmXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHGO|IyOCEQvF2= MkjjO|IhcA>? NFzRRWhFVVOR NWrRXocyUUN3ME2xNEDPxE1? M{G0c|I{QDR2MEO4
Calu-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfjeYsyOCEQvF2= MUi3NkBp NG\OSFdFVVOR MVnJR|UxRTFyIN88US=> Ml7TNlM5PDRyM{i=
HCC-2998 MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWGxNEDPxE1? NXrl[YsxPzJiaB?= M{\xO2ROW09? MV7JR|UxRTFyIN88US=> NITKOZEzOzh2NECzPC=>
LS1034 MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXOR2hWOTBizszN NY\YeXVFPzJiaB?= M{PDOGROW09? NFzLZ4RKSzVyPUGwJO69VQ>? Ml;TNlM5PDRyM{i=
CHP-212 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr6NHUyOCEQvF2= NXPLcWN3PzJiaB?= NUHaVmRjTE2VTx?= NYXw[IdsUUN3ME2xNEDPxE1? NIGzRpMzOzh2NECzPC=>
SK-N-AS Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW3S|EyOCEQvF2= NFzIPJY4OiCq M{nwcmROW09? MUfJR|UxRTFyIN88US=> NIC1e3czOzh2NECzPC=>
BFTC-905 NVXjW25ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmxNEDPxE1? Mn73O|IhcA>? NVnz[lZ6TE2VTx?= MlS4TWM2OD1zMDFOwG0> NVvF[lhKOjN6NESwN|g>
HuT78 NVztdlRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUexNEDPxE1? NEnnWmk4OiCq M{Wwc2ROW09? M{LLS2lEPTB;NUKgcm0> M{K0TlI{QDR2MEO4
RPMI-8226 M4fFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTvU|lSOTBizszN MnezO|IhcA>? NWrmbpdqTE2VTx?= MX\JR|UxRTJ4MzDuUS=> NXL5Olc3OjN6NESwN|g>
BC-3 NEnoOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi2NVAh|ryP MWe3NkBp MWjEUXNQ M3jvXWlEPTB;Mke3JI5O MlzENlM5PDRyM{i=
ACHN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzMNVAh|ryP MkLZO|IhcA>? NVe5dY9VTE2VTx?= MUTJR|UxRTJ7NDDuUS=> NX\jfmdVOjN6NESwN|g>
JRT3-T35 M2X3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\a[WQyOCEQvF2= NVvXSVV1PzJiaB?= MWXEUXNQ M1e5fWlEPTB;Mkm1JI5O NVP6WpN2OjN6NESwN|g>
SK-MES-1 M2myemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYGxNEDPxE1? M1rFTVczKGh? M4r4OmROW09? MmTRTWM2OD1|Mkmgcm0> NITlWnkzOzh2NECzPC=>
CESS MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLaNVAh|ryP NGnBWlk4OiCq M3jiTGROW09? MoH2TWM2OD12OUegcm0> NFG0U4szOzh2NECzPC=>
H4 M1rSXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vQclExKM7:TR?= NVfnbYNmPzJiaB?= M{HmemROW09? MkToTWM2OD14MUmgcm0> Mn;QNlM5PDRyM{i=
BC-1 NWXGUY1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUSxNEDPxE1? M17hPVczKGh? MnuzSG1UVw>? NWOydFNyUUN3ME23NFQhdk1? NXvPeI5vOjN6NESwN|g>
DB NWHFW24zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTYNVAh|ryP NY\ZTYZvPzJiaB?= M1z3NGROW09? M3y4[mlEPTB;OEezJI5O MnjINlM5PDRyM{i=
RPMI-6666 NV7JOWlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX2xNEDPxE1? Mo\6O|IhcA>? M2X1dGROW09? MV3JR|UxRTl{ODDuUS=> NYf0ZoFmOjN6NESwN|g>
MC/CAR Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3yzVVExKM7:TR?= NV3Re2E1PzJiaB?= MWPEUXNQ NWS3eWNbUUN3ME2xMlAxOiEQvF2= MUWyN|g1PDB|OB?=
SNU-1 NIHvSWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\EdYdNOTBizszN MnruO|IhcA>? MVPEUXNQ MnvYTWM2OD1zLkWwNUDPxE1? MUGyN|g1PDB|OB?=
CEM/C1 M4Liemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD2PIwyOCEQvF2= M4LHclczKGh? NGjuWXBFVVOR NV3P[msxUUN3ME2xMlc4OyEQvF2= NHXZUoYzOzh2NECzPC=>
GDM-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDsNVAh|ryP M2nHZlczKGh? MnLDSG1UVw>? M4DBbWlEPTB;MT65PVch|ryP NX7GN4EzOjN6NESwN|g>
HT-1080 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HE[VExKM7:TR?= M4TTdlczKGh? NIjlbYtFVVOR NWDuWHRpUUN3ME2yMlAxPCEQvF2= M{Hke|I{QDR2MEO4
HL-60 NF;VSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3VNVAh|ryP MnXwO|IhcA>? NYm2T2V3TE2VTx?= NV7m[|RPUUN3ME2yMlE4QCEQvF2= NYTyU3hxOjN6NESwN|g>
C3A NXrhbZNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTKcVAyOCEQvF2= MkO4O|IhcA>? MkfVSG1UVw>? NF75e4tKSzVyPUWuOFE1KM7:TR?= MYSyN|g1PDB|OB?=
MES-SA MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUixNEDPxE1? MknCO|IhcA>? MoDpSG1UVw>? M2HpXWlEPTB;Nj65PFkh|ryP M3e2SlI{QDR2MEO4
22Rv1 NHzGRZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXOxNEDPxE1? NHy0cnM4OiCq MmrVSG1UVw>? NV3wPXBHUUN3ME2xNEDPxE1? NYnBN3FuOjN6NESwN|g>
647-V MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXvNVAh|ryP NFLFb5U4OiCq NXT3dnlrTE2VTx?= M4rJUWlEPTB;MUCg{txO MYCyN|g1PDB|OB?=
786-O NV3zOo01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i5NFExKM7:TR?= NYe4cnFsPzJiaB?= NYf0d2NsTE2VTx?= MnXYTWM2OD1zMDFOwG0> M{fPZ|I{QDR2MEO4
A172 M1L1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fVWlExKM7:TR?= MYe3NkBp MmDpSG1UVw>? MWrJR|UxRTFyIN88US=> MljBNlM5PDRyM{i=
A204 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrqbW0yOCEQvF2= MVW3NkBp NWfENodvTE2VTx?= NWTWPYZuUUN3ME2xNEDPxE1? NFrXcGgzOzh2NECzPC=>
A427 NFXJV29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITrfXEyOCEQvF2= NUDiXVA4PzJiaB?= MljkSG1UVw>? M2T6OGlEPTB;MUCg{txO NImwNVAzOzh2NECzPC=>
A431 NUXaPHZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnSWXoyOCEQvF2= NVrKXG1jPzJiaB?= NVnWV5c1TE2VTx?= M13zPGlEPTB;MUCg{txO NGnnbVAzOzh2NECzPC=>
A2780 M3;SOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjsNpM{OTBizszN M4DOUlczKGh? M3LyXmROW09? NIPJfZNKSzVyPUGwJO69VQ>? Mn3aNlM5PDRyM{i=
ARH-77 NUm2eoc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nJVVExKM7:TR?= M1;uTVczKGh? NWrYNHVwTE2VTx?= M3;QNGlEPTB;MUCg{txO M336SVI{QDR2MEO4
Be(2)C NHvQU3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DzUlExKM7:TR?= MoHsO|IhcA>? NV\4U5FLTE2VTx?= Mm\YTWM2OD1zMDFOwG0> NYS0NXd2OjN6NESwN|g>
BT-20 M3H3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC4[5dlOTBizszN NH6xTpI4OiCq NUC5[YR4TE2VTx?= MmLqTWM2OD1zMDFOwG0> NVyzSXczOjN6NESwN|g>
BxPc3 M3K4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\yVoQyOCEQvF2= NH:2TXM4OiCq NFnTdJlFVVOR NIrhR4hKSzVyPUGwJO69VQ>? M2S4PFI{QDR2MEO4
C-4 I MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWOxNEDPxE1? M3zNfFczKGh? MkXjSG1UVw>? MnPETWM2OD1zMDFOwG0> MVGyN|g1PDB|OB?=
C33A NHjmVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;YcVExKM7:TR?= NVH0WWpyPzJiaB?= NVjycnJ{TE2VTx?= M{XwcGlEPTB;MUCg{txO NVfi[2FSOjN6NESwN|g>
CAL-27 NHzQd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHUb2xKOTBizszN M4fvUFczKGh? MY\EUXNQ NYPFWZBMUUN3ME2xNEDPxE1? NFn3OIMzOzh2NECzPC=>
CAL-62 NUfxfJRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXGdmsyOCEQvF2= NVSxO4N[PzJiaB?= M3nKcmROW09? NFrJUllKSzVyPUGwJO69VQ>? MXOyN|g1PDB|OB?=
Calu-3 MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNEDPxE1? MnfrO|IhcA>? MkXxSG1UVw>? MYLJR|UxRTFyIN88US=> M1q4T|I{QDR2MEO4
CaOV3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDQNHUyOCEQvF2= MojJO|IhcA>? M3;lSmROW09? M4WyW2lEPTB;MUCg{txO MXSyN|g1PDB|OB?=
CGTHW1 NIeze|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\WNpltOTBizszN MnTnO|IhcA>? M{XDdWROW09? NV7pOYdGUUN3ME2xNEDPxE1? NVzWeHF2OjN6NESwN|g>
CHL-1 NYLEV2VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUexNEDPxE1? M3j0c|czKGh? M2DpXWROW09? MkPKTWM2OD1zMDFOwG0> NWfKV2dpOjN6NESwN|g>
Colo320DM NH;6TWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVSxNEDPxE1? MWK3NkBp NITvS2pFVVOR NEfUVG5KSzVyPUGwJO69VQ>? NX7Yb|dvOjN6NESwN|g>
Colo704 NX3kWlNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL1NVAh|ryP MXW3NkBp M2LQSWROW09? NX7CV2RpUUN3ME2xNEDPxE1? NXrJc2t[OjN6NESwN|g>
COR-L23 M{TWZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXoUpoyOCEQvF2= NFq1WFI4OiCq NHr1eYFFVVOR NEfBWmpKSzVyPUGwJO69VQ>? MkDVNlM5PDRyM{i=
CRO-AP2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvsTFEyOCEQvF2= NXHXW2drPzJiaB?= MXTEUXNQ NXe5TWdzUUN3ME2xNEDPxE1? MY[yN|g1PDB|OB?=
Daudi MlzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP3Vo1VOTBizszN NH\1fVk4OiCq MVrEUXNQ M3G1SmlEPTB;MUCg{txO NGXaflUzOzh2NECzPC=>
DOTC 24510 NF\tZ49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\WNVAh|ryP MkXOO|IhcA>? M1LndmROW09? MXTJR|UxRTFyIN88US=> Mn23NlM5PDRyM{i=
DU-145 NIWxWGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWKxNEDPxE1? MXy3NkBp MWXEUXNQ MVXJR|UxRTFyIN88US=> NGrmfFIzOzh2NECzPC=>
EB-3 NIe1VIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWGxNEDPxE1? MXu3NkBp M2XueGROW09? NGq4TmpKSzVyPUGwJO69VQ>? NYm5UZAzOjN6NESwN|g>
EFM-19 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6xNEDPxE1? Mn;QO|IhcA>? NHK5bWlFVVOR MWHJR|UxRTFyIN88US=> M{j0fVI{QDR2MEO4
EKVX M1\Ic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKxNVAh|ryP Mkm2O|IhcA>? MVPEUXNQ NV7zPYw2UUN3ME2xNEDPxE1? MlnwNlM5PDRyM{i=
FaDu MnzmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHSSoIyOCEQvF2= MVe3NkBp MorrSG1UVw>? MXnJR|UxRTFyIN88US=> MkHXNlM5PDRyM{i=
G401 NXX4[3ZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PxNlExKM7:TR?= MV63NkBp M4DxWmROW09? M2\3R2lEPTB;MUCg{txO MknxNlM5PDRyM{i=
HCC-70 M4izUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWWxNEDPxE1? NXvPUVJ2PzJiaB?= M2jKcWROW09? M{nMbmlEPTB;MUCg{txO NGnBU3AzOzh2NECzPC=>
HCC-1954 NF;nW|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjZNVAh|ryP MUW3NkBp NXrRV|VUTE2VTx?= MUfJR|UxRTFyIN88US=> MXmyN|g1PDB|OB?=
Hela NITjd4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DsWFExKM7:TR?= M3\ZVlczKGh? M1;X[WROW09? M{SxdWlEPTB;MUCg{txO NUDCdoR6OjN6NESwN|g>
Hep3B NULC[mRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\4NVAh|ryP NV7udmo5PzJiaB?= M364cWROW09? NEXjUnVKSzVyPUGwJO69VQ>? NYm4PWdVOjN6NESwN|g>
HMCB NHjzToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzoXooyOCEQvF2= NHnaVlU4OiCq MX\EUXNQ NVzr[YJ2UUN3ME2xNEDPxE1? NH;OZY0zOzh2NECzPC=>
HN5 NYLnOlRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3uxTVExKM7:TR?= M3TP[VczKGh? NHfzSoRFVVOR NVjV[5ZkUUN3ME2xNEDPxE1? MUeyN|g1PDB|OB?=
HOS M3TrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M122XVExKM7:TR?= M3W1TFczKGh? MljMSG1UVw>? Mn;kTWM2OD1zMDFOwG0> Mmr0NlM5PDRyM{i=
HPAF-II MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TOe|ExKM7:TR?= MlLUO|IhcA>? NUXzSnFSTE2VTx?= MY\JR|UxRTFyIN88US=> NFf3N48zOzh2NECzPC=>
Hs746.T MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nsclExKM7:TR?= NIjNN2c4OiCq MlPsSG1UVw>? NXvLZVJlUUN3ME2xNEDPxE1? NGPHdmszOzh2NECzPC=>
HT NU[zfWVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHCNVAh|ryP MlPsO|IhcA>? M{T4WWROW09? MoDNTWM2OD1zMDFOwG0> NXOzbVg1OjN6NESwN|g>
HT-3 MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNEDPxE1? NUW5b3ZEPzJiaB?= NUHVR2JuTE2VTx?= NY[2cmJsUUN3ME2xNEDPxE1? MUeyN|g1PDB|OB?=
HuNS-1 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfkUIgyOCEQvF2= M37HeFczKGh? M4qzemROW09? MYnJR|UxRTFyIN88US=> NIDPTIgzOzh2NECzPC=>
IGROV1 NXq5V3dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDufFUyOCEQvF2= MVy3NkBp NYPtSWR[TE2VTx?= M3;JVGlEPTB;MUCg{txO NXzRZlBxOjN6NESwN|g>
J82 M1O0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrwc2wyOCEQvF2= M{\wXFczKGh? NYjGT2ppTE2VTx?= NXe0UG17UUN3ME2xNEDPxE1? NXy0VXl7OjN6NESwN|g>
JM1 NIXYV5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUWxNEDPxE1? MUi3NkBp MX7EUXNQ NE\I[ZVKSzVyPUGwJO69VQ>? Ml3INlM5PDRyM{i=
Kato III MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUmxNEDPxE1? MX63NkBp NFGxWYRFVVOR NIDEXplKSzVyPUGwJO69VQ>? M2C2R|I{QDR2MEO4
KHOS-240S MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVKxNEDPxE1? MlO3O|IhcA>? NYK0NXU2TE2VTx?= M1TKZmlEPTB;MUCg{txO M1n4[VI{QDR2MEO4
KM-12 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmxNEDPxE1? NY\rVVNOPzJiaB?= MXrEUXNQ M4mzV2lEPTB;MUCg{txO MkTDNlM5PDRyM{i=
KPL-1 MoO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXuxNEDPxE1? NUi2d3Z6PzJiaB?= NEXORYRFVVOR NIG5VmlKSzVyPUGwJO69VQ>? NVXFcYQ5OjN6NESwN|g>
KYSE-30 NGe3PHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnSTJMyOCEQvF2= NHWyWno4OiCq NF:0dYRFVVOR MVfJR|UxRTFyIN88US=> NX3oRng3OjN6NESwN|g>
LNCaP MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUWxNEDPxE1? MXm3NkBp M{KyT2ROW09? M3fFVmlEPTB;MUCg{txO MWiyN|g1PDB|OB?=
MCF-7 MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX:xNEDPxE1? NWnGcVREPzJiaB?= MXzEUXNQ MkDyTWM2OD1zMDFOwG0> MlPINlM5PDRyM{i=
MC-IXC Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3iwdlExKM7:TR?= M1;XUFczKGh? M2jNfWROW09? NYnqUYZZUUN3ME2xNEDPxE1? M4rDSFI{QDR2MEO4
MDA-MB-175 VII M{Swb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWribppkOTBizszN MnLqO|IhcA>? MUPEUXNQ M{PB[mlEPTB;MUCg{txO MXmyN|g1PDB|OB?=
MDA-MB-468 MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjINVAh|ryP M1THUVczKGh? M1mwZmROW09? M4HNc2lEPTB;MUCg{txO MlWwNlM5PDRyM{i=
MiaPaCa NFPpWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4KydVExKM7:TR?= MVe3NkBp NVvZOJk1TE2VTx?= NIn3XYZKSzVyPUGwJO69VQ>? NFHycmYzOzh2NECzPC=>
Molt-4 MnLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrwfHMyOCEQvF2= MUC3NkBp MkDzSG1UVw>? M3vLSGlEPTB;MUCg{txO NXXiPY9VOjN6NESwN|g>
NCI-ADR/RES MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfXNVAh|ryP M1TVNlczKGh? M{LzSGROW09? MV7JR|UxRTFyIN88US=> NX\ESWlDOjN6NESwN|g>
NCI-H69 MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i1b|ExKM7:TR?= M4TIT|czKGh? NEOwTFJFVVOR M2fsWmlEPTB;MUCg{txO M17kblI{QDR2MEO4
NCI-H82 Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWCxNEDPxE1? MWq3NkBp M17nOWROW09? NHrzdopKSzVyPUGwJO69VQ>? NXvGUWVjOjN6NESwN|g>
NCI-N87 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLTeowyOCEQvF2= M3zvflczKGh? M1S5cWROW09? MYHJR|UxRTFyIN88US=> NET3eFYzOzh2NECzPC=>
NCI-H146 NHLCSotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTXOIRXOTBizszN NYDtVVIyPzJiaB?= MYLEUXNQ MofkTWM2OD1zMDFOwG0> M4j0U|I{QDR2MEO4
NCI-H157 NUnIRlUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSxNEDPxE1? M1PQWFczKGh? MoPWSG1UVw>? NYjhPVY5UUN3ME2xNEDPxE1? NUHxfpNOOjN6NESwN|g>
NCI-H187 M2XOb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnZTWNQOTBizszN M4PEb|czKGh? MlHFSG1UVw>? NF;1TI9KSzVyPUGwJO69VQ>? MXyyN|g1PDB|OB?=
NCI-H209 MmDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnGUW4yOCEQvF2= Mmf5O|IhcA>? MnfrSG1UVw>? MlywTWM2OD1zMDFOwG0> Mly5NlM5PDRyM{i=
NCI-H226 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnre3BGOTBizszN M13iTlczKGh? M4Xle2ROW09? NEHQR4ZKSzVyPUGwJO69VQ>? NWTjc3FVOjN6NESwN|g>
NCI-H292 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUCxNEDPxE1? MkjkO|IhcA>? NH;jSpRFVVOR M2jVfGlEPTB;MUCg{txO Mlq0NlM5PDRyM{i=
NCI-H322 M{eweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV61SpF3OTBizszN MXK3NkBp M33pSGROW09? MmLtTWM2OD1zMDFOwG0> MXWyN|g1PDB|OB?=
NCI-H358 NUnPV|F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjLeWN[OTBizszN M1W1cVczKGh? NIfKcW1FVVOR MnLPTWM2OD1zMDFOwG0> NH:x[pIzOzh2NECzPC=>
NCI-H520 NVfyOYZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jSPFExKM7:TR?= Mo\kO|IhcA>? NWDpS4NPTE2VTx?= NEnhXmZKSzVyPUGwJO69VQ>? M1O0VVI{QDR2MEO4
NCI-H526 M4PhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr5NVAh|ryP NX;wc3JjPzJiaB?= M4j2dGROW09? M3q2S2lEPTB;MUCg{txO MUmyN|g1PDB|OB?=
NCI-H630 NXrFNWVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfmZZcyOCEQvF2= MYC3NkBp NF7Yd3RFVVOR NYDsd41IUUN3ME2xNEDPxE1? NF\PTZUzOzh2NECzPC=>
NCI-H661 M1i2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWCxNEDPxE1? MXK3NkBp MUDEUXNQ MV\JR|UxRTFyIN88US=> MWqyN|g1PDB|OB?=
NCI-H716 NIfpN2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDOVHl{OTBizszN NEHiTlE4OiCq MlG2SG1UVw>? M3jlSWlEPTB;MUCg{txO NUPJ[FJ3OjN6NESwN|g>
NCI-H1563 Mnu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrtUXU5OTBizszN MUO3NkBp MnTxSG1UVw>? MVzJR|UxRTFyIN88US=> NH[yUZkzOzh2NECzPC=>
NCI-H1792 M2fYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn0NVAh|ryP NHW3OWI4OiCq MV3EUXNQ M1fsZmlEPTB;MUCg{txO M3nI[lI{QDR2MEO4
NCI-H2030 NGLzVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;TWFExKM7:TR?= NGjwSoQ4OiCq NVrCRZMxTE2VTx?= MVHJR|UxRTFyIN88US=> MnLmNlM5PDRyM{i=
NCI-H2052 M3LPemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj1NVAh|ryP Mn;0O|IhcA>? NFz6SHFFVVOR MlfDTWM2OD1zMDFOwG0> NWCxfGVwOjN6NESwN|g>
NCI-H2122 MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXZNVAh|ryP Ml7yO|IhcA>? NX[yeGxJTE2VTx?= M4\5SWlEPTB;MUCg{txO M2TpNlI{QDR2MEO4
NCI-H2228 M1Tl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTXV5gyOCEQvF2= MYS3NkBp NUTDXZVrTE2VTx?= M3jTSGlEPTB;MUCg{txO NFraO|AzOzh2NECzPC=>
OE-19 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHSNVAh|ryP NXzGd25GPzJiaB?= M17odWROW09? NIHDOoFKSzVyPUGwJO69VQ>? NH3XToYzOzh2NECzPC=>
OE-21 NGjIUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLpNVAh|ryP MoS4O|IhcA>? NWHNb|czTE2VTx?= NWW3bI5MUUN3ME2xNEDPxE1? MoLUNlM5PDRyM{i=
OE-33 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzlNVAh|ryP NIfUOpk4OiCq MYLEUXNQ MWPJR|UxRTFyIN88US=> NFGxflUzOzh2NECzPC=>
OVCAR-3 NGi5VG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTxbXNmOTBizszN Mn\4O|IhcA>? MkLOSG1UVw>? NWLtXXZXUUN3ME2xNEDPxE1? M2DXbVI{QDR2MEO4
OVCAR-4 M2Ha[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOxNEDPxE1? MWK3NkBp MXfEUXNQ NXvFS4d{UUN3ME2xNEDPxE1? NXjmO2VSOjN6NESwN|g>
OVCAR-5 MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\x[2kyOCEQvF2= MoXBO|IhcA>? MXLEUXNQ MXjJR|UxRTFyIN88US=> M1ftTlI{QDR2MEO4
P3HR-1 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DWUVExKM7:TR?= MnHEO|IhcA>? M3HoWWROW09? MlT4TWM2OD1zMDFOwG0> NGWwPVMzOzh2NECzPC=>
PC-3 M{S1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVmxNEDPxE1? MWO3NkBp NED0XJZFVVOR MoLZTWM2OD1zMDFOwG0> NFzle3AzOzh2NECzPC=>
Raji NHHlfIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoewNVAh|ryP NICw[|Y4OiCq NVzod|NFTE2VTx?= MUXJR|UxRTFyIN88US=> M2LpNFI{QDR2MEO4
RD MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTNfHAyOCEQvF2= MnniO|IhcA>? MWfEUXNQ M33OZWlEPTB;MUCg{txO M3X2bVI{QDR2MEO4
RD-ES Moq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXmNVAh|ryP NXqwS5JIPzJiaB?= NV;qRY9jTE2VTx?= MoHsTWM2OD1zMDFOwG0> MUGyN|g1PDB|OB?=
RL NIX0VFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHmxVXYyOCEQvF2= NWnxVJVsPzJiaB?= NXzvendkTE2VTx?= NFTIWm5KSzVyPUGwJO69VQ>? MnnWNlM5PDRyM{i=
SaOS2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3RUWxNOTBizszN NHjGSHA4OiCq NFPWVIFFVVOR Mlr1TWM2OD1zMDFOwG0> NIXObXozOzh2NECzPC=>
SCC-9 NE\IfHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmS1NVAh|ryP NXS1fG1JPzJiaB?= NUnxPIx4TE2VTx?= MXPJR|UxRTFyIN88US=> M2HKb|I{QDR2MEO4
SCC-12 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT0SXJUOTBizszN MlzzO|IhcA>? M2mwZWROW09? NE[0[2dKSzVyPUGwJO69VQ>? MVSyN|g1PDB|OB?=
SCC-13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTXNVAh|ryP MV23NkBp Ml3ZSG1UVw>? NXy3dFJbUUN3ME2xNEDPxE1? NFn6XpEzOzh2NECzPC=>
SCC-15 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6xNEDPxE1? MWK3NkBp NWPT[INYTE2VTx?= MlnnTWM2OD1zMDFOwG0> NWrCXow5OjN6NESwN|g>
SCC-25 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLBSFgyOCEQvF2= NH\PRVU4OiCq NEe5bJJFVVOR NEH4VlJKSzVyPUGwJO69VQ>? M3PmdlI{QDR2MEO4
SCLC-3 NYW2U5ppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK1cHMyOCEQvF2= Mk\QO|IhcA>? NFf5WG9FVVOR MWjJR|UxRTFyIN88US=> M37DUlI{QDR2MEO4
SF-268 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIftO|IyOCEQvF2= MXW3NkBp M3vtXmROW09? M2LNfWlEPTB;MUCg{txO NIDQWpozOzh2NECzPC=>
SF-295 NYX4Wo1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLzNGwyOCEQvF2= MoLYO|IhcA>? NUDzSVV[TE2VTx?= MUTJR|UxRTFyIN88US=> Mne2NlM5PDRyM{i=
SJRH30 MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfWZnpmOTBizszN NFjUR2Y4OiCq MnziSG1UVw>? NXvUWHlSUUN3ME2xNEDPxE1? NYG5UGlmOjN6NESwN|g>
SK-BR-3 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13scVExKM7:TR?= MmjrO|IhcA>? M4f1R2ROW09? MXLJR|UxRTFyIN88US=> MWKyN|g1PDB|OB?=
SK-LMS-1 NID0UGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jFNlExKM7:TR?= NF3mNHo4OiCq NVTpUpBRTE2VTx?= Moi0TWM2OD1zMDFOwG0> NHqwNlIzOzh2NECzPC=>
SK-N-DZ NHfHWXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr5NVAh|ryP NEnCT|Q4OiCq M1WzeGROW09? NX30OIRCUUN3ME2xNEDPxE1? MkO4NlM5PDRyM{i=
SK-N-F1 NYq4dJNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjBVG4yOCEQvF2= Mor0O|IhcA>? NXTPe4NCTE2VTx?= NGPmR2VKSzVyPUGwJO69VQ>? MnjNNlM5PDRyM{i=
SKOV-3 NInaemNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{joUlExKM7:TR?= NGHZNXo4OiCq MXTEUXNQ MnLyTWM2OD1zMDFOwG0> MViyN|g1PDB|OB?=
SK-UT-1 NHHYbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\ENVAh|ryP NYrRT|JMPzJiaB?= NVXmV4VkTE2VTx?= MYDJR|UxRTFyIN88US=> NFOzfIEzOzh2NECzPC=>
SN12C NXy2S5B{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LKV|ExKM7:TR?= M2rnPVczKGh? NV\S[4xMTE2VTx?= NUXCO21{UUN3ME2xNEDPxE1? MkLXNlM5PDRyM{i=
SNB-19 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nMdVExKM7:TR?= NV32SmpWPzJiaB?= MnHMSG1UVw>? MVXJR|UxRTFyIN88US=> MUOyN|g1PDB|OB?=
SNU-5 Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fWN|ExKM7:TR?= NYfiWFJSPzJiaB?= NGrne29FVVOR NVTDW|NNUUN3ME2xNEDPxE1? MXKyN|g1PDB|OB?=
SNU-16 NEG4[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuxNEDPxE1? MnK4O|IhcA>? NXjRfopGTE2VTx?= MmT3TWM2OD1zMDFOwG0> NF;iR|MzOzh2NECzPC=>
SNU-398 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzNNVAh|ryP NI\obHY4OiCq Mn;PSG1UVw>? MnrFTWM2OD1zMDFOwG0> NHTvXoozOzh2NECzPC=>
SNU-449 NH20[mNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HwOVExKM7:TR?= M3\3dVczKGh? MXTEUXNQ M3XCe2lEPTB;MUCg{txO MYOyN|g1PDB|OB?=
SR MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojXNVAh|ryP MUK3NkBp NXWw[XR6TE2VTx?= MmHITWM2OD1zMDFOwG0> M13Xe|I{QDR2MEO4
ST486 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfkOJdUOTBizszN NFnheIw4OiCq M3jSfGROW09? NYfpbI1WUUN3ME2xNEDPxE1? Mn3GNlM5PDRyM{i=
SW579 NHTCNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MliwNVAh|ryP Ml7qO|IhcA>? NVzyeZd5TE2VTx?= NXPIXoZiUUN3ME2xNEDPxE1? MWiyN|g1PDB|OB?=
SW684 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PvWlExKM7:TR?= M2jjb|czKGh? MWTEUXNQ NWrmU5RoUUN3ME2xNEDPxE1? MYOyN|g1PDB|OB?=
SW-780 MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH1bHYyOCEQvF2= MVO3NkBp NFjXPYZFVVOR NVW0UYV[UUN3ME2xNEDPxE1? NEK4cGkzOzh2NECzPC=>
SW900 MmTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3GNVAh|ryP MofDO|IhcA>? MXzEUXNQ MlnITWM2OD1zMDFOwG0> NV2xVop{OjN6NESwN|g>
SW1088 NIXKU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XoRVExKM7:TR?= M2nCdlczKGh? M2OyXmROW09? M3HESGlEPTB;MUCg{txO NV\UN2FoOjN6NESwN|g>
SW1463 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjMOXUyOCEQvF2= NGTob3Y4OiCq M3rvPGROW09? NUnFNFZRUUN3ME2xNEDPxE1? NFrNTWszOzh2NECzPC=>
SW1990 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7ZNVAh|ryP MXm3NkBp NYfk[|hFTE2VTx?= MljPTWM2OD1zMDFOwG0> NUX2WldXOjN6NESwN|g>
T47D NIP6Wm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHsdI9vOTBizszN NYq1R3M3PzJiaB?= NGPtVopFVVOR NEKxXnhKSzVyPUGwJO69VQ>? MVKyN|g1PDB|OB?=
TE381.T M{PvSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[yUVExKM7:TR?= MVy3NkBp NGTXOIhFVVOR M1jrO2lEPTB;MUCg{txO NVXKVGE2OjN6NESwN|g>
TK-10 NWnHN4RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTtfnQ6OTBizszN MYi3NkBp MWLEUXNQ NUW1WnVIUUN3ME2xNEDPxE1? MWGyN|g1PDB|OB?=
U2OS NVfQbXA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfQTnh4OTBizszN Mk\NO|IhcA>? NX7uNXVOTE2VTx?= NYXncHYzUUN3ME2xNEDPxE1? M{HMcFI{QDR2MEO4
U251 NGTnSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXNNVAh|ryP MnTZO|IhcA>? NEnBe4NFVVOR Mn3zTWM2OD1zMDFOwG0> MXGyN|g1PDB|OB?=
UACC-812 NVjE[VhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\CZlZbOTBizszN MlWyO|IhcA>? NFzJUJFFVVOR MXfJR|UxRTFyIN88US=> NWLWW5FlOjN6NESwN|g>
YAPC NVTvfZM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTVNVAh|ryP NUO1b5EzPzJiaB?= NFvpfnFFVVOR NGezWm1KSzVyPUGwJO69VQ>? M3O5NlI{QDR2MEO4
ZR-75-1 NHrCN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDISpcyOCEQvF2= MWi3NkBp NH3EUnVFVVOR MVLJR|UxRTFyIN88US=> MlPENlM5PDRyM{i=
A375 MVvGeY5kfGmxbjDhd5NigQ>? M1ToflEvOiEQvF2= NETK[IU1KGh? NXzvUGs5TE2VTx?= M2GwNmlvcGmkaYTpc44hd2ZicHjvd5Bpd3K7bHH0bY9vKG:oIF3FT{whTVKNLDDhcoQhWz[S NH64fFIzOjN6OUS3NS=>
YUSIT1 Mki3SpVv[3Srb36gZZN{[Xl? NHKyXG5FVVOR NGD4SVRz\WS3Y3XkJJNmdnOrdHn2bZR6KHerdHigTWM2OCB-IECuOUDPxE1? MoH1NlI{QDl2N{G=
MeWo NELneZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1LCXmROW09? M3G3cmlEPTBiPTC5PFchdk1? M{fFbVI3ODF6NUK0
WiDr NXf1WlZGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1v3O2ROW09? M4LHOGlEPTBiPTC3OkBvVQ>? MmnwNlYxOTh3MkS=
Colo-205 M1GzdWZ2dmO2aX;uJIF{e2G7 M3TMUFEh|ryP NHTFXIk1KGR? MUPEUXNQ MX3JcoR2[2WmIHGgbIlocGy7IHPvcZBiemGkbHWgZ49ueGGldHnvckBxcGWwb4T5dIU> NWH1SWhLOjV|OEGxOVI>
RBW-1 NFPDZ5hHfW6ldHnvckBie3OjeR?= M2[wUVEh|ryP NIq5copFVVOR MWjOc{Bz\WS3Y4Tpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> NVfFZY5iOjR6OEW2PVA>
RBO-1 M1nNZmZ2dmO2aX;uJIF{e2G7 NUHNU2FZOSEQvF2= M{nyPGROW09? MYDJcohq[mm2aX;uJI9nKE2nazCxM|IheGixc4Doc5J6dGG2aX;u NFPNTnczPDh6NU[5NC=>
RBO-2 NX3JZ4hvTnWwY4Tpc44h[XO|YYm= Mn6wNUDPxE1? NXnvOY0{TE2VTx?= MWnJcohq[mm2aX;uJI9nKCCPZXugNU8zKHCqb4PwbI9zgWyjdHnvci=> M17lcVI1QDh3Nkmw
RBOW MmnuSpVv[3Srb36gZZN{[Xl? NWnubFhGOSEQvF2= MoHzSG1UVw>? NVnOdoNRUW6qaXLpeIlwdiCxZjCgUYVsKDFxMjDwbI9{eGixconsZZRqd25? MlnLNlQ5QDV4OUC=
M257 NHK1cYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj6WoUyODBibl2= MXi3NkBp NIHZWIVFd2W|IH7veEBqdmirYnn0JJBzd2yrZnXyZZRqd25ib3[gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= M1rGOlI{OzF5NES2
LCP NWnlfog1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWOxNFAhdk1? MmG1O|IhcA>? M4nhc2lvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCOQ2CgZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMGKgcZV1[W62YYTpc44> M2Cy[VI{OzF5NES2
WM266 NGW3R45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH6XncyODBibl2= NULLXYFsPzJiaB?= NGPpVnpKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiV12yOlYh[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNWQhdXW2YX70ZZRqd25? M4TvblI{OzF5NES2
M257 NYLld4lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjWS5gyODBibl2= NUD0[JVPPzJiaB?= M4TJTmRw\XNibn;0JIlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= MnSxNlM{OTd2NE[=
LCP NFLtWJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jEO|ExOCCwTR?= NHXBRYw4OiCq MYjJcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v MXuyN|MyPzR2Nh?=
WM266 MlPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknxNVAxKG6P NEXZd4o4OiCq NGjYZmdKdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gW20zPjZiY3XscEBp[XKkb4XybY5oKEKUQV[gWlYxOERibYX0ZY51[XSrb36= NVzjO3p[OjN|MUe0OFY>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --
NCT03340506 Recruiting Drug: dabrafenib|Drug: trametinib Melanoma|Non Small Cell Lung Cancer|Solid Tumor|Rare Cancers|High Grade Glioma Novartis Pharmaceuticals|Novartis December 28 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID