Dabrafenib (GSK2118436)

For research use only. Not for use in humans.

Catalog No.S2807

135 publications

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Selleck's Dabrafenib (GSK2118436) has been cited by 135 publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MoDHT4lv[XOnIFHzd4F6 NIj3XWtKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygTIl{KHSjZ3fl[EBDNVKjZjDWOlAxTSCvdYThcpQh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyClbz3lfJBz\XO|aX7nJGNFSzN5IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGKrb4Tpcplt[XSnZD3NSWsheHKxdHXpckBxcG:|cHjvdplt[XSrb36gZpkhSWyyaHHTZ5Jm\W5iYYPzZZkhf2m2aDDJR|UxKG:oIECuNFAxPyEQvF2= NWHkfpBSOjR7MEC2O|M>
SK-MEL-28 M4rDcmtqdmG|ZTDBd5NigQ>? M2TjelEhcA>? MXHJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP M1fXSFI1QTByNkez
HepG2 MmSyT4lv[XOnIFHzd4F6 NIm5UZpKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDFVmsheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwOEDPxE1? MVWyOFkxODZ5Mx?=
COLO205 NF7BbmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zZfGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= NIfMV2QzPDlyME[3Ny=>
HepG2 NYf0OpI3TnWwY4Tpc44hSXO|YYm= MorvOFUhdWmw MoDFSG1UVw>? MVTJcohq[mm2aX;uJI9nKEGua{WgbY4hXEeILXLleIEue3SrbYXsZZRm\CCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBUdWGmMjDwbI9{eGixconsZZRqd25idILlZZRm\CCob4KgOFUhdWmwczDwdolweiC2bzDUS2Yu[mW2YTDzeIlufWyjdHnvckBu\WG|dYLl[EBi\nSncjC2NEBucW6|IHL5JI9lgXO|ZYmgZoxwfCC|Y3HucoVzKGGwYXz5d4l{KHerdHigTWM2OCCxZjCzMlch|ryP NEjMT44zPDlyME[3Ny=>
HFF Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r0SFExKM7:TR?= Mme5O|IhcA>? MYLEUXNQ MVPJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhcHWvYX6gTGZHKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhSi2UYX[ge4l1cCCLQ{WwJI9nKDNizszN NV;RSmdwOjN6NESwN|g>
SK-MEL-28 NUHlV|ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPDNVAh|ryP Ml\RO|IhcA>? MVLEUXNQ MoHDTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> NEjSXIEzOzh2NECzPC=>
A375P-F11 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;Te5gyOCEQvF2= NUHGO2NbPzJiaB?= NHvOPZZFVVOR M1W0WGlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCDM{e1VE1HOTFiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB5MTFOwG0> MWqyN|g1PDB|OB?=
MALME-3M NFzGd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTUNVAh|ryP M3ztcFczKGh? M{K5fWROW09? MXfJR|UxRTFibl2= NHTLRYMzOzh2NECzPC=>
UACC-62 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj5WYEyOCEQvF2= M1PUXlczKGh? NF;q[GdFVVOR NHLucYxKSzVyPUGgcm0> NFTvSlEzOzh2NECzPC=>
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Colo 205 MkixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDVN2wyOCEQvF2= MkTGO|IhcA>? MU\EUXNQ NHntV4xKSzVyPUegcm0> MnvLNlM5PDRyM{i=
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ES-2 M3rpW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LMZlExKM7:TR?= MkTYO|IhcA>? MV\EUXNQ M{\mTmlEPTB;NUOgcm0> NVmyS5JuOjN6NESwN|g>
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GCT M33DTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3VOJlOOTBizszN M{Hh[|czKGh? NI\iPZBFVVOR Mn34TWM2OD1zMDFOwG0> MWOyN|g1PDB|OB?=
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NCI-H508 MkX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHKNVAh|ryP M3XIUVczKGh? MV\EUXNQ M2LHTmlEPTB;MUCg{txO MW[yN|g1PDB|OB?=
MDA-MB-231 MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe3WoxzOTBizszN NEew[Ys4OiCq NYXCfIs6TE2VTx?= M3fpXWlEPTB;MUCg{txO MnvPNlM5PDRyM{i=
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SW-837 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M334cVExKM7:TR?= NWLobYVkPzJiaB?= NXvoNlNUTE2VTx?= MYXJR|UxRTFyIN88US=> NXHJdHJiOjN6NESwN|g>
UMUC-3 NXr4WVluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PodFExKM7:TR?= MV63NkBp MX\EUXNQ M4rqOGlEPTB;MUCg{txO M1fMbVI{QDR2MEO4
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NCI-H460 MmfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX5SlBlOTBizszN MUm3NkBp MXvEUXNQ M1XVbGlEPTB;MUCg{txO M1PPNVI{QDR2MEO4
Calu-6 M2TaNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;YNVAh|ryP NHzYZ2w4OiCq NXHxN3d3TE2VTx?= M2WxdWlEPTB;MUCg{txO M37zZlI{QDR2MEO4
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A431 M3;WeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zobFExKM7:TR?= NW[wU|hGPzJiaB?= NIDDdJlFVVOR NVfHSI5[UUN3ME2xNEDPxE1? M1TTVlI{QDR2MEO4
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ARH-77 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvj[m0yOCEQvF2= MYW3NkBp NVXMR5pUTE2VTx?= M1fDcmlEPTB;MUCg{txO M1;TOlI{QDR2MEO4
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BT-20 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq4W3FLOTBizszN MoPiO|IhcA>? NFvLU2FFVVOR MnnxTWM2OD1zMDFOwG0> NVzoeol7OjN6NESwN|g>
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CAL-27 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT6TFJWOTBizszN NHqyc3Y4OiCq M1jBOmROW09? M2fSOGlEPTB;MUCg{txO M4HzNVI{QDR2MEO4
CAL-62 Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDpSHhJOTBizszN MVK3NkBp MWjEUXNQ MWTJR|UxRTFyIN88US=> NELkZZMzOzh2NECzPC=>
Calu-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVexNEDPxE1? NITTT5I4OiCq NFXVVGdFVVOR NVLGVWFFUUN3ME2xNEDPxE1? NUOxeYpMOjN6NESwN|g>
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CHL-1 MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHu1OFAyOCEQvF2= NEm2e|A4OiCq MUjEUXNQ MVTJR|UxRTFyIN88US=> MXiyN|g1PDB|OB?=
Colo320DM NFnKPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHZW4lMOTBizszN MYW3NkBp Mn\1SG1UVw>? MkSxTWM2OD1zMDFOwG0> M4PpN|I{QDR2MEO4
Colo704 MojmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV6xNEDPxE1? M3LjTlczKGh? NEjYenBFVVOR M4\BU2lEPTB;MUCg{txO M1rwOlI{QDR2MEO4
COR-L23 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzo[lEyOCEQvF2= MUe3NkBp MofOSG1UVw>? MoLJTWM2OD1zMDFOwG0> MlzMNlM5PDRyM{i=
CRO-AP2 NHT1eYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnYNVAh|ryP NUC2OZpLPzJiaB?= NGnJV|dFVVOR MUDJR|UxRTFyIN88US=> M4nw[lI{QDR2MEO4
Daudi MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrzR5J1OTBizszN MoThO|IhcA>? MXTEUXNQ MXnJR|UxRTFyIN88US=> NHnYUFczOzh2NECzPC=>
DOTC 24510 M{f6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7SSm5TOTBizszN MWC3NkBp NVLIRndlTE2VTx?= MVfJR|UxRTFyIN88US=> MX2yN|g1PDB|OB?=
DU-145 M2f6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W2blExKM7:TR?= NULBWIt1PzJiaB?= NWX4bGd1TE2VTx?= MnK4TWM2OD1zMDFOwG0> MV[yN|g1PDB|OB?=
EB-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHDWnFOOTBizszN M13melczKGh? MULEUXNQ NIm1b25KSzVyPUGwJO69VQ>? NWLwWIJDOjN6NESwN|g>
EFM-19 NVm1XWU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? NVX4WXU{PzJiaB?= MUXEUXNQ MoOwTWM2OD1zMDFOwG0> NF\PO5ozOzh2NECzPC=>
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G401 M{n2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;QbVExKM7:TR?= Mo[3O|IhcA>? NW\MeXdRTE2VTx?= NYPw[WpLUUN3ME2xNEDPxE1? MmHwNlM5PDRyM{i=
HCC-70 NUHxcFRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HGbFExKM7:TR?= NWnaRYppPzJiaB?= M33oUWROW09? NYO0UW9YUUN3ME2xNEDPxE1? MXyyN|g1PDB|OB?=
HCC-1954 MnzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP2NVAh|ryP M4KwbFczKGh? NGPI[HZFVVOR M37zV2lEPTB;MUCg{txO MnHwNlM5PDRyM{i=
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Hep3B MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELZRWUyOCEQvF2= MmG5O|IhcA>? NEDjco9FVVOR MmroTWM2OD1zMDFOwG0> NXjxcWZiOjN6NESwN|g>
HMCB NIXjcoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWKxNEDPxE1? MUS3NkBp MV;EUXNQ MmGwTWM2OD1zMDFOwG0> NIPCOY4zOzh2NECzPC=>
HN5 M1f6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfLTXcyOCEQvF2= NVnrcmhoPzJiaB?= NWn5VHdOTE2VTx?= NGfx[WZKSzVyPUGwJO69VQ>? MojPNlM5PDRyM{i=
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HPAF-II MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVOxNEDPxE1? Mme2O|IhcA>? MUjEUXNQ MXjJR|UxRTFyIN88US=> MoHQNlM5PDRyM{i=
Hs746.T NWjp[pluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUKxNEDPxE1? NILFPZo4OiCq MWPEUXNQ MmHOTWM2OD1zMDFOwG0> NELMXYgzOzh2NECzPC=>
HT NEPyW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTzbGZlOTBizszN NULZV|QyPzJiaB?= NFXZXYtFVVOR NFj4cGpKSzVyPUGwJO69VQ>? MX[yN|g1PDB|OB?=
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HuNS-1 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7tNVAh|ryP MWO3NkBp NXPqdFV5TE2VTx?= NWDjbnBiUUN3ME2xNEDPxE1? MVyyN|g1PDB|OB?=
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JM1 NEe5boJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnn[poyOCEQvF2= NXX3flBTPzJiaB?= MmKzSG1UVw>? MoTLTWM2OD1zMDFOwG0> NF\SNm4zOzh2NECzPC=>
Kato III Mmj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYqxNEDPxE1? NIOyVo04OiCq MVnEUXNQ Ml;LTWM2OD1zMDFOwG0> NIjnXWozOzh2NECzPC=>
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KM-12 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPIPVE1OTBizszN NFjOSJo4OiCq NEnmXnJFVVOR M4\VZmlEPTB;MUCg{txO MVeyN|g1PDB|OB?=
KPL-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELtOXIyOCEQvF2= MmjaO|IhcA>? MWPEUXNQ NHz0cWtKSzVyPUGwJO69VQ>? MlP3NlM5PDRyM{i=
KYSE-30 M3HXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjOe5NtOTBizszN M1\mfFczKGh? NX\pdHM5TE2VTx?= NWXHToVtUUN3ME2xNEDPxE1? M3:4OlI{QDR2MEO4
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MCF-7 NXvwR5Z7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYqxNEDPxE1? MV63NkBp MkXGSG1UVw>? NGXCPVNKSzVyPUGwJO69VQ>? MoDsNlM5PDRyM{i=
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MDA-MB-175 VII M1eyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7KNVAh|ryP NUG0ZXUyPzJiaB?= Mke4SG1UVw>? NWftbIxGUUN3ME2xNEDPxE1? NWHid5VzOjN6NESwN|g>
MDA-MB-468 NHTR[GZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PXN|ExKM7:TR?= M{PFTlczKGh? M2XLbmROW09? MX\JR|UxRTFyIN88US=> MlzuNlM5PDRyM{i=
MiaPaCa Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPFNVAh|ryP NYjKVWVVPzJiaB?= NIKzNVNFVVOR NGXHWIZKSzVyPUGwJO69VQ>? M1rYUlI{QDR2MEO4
Molt-4 NWnKVINsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\tV|ExKM7:TR?= M1HJVFczKGh? NFjSbolFVVOR MW\JR|UxRTFyIN88US=> NWjMXI46OjN6NESwN|g>
NCI-ADR/RES MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P6TVExKM7:TR?= M2XYWlczKGh? MXjEUXNQ M3;mRWlEPTB;MUCg{txO MVyyN|g1PDB|OB?=
NCI-H69 NXXBUI12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPPbIo3OTBizszN MkHmO|IhcA>? NVO4cXF2TE2VTx?= M2D3[WlEPTB;MUCg{txO NHnGUFQzOzh2NECzPC=>
NCI-H82 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr0NVAh|ryP M2DuU|czKGh? NIXXNoZFVVOR MofhTWM2OD1zMDFOwG0> NF3TcXUzOzh2NECzPC=>
NCI-N87 NFTtUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUSxNEDPxE1? MojIO|IhcA>? NEDQSVhFVVOR M3\NdmlEPTB;MUCg{txO NXfjfYQxOjN6NESwN|g>
NCI-H146 M4jMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETmRW0yOCEQvF2= MUG3NkBp NWjtTI9OTE2VTx?= NHfsZmFKSzVyPUGwJO69VQ>? MmXUNlM5PDRyM{i=
NCI-H157 Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\zNVAh|ryP MlziO|IhcA>? MofqSG1UVw>? Mk\QTWM2OD1zMDFOwG0> MkjxNlM5PDRyM{i=
NCI-H187 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TadVExKM7:TR?= MoT1O|IhcA>? MWnEUXNQ NV;j[FdNUUN3ME2xNEDPxE1? NFPJRlkzOzh2NECzPC=>
NCI-H209 Ml35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnPSos6OTBizszN M{XIO|czKGh? NVjVXJdmTE2VTx?= NITMPI5KSzVyPUGwJO69VQ>? MoHuNlM5PDRyM{i=
NCI-H226 MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTZNVAh|ryP MXq3NkBp MlLTSG1UVw>? M1\CbGlEPTB;MUCg{txO NWC1fHJYOjN6NESwN|g>
NCI-H292 M{HuS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr5WIp{OTBizszN Mnv2O|IhcA>? MmT5SG1UVw>? M{X6eWlEPTB;MUCg{txO NYDJRmEyOjN6NESwN|g>
NCI-H322 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q4PFExKM7:TR?= M4nsdlczKGh? NYHRO2R7TE2VTx?= Ml2xTWM2OD1zMDFOwG0> MnLVNlM5PDRyM{i=
NCI-H358 M{nYTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXGNVAh|ryP MmKwO|IhcA>? M3ru[WROW09? MmDyTWM2OD1zMDFOwG0> MmTSNlM5PDRyM{i=
NCI-H520 M3j6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKyNVAh|ryP NEXNR3Q4OiCq NF7ZNm1FVVOR M2n1VGlEPTB;MUCg{txO NF7IeoIzOzh2NECzPC=>
NCI-H526 NF;RRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nzRlExKM7:TR?= M2HpNFczKGh? NUP4b2RRTE2VTx?= MnXzTWM2OD1zMDFOwG0> MXqyN|g1PDB|OB?=
NCI-H630 M1Tlc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoOzNVAh|ryP NEn4WJM4OiCq MnLMSG1UVw>? MXTJR|UxRTFyIN88US=> MoPwNlM5PDRyM{i=
NCI-H661 MnnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL4U3QxOTBizszN MU[3NkBp Ml3jSG1UVw>? NFG3clhKSzVyPUGwJO69VQ>? MX6yN|g1PDB|OB?=
NCI-H716 NGfndVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPyNVAh|ryP M{XOXlczKGh? Ml\USG1UVw>? M3LLTGlEPTB;MUCg{txO NYHRUlZvOjN6NESwN|g>
NCI-H1563 MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj3dlYyOCEQvF2= Mlj6O|IhcA>? MUPEUXNQ NYXTPWpoUUN3ME2xNEDPxE1? NXnxfnpsOjN6NESwN|g>
NCI-H1792 NUewPJV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;FSVUyOCEQvF2= MUS3NkBp MmjISG1UVw>? NFuwXWhKSzVyPUGwJO69VQ>? NY\RS4dMOjN6NESwN|g>
NCI-H2030 MojZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoG1NVAh|ryP NWGxd3lQPzJiaB?= M1HxNWROW09? NWnxNldvUUN3ME2xNEDPxE1? MmHwNlM5PDRyM{i=
NCI-H2052 NV[4bHVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[xNEDPxE1? NEnQSVg4OiCq NWfDb4JjTE2VTx?= M3Pie2lEPTB;MUCg{txO MYeyN|g1PDB|OB?=
NCI-H2122 M3raSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X3XFExKM7:TR?= M3;hW|czKGh? NWjrU41[TE2VTx?= NVWzcmRJUUN3ME2xNEDPxE1? MlrFNlM5PDRyM{i=
NCI-H2228 MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;GRVExKM7:TR?= Ml\iO|IhcA>? M{PCdWROW09? MXrJR|UxRTFyIN88US=> NYX3RWQ3OjN6NESwN|g>
OE-19 NE\0[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHny[IMyOCEQvF2= NGDYdIg4OiCq MUnEUXNQ NGjQSVJKSzVyPUGwJO69VQ>? M{fKblI{QDR2MEO4
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OE-33 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj5[lBpOTBizszN MmrOO|IhcA>? M3fLVGROW09? M4LKU2lEPTB;MUCg{txO NUD4e49qOjN6NESwN|g>
OVCAR-3 Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTPe5hoOTBizszN MX63NkBp M4TQcGROW09? MlHtTWM2OD1zMDFOwG0> MlH6NlM5PDRyM{i=
OVCAR-4 NHTBbndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnmUoYyOCEQvF2= NH7HWJI4OiCq MXnEUXNQ NXzoZ3RUUUN3ME2xNEDPxE1? MmfhNlM5PDRyM{i=
OVCAR-5 MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHUVJUyOCEQvF2= M3;pdFczKGh? MlnCSG1UVw>? MV3JR|UxRTFyIN88US=> NHHiUFQzOzh2NECzPC=>
P3HR-1 M4Htb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDjZW1WOTBizszN MVq3NkBp NEm1dIZFVVOR NVX6e2hEUUN3ME2xNEDPxE1? M3;0WVI{QDR2MEO4
PC-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWxNEDPxE1? MWi3NkBp MV7EUXNQ NICzRXJKSzVyPUGwJO69VQ>? M1HEPFI{QDR2MEO4
Raji NIHFZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHO[3QyOCEQvF2= MWG3NkBp MUfEUXNQ M1\uUmlEPTB;MUCg{txO M1HBXFI{QDR2MEO4
RD MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfmd5YyOCEQvF2= MXi3NkBp NYjkN45jTE2VTx?= NWfRV49iUUN3ME2xNEDPxE1? NXvk[5B3OjN6NESwN|g>
RD-ES NETGUIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jlcVExKM7:TR?= MlvGO|IhcA>? NWexcoMzTE2VTx?= NYnUWIxKUUN3ME2xNEDPxE1? MnrnNlM5PDRyM{i=
RL MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDIUlBZOTBizszN MVS3NkBp MnTISG1UVw>? MVrJR|UxRTFyIN88US=> NVfYeoUzOjN6NESwN|g>
SaOS2 M{DIZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml2xNVAh|ryP NF3SW2U4OiCq M2nuTmROW09? NIHRV4tKSzVyPUGwJO69VQ>? MVqyN|g1PDB|OB?=
SCC-9 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T6UVExKM7:TR?= MnG5O|IhcA>? M4\T[2ROW09? NFLlOWRKSzVyPUGwJO69VQ>? NHHaXWczOzh2NECzPC=>
SCC-12 NGrOUY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\FNVAh|ryP NUi1VWtsPzJiaB?= MUfEUXNQ MWLJR|UxRTFyIN88US=> MoXxNlM5PDRyM{i=
SCC-13 NFPUSY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7K[nV{OTBizszN MnqxO|IhcA>? NVHVSlhMTE2VTx?= MkXXTWM2OD1zMDFOwG0> MXiyN|g1PDB|OB?=
SCC-15 NE\hNZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPBUm1pOTBizszN NFnR[W04OiCq NGrFeGFFVVOR M4nLe2lEPTB;MUCg{txO MXiyN|g1PDB|OB?=
SCC-25 NFy4OmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULw[XhUOTBizszN M3jWV|czKGh? Mom3SG1UVw>? MX\JR|UxRTFyIN88US=> NXi1dFkxOjN6NESwN|g>
SCLC-3 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfwVGNrOTBizszN NXfCOohOPzJiaB?= Mn;QSG1UVw>? MVnJR|UxRTFyIN88US=> NVjNWXcxOjN6NESwN|g>
SF-268 NVeyeWVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTFeIcyOCEQvF2= NInoN244OiCq NXjvOXQ4TE2VTx?= MlLwTWM2OD1zMDFOwG0> NYHrXW01OjN6NESwN|g>
SF-295 NVzUXVNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYOxNEDPxE1? MlHaO|IhcA>? M4m2W2ROW09? MV;JR|UxRTFyIN88US=> NHzMPYozOzh2NECzPC=>
SJRH30 NGXyOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYi5bldyOTBizszN MV[3NkBp NVLlbWJsTE2VTx?= NX\ZSFB5UUN3ME2xNEDPxE1? MlT4NlM5PDRyM{i=
SK-BR-3 M4mzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:xWm55OTBizszN NHHvOXA4OiCq MnTjSG1UVw>? NYK5SGw4UUN3ME2xNEDPxE1? MlfnNlM5PDRyM{i=
SK-LMS-1 M{ft[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmX2NVAh|ryP MV63NkBp M2XjN2ROW09? NGLGbnBKSzVyPUGwJO69VQ>? MluyNlM5PDRyM{i=
SK-N-DZ M1;nfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zDcFExKM7:TR?= M1PQVFczKGh? NVXCcWFxTE2VTx?= M{fjV2lEPTB;MUCg{txO MkHzNlM5PDRyM{i=
SK-N-F1 NU\rNZpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHZNVAh|ryP MUe3NkBp MVjEUXNQ M{DmPWlEPTB;MUCg{txO NWX3fnFLOjN6NESwN|g>
SKOV-3 NGLoVppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC0WHcyOCEQvF2= MX23NkBp MX;EUXNQ M2PoR2lEPTB;MUCg{txO MmrONlM5PDRyM{i=
SK-UT-1 NIf2RolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jNdFExKM7:TR?= M1[xbFczKGh? M{LHO2ROW09? MoXpTWM2OD1zMDFOwG0> MX[yN|g1PDB|OB?=
SN12C NF7UbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli0NVAh|ryP MVi3NkBp M{jMZmROW09? MVnJR|UxRTFyIN88US=> MV[yN|g1PDB|OB?=
SNB-19 M3foTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnNSZZMOTBizszN M{[0OFczKGh? M1uz[WROW09? M4XUNWlEPTB;MUCg{txO NG\p[FIzOzh2NECzPC=>
SNU-5 M{HPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvKVGkyOCEQvF2= MYK3NkBp MYLEUXNQ MnPBTWM2OD1zMDFOwG0> Mn31NlM5PDRyM{i=
SNU-16 M2mzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHiNVAh|ryP MVu3NkBp Ml;ZSG1UVw>? M4GzUGlEPTB;MUCg{txO M4nGe|I{QDR2MEO4
SNU-398 M{PGSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPZNVAh|ryP M2n5[VczKGh? NXLLT3FUTE2VTx?= Ml36TWM2OD1zMDFOwG0> M37YTFI{QDR2MEO4
SNU-449 NUj2U4FkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC5dGM{OTBizszN NUWxOll1PzJiaB?= MWnEUXNQ NUDIWlVoUUN3ME2xNEDPxE1? NIrtNW0zOzh2NECzPC=>
SR MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmSxNVAh|ryP MlTUO|IhcA>? MnLaSG1UVw>? M4HjSmlEPTB;MUCg{txO MojJNlM5PDRyM{i=
ST486 M4Pi[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrObVhtOTBizszN MnfJO|IhcA>? NH[5cm9FVVOR NXTCTG5uUUN3ME2xNEDPxE1? NHTJO4kzOzh2NECzPC=>
SW579 M3rwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7PdlIyOCEQvF2= MWi3NkBp NGPCbJZFVVOR M1XGXWlEPTB;MUCg{txO M{n0cVI{QDR2MEO4
SW684 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvWNVAh|ryP MoPkO|IhcA>? NIDMZ4ZFVVOR M3iw[2lEPTB;MUCg{txO NEDyeowzOzh2NECzPC=>
SW-780 NEHGb|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vUWFExKM7:TR?= M2DkW|czKGh? MV;EUXNQ MkC4TWM2OD1zMDFOwG0> NVrOW3FqOjN6NESwN|g>
SW900 MmPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nZO|ExKM7:TR?= M2joOFczKGh? MYLEUXNQ Mkj1TWM2OD1zMDFOwG0> M1jhbFI{QDR2MEO4
SW1088 NUTuTJc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D3VVExKM7:TR?= MnrwO|IhcA>? NYraepI3TE2VTx?= MnfWTWM2OD1zMDFOwG0> NXjYXI5IOjN6NESwN|g>
SW1463 NYHpN2wzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nKVVExKM7:TR?= NHHCWYo4OiCq NY\OPWVGTE2VTx?= MYnJR|UxRTFyIN88US=> MkTPNlM5PDRyM{i=
SW1990 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\vd2MyOCEQvF2= M1;PbFczKGh? NW\LZXpFTE2VTx?= MV7JR|UxRTFyIN88US=> NWf4e2VTOjN6NESwN|g>
T47D MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH76RpoyOCEQvF2= NWrSU3pbPzJiaB?= NFzYcWVFVVOR M{LVdmlEPTB;MUCg{txO NYHPNpRrOjN6NESwN|g>
TE381.T Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz0VVgyOCEQvF2= MmiyO|IhcA>? MkL1SG1UVw>? Mn7XTWM2OD1zMDFOwG0> NE\rRmczOzh2NECzPC=>
TK-10 NVXYWplST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWGxNEDPxE1? NEXqcGw4OiCq NXK1T|NyTE2VTx?= NHXvPGpKSzVyPUGwJO69VQ>? M1rTVFI{QDR2MEO4
U2OS MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HOXFExKM7:TR?= M3HON|czKGh? M4LP[GROW09? MUTJR|UxRTFyIN88US=> MYCyN|g1PDB|OB?=
U251 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfV[W4yOCEQvF2= NWjBeFRNPzJiaB?= MoHsSG1UVw>? NWfTcnREUUN3ME2xNEDPxE1? NYS3XpliOjN6NESwN|g>
UACC-812 NH;UeoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYixNEDPxE1? NF3LOlc4OiCq NFXKPWNFVVOR MVrJR|UxRTFyIN88US=> NYfEcWp5OjN6NESwN|g>
YAPC MnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVyxNEDPxE1? MknMO|IhcA>? MWnEUXNQ NHvsWVZKSzVyPUGwJO69VQ>? M1fteFI{QDR2MEO4
ZR-75-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTzV28yOCEQvF2= M1q0XlczKGh? M4HYeWROW09? NULhUpE6UUN3ME2xNEDPxE1? MoHnNlM5PDRyM{i=
A375 M3PBfWZ2dmO2aX;uJIF{e2G7 MWOxMlIh|ryP NWi3emhvPCCq NWHNNoloTE2VTx?= NVj3RWZqUW6qaXLpeIlwdiCxZjDwbI9{eGixconsZZRqd25ib3[gUWVMNCCHUlusJIFv\CCVNmC= Mk\vNlI{QDl2N{G=
YUSIT1 M3PjNWZ2dmO2aX;uJIF{e2G7 NUfZ[npLTE2VTx?= MnTHdoVlfWOnZDDz[Y5{cXSrdnn0fUB4cXSqIFnDOVAhRiByLkWg{txO MYqyNlM5QTR5MR?=
MeWo NILKfGFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYHEUXNQ MVPJR|UxKD1iOUi3JI5O NWC4OYpZOjZyMUi1NlQ>
WiDr M3PTeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEf1PHJFVVOR NYrEbJJnUUN3MDC9JFc3KG6P NVfG[II{OjZyMUi1NlQ>
Colo-205 NX\6OVFvTnWwY4Tpc44h[XO|YYm= NVf0b5lZOSEQvF2= MmTvOEBl NVTFcYlWTE2VTx?= MofCTY5lfWOnZDDhJIhq\2iueTDjc41x[XKjYnzlJINwdXCjY4Tpc44heGinbn;0fZBm NH3O[3UzPTN6MUG1Ni=>
RBW-1 NUS0NVRRTnWwY4Tpc44h[XO|YYm= NEfXWYMyKM7:TR?= MmC0SG1UVw>? MWjOc{Bz\WS3Y4Tpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> M1PMSVI1QDh3Nkmw
RBO-1 NUnJUm9zTnWwY4Tpc44h[XO|YYm= M4\PRlEh|ryP NILrdIhFVVOR NFXyV4NKdmirYnn0bY9vKG:oIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NHnzOVUzPDh6NU[5NC=>
RBO-2 NGXxN|lHfW6ldHnvckBie3OjeR?= NELyNoUyKM7:TR?= NUG2R4lZTE2VTx?= MkPlTY5pcWKrdHnvckBw\iBiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> MkjENlQ5QDV4OUC=
RBOW MWrGeY5kfGmxbjDhd5NigQ>? NXGzeGZIOSEQvF2= MkH2SG1UVw>? MWDJcohq[mm2aX;uJI9nKCCPZXugNU8zKHCqb4PwbI9zgWyjdHnvci=> MmjkNlQ5QDV4OUC=
M257 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jBPFExOCCwTR?= M{DlNVczKGh? M2jvV2Rw\XNibn;0JIlvcGmkaYSgdJJwdGmoZYLheIlwdiCxZjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= NHXKb|gzOzNzN{S0Oi=>
LCP M3fRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnFS4wyODBibl2= NFLaWXI4OiCq NFWwUXFKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v Ml20NlM{OTd2NE[=
WM266 M{LWV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX6xNFAhdk1? NV\TeWZPPzJiaB?= NVf0fGVkUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFFFKG23dHHueIF1cW:w M4n3[|I{OzF5NES2
M257 NF7FSJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7yNVAxKG6P MmPDO|IhcA>? NGfUTFlFd2W|IH7veEBqdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= M1jEbVI{OzF5NES2
LCP M{nuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIj4WXEyODBibl2= MnPoO|IhcA>? MmTNTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? MW[yN|MyPzR2Nh?=
WM266 M1;1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTadZEyODBibl2= MVW3NkBp NFOxPW1KdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gW20zPjZiY3XscEBp[XKkb4XybY5oKEKUQV[gWlYxOERibYX0ZY51[XSrb36= NVfXbGNpOjN|MUe0OFY>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --
NCT03340506 Recruiting Drug: dabrafenib|Drug: trametinib Melanoma|Non Small Cell Lung Cancer|Solid Tumor|Rare Cancers|High Grade Glioma Novartis Pharmaceuticals|Novartis December 28 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID