Dabrafenib (GSK2118436)

For research use only.

Catalog No.S2807

164 publications

Dabrafenib (GSK2118436) Chemical Structure

CAS No. 1195765-45-7

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Selleck's Dabrafenib (GSK2118436) has been cited by 164 publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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SK-MEL-28 MWfLbY5ie2ViQYPzZZk> M{XoZ|EhcA>? MXzJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP MWmyOFkxODZ5Mx?=
HepG2 M{XPWGtqdmG|ZTDBd5NigQ>? M1q4T2lvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? NELJWWszPDlyME[3Ny=>
COLO205 NGjaWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPofo5KdmirYnn0bY9vKG:oIHj1cYFvKEORTF:yNFUh[2WubDDwdo9tcW[ncnH0bY9vKHerdHigTWM2OCCxZjCwMlAxPyEQvF2= NWTWbIVjOjR7MEC2O|M>
HepG2 NFnPU2RHfW6ldHnvckBCe3OjeR?= MYG0OUBucW5? M13n[WROW09? NFvkRYdKdmirYnn0bY9vKG:oIFHsb|UhcW5iVFfGMYJmfGFvc4TpcZVt[XSnZDDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCVbXHkNkBxcG:|cHjvdplt[XSrb36geJJm[XSnZDDmc5IhPDVibXnud{BxemmxcjD0c{BVT0ZvYnX0ZUB{fGmvdXzheIlwdiCvZXHzeZJm\CCjZoTldkA3OCCvaX7zJIJ6KG:meYPz[Zkh[myxdDDzZ4FvdmW{IHHuZYx6e2m|IIfpeIghUUN3MDDv[kA{NjdizszN NFH4[|gzPDlyME[3Ny=>
HFF NILSVotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWSxNEDPxE1? MmrJO|IhcA>? MWDEUXNQ NGLqVIlKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiaIXtZY4hUE[IIHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGViQj3SZYYhf2m2aDDJR|UxKG:oIEOg{txO M4Pi[VI{QDR2MEO4
SK-MEL-28 M17Ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j5blExKM7:TR?= NUnqS3FYPzJiaB?= M1vqW2ROW09? MmnOTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> NXHnPJhlOjN6NESwN|g>
A375P-F11 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESwfWMyOCEQvF2= M1jhT|czKGh? NWjMVY9tTE2VTx?= NV7qW3hxUW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSt[JJqfmWwIFGzO|VRNUZzMTDj[YxtKHC{b3zp[oVz[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEexJO69VQ>? NFvhdWkzOzh2NECzPC=>
MALME-3M NGLreohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zGfVExKM7:TR?= NIO1UFE4OiCq M2HpfmROW09? M3PFbmlEPTB;MTDuUS=> MWeyN|g1PDB|OB?=
UACC-62 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU[xNEDPxE1? MlrtO|IhcA>? M2m3c2ROW09? NWnaTWo{UUN3ME2xJI5O MVqyN|g1PDB|OB?=
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SK-MEL-1 M2\nXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m4[lExKM7:TR?= NXfTcIdVPzJiaB?= MYLEUXNQ NYXRVmhWUUN3ME2yJI5O NV;2S2V5OjN6NESwN|g>
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SK-MEL-28 MofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnFTHF{OTBizszN MWi3NkBp NWTT[WFpTE2VTx?= MWLJR|UxRTNibl2= NWPobVdqOjN6NESwN|g>
A375 NFXDbZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmxNEDPxE1? NV7OVYE5PzJiaB?= NX;vVZE3TE2VTx?= NWHDOJlxUUN3ME20JI5O M13NfFI{QDR2MEO4
DU-4475 NEnjcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnKT4UyOCEQvF2= MoHPO|IhcA>? MWHEUXNQ M{LtcGlEPTB;NTDuUS=> MYiyN|g1PDB|OB?=
UACC-257 NHvTTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLOUYgyOCEQvF2= NH6ycWE4OiCq NGPscpFFVVOR MnPvTWM2OD14IH7N NWL4RocxOjN6NESwN|g>
Colo 205 NF;yPWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUWxNEDPxE1? M4DoelczKGh? NUHK[Jc1TE2VTx?= M2XCfWlEPTB;NzDuUS=> M2PBVFI{QDR2MEO4
SK-MEL-3 MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfKR2x1OTBizszN M4LwOlczKGh? MUXEUXNQ NWT0e4U3UUN3ME23JI5O M{nr[|I{QDR2MEO4
SH-4 MmLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUmxNEDPxE1? MmXiO|IhcA>? M4jGOGROW09? MWXJR|UxRThibl2= M13UclI{QDR2MEO4
A101D NH7I[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP3NVAh|ryP NE\t[IM4OiCq M2m1OGROW09? M4W5NWlEPTB;OTDuUS=> MUCyN|g1PDB|OB?=
ES-2 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y3XVExKM7:TR?= M3\RUlczKGh? M2rQcmROW09? MmG3TWM2OD13MzDuUS=> NUTlO|B1OjN6NESwN|g>
HT-29 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW[xNEDPxE1? MoPuO|IhcA>? NIrHNlVFVVOR NHvldmdKSzVyPU[2JI5O MneyNlM5PDRyM{i=
SW1417 M1zYbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DuTlExKM7:TR?= NYnN[GVkPzJiaB?= NG\RNplFVVOR MVjJR|UxRTF3ODDuUS=> NV62UGlSOjN6NESwN|g>
SW872 NHrwSJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXCNVAh|ryP NHrRV2Q4OiCq M3X2OGROW09? NH7rO45KSzVyPUO3O{BvVQ>? NVfROlE3OjN6NESwN|g>
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GCT MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnSdJZMOTBizszN NH[3d5Q4OiCq MVLEUXNQ NFPSVYFKSzVyPUGwJO69VQ>? NWPoW3Z2OjN6NESwN|g>
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YUMAC M4nKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK4NlhbOTBizszN NITidZE4OiCq NFT2Xm5FVVOR Mn;uTWM2OD13IH7N NF;LVlgzOzh2NECzPC=>
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NCI-H508 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37vSlExKM7:TR?= NILVRZY4OiCq NF3mRopFVVOR NVXhZ4RkUUN3ME2xNEDPxE1? MUSyN|g1PDB|OB?=
MDA-MB-231 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzFSGp{OTBizszN NWnPdWxnPzJiaB?= NITzRWRFVVOR NV7idnVnUUN3ME2xNEDPxE1? NULqfZJ3OjN6NESwN|g>
SW756 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX:xNEDPxE1? MUi3NkBp MUjEUXNQ NX;4Tpo1UUN3ME2xNEDPxE1? NHLEeFQzOzh2NECzPC=>
SW-837 M2TXNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HaRVExKM7:TR?= MoPFO|IhcA>? MljqSG1UVw>? NGXnbYNKSzVyPUGwJO69VQ>? MUOyN|g1PDB|OB?=
UMUC-3 NWj1O45nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnBZWcyOCEQvF2= MoHFO|IhcA>? NFLBVWtFVVOR MYnJR|UxRTFyIN88US=> M4PHWFI{QDR2MEO4
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A549 NVfQW4lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWCxNEDPxE1? NWS2PZMzPzJiaB?= MoizSG1UVw>? NWDGV2NzUUN3ME2xNEDPxE1? M13EWVI{QDR2MEO4
SHP-77 MmTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf2e3oyOCEQvF2= MYi3NkBp Ml\4SG1UVw>? NYfIfpl2UUN3ME2xNEDPxE1? MXSyN|g1PDB|OB?=
SW480 NEXoXoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYixNEDPxE1? MmTyO|IhcA>? NH3aNYZFVVOR NIjJfXFKSzVyPUGwJO69VQ>? MVWyN|g1PDB|OB?=
DLD-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\qeWYyOCEQvF2= M4[wbFczKGh? NV\WdIxVTE2VTx?= NVPRT4lOUUN3ME2xNEDPxE1? MVyyN|g1PDB|OB?=
HCT-116 MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzobmoyOCEQvF2= MYK3NkBp MUnEUXNQ M{HUOGlEPTB;MUCg{txO MYCyN|g1PDB|OB?=
NCI-H747 NHj6Z5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17m[FExKM7:TR?= NFLOVJc4OiCq NWLnZZVpTE2VTx?= Mlv2TWM2OD1zMDFOwG0> M2fFSVI{QDR2MEO4
T-84 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVKxNEDPxE1? M2HjZVczKGh? M3;xNWROW09? MkDkTWM2OD1zMDFOwG0> Mn;yNlM5PDRyM{i=
NCI-H460 NIjNZmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV74RphSOTBizszN M13YT|czKGh? Ml7aSG1UVw>? MmLVTWM2OD1zMDFOwG0> MWqyN|g1PDB|OB?=
Calu-6 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\jXFJXOTBizszN M1HDWVczKGh? MYnEUXNQ MYnJR|UxRTFyIN88US=> NFzXcFMzOzh2NECzPC=>
HCC-2998 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWCxNEDPxE1? M1XJc|czKGh? NGj2UXJFVVOR MUHJR|UxRTFyIN88US=> M{\HWlI{QDR2MEO4
LS1034 NFrVdo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\aOHgyOCEQvF2= MYq3NkBp NInr[m5FVVOR NYq1b5JsUUN3ME2xNEDPxE1? Mkn6NlM5PDRyM{i=
CHP-212 NVrCS|V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUexNEDPxE1? M4nSTFczKGh? NI\S[WlFVVOR NYPoSoFEUUN3ME2xNEDPxE1? NV35fXpSOjN6NESwN|g>
SK-N-AS M4XTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT4NVAh|ryP MYS3NkBp M4CyUGROW09? MVvJR|UxRTFyIN88US=> NWfYUINPOjN6NESwN|g>
BFTC-905 NF\RRZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrlNVAh|ryP MnLsO|IhcA>? NWrrXXhLTE2VTx?= NIrPb25KSzVyPUGwJO69VQ>? MlzINlM5PDRyM{i=
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BC-3 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUWxNEDPxE1? M4DpUVczKGh? MVjEUXNQ NFjDT2FKSzVyPUK3O{BvVQ>? MYiyN|g1PDB|OB?=
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H4 M1fKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DxVlExKM7:TR?= MmfHO|IhcA>? MV7EUXNQ Mke4TWM2OD14MUmgcm0> MWOyN|g1PDB|OB?=
BC-1 M4fyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nIfFExKM7:TR?= NYnKRVRYPzJiaB?= MlPiSG1UVw>? MmrvTWM2OD15MESgcm0> M{HnV|I{QDR2MEO4
DB NUDKbG04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3FNVAh|ryP MWK3NkBp MYXEUXNQ MX;JR|UxRTh5MzDuUS=> MojKNlM5PDRyM{i=
RPMI-6666 NFzjXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYexNEDPxE1? M4HiXVczKGh? MnLhSG1UVw>? M2DDdWlEPTB;OUK4JI5O NIX0TnAzOzh2NECzPC=>
MC/CAR M1fROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlizNVAh|ryP NULofJU6PzJiaB?= Ml32SG1UVw>? Ml3oTWM2OD1zLkCwNkDPxE1? NHTmUZkzOzh2NECzPC=>
SNU-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHONVAh|ryP MnvRO|IhcA>? MoW3SG1UVw>? NHfxRVBKSzVyPUGuOVAyKM7:TR?= NXHaV25VOjN6NESwN|g>
CEM/C1 NFHDbVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm1NVAh|ryP NX\qPW1wPzJiaB?= NXvvXHpUTE2VTx?= M{fPVWlEPTB;MT63O|Mh|ryP NVXlXVJzOjN6NESwN|g>
GDM-1 NFSwV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3oNVAh|ryP MYS3NkBp NVvN[5VMTE2VTx?= NVjK[mxTUUN3ME2xMlk6PyEQvF2= NXLa[ZpSOjN6NESwN|g>
HT-1080 NGS1UIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYixNEDPxE1? NGfzW3A4OiCq NFL2d3pFVVOR M3OycmlEPTB;Mj6wNFQh|ryP M4O3[lI{QDR2MEO4
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MES-SA NH;FS4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr1NVAh|ryP NWPhSJdtPzJiaB?= MVLEUXNQ MWXJR|UxRTZwOUi5JO69VQ>? Mn;YNlM5PDRyM{i=
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786-O NYDsfXI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\ITmsyOTBizszN MoDBO|IhcA>? M{TLXWROW09? Mkn0TWM2OD1zMDFOwG0> MUGyN|g1PDB|OB?=
A172 M3LmN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[xNEDPxE1? NVvUbFFmPzJiaB?= NIH1[ZBFVVOR NUHFN4J{UUN3ME2xNEDPxE1? NV3vTnU{OjN6NESwN|g>
A204 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j1cFExKM7:TR?= NGD2cVU4OiCq NGrse|NFVVOR MlzSTWM2OD1zMDFOwG0> M4SxOFI{QDR2MEO4
A427 NX65TGdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXW2SYY{OTBizszN MXq3NkBp MlnCSG1UVw>? NH7PSHJKSzVyPUGwJO69VQ>? NFvGXYczOzh2NECzPC=>
A431 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm2TFVvOTBizszN MmX2O|IhcA>? NHrIV2FFVVOR MYXJR|UxRTFyIN88US=> MnvUNlM5PDRyM{i=
A2780 NIDkWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ewbVExKM7:TR?= NYrkZYhpPzJiaB?= MYrEUXNQ NID6VmFKSzVyPUGwJO69VQ>? MlvKNlM5PDRyM{i=
ARH-77 M3:0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PJU|ExKM7:TR?= NGL0bHU4OiCq NFS0RZdFVVOR NUftXpJPUUN3ME2xNEDPxE1? NXu5OJM5OjN6NESwN|g>
Be(2)C MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rSNFExKM7:TR?= M4jLVlczKGh? MXrEUXNQ NHPVNXpKSzVyPUGwJO69VQ>? M1G3WVI{QDR2MEO4
BT-20 MlXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K4bFExKM7:TR?= NFiwTJc4OiCq MnXkSG1UVw>? MYLJR|UxRTFyIN88US=> NELFeZEzOzh2NECzPC=>
BxPc3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vJU|ExKM7:TR?= NVmw[VBbPzJiaB?= NUjVWIwxTE2VTx?= NW\IPZRxUUN3ME2xNEDPxE1? Moe2NlM5PDRyM{i=
C-4 I NILTU|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HGSFExKM7:TR?= NWewTZdiPzJiaB?= MYLEUXNQ Mnv5TWM2OD1zMDFOwG0> NUXjOHZLOjN6NESwN|g>
C33A NULkPFJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrscmVOOTBizszN MVi3NkBp MlW4SG1UVw>? NV3ZSndqUUN3ME2xNEDPxE1? NHvvc5kzOzh2NECzPC=>
CAL-27 NW\jPFVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDQUlEyOCEQvF2= MYi3NkBp MUnEUXNQ NHu3SYxKSzVyPUGwJO69VQ>? NH;W[JYzOzh2NECzPC=>
CAL-62 NFL2Oo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jHNlExKM7:TR?= M1HEeFczKGh? MXPEUXNQ M3PySWlEPTB;MUCg{txO MUiyN|g1PDB|OB?=
Calu-3 NG\EdIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDDNVAh|ryP NH7BUoM4OiCq NVmzcpdWTE2VTx?= MoDRTWM2OD1zMDFOwG0> NV[2RZk4OjN6NESwN|g>
CaOV3 NHXXO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTmNVAh|ryP MUS3NkBp NV;PdJJ{TE2VTx?= M3i2S2lEPTB;MUCg{txO M{HF[VI{QDR2MEO4
CGTHW1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWSxNEDPxE1? NYm0W4pHPzJiaB?= NGWxSoJFVVOR MknoTWM2OD1zMDFOwG0> NUO0d|hEOjN6NESwN|g>
CHL-1 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfzOlIxOTBizszN M{TEdVczKGh? Mn20SG1UVw>? M{fkcGlEPTB;MUCg{txO MWeyN|g1PDB|OB?=
Colo320DM NFHJOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[yNVAh|ryP NVvje4J1PzJiaB?= MkjjSG1UVw>? NVflZ2VUUUN3ME2xNEDPxE1? MYWyN|g1PDB|OB?=
Colo704 Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DGZlExKM7:TR?= MWK3NkBp NWfCTpp7TE2VTx?= MUTJR|UxRTFyIN88US=> MWqyN|g1PDB|OB?=
COR-L23 M{XLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny4NVAh|ryP NHfDW4o4OiCq M3rxNGROW09? NX3yWnVyUUN3ME2xNEDPxE1? MXuyN|g1PDB|OB?=
CRO-AP2 M2TJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HuOlExKM7:TR?= MnfhO|IhcA>? NF7zUlBFVVOR NX\zUmV[UUN3ME2xNEDPxE1? NYG5b4VPOjN6NESwN|g>
Daudi NG\V[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVqxNEDPxE1? NF;nTHg4OiCq NIDaSmhFVVOR M4fXUWlEPTB;MUCg{txO M2jjb|I{QDR2MEO4
DOTC 24510 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnUeId5OTBizszN NEfQSVU4OiCq M3W3PWROW09? Ml\PTWM2OD1zMDFOwG0> M4\BS|I{QDR2MEO4
DU-145 NYTWTpNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3kVXhXOTBizszN M3jmd|czKGh? NUPyWGt7TE2VTx?= MWHJR|UxRTFyIN88US=> NUL0[2JROjN6NESwN|g>
EB-3 NUj4VHlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWmxNEDPxE1? NWDnO4F5PzJiaB?= NIDpOFNFVVOR NULjZndbUUN3ME2xNEDPxE1? M{HMZVI{QDR2MEO4
EFM-19 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWxNEDPxE1? NGG2RlQ4OiCq MXXEUXNQ MV\JR|UxRTFyIN88US=> NYq0[GYxOjN6NESwN|g>
EKVX Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXWxNEDPxE1? NEXzS|k4OiCq NEPGOYVFVVOR MXHJR|UxRTFyIN88US=> NGTwbYgzOzh2NECzPC=>
FaDu NFLFS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\pblExKM7:TR?= M3u3[lczKGh? MXrEUXNQ NVO5RYNQUUN3ME2xNEDPxE1? MkjCNlM5PDRyM{i=
G401 Mo\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWixNEDPxE1? MlfLO|IhcA>? MkC5SG1UVw>? NIrD[3VKSzVyPUGwJO69VQ>? MXWyN|g1PDB|OB?=
HCC-70 NFnWWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13sdlExKM7:TR?= NEDKXIk4OiCq MXzEUXNQ MlHyTWM2OD1zMDFOwG0> NUi0c2lzOjN6NESwN|g>
HCC-1954 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPZSGkyOCEQvF2= MWC3NkBp M1;lWWROW09? M4jpemlEPTB;MUCg{txO NHu4dm4zOzh2NECzPC=>
Hela NFS0UWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T6N|ExKM7:TR?= MoP3O|IhcA>? MmfqSG1UVw>? NF\sO5FKSzVyPUGwJO69VQ>? MmrDNlM5PDRyM{i=
Hep3B MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XHXVExKM7:TR?= MnnPO|IhcA>? NWLXW4dQTE2VTx?= NHPk[3BKSzVyPUGwJO69VQ>? MnzQNlM5PDRyM{i=
HMCB NHzPZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;oNVAh|ryP NIHQb5U4OiCq MWTEUXNQ MV7JR|UxRTFyIN88US=> MnTkNlM5PDRyM{i=
HN5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDmS|NHOTBizszN MlrzO|IhcA>? M1jGT2ROW09? M3i4[WlEPTB;MUCg{txO Mn;PNlM5PDRyM{i=
HOS Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P0NVExKM7:TR?= M13mTlczKGh? M1q2fGROW09? MXTJR|UxRTFyIN88US=> NVSwUFVOOjN6NESwN|g>
HPAF-II NWH1e4dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH6NVAh|ryP NVXodmlnPzJiaB?= MkO5SG1UVw>? MX\JR|UxRTFyIN88US=> MUSyN|g1PDB|OB?=
Hs746.T NXvKN2xsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[xNEDPxE1? MWO3NkBp MVHEUXNQ Ml;rTWM2OD1zMDFOwG0> M{H3e|I{QDR2MEO4
HT NIHh[YdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCwNVAh|ryP MkTkO|IhcA>? MWXEUXNQ MnO1TWM2OD1zMDFOwG0> NGn2NoczOzh2NECzPC=>
HT-3 NVnZN2k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX5NVAh|ryP NX36RYl{PzJiaB?= MUXEUXNQ NGX4WIJKSzVyPUGwJO69VQ>? NYqxSGsxOjN6NESwN|g>
HuNS-1 M{LLcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3PfnhEOTBizszN MlTlO|IhcA>? NXrUUGVtTE2VTx?= M{DU[mlEPTB;MUCg{txO MXWyN|g1PDB|OB?=
IGROV1 Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7yNVAh|ryP NFyxbnk4OiCq NGHINm9FVVOR NWLI[Zk5UUN3ME2xNEDPxE1? NGLje|EzOzh2NECzPC=>
J82 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\CNlExKM7:TR?= MUi3NkBp MXzEUXNQ Mm\pTWM2OD1zMDFOwG0> Mn\ONlM5PDRyM{i=
JM1 NXuxRpNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjHcnMyOCEQvF2= MXK3NkBp MlT2SG1UVw>? NX\LfW5DUUN3ME2xNEDPxE1? NHflO2czOzh2NECzPC=>
Kato III MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XCR|ExKM7:TR?= M1rXbFczKGh? MoLoSG1UVw>? NE\KTWlKSzVyPUGwJO69VQ>? NEXhN|czOzh2NECzPC=>
KHOS-240S M3zMWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjJNVAh|ryP MlrpO|IhcA>? Mlq5SG1UVw>? MnPhTWM2OD1zMDFOwG0> NF2zUI4zOzh2NECzPC=>
KM-12 NGToOHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLFOYwyOCEQvF2= MV[3NkBp MUHEUXNQ Ml21TWM2OD1zMDFOwG0> NEfVVIYzOzh2NECzPC=>
KPL-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\CeVloOTBizszN NXn5dog4PzJiaB?= NVrXeGRMTE2VTx?= M{D1U2lEPTB;MUCg{txO M{TDUlI{QDR2MEO4
KYSE-30 NEHYbnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D3VlExKM7:TR?= NIrYO4M4OiCq M{\EPWROW09? M1;4bmlEPTB;MUCg{txO MXeyN|g1PDB|OB?=
LNCaP MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELWcXIyOCEQvF2= MV23NkBp NV7CRolETE2VTx?= MkGwTWM2OD1zMDFOwG0> MWeyN|g1PDB|OB?=
MCF-7 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL0N|YyOCEQvF2= MYO3NkBp NFmzS|VFVVOR MUnJR|UxRTFyIN88US=> M4jm[|I{QDR2MEO4
MC-IXC NF7VXWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\4NVAh|ryP MWS3NkBp NIK3XFJFVVOR MWLJR|UxRTFyIN88US=> MnGxNlM5PDRyM{i=
MDA-MB-175 VII NWXTRpdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TwfFExKM7:TR?= NE[z[2s4OiCq NFnJOZJFVVOR MY\JR|UxRTFyIN88US=> NG\hc4gzOzh2NECzPC=>
MDA-MB-468 M37GOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjQVJIyOCEQvF2= MYm3NkBp NYrCVXhjTE2VTx?= NXnqXmpVUUN3ME2xNEDPxE1? NI\sWWYzOzh2NECzPC=>
MiaPaCa NInOXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHZNVAh|ryP M1zm[lczKGh? MY\EUXNQ Mor0TWM2OD1zMDFOwG0> NFHPWpIzOzh2NECzPC=>
Molt-4 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVGxNEDPxE1? NVL6em9OPzJiaB?= NVO0W4hDTE2VTx?= NE\KfnNKSzVyPUGwJO69VQ>? MV6yN|g1PDB|OB?=
NCI-ADR/RES MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLh[FNjOTBizszN MXi3NkBp NYnDb5YyTE2VTx?= NX\XXVJSUUN3ME2xNEDPxE1? M4CyU|I{QDR2MEO4
NCI-H69 MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYqxNEDPxE1? NYi2fIxnPzJiaB?= M2LVXmROW09? M33LU2lEPTB;MUCg{txO MVSyN|g1PDB|OB?=
NCI-H82 M1rOU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHPeHEyOCEQvF2= M{XYOVczKGh? M2fOb2ROW09? NXLjeGdVUUN3ME2xNEDPxE1? MXGyN|g1PDB|OB?=
NCI-N87 NHT2e2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYCxNEDPxE1? MnrGO|IhcA>? NVXmdlNsTE2VTx?= NIfp[IpKSzVyPUGwJO69VQ>? MXGyN|g1PDB|OB?=
NCI-H146 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW4U2gyOCEQvF2= MVe3NkBp MVPEUXNQ M3P3R2lEPTB;MUCg{txO NF;yfoszOzh2NECzPC=>
NCI-H157 NHX1PGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEflV2QyOCEQvF2= NFjxfmw4OiCq MlXmSG1UVw>? MkXETWM2OD1zMDFOwG0> MoDQNlM5PDRyM{i=
NCI-H187 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HnXFExKM7:TR?= NF\3S4M4OiCq MU\EUXNQ MYrJR|UxRTFyIN88US=> MYGyN|g1PDB|OB?=
NCI-H209 NWC3O5F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWmxNEDPxE1? NYLrdHRjPzJiaB?= MnnsSG1UVw>? M12xWWlEPTB;MUCg{txO NHLQT5EzOzh2NECzPC=>
NCI-H226 M3n5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\zdVExKM7:TR?= NIXtT2g4OiCq M3;ocmROW09? NHHneHBKSzVyPUGwJO69VQ>? NF\0NpgzOzh2NECzPC=>
NCI-H292 NF7PPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX6xNEDPxE1? MX23NkBp Mly3SG1UVw>? M4DDN2lEPTB;MUCg{txO MYOyN|g1PDB|OB?=
NCI-H322 M{XpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnPfW54OTBizszN NWWxdpJmPzJiaB?= NGK0PHFFVVOR M1y3eGlEPTB;MUCg{txO NV7mOodrOjN6NESwN|g>
NCI-H358 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HpOVExKM7:TR?= M{nQPFczKGh? M1vpPWROW09? NGXieW5KSzVyPUGwJO69VQ>? MUOyN|g1PDB|OB?=
NCI-H520 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Lq[VExKM7:TR?= MXy3NkBp M3\1ZmROW09? MVzJR|UxRTFyIN88US=> MorHNlM5PDRyM{i=
NCI-H526 NGK2XG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPKSolzOTBizszN NH62UXM4OiCq MnqwSG1UVw>? NWHyR253UUN3ME2xNEDPxE1? NHKyW24zOzh2NECzPC=>
NCI-H630 NIPYSIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LId|ExKM7:TR?= NVe5[Jl{PzJiaB?= NX;5OnRXTE2VTx?= Ml;jTWM2OD1zMDFOwG0> MWqyN|g1PDB|OB?=
NCI-H661 M3zmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLjXocyOCEQvF2= NFKzUHQ4OiCq Ml[3SG1UVw>? MmS5TWM2OD1zMDFOwG0> MXGyN|g1PDB|OB?=
NCI-H716 NELlZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj4NVRCOTBizszN M{D5fVczKGh? NVTRW|M6TE2VTx?= MYPJR|UxRTFyIN88US=> MVKyN|g1PDB|OB?=
NCI-H1563 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXNUm0yOCEQvF2= NGnifJM4OiCq MWjEUXNQ M3jLUmlEPTB;MUCg{txO MkHHNlM5PDRyM{i=
NCI-H1792 M1\ISWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr5RVI1OTBizszN MYS3NkBp NV22doxZTE2VTx?= MV3JR|UxRTFyIN88US=> M{X3T|I{QDR2MEO4
NCI-H2030 MoTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHOVVJmOTBizszN NX7PclF6PzJiaB?= Mk\JSG1UVw>? MX3JR|UxRTFyIN88US=> M4nGUVI{QDR2MEO4
NCI-H2052 NWqydHp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXqRlgyOTBizszN NIXLSYI4OiCq NXrBfJR5TE2VTx?= MYLJR|UxRTFyIN88US=> NYHXdpN[OjN6NESwN|g>
NCI-H2122 NXXyRWVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrkNVAh|ryP MVe3NkBp M3GzUGROW09? Ml32TWM2OD1zMDFOwG0> NW\uXIhEOjN6NESwN|g>
NCI-H2228 MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S4Z|ExKM7:TR?= NVHUV4g3PzJiaB?= MYDEUXNQ MX\JR|UxRTFyIN88US=> NVvqSphjOjN6NESwN|g>
OE-19 NXmzd4tuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnESGtuOTBizszN NXn0ZYFUPzJiaB?= MlLMSG1UVw>? NVziWYc2UUN3ME2xNEDPxE1? NIPSRZYzOzh2NECzPC=>
OE-21 NYfSdGFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3oSZdLOTBizszN MlzoO|IhcA>? MormSG1UVw>? MVnJR|UxRTFyIN88US=> MXeyN|g1PDB|OB?=
OE-33 NGD6bWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr3R3lzOTBizszN MoHOO|IhcA>? M1\zNGROW09? NGL3bW1KSzVyPUGwJO69VQ>? NUe1Voh{OjN6NESwN|g>
OVCAR-3 NH7oZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\RNolOOTBizszN MoPwO|IhcA>? MnnGSG1UVw>? MmDNTWM2OD1zMDFOwG0> M4\KWFI{QDR2MEO4
OVCAR-4 NUPQNWNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnCUFV6OTBizszN NX;BWmZ[PzJiaB?= MVrEUXNQ MkDETWM2OD1zMDFOwG0> Ml7hNlM5PDRyM{i=
OVCAR-5 NIfBWlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HxblExKM7:TR?= NH7aRXo4OiCq NUPido8zTE2VTx?= M1rFTGlEPTB;MUCg{txO NWPybYdROjN6NESwN|g>
P3HR-1 M4\NRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPpNVAh|ryP MYC3NkBp MWPEUXNQ M4LLdmlEPTB;MUCg{txO M1HN[FI{QDR2MEO4
PC-3 NUn1WFkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrFNVAh|ryP MUW3NkBp MVzEUXNQ MXrJR|UxRTFyIN88US=> MYWyN|g1PDB|OB?=
Raji MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHpRnRyOTBizszN NXLkTIJGPzJiaB?= M4HNR2ROW09? NGH5bo5KSzVyPUGwJO69VQ>? MmjONlM5PDRyM{i=
RD NHHYRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXrcZEyOCEQvF2= M1i0dlczKGh? M{\wS2ROW09? NYfQT5V4UUN3ME2xNEDPxE1? M4jMeVI{QDR2MEO4
RD-ES MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnzXpY2OTBizszN MYq3NkBp MorqSG1UVw>? MXjJR|UxRTFyIN88US=> MV[yN|g1PDB|OB?=
RL MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT6W4JTOTBizszN MkfIO|IhcA>? NH\sN2RFVVOR Ml7FTWM2OD1zMDFOwG0> M2LVRVI{QDR2MEO4
SaOS2 M3vMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NESzR|cyOCEQvF2= M{jOdFczKGh? M2TmWmROW09? M4D4TmlEPTB;MUCg{txO MVKyN|g1PDB|OB?=
SCC-9 M1TjUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUOxNEDPxE1? NWT6cppKPzJiaB?= MU\EUXNQ MXzJR|UxRTFyIN88US=> M1fXWFI{QDR2MEO4
SCC-12 NULKZ3g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGxNEDPxE1? MnjWO|IhcA>? M3HHbmROW09? M4m2bGlEPTB;MUCg{txO NGn1bHgzOzh2NECzPC=>
SCC-13 M{m1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rCSFExKM7:TR?= MXi3NkBp M4XQXGROW09? MXXJR|UxRTFyIN88US=> MoHuNlM5PDRyM{i=
SCC-15 NFjlW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\wOVExKM7:TR?= NYK1NpE4PzJiaB?= NXL2fFE1TE2VTx?= NGLEdHNKSzVyPUGwJO69VQ>? M1LpSVI{QDR2MEO4
SCC-25 M{PqWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjoNVAh|ryP MVm3NkBp M{DGbWROW09? M{HOS2lEPTB;MUCg{txO MVyyN|g1PDB|OB?=
SCLC-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLBWGIyOCEQvF2= MmW4O|IhcA>? MnHHSG1UVw>? MUHJR|UxRTFyIN88US=> M1zTR|I{QDR2MEO4
SF-268 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17ZXFExKM7:TR?= NUPnUYlSPzJiaB?= MWLEUXNQ MWXJR|UxRTFyIN88US=> MX[yN|g1PDB|OB?=
SF-295 NEnVfXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7BeopQOTBizszN MYC3NkBp MV;EUXNQ NH\3d|lKSzVyPUGwJO69VQ>? NUixfmtnOjN6NESwN|g>
SJRH30 NVrBbWd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHyNVAh|ryP NELrV2Q4OiCq MYrEUXNQ Mn;oTWM2OD1zMDFOwG0> NGHaRlMzOzh2NECzPC=>
SK-BR-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L1PVExKM7:TR?= MnT6O|IhcA>? NX;EfmlPTE2VTx?= M1vuVmlEPTB;MUCg{txO MVmyN|g1PDB|OB?=
SK-LMS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L2VFExKM7:TR?= MlrSO|IhcA>? M3;1W2ROW09? M1PUemlEPTB;MUCg{txO MnnoNlM5PDRyM{i=
SK-N-DZ NGTGNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DacFExKM7:TR?= MlraO|IhcA>? NF7vS5NFVVOR M{noPWlEPTB;MUCg{txO MmD5NlM5PDRyM{i=
SK-N-F1 NWHUNWROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfTUZg6OTBizszN NEfOcGI4OiCq NH2ybHZFVVOR NFy2UZBKSzVyPUGwJO69VQ>? Mon2NlM5PDRyM{i=
SKOV-3 M3vx[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUexNEDPxE1? M3niPFczKGh? MkPNSG1UVw>? Ml[yTWM2OD1zMDFOwG0> NXTtVpc6OjN6NESwN|g>
SK-UT-1 MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT1fI85OTBizszN NYXKfW5XPzJiaB?= M3XrNmROW09? MV;JR|UxRTFyIN88US=> M4LmZ|I{QDR2MEO4
SN12C Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj3NYMyOCEQvF2= MmPTO|IhcA>? MV;EUXNQ M4DkO2lEPTB;MUCg{txO M1jCXVI{QDR2MEO4
SNB-19 Mn\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmwSJgyOCEQvF2= NEn3bmY4OiCq NEm3SFNFVVOR M2nhTGlEPTB;MUCg{txO MWeyN|g1PDB|OB?=
SNU-5 M37VSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHvNVAh|ryP NXjZZnIzPzJiaB?= NWLHT5c2TE2VTx?= NWC1NmRZUUN3ME2xNEDPxE1? NGH3WI8zOzh2NECzPC=>
SNU-16 M2DOUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f4SVExKM7:TR?= NGPaS244OiCq NV:x[JV{TE2VTx?= NVTOcJRoUUN3ME2xNEDPxE1? NHuxd4ozOzh2NECzPC=>
SNU-398 NEPie4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjGSWRlOTBizszN M2jyRVczKGh? NX\QRoE3TE2VTx?= NWTDfFNmUUN3ME2xNEDPxE1? MorZNlM5PDRyM{i=
SNU-449 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLRNVAh|ryP MnzFO|IhcA>? NInMfItFVVOR M37ofGlEPTB;MUCg{txO NYDhToV4OjN6NESwN|g>
SR M{DjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnYNVAh|ryP MlryO|IhcA>? MmfESG1UVw>? MlHwTWM2OD1zMDFOwG0> MmLHNlM5PDRyM{i=
ST486 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVGxNEDPxE1? MonVO|IhcA>? M1HlNGROW09? NEX2TZdKSzVyPUGwJO69VQ>? M2SwblI{QDR2MEO4
SW579 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zad|ExKM7:TR?= MWW3NkBp NFj6XZpFVVOR NHPKZW9KSzVyPUGwJO69VQ>? NFzoZmozOzh2NECzPC=>
SW684 NXLHW5VuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LEUVExKM7:TR?= MYm3NkBp M1v0Z2ROW09? M4rrVmlEPTB;MUCg{txO MmnsNlM5PDRyM{i=
SW-780 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL3V2syOCEQvF2= MYi3NkBp NVvOSJZjTE2VTx?= MXHJR|UxRTFyIN88US=> MYSyN|g1PDB|OB?=
SW900 NWfqc4l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInF[oEyOCEQvF2= MojQO|IhcA>? MoWxSG1UVw>? MlXUTWM2OD1zMDFOwG0> MWSyN|g1PDB|OB?=
SW1088 NYr4e3pnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvyUotQOTBizszN M4fWWlczKGh? MnvxSG1UVw>? M3juO2lEPTB;MUCg{txO NUPq[nptOjN6NESwN|g>
SW1463 NVr3cIdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S1N|ExKM7:TR?= M4j6blczKGh? MU\EUXNQ Mo[3TWM2OD1zMDFOwG0> NWfL[oJ[OjN6NESwN|g>
SW1990 MnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvSNVlnOTBizszN NG\OTJg4OiCq MkDFSG1UVw>? MorjTWM2OD1zMDFOwG0> NFrQ[FczOzh2NECzPC=>
T47D MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvaNVAh|ryP NIjXRmg4OiCq M{XtZWROW09? Mk\CTWM2OD1zMDFOwG0> NVrQOFVnOjN6NESwN|g>
TE381.T MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWxNEDPxE1? MnfHO|IhcA>? M2TqVGROW09? NH71eGNKSzVyPUGwJO69VQ>? MmfwNlM5PDRyM{i=
TK-10 M4LKbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Xs[|ExKM7:TR?= NXPZb3RIPzJiaB?= M{T4eWROW09? NUPlW4VyUUN3ME2xNEDPxE1? M{nVeVI{QDR2MEO4
U2OS NVro[ZVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTCNlhxOTBizszN Mkf2O|IhcA>? NYWxZpNmTE2VTx?= Mo\4TWM2OD1zMDFOwG0> MXGyN|g1PDB|OB?=
U251 MkfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETNWoIyOCEQvF2= NFnWd|A4OiCq MmrmSG1UVw>? NIPa[GVKSzVyPUGwJO69VQ>? M1z2VlI{QDR2MEO4
UACC-812 NFLtcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq2PGZROTBizszN M1joTlczKGh? MX7EUXNQ Ml\pTWM2OD1zMDFOwG0> M1XUNFI{QDR2MEO4
YAPC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? M37OTVczKGh? MWHEUXNQ NXvke4lkUUN3ME2xNEDPxE1? NYfI[5ROOjN6NESwN|g>
ZR-75-1 NXvKSZFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\nNVAh|ryP MVy3NkBp M1zldGROW09? MV;JR|UxRTFyIN88US=> MVmyN|g1PDB|OB?=
A375 Mo\xSpVv[3Srb36gZZN{[Xl? NVL0N3gzOS5{IN88US=> MUS0JIg> NVT2T3lUTE2VTx?= MYHJcohq[mm2aX;uJI9nKHCqb4PwbI9zgWyjdHnvckBw\iCPRVusJGVTUyxiYX7kJHM3WA>? MX2yNlM5QTR5MR?=
YUSIT1 M1rmUWZ2dmO2aX;uJIF{e2G7 NHj4dVRFVVOR MkPzdoVlfWOnZDDz[Y5{cXSrdnn0fUB4cXSqIFnDOVAhRiByLkWg{txO M1\1bFIzOzh7NEex
MeWo NYrqU|kzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{LTXWROW09? NWXUN3JEUUN3MDC9JFk5PyCwTR?= M4PJOlI3ODF6NUK0
WiDr MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX7tNYNRTE2VTx?= MnHaTWM2OCB;IEe2JI5O MWKyOlAyQDV{NB?=
Colo-205 MX\GeY5kfGmxbjDhd5NigQ>? NETT[mEyKM7:TR?= Mme4OEBl MmTuSG1UVw>? NVzBOG5ZUW6mdXPl[EBiKGirZ3jsfUBkd22yYYLhZoxmKGOxbYDhZ5Rqd25icHjlco91gXCn NVOyTIhvOjV|OEGxOVI>
RBW-1 Mm\iSpVv[3Srb36gZZN{[Xl? MUSxJO69VQ>? MlHPSG1UVw>? MnPZUo8hemWmdXP0bY9vKG:oIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NIW1RmYzPDh6NU[5NC=>
RBO-1 M3ezfGZ2dmO2aX;uJIF{e2G7 NI\jSFUyKM7:TR?= NGDZeWZFVVOR M3fafGlvcGmkaYTpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> NUf5NWxIOjR6OEW2PVA>
RBO-2 M2T5TWZ2dmO2aX;uJIF{e2G7 MlHoNUDPxE1? NEThSXNFVVOR NUfRc5JtUW6qaXLpeIlwdiCxZjCgUYVsKDFxMjDwbI9{eGixconsZZRqd25? M{X5VlI1QDh3Nkmw
RBOW MnXwSpVv[3Srb36gZZN{[Xl? NFTZOoUyKM7:TR?= NFrnPVNFVVOR MXjJcohq[mm2aX;uJI9nKCCPZXugNU8zKHCqb4PwbI9zgWyjdHnvci=> M1GyNlI1QDh3Nkmw
M257 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELSdGgyODBibl2= NVKw[YhuPzJiaB?= NUHRZYxHTG:nczDuc5QhcW6qaXLpeEBxem:uaX\ldoF1cW:wIH;mJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG NGPzclAzOzNzN{S0Oi=>
LCP MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXIU4QyODBibl2= M1XwOVczKGh? MofKTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKEyFUDDj[YxtKGijcnLveZJqdmdiQmLBSkBXPjByUjDteZRidnSjdHnvci=> NVjVXpNGOjN|MUe0OFY>
WM266 M33IRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NESzWYgyODBibl2= NV70SI1mPzJiaB?= M1P0OGlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCZTUK2OkBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCxSEBufXSjboTheIlwdg>? NELnS5IzOzNzN{S0Oi=>
M257 NYX0V|dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTQNVAxKG6P NWm2[JB5PzJiaB?= NYDZ[5Q6TG:nczDuc5QhcW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG NIj6cmYzOzNzN{S0Oi=>
LCP Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PiTVExOCCwTR?= NYXBPWZkPzJiaB?= MojHTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? NX;J[pRxOjN|MUe0OFY>
WM266 Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHP[25WOTByIH7N M1zVUFczKGh? MlPuTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFBFKG23dHHueIF1cW:w NGLoXJAzOzNzN{S0Oi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04452877 Not yet recruiting Drug: Dabrafenib|Drug: Trametinib Carcinoma Non-Small-Cell Lung Novartis Pharmaceuticals|Novartis August 31 2020 Phase 2
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID