Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Cited by 21 Publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MmCzT4lv[XOnIFHzd4F6 MVLJcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiSHnzJJRi\2enZDDCMXJi\iCYNkCwSUBufXSjboSg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIHnud4VkfCClZXzsd{Bkdy2neIDy[ZN{cW6pIFPER|M4KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJIJqd3SrbonsZZRm\C2PRVugdJJwfGWrbjDwbI9{eGixconsZZRqd25iYomgRYxxcGGVY4Ll[Y4h[XO|YYmge4l1cCCLQ{WwJI9nKDBwMECwO{DPxE1? Mn3UNlQ6ODB4N{O=
SK-MEL-28 NFjBc4hMcW6jc3WgRZN{[Xl? MoPsNUBp NH7rOmFKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN NED0WJgzPDlyME[3Ny=>
HepG2 MXPLbY5ie2ViQYPzZZk> Moi0TY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iRWLLJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5yMESg{txO Mk[zNlQ6ODB4N{O=
COLO205 NU\0[pBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{OxUmlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= MXiyOFkxODZ5Mx?=
HepG2 NED1[VlHfW6ldHnvckBCe3OjeR?= NWjYSINFPDVibXnu NYn0do55TE2VTx?= M{Xtc2lvcGmkaYTpc44hd2ZiQXzrOUBqdiCWR1[tZoV1[S2|dHnteYxifGWmIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFOvYXSyJJBpd3OyaH;yfYxifGmxbjD0doVifGWmIH\vdkA1PSCvaX7zJJBzcW:{IITvJHRITi2kZYThJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFYxKG2rboOgZpkhd2S7c4PlfUBjdG:2IIPjZY5v\XJiYX7hcJl{cXNid3n0bEBKSzVyIH;mJFMvPyEQvF2= NEP6c2QzPDlyME[3Ny=>
HFF NGLTWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK2NVAh|ryP NISwWJU4OiCq M4nXVmROW09? NXPFU2F[UW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIHj1cYFvKEiIRjDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIFKtVoFnKHerdHigTWM2OCCxZjCzJO69VQ>? NGDjR4czOzh2NECzPC=>
SK-MEL-28 NIftTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLrNVAh|ryP NIX3NmI4OiCq NX;sdohUTE2VTx?= M3fmOmlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCVSz3NSWwuOjhiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB2MzFOwG0> NWfzdXcyOjN6NESwN|g>
A375P-F11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILGNlkyOCEQvF2= M3;Wc|czKGh? NEn4V3RFVVOR NHr1[VFKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iQUO3OXAuTjFzIHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yN{Gg{txO MVeyN|g1PDB|OB?=
MALME-3M MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYCxNEDPxE1? NX7O[IpGPzJiaB?= M{O4cmROW09? NGTt[VFKSzVyPUGgcm0> NEmzO4kzOzh2NECzPC=>
UACC-62 NYDBT2lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? M{fKeFczKGh? NWjESmhyTE2VTx?= M{HPeGlEPTB;MTDuUS=> MXSyN|g1PDB|OB?=
C32TG M4LKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M173SVExKM7:TR?= MkTvO|IhcA>? NHzuR2NFVVOR NVTUOnV[UUN3ME2xJI5O NF;vXHEzOzh2NECzPC=>
SK-MEL-1 M{fscGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYixNEDPxE1? MljGO|IhcA>? M4LhSmROW09? MoOxTWM2OD1{IH7N M1vtWVI{QDR2MEO4
M14 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzvbJd6OTBizszN MlG3O|IhcA>? M3mzdGROW09? MlvhTWM2OD1{IH7N NYSyRlZMOjN6NESwN|g>
SK-MEL-28 M2TmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWixNEDPxE1? MXu3NkBp MnfrSG1UVw>? NY\vRlJlUUN3ME2zJI5O Mkj2NlM5PDRyM{i=
A375 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXexNEDPxE1? NXjI[HRMPzJiaB?= MUfEUXNQ NUH4Z2V3UUN3ME20JI5O NF\JTW4zOzh2NECzPC=>
DU-4475 NESxS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX3VlVQOTBizszN NG\NNpM4OiCq M2fSTWROW09? M3nkRmlEPTB;NTDuUS=> MXWyN|g1PDB|OB?=
UACC-257 NGjkS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDCNVAh|ryP NX3rXGJoPzJiaB?= M13rNmROW09? M1fycmlEPTB;NjDuUS=> M{niVVI{QDR2MEO4
Colo 205 MkTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknZNVAh|ryP NEO5bJY4OiCq M3\O[WROW09? M4qzSWlEPTB;NzDuUS=> MWWyN|g1PDB|OB?=
SK-MEL-3 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K5dFExKM7:TR?= M4D6R|czKGh? NF7sNIZFVVOR NHLJV2VKSzVyPUegcm0> MWGyN|g1PDB|OB?=
SH-4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7CTWQyOCEQvF2= Mn\XO|IhcA>? NH7mVYVFVVOR NHTR[VRKSzVyPUigcm0> NY\WXpFCOjN6NESwN|g>
A101D NFK2R4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILTZVkyOCEQvF2= M{S1O|czKGh? Mmn4SG1UVw>? NXnlPGg2UUN3ME25JI5O M{LnNlI{QDR2MEO4
ES-2 NYj6[3hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOwNVAh|ryP NUXJXZkyPzJiaB?= M4HlcGROW09? NIL3dlVKSzVyPUWzJI5O MmTBNlM5PDRyM{i=
HT-29 NWi4V3k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSxNEDPxE1? MV23NkBp MWjEUXNQ NVq3WXdZUUN3ME22OkBvVQ>? NVPj[5dDOjN6NESwN|g>
SW1417 NHHsWmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWyeYZoOTBizszN NFz3fFk4OiCq NEm5VI9FVVOR MlS0TWM2OD1zNUigcm0> MVOyN|g1PDB|OB?=
SW872 NGn5O3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ztelExKM7:TR?= NVLHR2hqPzJiaB?= NH\UdnhFVVOR M1n3eGlEPTB;M{e3JI5O NHPuZ|QzOzh2NECzPC=>
RKO NVK0d|FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fndFExKM7:TR?= MkDmO|IhcA>? NWW1eZBZTE2VTx?= NVXHUlVWUUN3ME2yMlUzOiEQvF2= MnP4NlM5PDRyM{i=
A673 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjnSWpbOTBizszN MkfpO|IhcA>? MkiySG1UVw>? NX3TNFRFUUN3ME2xNEDPxE1? MYCyN|g1PDB|OB?=
GCT MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULnNFFyOTBizszN M37hTlczKGh? NFnHflJFVVOR MortTWM2OD1zMDFOwG0> NHPXS3AzOzh2NECzPC=>
WM-115 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXexNEDPxE1? MWK3NkBp M2O3WmROW09? MXTJR|UxRTVibl2= NYnqUWxWOjN6NESwN|g>
YUMAC MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjDNVAh|ryP NFW5cIo4OiCq MXvEUXNQ NH;4ZpRKSzVyPUWgcm0> M1PSclI{QDR2MEO4
OV-90 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HLXVExKM7:TR?= MmG0O|IhcA>? NI\TTXhFVVOR MlnmTWM2OD1{OTDuUS=> MknlNlM5PDRyM{i=
NCI-H508 NVLrRohnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorVNVAh|ryP MkWxO|IhcA>? M{\lSGROW09? NUjpS5ZCUUN3ME2xNEDPxE1? M3\WdVI{QDR2MEO4
MDA-MB-231 M{T4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7oUJVWOTBizszN NHvmTGw4OiCq MUfEUXNQ MXPJR|UxRTFyIN88US=> MU[yN|g1PDB|OB?=
SW756 M1jq[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDjNVAh|ryP NGnEdHk4OiCq MWDEUXNQ NHTjO|BKSzVyPUGwJO69VQ>? MnPqNlM5PDRyM{i=
SW-837 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3iyN|ExKM7:TR?= M2PIOlczKGh? NUPWZlFGTE2VTx?= NGnDUHVKSzVyPUGwJO69VQ>? NX3pbXZmOjN6NESwN|g>
UMUC-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\TcFV{OTBizszN NIHWdpE4OiCq MX3EUXNQ Ml\HTWM2OD1zMDFOwG0> MYGyN|g1PDB|OB?=
LS-174T NX35VGFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfsNVAh|ryP NUfK[WFFPzJiaB?= NGftfIhFVVOR NHzaeJdKSzVyPUGwJO69VQ>? M4T2R|I{QDR2MEO4
A549 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjPbVkyOCEQvF2= MYC3NkBp MWjEUXNQ MVjJR|UxRTFyIN88US=> NV7PTHNpOjN6NESwN|g>
SHP-77 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjMdooyOCEQvF2= M{XzN|czKGh? NH3lXXVFVVOR Mn3HTWM2OD1zMDFOwG0> MoXJNlM5PDRyM{i=
SW480 NUH4bXRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDUNVAh|ryP M{XSW|czKGh? NVzWU5hETE2VTx?= MXrJR|UxRTFyIN88US=> M1j2[lI{QDR2MEO4
DLD-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW[xNEDPxE1? M{fQOVczKGh? NE\mTI1FVVOR M4PNXGlEPTB;MUCg{txO MkTHNlM5PDRyM{i=
HCT-116 M323[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvufFYyOCEQvF2= M1TwN|czKGh? MX3EUXNQ MWjJR|UxRTFyIN88US=> NWno[XlmOjN6NESwN|g>
NCI-H747 NYrqTJFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWqye3BkOTBizszN NF;aTHo4OiCq M2[2W2ROW09? M4\TSGlEPTB;MUCg{txO NHfmZXMzOzh2NECzPC=>
T-84 NXjub4p2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC4Vm92OTBizszN NInDS5g4OiCq MVHEUXNQ MU\JR|UxRTFyIN88US=> M2jJblI{QDR2MEO4
NCI-H460 NWXGXHIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrnNVAh|ryP MYO3NkBp NHr3fohFVVOR MnHnTWM2OD1zMDFOwG0> NGrCXHUzOzh2NECzPC=>
Calu-6 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrQcJQyOCEQvF2= NH7NfmY4OiCq MXHEUXNQ NGLXWHVKSzVyPUGwJO69VQ>? NYjxfYhnOjN6NESwN|g>
HCC-2998 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXQNFkyOCEQvF2= NVP1W4dxPzJiaB?= NYDkO|A5TE2VTx?= MYfJR|UxRTFyIN88US=> MmjhNlM5PDRyM{i=
LS1034 M164RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnENHgyOCEQvF2= M1u1[VczKGh? NFTubnlFVVOR M{\MUmlEPTB;MUCg{txO NV22OJB6OjN6NESwN|g>
CHP-212 M1va[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? NICwcIY4OiCq NGjLeJBFVVOR MYfJR|UxRTFyIN88US=> NHq3WIwzOzh2NECzPC=>
SK-N-AS M4TSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PaWFExKM7:TR?= MkTpO|IhcA>? MXHEUXNQ NWexV2hDUUN3ME2xNEDPxE1? M1f5TFI{QDR2MEO4
BFTC-905 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVexNEDPxE1? M2W3U|czKGh? M1\nTWROW09? MknBTWM2OD1zMDFOwG0> MljyNlM5PDRyM{i=
HuT78 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTNNVAh|ryP MoLMO|IhcA>? NEDhc5dFVVOR NWXN[IRkUUN3ME21NkBvVQ>? NEnCTY8zOzh2NECzPC=>
RPMI-8226 MlHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXqxNEDPxE1? NICwcJY4OiCq MkfMSG1UVw>? M1vmR2lEPTB;Mk[zJI5O MVKyN|g1PDB|OB?=
BC-3 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G0WVExKM7:TR?= MlPpO|IhcA>? NGiySItFVVOR NXLPXYcyUUN3ME2yO|chdk1? NYn6T4dHOjN6NESwN|g>
ACHN Mkf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXeweW1zOTBizszN MmfBO|IhcA>? MnW4SG1UVw>? M{T0WWlEPTB;Mkm0JI5O MYGyN|g1PDB|OB?=
JRT3-T35 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorLNVAh|ryP MV23NkBp Mn3iSG1UVw>? NYLwT5RwUUN3ME2yPVUhdk1? M{C1[FI{QDR2MEO4
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BC-1 M2jWSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrnNVAh|ryP MnjuO|IhcA>? NUXYVW5FTE2VTx?= MmG3TWM2OD15MESgcm0> M{PFbVI{QDR2MEO4
DB MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfrcWoyOCEQvF2= NUfKXIk3PzJiaB?= MUfEUXNQ MlPQTWM2OD16N{Ogcm0> MYKyN|g1PDB|OB?=
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HT-1080 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXlcWwyOCEQvF2= M3zNOFczKGh? MVHEUXNQ Mlj1TWM2OD1{LkCwOEDPxE1? Mnr1NlM5PDRyM{i=
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C3A MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnLPW9zOTBizszN Mo\QO|IhcA>? NYLkOnBCTE2VTx?= MoTuTWM2OD13LkSxOEDPxE1? MWCyN|g1PDB|OB?=
MES-SA NELQcYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYixNEDPxE1? NH7oeo84OiCq M3vxXmROW09? NVz4eWN6UUN3ME22Mlk5QSEQvF2= NHq4bFAzOzh2NECzPC=>
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786-O MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXyxNEDPxE1? M{jZV|czKGh? Mn3wSG1UVw>? MX\JR|UxRTFyIN88US=> MU[yN|g1PDB|OB?=
A172 NV7PZZZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNEDPxE1? MYK3NkBp MUjEUXNQ M1HUbGlEPTB;MUCg{txO MlSxNlM5PDRyM{i=
A204 M{jlO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnzNVAh|ryP MVW3NkBp M4HlTGROW09? NFjGPXpKSzVyPUGwJO69VQ>? NWm4V5NVOjN6NESwN|g>
A427 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;sT|ExKM7:TR?= MkLmO|IhcA>? NEnFU2ZFVVOR MlfqTWM2OD1zMDFOwG0> NGXjb|EzOzh2NECzPC=>
A431 M1HwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP4NVAh|ryP Mk\uO|IhcA>? M1TFcmROW09? MU\JR|UxRTFyIN88US=> NYW5bohpOjN6NESwN|g>
A2780 NWLyZ2wyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKxNEDPxE1? MnjJO|IhcA>? MXjEUXNQ Mn7YTWM2OD1zMDFOwG0> NV\VPYJsOjN6NESwN|g>
ARH-77 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjrNVAh|ryP NHrzUJM4OiCq NXLQUZZKTE2VTx?= MVvJR|UxRTFyIN88US=> NF\abmwzOzh2NECzPC=>
Be(2)C NHTaSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDrco55OTBizszN MkDIO|IhcA>? M37EVWROW09? M2jlXWlEPTB;MUCg{txO NGT0WI0zOzh2NECzPC=>
BT-20 M1vufWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofDNVAh|ryP MWm3NkBp MUDEUXNQ NHTkOXRKSzVyPUGwJO69VQ>? MofQNlM5PDRyM{i=
BxPc3 NV3OZ3ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYixNEDPxE1? MlLxO|IhcA>? NFHo[nNFVVOR NGjCNZVKSzVyPUGwJO69VQ>? MnmzNlM5PDRyM{i=
C-4 I MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXyxNEDPxE1? M1PONFczKGh? MnS4SG1UVw>? NX[wemVHUUN3ME2xNEDPxE1? M13zXVI{QDR2MEO4
C33A NF;GSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDKUosyOCEQvF2= NGTKVlc4OiCq M3u1UGROW09? M17p[WlEPTB;MUCg{txO MkjPNlM5PDRyM{i=
CAL-27 NX:4cWF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MliwNVAh|ryP M2P0b|czKGh? NIDQSo5FVVOR MlzhTWM2OD1zMDFOwG0> NXSyVYhmOjN6NESwN|g>
CAL-62 NFewcIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv5NVAh|ryP NG\ZUWw4OiCq M4L1dWROW09? M2\YVWlEPTB;MUCg{txO MXyyN|g1PDB|OB?=
Calu-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[xNEDPxE1? MUS3NkBp MYrEUXNQ NWnm[3lIUUN3ME2xNEDPxE1? MkC5NlM5PDRyM{i=
CaOV3 MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUSxNEDPxE1? NXHqVFJDPzJiaB?= MYTEUXNQ MnTSTWM2OD1zMDFOwG0> NXrjTVZiOjN6NESwN|g>
CGTHW1 NFLtWXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? NILDSFA4OiCq NIfHV4tFVVOR MXHJR|UxRTFyIN88US=> M1TpUFI{QDR2MEO4
CHL-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e0O|ExKM7:TR?= MmDPO|IhcA>? M4\DPWROW09? MVnJR|UxRTFyIN88US=> NW\HNFlSOjN6NESwN|g>
Colo320DM MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{mydFExKM7:TR?= NVzodoVQPzJiaB?= MmSxSG1UVw>? M{DvcmlEPTB;MUCg{txO M{nhUVI{QDR2MEO4
Colo704 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfWNVAh|ryP NHWzVGg4OiCq NX7BO4hOTE2VTx?= NFvkbJBKSzVyPUGwJO69VQ>? NUHqbHJvOjN6NESwN|g>
COR-L23 NV7UNVd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUSxNEDPxE1? NXvHUJd3PzJiaB?= MUXEUXNQ MnTTTWM2OD1zMDFOwG0> NInkTWczOzh2NECzPC=>
CRO-AP2 NETocFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3WT2xZOTBizszN M4nMeFczKGh? MlPiSG1UVw>? NH3rPJJKSzVyPUGwJO69VQ>? M4G2fVI{QDR2MEO4
Daudi MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3OfZUyOCEQvF2= MUe3NkBp NGf2VmxFVVOR MV7JR|UxRTFyIN88US=> NUTFeWJpOjN6NESwN|g>
DOTC 24510 NWPCT4lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;ObVAyOCEQvF2= MV[3NkBp NFnPb4tFVVOR MV3JR|UxRTFyIN88US=> MlTuNlM5PDRyM{i=
DU-145 MoT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TvfFExKM7:TR?= NGC4Om04OiCq M2fUWmROW09? NUfrSpBlUUN3ME2xNEDPxE1? MnzINlM5PDRyM{i=
EB-3 NFnxOYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[xNEDPxE1? MoTUO|IhcA>? NG\IVXdFVVOR MVzJR|UxRTFyIN88US=> NVLSVZVEOjN6NESwN|g>
EFM-19 Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNEDPxE1? MV63NkBp NYX2VpNQTE2VTx?= MY\JR|UxRTFyIN88US=> M{fCSVI{QDR2MEO4
EKVX Mlr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XYN|ExKM7:TR?= M{K1eFczKGh? MWTEUXNQ MYXJR|UxRTFyIN88US=> NYHVXXBUOjN6NESwN|g>
FaDu MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHkVolNOTBizszN NXj5W2lIPzJiaB?= M1[2VGROW09? MUDJR|UxRTFyIN88US=> MXqyN|g1PDB|OB?=
G401 M3v2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLae3MyOCEQvF2= NHnYeG04OiCq NGWye3JFVVOR M1:1NmlEPTB;MUCg{txO MmflNlM5PDRyM{i=
HCC-70 M4DZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVSxNEDPxE1? NYHo[3lnPzJiaB?= MmmySG1UVw>? MYjJR|UxRTFyIN88US=> MYmyN|g1PDB|OB?=
HCC-1954 NFL4U4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[0UFExKM7:TR?= Ml7HO|IhcA>? NVn2UXJjTE2VTx?= NH7FZ3ZKSzVyPUGwJO69VQ>? NG\yNXMzOzh2NECzPC=>
Hela MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHyNVAh|ryP M4Lac|czKGh? NV3yd|JDTE2VTx?= NHv5N|lKSzVyPUGwJO69VQ>? NFfVNG0zOzh2NECzPC=>
Hep3B NUmwfIRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX0NVAh|ryP MknTO|IhcA>? M1jy[mROW09? NGPOb2lKSzVyPUGwJO69VQ>? MVOyN|g1PDB|OB?=
HMCB M3v5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOxNEDPxE1? MUe3NkBp Mlf0SG1UVw>? M170ZWlEPTB;MUCg{txO NXzLV5VCOjN6NESwN|g>
HN5 NVvGT5cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjlOFAyOCEQvF2= M175b|czKGh? MULEUXNQ MVHJR|UxRTFyIN88US=> NHi3cZAzOzh2NECzPC=>
HOS MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M321XVExKM7:TR?= NVThPJR6PzJiaB?= NWKwPWlKTE2VTx?= MYXJR|UxRTFyIN88US=> MnjkNlM5PDRyM{i=
HPAF-II M2XUe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjLXYU6OTBizszN NEnxOIQ4OiCq NWfmXGFoTE2VTx?= NYT0WpJOUUN3ME2xNEDPxE1? NUDGV3BzOjN6NESwN|g>
Hs746.T M1\xVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT3NVAh|ryP NVTtfWRyPzJiaB?= NGrofolFVVOR NU\vdpo5UUN3ME2xNEDPxE1? NXHkZ4NSOjN6NESwN|g>
HT NVzpRoc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG0OVBYOTBizszN MYm3NkBp NGLEW|BFVVOR MkDjTWM2OD1zMDFOwG0> NFjGdoEzOzh2NECzPC=>
HT-3 M2\V[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTyUlFsOTBizszN MkPhO|IhcA>? MXzEUXNQ M2HjVWlEPTB;MUCg{txO MnuzNlM5PDRyM{i=
HuNS-1 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f4e|ExKM7:TR?= NWjXUWtFPzJiaB?= MVvEUXNQ NGHp[YNKSzVyPUGwJO69VQ>? M{P5WlI{QDR2MEO4
IGROV1 NYixXoJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn1NVAh|ryP M2\ufVczKGh? NYrBeHNjTE2VTx?= NULk[WJyUUN3ME2xNEDPxE1? NUO3Wmt{OjN6NESwN|g>
J82 M4fpWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XCSlExKM7:TR?= NWn0U2djPzJiaB?= NW[2PGU4TE2VTx?= MkLXTWM2OD1zMDFOwG0> MXuyN|g1PDB|OB?=
JM1 Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknCNVAh|ryP NHTifWY4OiCq NImwXWdFVVOR NGPGNWJKSzVyPUGwJO69VQ>? Ml7TNlM5PDRyM{i=
Kato III NFnuNFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf5VlgyOCEQvF2= MlyyO|IhcA>? M1W0XGROW09? NGj2XHFKSzVyPUGwJO69VQ>? M3fFUVI{QDR2MEO4
KHOS-240S Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\XdWgyOCEQvF2= M3HXO|czKGh? M{fU[2ROW09? NX3nNpRnUUN3ME2xNEDPxE1? MXuyN|g1PDB|OB?=
KM-12 MlzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUixdItVOTBizszN MVm3NkBp NVLld4RLTE2VTx?= M3jhWGlEPTB;MUCg{txO NV2yNJJlOjN6NESwN|g>
KPL-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHXUIxsOTBizszN MoCxO|IhcA>? NXTUVYJpTE2VTx?= NIfqfWNKSzVyPUGwJO69VQ>? MUGyN|g1PDB|OB?=
KYSE-30 NFO1TIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zkTlExKM7:TR?= NF7k[244OiCq NGLyTZFFVVOR NFexXW1KSzVyPUGwJO69VQ>? MlfTNlM5PDRyM{i=
LNCaP NWrhfW1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF31[mcyOCEQvF2= Ml3oO|IhcA>? NF6xR|JFVVOR NGrue4ZKSzVyPUGwJO69VQ>? NVPofYRrOjN6NESwN|g>
MCF-7 MoDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnsNVAh|ryP M{D4NlczKGh? Mn7uSG1UVw>? MVvJR|UxRTFyIN88US=> NFnDZlgzOzh2NECzPC=>
MC-IXC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorxNVAh|ryP MVW3NkBp MnvzSG1UVw>? MVjJR|UxRTFyIN88US=> M1O0R|I{QDR2MEO4
MDA-MB-175 VII NVLueIVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYexUHR[OTBizszN NHH0d444OiCq NE[2UlRFVVOR NWnp[4Q{UUN3ME2xNEDPxE1? MWqyN|g1PDB|OB?=
MDA-MB-468 NWj5NnpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDvW4wyOCEQvF2= NXTFe45DPzJiaB?= NXPxN5JMTE2VTx?= MV;JR|UxRTFyIN88US=> NXrUXZR1OjN6NESwN|g>
MiaPaCa NELL[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvHTJYyOCEQvF2= MW[3NkBp NWHPT29[TE2VTx?= NILiT5FKSzVyPUGwJO69VQ>? MlKwNlM5PDRyM{i=
Molt-4 NHHxbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTONVAh|ryP NWryc|Z6PzJiaB?= NET2R|VFVVOR NXy1WoF1UUN3ME2xNEDPxE1? NWTxOY4{OjN6NESwN|g>
NCI-ADR/RES MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDHPHN5OTBizszN MnjqO|IhcA>? NVntTVR2TE2VTx?= MofOTWM2OD1zMDFOwG0> M3XGO|I{QDR2MEO4
NCI-H69 NGTIZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjWOXUyOCEQvF2= NUHE[|A6PzJiaB?= M2LneWROW09? M{D3VWlEPTB;MUCg{txO MkHLNlM5PDRyM{i=
NCI-H82 NIjHdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfoNVAh|ryP MWK3NkBp NFfnNXJFVVOR NHu2VXhKSzVyPUGwJO69VQ>? Mne4NlM5PDRyM{i=
NCI-N87 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnhU2cyOCEQvF2= NIXCem04OiCq MWDEUXNQ MWTJR|UxRTFyIN88US=> MkTwNlM5PDRyM{i=
NCI-H146 NXXhNXJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWGxNEDPxE1? MXq3NkBp NVHkZWVNTE2VTx?= MVPJR|UxRTFyIN88US=> NUSzXFJjOjN6NESwN|g>
NCI-H157 NF7ucVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEG4R4UyOCEQvF2= NX:1Vok5PzJiaB?= MWfEUXNQ MWfJR|UxRTFyIN88US=> MkHlNlM5PDRyM{i=
NCI-H187 NIrqWmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{faVVExKM7:TR?= NFXsflc4OiCq M2\1eWROW09? MoDVTWM2OD1zMDFOwG0> MoH3NlM5PDRyM{i=
NCI-H209 Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjMNVAh|ryP M1;IV|czKGh? MWTEUXNQ MXPJR|UxRTFyIN88US=> MV:yN|g1PDB|OB?=
NCI-H226 NHzXRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDPNVAh|ryP MnrpO|IhcA>? NFntZnJFVVOR NVLmVmYxUUN3ME2xNEDPxE1? MYmyN|g1PDB|OB?=
NCI-H292 NH;4[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfDb2hVOTBizszN MlHHO|IhcA>? Mn;WSG1UVw>? NIjCO5VKSzVyPUGwJO69VQ>? NFrnT5EzOzh2NECzPC=>
NCI-H322 NUjmSI42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXtNVAh|ryP MnPiO|IhcA>? MkP3SG1UVw>? NG\T[HFKSzVyPUGwJO69VQ>? NGPtcGkzOzh2NECzPC=>
NCI-H358 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;SNVAh|ryP NX[5SHV4PzJiaB?= NVjWT4NbTE2VTx?= NVvsb|R5UUN3ME2xNEDPxE1? NV3ufG9sOjN6NESwN|g>
NCI-H520 MoLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljuNVAh|ryP M{fOb|czKGh? MmjxSG1UVw>? M3nheGlEPTB;MUCg{txO M2XtWVI{QDR2MEO4
NCI-H526 M{W0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXmxNEDPxE1? MVK3NkBp M3PYdGROW09? MkTpTWM2OD1zMDFOwG0> NWq0dmZ[OjN6NESwN|g>
NCI-H630 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XLelExKM7:TR?= Mmj1O|IhcA>? M2jpd2ROW09? M{LWS2lEPTB;MUCg{txO NF\3XZIzOzh2NECzPC=>
NCI-H661 NInpWmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOwNVAh|ryP MW[3NkBp NE\IbGhFVVOR NYnRc3BrUUN3ME2xNEDPxE1? M2XrUVI{QDR2MEO4
NCI-H716 MnOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVuxNEDPxE1? NUDxNI5kPzJiaB?= M{nMOmROW09? NFH0e4NKSzVyPUGwJO69VQ>? MlTZNlM5PDRyM{i=
NCI-H1563 NEe2d21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nqSFExKM7:TR?= MkPKO|IhcA>? MVLEUXNQ M1jDUmlEPTB;MUCg{txO NGXaOIIzOzh2NECzPC=>
NCI-H1792 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\HNFExKM7:TR?= Mmj6O|IhcA>? MmLkSG1UVw>? Mnf3TWM2OD1zMDFOwG0> MX[yN|g1PDB|OB?=
NCI-H2030 NEHmU2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTTNVAh|ryP M3:xPFczKGh? NIHVVpBFVVOR M13VUWlEPTB;MUCg{txO M3\JU|I{QDR2MEO4
NCI-H2052 M4DZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHESWsyOCEQvF2= NYftZnp{PzJiaB?= NXjjU3VKTE2VTx?= MoTVTWM2OD1zMDFOwG0> Mon1NlM5PDRyM{i=
NCI-H2122 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILLVpIyOCEQvF2= NHfD[244OiCq NGPFOmNFVVOR MlTITWM2OD1zMDFOwG0> MXGyN|g1PDB|OB?=
NCI-H2228 M3LPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWL4S3V3OTBizszN NX7hZ|BPPzJiaB?= M{jzc2ROW09? NUnVfIJsUUN3ME2xNEDPxE1? NVyxO5hYOjN6NESwN|g>
OE-19 MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPmO3QyOCEQvF2= NGDCfVk4OiCq NVv0b5JwTE2VTx?= MYTJR|UxRTFyIN88US=> M3\mXFI{QDR2MEO4
OE-21 NHGxXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:xNEDPxE1? NVHaZXZPPzJiaB?= NIK5NYhFVVOR NFnSSVJKSzVyPUGwJO69VQ>? M{TlUFI{QDR2MEO4
OE-33 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\wVmNPOTBizszN MnzHO|IhcA>? NH3zV5FFVVOR MVvJR|UxRTFyIN88US=> NIPCRoszOzh2NECzPC=>
OVCAR-3 M1\uOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L0SlExKM7:TR?= NWf4R2o6PzJiaB?= M361SGROW09? NF\PPVFKSzVyPUGwJO69VQ>? MVyyN|g1PDB|OB?=
OVCAR-4 NGj4dZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7vXYZEOTBizszN Mm[2O|IhcA>? M1rEVGROW09? NW[3dY9OUUN3ME2xNEDPxE1? M2i2O|I{QDR2MEO4
OVCAR-5 NUHwO3JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXqxNEDPxE1? NIW1SIw4OiCq NVq4fmNPTE2VTx?= MV7JR|UxRTFyIN88US=> M1G3eVI{QDR2MEO4
P3HR-1 NVTydnZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGmzUI4yOCEQvF2= MmLVO|IhcA>? NVL2WYl3TE2VTx?= M{jOc2lEPTB;MUCg{txO MnnxNlM5PDRyM{i=
PC-3 NVTNclBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzKTFBMOTBizszN M{DDNFczKGh? M4jrWWROW09? NGmweVhKSzVyPUGwJO69VQ>? MXeyN|g1PDB|OB?=
Raji MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n3S|ExKM7:TR?= NHe4SWs4OiCq M4X1RWROW09? NIHSWpZKSzVyPUGwJO69VQ>? NIXO[pQzOzh2NECzPC=>
RD MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[xNEDPxE1? M37xe|czKGh? M4jrWGROW09? NHvMUXhKSzVyPUGwJO69VQ>? M4C1WlI{QDR2MEO4
RD-ES MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYCxNEDPxE1? NYLPd5JxPzJiaB?= MV7EUXNQ MVPJR|UxRTFyIN88US=> MYmyN|g1PDB|OB?=
RL NF;yPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLTNVAh|ryP NYHY[|IzPzJiaB?= NF\M[YlFVVOR NHradGdKSzVyPUGwJO69VQ>? MV[yN|g1PDB|OB?=
SaOS2 NYjIUFlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P3W|ExKM7:TR?= NWrEWnBMPzJiaB?= M1LHTGROW09? MV7JR|UxRTFyIN88US=> M3:zZlI{QDR2MEO4
SCC-9 Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDiR|EyOCEQvF2= NXXzTVd7PzJiaB?= M1TyWWROW09? MVXJR|UxRTFyIN88US=> MX2yN|g1PDB|OB?=
SCC-12 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV6z[205OTBizszN MnPjO|IhcA>? NFzXcZNFVVOR NIjpfFhKSzVyPUGwJO69VQ>? NGftV4ozOzh2NECzPC=>
SCC-13 NFnGTJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDlNmQyOCEQvF2= M1\kfFczKGh? M{L5Z2ROW09? M2jmSGlEPTB;MUCg{txO NFX0b3IzOzh2NECzPC=>
SCC-15 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fWSlExKM7:TR?= NGDs[pM4OiCq NYXuXnV6TE2VTx?= M16wWmlEPTB;MUCg{txO MoP3NlM5PDRyM{i=
SCC-25 NVPRco5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFuwTVcyOCEQvF2= MkPtO|IhcA>? Moe1SG1UVw>? NV7O[mpIUUN3ME2xNEDPxE1? Mnf5NlM5PDRyM{i=
SCLC-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\EeVFFOTBizszN M{\6W|czKGh? M4fzeWROW09? M{jOfmlEPTB;MUCg{txO M2LNRlI{QDR2MEO4
SF-268 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjGNVAh|ryP Mk\EO|IhcA>? NVmyb402TE2VTx?= NV7RdVdNUUN3ME2xNEDPxE1? M37xTVI{QDR2MEO4
SF-295 MkDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInXRnYyOCEQvF2= MYm3NkBp NH6zWGtFVVOR Mn62TWM2OD1zMDFOwG0> M1PFdFI{QDR2MEO4
SJRH30 NGTPS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS2NVAh|ryP M4G2S|czKGh? Mn;rSG1UVw>? MkXzTWM2OD1zMDFOwG0> MUGyN|g1PDB|OB?=
SK-BR-3 NI\FVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXixNEDPxE1? M3LtO|czKGh? M2mzcGROW09? NI\6bIFKSzVyPUGwJO69VQ>? NY[wOIhzOjN6NESwN|g>
SK-LMS-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm0cVkyOCEQvF2= MofqO|IhcA>? NHXWNlhFVVOR NFLwSnhKSzVyPUGwJO69VQ>? MnnCNlM5PDRyM{i=
SK-N-DZ M3vOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLGTXpPOTBizszN MYK3NkBp NWLkOlY3TE2VTx?= NUjmPGt{UUN3ME2xNEDPxE1? NI\rb|IzOzh2NECzPC=>
SK-N-F1 NHHLVJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjKb4h[OTBizszN M3vGcFczKGh? NXjjUXhyTE2VTx?= M1XXR2lEPTB;MUCg{txO NXfCWIVOOjN6NESwN|g>
SKOV-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnMSWZYOTBizszN NGrIT5U4OiCq MlzpSG1UVw>? NXLtbFFGUUN3ME2xNEDPxE1? NVLw[pZYOjN6NESwN|g>
SK-UT-1 NFHudWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:yd|ExKM7:TR?= MkHNO|IhcA>? M4nlbWROW09? NGP4N4NKSzVyPUGwJO69VQ>? MnOzNlM5PDRyM{i=
SN12C MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH0NVAh|ryP NEPpOWY4OiCq NEntNY1FVVOR NIL3eoFKSzVyPUGwJO69VQ>? NVvMVmw5OjN6NESwN|g>
SNB-19 NEHsb4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnsRWUyOCEQvF2= MmHCO|IhcA>? MX\EUXNQ NHOxVJRKSzVyPUGwJO69VQ>? MUGyN|g1PDB|OB?=
SNU-5 NFnzPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjKfnlVOTBizszN NGjLPVk4OiCq M2fYOWROW09? NW\TSlRnUUN3ME2xNEDPxE1? Mm\2NlM5PDRyM{i=
SNU-16 M4fWe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYKxNEDPxE1? MWW3NkBp MYHEUXNQ MlqzTWM2OD1zMDFOwG0> MXeyN|g1PDB|OB?=
SNU-398 MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnleoMyOCEQvF2= MofGO|IhcA>? MXPEUXNQ MoC4TWM2OD1zMDFOwG0> MYiyN|g1PDB|OB?=
SNU-449 Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO4OWgyOCEQvF2= NUDUU4tHPzJiaB?= NGG4dFFFVVOR NYnJemM4UUN3ME2xNEDPxE1? NF;nfJczOzh2NECzPC=>
SR M4DSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjMNVAh|ryP NG\qc5U4OiCq MWDEUXNQ NYHreZduUUN3ME2xNEDPxE1? MUKyN|g1PDB|OB?=
ST486 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrpNVAh|ryP MW[3NkBp NHfqe3ZFVVOR M{Wze2lEPTB;MUCg{txO M3e5elI{QDR2MEO4
SW579 NV\NbHlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XwWlExKM7:TR?= MofaO|IhcA>? M3z5R2ROW09? NH:5WI9KSzVyPUGwJO69VQ>? M2fHSlI{QDR2MEO4
SW684 NH\PNXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWxNEDPxE1? NXTmXZVyPzJiaB?= MXHEUXNQ Mlz5TWM2OD1zMDFOwG0> NYf6cIhFOjN6NESwN|g>
SW-780 M4D6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWixNEDPxE1? NFfWeGg4OiCq NUH2TGtJTE2VTx?= MmLyTWM2OD1zMDFOwG0> MorENlM5PDRyM{i=
SW900 MmXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HPfVExKM7:TR?= NVXlfVZWPzJiaB?= NIrGbFFFVVOR MWHJR|UxRTFyIN88US=> MWGyN|g1PDB|OB?=
SW1088 NUjvPGJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXaNVAh|ryP MUe3NkBp Ml7iSG1UVw>? NUPLTXk6UUN3ME2xNEDPxE1? Mn[yNlM5PDRyM{i=
SW1463 NFzwXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC0NVAh|ryP MlnuO|IhcA>? NH25fYJFVVOR M4L2NmlEPTB;MUCg{txO M4rSXlI{QDR2MEO4
SW1990 Mn;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH1[nlVOTBizszN M{TkWFczKGh? MlLmSG1UVw>? NXrNTmJzUUN3ME2xNEDPxE1? NXPodmU2OjN6NESwN|g>
T47D MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljZNVAh|ryP NE\MR2c4OiCq NVz5OWZSTE2VTx?= M1P5[2lEPTB;MUCg{txO M3nRfFI{QDR2MEO4
TE381.T MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTYNVAh|ryP MkGxO|IhcA>? NX7ad|U1TE2VTx?= NGe0Oo5KSzVyPUGwJO69VQ>? M3XZSlI{QDR2MEO4
TK-10 M3rDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfLV2UyOCEQvF2= MXq3NkBp NEe2fJBFVVOR M{TFR2lEPTB;MUCg{txO Mki3NlM5PDRyM{i=
U2OS MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNEDPxE1? M{DoWlczKGh? M2D3NWROW09? NUP0cXdqUUN3ME2xNEDPxE1? NYCyOVdIOjN6NESwN|g>
U251 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHRTG52OTBizszN M3PvSlczKGh? MYTEUXNQ MULJR|UxRTFyIN88US=> NFjYO2YzOzh2NECzPC=>
UACC-812 M3;BNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrhNVAh|ryP MVq3NkBp NWLjWGxtTE2VTx?= NVvrUpVIUUN3ME2xNEDPxE1? M2KxZVI{QDR2MEO4
YAPC NV\FR2FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjNb|YyOCEQvF2= M1;iN|czKGh? M4L2d2ROW09? MlyxTWM2OD1zMDFOwG0> NHq4enYzOzh2NECzPC=>
ZR-75-1 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LFUVExKM7:TR?= MliwO|IhcA>? NYHr[FV4TE2VTx?= MYLJR|UxRTFyIN88US=> M37ZfVI{QDR2MEO4
A375 NFXrXFdHfW6ldHnvckBie3OjeR?= NY\YUZM1OS5{IN88US=> MU[0JIg> NVnMfmpMTE2VTx?= M2e1cGlvcGmkaYTpc44hd2ZicHjvd5Bpd3K7bHH0bY9vKG:oIF3FT{whTVKNLDDhcoQhWz[S M3f1[|IzOzh7NEex
YUSIT1 MWjGeY5kfGmxbjDhd5NigQ>? NEDZXoJFVVOR MYXy[YR2[2WmIIPlcpNqfGm4aYT5JJdqfGhiSVO1NEA,KDBwNTFOwG0> MkLjNlI{QDl2N{G=
MeWo NV\LfYUzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3zMTGROW09? MoPKTWM2OCB;IEm4O{BvVQ>? NHfq[m8zPjBzOEWyOC=>
WiDr NX\2Um9vT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYr6bohoTE2VTx?= NG\zT2FKSzVyIE2gO|Yhdk1? NWrQUHdKOjZyMUi1NlQ>
Colo-205 MmS5SpVv[3Srb36gZZN{[Xl? M2fCXlEh|ryP MVS0JIQ> MYDEUXNQ MVfJcoR2[2WmIHGgbIlocGy7IHPvcZBiemGkbHWgZ49ueGGldHnvckBxcGWwb4T5dIU> M1TPNFI2OzhzMUWy
RBW-1 NWXn[GxXTnWwY4Tpc44h[XO|YYm= MkPONUDPxE1? MXnEUXNQ MUPOc{Bz\WS3Y4Tpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> NYXMNHRIOjR6OEW2PVA>
RBO-1 M3PhbWZ2dmO2aX;uJIF{e2G7 NHv4XI8yKM7:TR?= NG[zUXRFVVOR NUnaT49zUW6qaXLpeIlwdiCxZjDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? Ml;QNlQ5QDV4OUC=
RBO-2 NI\ScnRHfW6ldHnvckBie3OjeR?= NVfaOJFkOSEQvF2= MX3EUXNQ NV3zTZQyUW6qaXLpeIlwdiCxZjCgUYVsKDFxMjDwbI9{eGixconsZZRqd25? NFjoVJozPDh6NU[5NC=>
RBOW MUXGeY5kfGmxbjDhd5NigQ>? NVmw[oVZOSEQvF2= NUjme|A1TE2VTx?= NYP5TIFiUW6qaXLpeIlwdiCxZjCgUYVsKDFxMjDwbI9{eGixconsZZRqd25? NETpXZczPDh6NU[5NC=>
M257 M3;YRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUmxNFAhdk1? M3PZV|czKGh? MVXEc4V{KG6xdDDpcohq[mm2IIDyc4xq\mW{YYTpc44hd2ZiTUK1O{Bk\WyuIHjhdoJwfXKrbnege4lt\CC2eYDlJGJTSUZ? MUSyN|MyPzR2Nh?=
LCP Mof4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXSxNFAhdk1? Ml3NO|IhcA>? NVzzO5hIUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? NHfOWYIzOzNzN{S0Oi=>
WM266 M2rWemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jIRVExOCCwTR?= M4qzdVczKGh? NYfFSXVCUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFFFKG23dHHueIF1cW:w NV\uWnBIOjN|MUe0OFY>
M257 M{LhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zxWFExOCCwTR?= MUC3NkBp MlvMSI9meyCwb4SgbY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIF2yOVch[2WubDDoZZJjd3W{aX7nJJdqdGRidInw[UBDWkGI MXSyN|MyPzR2Nh?=
LCP NEjoeJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrENVAxKG6P MkjMO|IhcA>? M3PB[WlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDMR3Ah[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNHIhdXW2YX70ZZRqd25? NHHrOJAzOzNzN{S0Oi=>
WM266 M3XUXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:4PYkyODBibl2= M2DUNlczKGh? M4LwZmlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDXUVI3PiClZXzsJIhiemKxdYLpcochSlKDRjDWOlAxTCCvdYThcpRifGmxbh?= NGj5OXIzOzNzN{S0Oi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
8 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03794297 Not yet recruiting BRAF NP_004324.2:p.V600X|Erdheim-Chester Disease National Cancer Institute (NCI) January 12 2020 Phase 2
NCT03794297 Not yet recruiting BRAF NP_004324.2:p.V600X|Erdheim-Chester Disease National Cancer Institute (NCI) January 12 2020 Phase 2
NCT03784014 Not yet recruiting Soft Tissue Sarcoma Institut National de la Santé Et de la Recherche Médicale France|Commissariat A L''energie Atomique|Institut Bergonié|Plateforme labellisée Inca – Institut Bergonié Bordeaux|Plateforme labellisée Inca – Hôpital Européen Georges Pompidou Paris|CIC-EC 1401/EUCLID March 2019 Phase 3
NCT03784014 Not yet recruiting Soft Tissue Sarcoma Institut National de la Santé Et de la Recherche Médicale France|Commissariat A L''energie Atomique|Institut Bergonié|Plateforme labellisée Inca – Institut Bergonié Bordeaux|Plateforme labellisée Inca – Hôpital Européen Georges Pompidou Paris|CIC-EC 1401/EUCLID March 2019 Phase 3
NCT03272464 Recruiting Melanoma Massachusetts General Hospital|Incyte Corporation November 30 2018 Phase 1
NCT03272464 Recruiting Melanoma Massachusetts General Hospital|Incyte Corporation November 30 2018 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID