Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Cited by 135 Publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NYXJXoxiU2mwYYPlJGF{e2G7 NF:zbFdKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygTIl{KHSjZ3fl[EBDNVKjZjDWOlAxTSCvdYThcpQh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyClbz3lfJBz\XO|aX7nJGNFSzN5IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGKrb4Tpcplt[XSnZD3NSWsheHKxdHXpckBxcG:|cHjvdplt[XSrb36gZpkhSWyyaHHTZ5Jm\W5iYYPzZZkhf2m2aDDJR|UxKG:oIECuNFAxPyEQvF2= NWrGWZoyOjR7MEC2O|M>
SK-MEL-28 MWHLbY5ie2ViQYPzZZk> NF3pcnYyKGh? M37VTGlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIGPLMW1GVC1{ODDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBGWkticHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxPCEQvF2= NFrXeZIzPDlyME[3Ny=>
HepG2 MWfLbY5ie2ViQYPzZZk> M{PGZWlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? MnzmNlQ6ODB4N{O=
COLO205 NYPEdJdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nSPGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= MW[yOFkxODZ5Mx?=
HepG2 M4rnOWZ2dmO2aX;uJGF{e2G7 NGfK[4g1PSCvaX6= M4[0VGROW09? Mn3oTY5pcWKrdHnvckBw\iCDbHu1JIlvKFSJRj3i[ZRiNXO2aX31cIF1\WRiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hW22jZEKgdIhwe3Cqb4L5cIF1cW:wIITy[YF1\WRiZn;yJFQ2KG2rboOgdJJqd3JidH:gWGdHNWKndHGgd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgOlAhdWmwczDifUBw\Hm|c3X5JIJtd3Ric3Phco5meiCjbnHsfZNqeyC5aYToJGlEPTBib3[gN{44KM7:TR?= NX7nRpVGOjR7MEC2O|M>
HFF MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVOxNEDPxE1? NGHIOGM4OiCq NVLQPHVXTE2VTx?= M3LycmlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCqdX3hckBJTkZiY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCELWLh[kB4cXSqIFnDOVAhd2ZiMzFOwG0> NHfzS2czOzh2NECzPC=>
SK-MEL-28 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO3dWdVOTBizszN M334TVczKGh? NYHId5VyTE2VTx?= M{XadGlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCVSz3NSWwuOjhiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB2MzFOwG0> NWHuWnRuOjN6NESwN|g>
A375P-F11 M4WyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfiVlZEOTBizszN MmjkO|IhcA>? M131XmROW09? NFK3bIFKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iQUO3OXAuTjFzIHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yN{Gg{txO NYHR[nNbOjN6NESwN|g>
MALME-3M MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT0NVAh|ryP NVHWZZplPzJiaB?= MVzEUXNQ NVTiXJBrUUN3ME2xJI5O MW[yN|g1PDB|OB?=
UACC-62 M4\yTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL6fmJFOTBizszN MYm3NkBp MkW1SG1UVw>? NVjYc45xUUN3ME2xJI5O MlHZNlM5PDRyM{i=
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M14 NHz3UmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXy[2wyOCEQvF2= MmnrO|IhcA>? M{[zZ2ROW09? NXHPcWg6UUN3ME2yJI5O NHL5fJIzOzh2NECzPC=>
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A375 M4XPR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUexNEDPxE1? NHPTeno4OiCq MlPhSG1UVw>? MUnJR|UxRTRibl2= Mn3nNlM5PDRyM{i=
DU-4475 M4jhcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrZNVAh|ryP NEO5flk4OiCq M13qVGROW09? MnnRTWM2OD13IH7N MXSyN|g1PDB|OB?=
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Colo 205 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XiWVExKM7:TR?= MnjLO|IhcA>? NFLYRVZFVVOR MnzjTWM2OD15IH7N NVTGNFFEOjN6NESwN|g>
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A101D NViyTIxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;KcIYyOCEQvF2= Mn7iO|IhcA>? MonYSG1UVw>? MYPJR|UxRTlibl2= NYW4THA4OjN6NESwN|g>
ES-2 NXzJV29LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rNdVExKM7:TR?= MUm3NkBp MoH3SG1UVw>? NXjzT4RwUUN3ME21N{BvVQ>? M1PvS|I{QDR2MEO4
HT-29 NVvjZoE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNEDPxE1? MmHPO|IhcA>? MYfEUXNQ MoHQTWM2OD14NjDuUS=> NWXuWXE5OjN6NESwN|g>
SW1417 M2TUOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[yNVAh|ryP MofVO|IhcA>? NGrZWnVFVVOR MX7JR|UxRTF3ODDuUS=> M2Tve|I{QDR2MEO4
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GCT M3fMUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXmxNEDPxE1? NGnUbJI4OiCq Mn;XSG1UVw>? M{nUOGlEPTB;MUCg{txO NH3qOWIzOzh2NECzPC=>
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YUMAC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7zNVAh|ryP MlXWO|IhcA>? MkjnSG1UVw>? NUHHUVF2UUN3ME21JI5O NWTE[oZUOjN6NESwN|g>
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NCI-H508 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPnNVAh|ryP MWi3NkBp MXHEUXNQ MoLCTWM2OD1zMDFOwG0> MUmyN|g1PDB|OB?=
MDA-MB-231 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYGxNEDPxE1? M1m4eFczKGh? NY\jVJhoTE2VTx?= MWPJR|UxRTFyIN88US=> MU[yN|g1PDB|OB?=
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SW-837 NF:yNotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTJNVAh|ryP NEW4Sos4OiCq NWrYfnNwTE2VTx?= MlvnTWM2OD1zMDFOwG0> M{PldFI{QDR2MEO4
UMUC-3 MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPmdY4yOCEQvF2= NYOwWohEPzJiaB?= MX;EUXNQ M3m3PWlEPTB;MUCg{txO NIjpflQzOzh2NECzPC=>
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SW480 M{\4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;Cc|kyOTBizszN NHzRUJM4OiCq M171PGROW09? Ml\BTWM2OD1zMDFOwG0> NGLrU3IzOzh2NECzPC=>
DLD-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO5NVAh|ryP NIrrdFg4OiCq MWTEUXNQ NXzHVWNRUUN3ME2xNEDPxE1? M{DB[|I{QDR2MEO4
HCT-116 NIXJSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrxRZQ3OTBizszN M{\zVlczKGh? Mmi4SG1UVw>? MV\JR|UxRTFyIN88US=> NID2[lEzOzh2NECzPC=>
NCI-H747 NWDNU4hNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NECyXIsyOCEQvF2= NYryend{PzJiaB?= NGf6TIdFVVOR NHixboNKSzVyPUGwJO69VQ>? Ml7tNlM5PDRyM{i=
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NCI-H460 M3\nZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[5NVAh|ryP MVe3NkBp MXLEUXNQ NWPvR3lMUUN3ME2xNEDPxE1? MmHnNlM5PDRyM{i=
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HCC-2998 NIPk[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;2fFExKM7:TR?= MYW3NkBp MnLoSG1UVw>? NVWzNHc3UUN3ME2xNEDPxE1? M1zCXFI{QDR2MEO4
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JRT3-T35 M{TUe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:4PI0yOCEQvF2= NH;KNG44OiCq M3HyUGROW09? NEf3W29KSzVyPUK5OUBvVQ>? NFLpV3gzOzh2NECzPC=>
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BC-1 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUexNEDPxE1? M2O1PVczKGh? MofUSG1UVw>? NX\xN4tuUUN3ME23NFQhdk1? M325RlI{QDR2MEO4
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A427 M2\jZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHwNVAh|ryP NX7tO3p4PzJiaB?= M3jabGROW09? NFu4enZKSzVyPUGwJO69VQ>? MkjUNlM5PDRyM{i=
A431 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[3NVAh|ryP NGDNcYs4OiCq MWXEUXNQ MnH1TWM2OD1zMDFOwG0> M{C2blI{QDR2MEO4
A2780 MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jublExKM7:TR?= NFLVZ404OiCq M{LLWWROW09? MWrJR|UxRTFyIN88US=> NVzkW2pQOjN6NESwN|g>
ARH-77 MoO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn25NVAh|ryP NHvRZ|c4OiCq MYjEUXNQ NV6wZXpJUUN3ME2xNEDPxE1? M2DYfFI{QDR2MEO4
Be(2)C MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUGxNEDPxE1? M2iwVVczKGh? MUjEUXNQ NXq3NXF6UUN3ME2xNEDPxE1? MoXkNlM5PDRyM{i=
BT-20 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv3T4tSOTBizszN MUC3NkBp MWTEUXNQ NY\hOo1jUUN3ME2xNEDPxE1? NHvIdIkzOzh2NECzPC=>
BxPc3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLqNVAh|ryP NFzzNIM4OiCq M2\wWGROW09? MnHPTWM2OD1zMDFOwG0> NWDyRpV1OjN6NESwN|g>
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CAL-27 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L4eFExKM7:TR?= MXe3NkBp M1Gz[mROW09? MnywTWM2OD1zMDFOwG0> MmjzNlM5PDRyM{i=
CAL-62 NEfNc4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETvSJEyOCEQvF2= MUS3NkBp MV7EUXNQ M1qyWWlEPTB;MUCg{txO NFvjZokzOzh2NECzPC=>
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Colo320DM NHntNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHMXJAyOCEQvF2= NGXBUI84OiCq M{LZRmROW09? NFzzNINKSzVyPUGwJO69VQ>? M4nhOlI{QDR2MEO4
Colo704 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnie5oyOCEQvF2= NHf5[GY4OiCq NYTQV49GTE2VTx?= NVLpVo9iUUN3ME2xNEDPxE1? NGm4SJIzOzh2NECzPC=>
COR-L23 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\hNVAh|ryP NGLsWZk4OiCq M3z3SWROW09? MXPJR|UxRTFyIN88US=> Mlq2NlM5PDRyM{i=
CRO-AP2 MonYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXixNEDPxE1? M{XsTVczKGh? NXrhO4FQTE2VTx?= Mn\1TWM2OD1zMDFOwG0> MVyyN|g1PDB|OB?=
Daudi M1vm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHGW48yOCEQvF2= M2fmXFczKGh? MnnHSG1UVw>? MWTJR|UxRTFyIN88US=> M4nOdFI{QDR2MEO4
DOTC 24510 M1TmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYCxNEDPxE1? NXj6O5Q4PzJiaB?= M2LMcGROW09? NHXuXYNKSzVyPUGwJO69VQ>? M3LxNVI{QDR2MEO4
DU-145 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfwNVAh|ryP MoLBO|IhcA>? M{PjNGROW09? NXPIZll[UUN3ME2xNEDPxE1? MnWwNlM5PDRyM{i=
EB-3 NI\lfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PNc|ExKM7:TR?= NVHveW9MPzJiaB?= NUnBRlZrTE2VTx?= M3znU2lEPTB;MUCg{txO NVPnXmtiOjN6NESwN|g>
EFM-19 M1zibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nuTVExKM7:TR?= MlS5O|IhcA>? M1n5NmROW09? M1LTemlEPTB;MUCg{txO M3TOdlI{QDR2MEO4
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Hep3B NFq4TFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHXNVAh|ryP NV\mOlZyPzJiaB?= MlPzSG1UVw>? MWTJR|UxRTFyIN88US=> NEWyTGozOzh2NECzPC=>
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Hs746.T NX7pUoJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGxNEDPxE1? MoLkO|IhcA>? MnLzSG1UVw>? MX\JR|UxRTFyIN88US=> MUWyN|g1PDB|OB?=
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HT-3 M{C5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrhNVAh|ryP NGLFdIo4OiCq MoXzSG1UVw>? NVPRXmtMUUN3ME2xNEDPxE1? MkjMNlM5PDRyM{i=
HuNS-1 M375NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUSxNEDPxE1? NXvlTJp2PzJiaB?= M{PQXmROW09? NIfm[JVKSzVyPUGwJO69VQ>? Ml\QNlM5PDRyM{i=
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J82 NX;vR5BDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fy[|ExKM7:TR?= MmT2O|IhcA>? M33MUWROW09? MYXJR|UxRTFyIN88US=> NYj1NYhYOjN6NESwN|g>
JM1 NVLNdItiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWCxNEDPxE1? NIT2R2Q4OiCq NGS4ZlNFVVOR M2jM[GlEPTB;MUCg{txO M3zidFI{QDR2MEO4
Kato III NG\Qd3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjJXGJZOTBizszN Mnf2O|IhcA>? NWj1OWhZTE2VTx?= NGXxc5NKSzVyPUGwJO69VQ>? NFXpfo4zOzh2NECzPC=>
KHOS-240S MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;J[JkyOCEQvF2= MlvkO|IhcA>? MVPEUXNQ MULJR|UxRTFyIN88US=> NEjSUXczOzh2NECzPC=>
KM-12 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXGxNEDPxE1? NH31UmI4OiCq M2n3WGROW09? MX;JR|UxRTFyIN88US=> NX;vNXRwOjN6NESwN|g>
KPL-1 MnjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mzbVExKM7:TR?= MoX2O|IhcA>? MWHEUXNQ M3\V[GlEPTB;MUCg{txO M2W1[lI{QDR2MEO4
KYSE-30 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj3WY8yOCEQvF2= M4KzS|czKGh? NIrnOGZFVVOR NIfRXodKSzVyPUGwJO69VQ>? MU[yN|g1PDB|OB?=
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MCF-7 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPNOlIyOCEQvF2= NIPzOWk4OiCq MWLEUXNQ M3v2b2lEPTB;MUCg{txO MkWwNlM5PDRyM{i=
MC-IXC NEDNZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojjNVAh|ryP MWe3NkBp MVzEUXNQ NYCzcYN3UUN3ME2xNEDPxE1? MoPINlM5PDRyM{i=
MDA-MB-175 VII MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlewNVAh|ryP NVW1bpZ7PzJiaB?= MUPEUXNQ MoL0TWM2OD1zMDFOwG0> MlXnNlM5PDRyM{i=
MDA-MB-468 Mk\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPGfGkyOCEQvF2= M3;ufVczKGh? MUTEUXNQ MYLJR|UxRTFyIN88US=> NIP3NIgzOzh2NECzPC=>
MiaPaCa MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYqxNEDPxE1? MV:3NkBp NETUXVVFVVOR M{\XXGlEPTB;MUCg{txO M4nIdVI{QDR2MEO4
Molt-4 Ml3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7iNVAh|ryP NF31eHM4OiCq NIT0XW1FVVOR NWPhN5IzUUN3ME2xNEDPxE1? Mk[yNlM5PDRyM{i=
NCI-ADR/RES MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G3V|ExKM7:TR?= M4DYOlczKGh? NIK3eZZFVVOR MlvtTWM2OD1zMDFOwG0> Mnv1NlM5PDRyM{i=
NCI-H69 NXfOT5piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHiWG0yOCEQvF2= NXrqRoF7PzJiaB?= NFrQ[opFVVOR M2Dq[WlEPTB;MUCg{txO Mm\YNlM5PDRyM{i=
NCI-H82 NULQeYlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWOxNEDPxE1? NFfRVHc4OiCq NFW3TJVFVVOR NICxPXJKSzVyPUGwJO69VQ>? NV3odmpZOjN6NESwN|g>
NCI-N87 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly2NVAh|ryP NUXXTlNmPzJiaB?= MV3EUXNQ NVjWR5ZbUUN3ME2xNEDPxE1? MmSwNlM5PDRyM{i=
NCI-H146 NHzjdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfqd5UyOCEQvF2= MWK3NkBp Mk\0SG1UVw>? M1\vVGlEPTB;MUCg{txO M{jIZ|I{QDR2MEO4
NCI-H157 MmjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn5NVAh|ryP MVu3NkBp MoHiSG1UVw>? Mn61TWM2OD1zMDFOwG0> MljXNlM5PDRyM{i=
NCI-H187 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPreVkyOCEQvF2= NYH2coNCPzJiaB?= M130WWROW09? NILuPHBKSzVyPUGwJO69VQ>? M{SySlI{QDR2MEO4
NCI-H209 M{K3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYmxNEDPxE1? NY\2[YNuPzJiaB?= NHjWPYRFVVOR NY\H[IZDUUN3ME2xNEDPxE1? NXrN[IJuOjN6NESwN|g>
NCI-H226 NI\FdHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljJNVAh|ryP MWS3NkBp MYHEUXNQ NF7DW4NKSzVyPUGwJO69VQ>? NX7Ib29EOjN6NESwN|g>
NCI-H292 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv2NVAh|ryP NXKyToxsPzJiaB?= NYXjbGdRTE2VTx?= Mk\1TWM2OD1zMDFOwG0> MnLDNlM5PDRyM{i=
NCI-H322 NV;ROlhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M163UVExKM7:TR?= MYm3NkBp NFXIRldFVVOR NIDKXY1KSzVyPUGwJO69VQ>? NH;SUpIzOzh2NECzPC=>
NCI-H358 MkfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;4VIVOOTBizszN M36yW|czKGh? NXjSVXJLTE2VTx?= M{fJNGlEPTB;MUCg{txO M4PDNFI{QDR2MEO4
NCI-H520 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mof4NVAh|ryP NYjTZ3p7PzJiaB?= NUS3OnB1TE2VTx?= MWPJR|UxRTFyIN88US=> NGTSV|UzOzh2NECzPC=>
NCI-H526 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWxNEDPxE1? NEXLRm04OiCq MlHZSG1UVw>? NIfkeGJKSzVyPUGwJO69VQ>? M1PkXVI{QDR2MEO4
NCI-H630 NEjRU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H4[lExKM7:TR?= NHfZTVY4OiCq NY\xdGtCTE2VTx?= M4nlUGlEPTB;MUCg{txO MWeyN|g1PDB|OB?=
NCI-H661 NE\5TGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVixNEDPxE1? MU[3NkBp MWrEUXNQ Ml;zTWM2OD1zMDFOwG0> MWGyN|g1PDB|OB?=
NCI-H716 Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPHZ41nOTBizszN MnzmO|IhcA>? NYjURmNKTE2VTx?= M1fRd2lEPTB;MUCg{txO M{XlXlI{QDR2MEO4
NCI-H1563 NHzrRmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rEZVExKM7:TR?= NGPsZXI4OiCq MXjEUXNQ Ml7aTWM2OD1zMDFOwG0> NX7v[HJNOjN6NESwN|g>
NCI-H1792 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TaZlExKM7:TR?= NIfEWIM4OiCq MkfSSG1UVw>? M2mxdmlEPTB;MUCg{txO NWnlRnFWOjN6NESwN|g>
NCI-H2030 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUWxNEDPxE1? NVvIOoE2PzJiaB?= MkXOSG1UVw>? M3y1TWlEPTB;MUCg{txO M4ToblI{QDR2MEO4
NCI-H2052 Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HK[FExKM7:TR?= Mnq0O|IhcA>? MX;EUXNQ Ml;KTWM2OD1zMDFOwG0> MWmyN|g1PDB|OB?=
NCI-H2122 NGrmd|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfxVVV3OTBizszN M1\vWVczKGh? MVfEUXNQ NFzpcotKSzVyPUGwJO69VQ>? MVuyN|g1PDB|OB?=
NCI-H2228 Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nDU|ExKM7:TR?= MWW3NkBp NWLEenkyTE2VTx?= M1jRcWlEPTB;MUCg{txO NFm4N3QzOzh2NECzPC=>
OE-19 NGXFNXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[xNEDPxE1? NULm[JVNPzJiaB?= MVnEUXNQ MWXJR|UxRTFyIN88US=> NWDsOpRKOjN6NESwN|g>
OE-21 MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojXNVAh|ryP MU[3NkBp M3jaXGROW09? MWjJR|UxRTFyIN88US=> MnnFNlM5PDRyM{i=
OE-33 M2ntVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHGycZUyOCEQvF2= NHPRNYo4OiCq NXXpZ4ZPTE2VTx?= MVvJR|UxRTFyIN88US=> NHLjVHQzOzh2NECzPC=>
OVCAR-3 NGfmVoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH4NVAh|ryP MkjNO|IhcA>? NVrRUXM2TE2VTx?= Mk\ITWM2OD1zMDFOwG0> NFTs[lczOzh2NECzPC=>
OVCAR-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXVNVAh|ryP NWjIXVJ7PzJiaB?= NVPUT2pHTE2VTx?= MV3JR|UxRTFyIN88US=> Mnu2NlM5PDRyM{i=
OVCAR-5 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnlVIcyOCEQvF2= NVHTUJl2PzJiaB?= MUDEUXNQ M4HRXWlEPTB;MUCg{txO MnjZNlM5PDRyM{i=
P3HR-1 NHH4VGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWOxNEDPxE1? NF2wS444OiCq MVfEUXNQ MU\JR|UxRTFyIN88US=> NH3zZpIzOzh2NECzPC=>
PC-3 NHO1O5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TVOFExKM7:TR?= M1j6WFczKGh? M4[5OmROW09? MmP4TWM2OD1zMDFOwG0> M3zlZ|I{QDR2MEO4
Raji NVvRWXpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPkW4V3OTBizszN NFLwPIo4OiCq NWHJ[FN5TE2VTx?= MV3JR|UxRTFyIN88US=> M1vWWFI{QDR2MEO4
RD MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\WNVAh|ryP NVn6[ItHPzJiaB?= NV3VWVdKTE2VTx?= MX;JR|UxRTFyIN88US=> MlG0NlM5PDRyM{i=
RD-ES MmHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv2NVAh|ryP NIftbnM4OiCq NHfUTIhFVVOR MULJR|UxRTFyIN88US=> NE[zR2gzOzh2NECzPC=>
RL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIG5cHcyOCEQvF2= NXLLVoVEPzJiaB?= MoCwSG1UVw>? MX\JR|UxRTFyIN88US=> NFzOWmozOzh2NECzPC=>
SaOS2 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nJbFExKM7:TR?= NV\k[ZA5PzJiaB?= MXrEUXNQ M2[y[WlEPTB;MUCg{txO M3exVFI{QDR2MEO4
SCC-9 MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSzNVAh|ryP NH;k[5E4OiCq MmLDSG1UVw>? NEDQfVFKSzVyPUGwJO69VQ>? MYWyN|g1PDB|OB?=
SCC-12 NIDxT|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7EbYF6OTBizszN NUTPTY1wPzJiaB?= M3n6dWROW09? NHOx[nVKSzVyPUGwJO69VQ>? MXuyN|g1PDB|OB?=
SCC-13 M{HiN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL4V3gyOCEQvF2= MWG3NkBp NGrHcmdFVVOR NHTQ[XlKSzVyPUGwJO69VQ>? MXKyN|g1PDB|OB?=
SCC-15 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUOxNEDPxE1? NEjR[Gc4OiCq Mlu0SG1UVw>? MoDaTWM2OD1zMDFOwG0> NGrQOZQzOzh2NECzPC=>
SCC-25 M{nreWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm3XVV[OTBizszN M2iyR|czKGh? MnTWSG1UVw>? NIrKT25KSzVyPUGwJO69VQ>? M1zLZlI{QDR2MEO4
SCLC-3 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXUNVAh|ryP NFnWVFk4OiCq MkjlSG1UVw>? M4nrVWlEPTB;MUCg{txO M3\lZ|I{QDR2MEO4
SF-268 NFTKRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX6xNEDPxE1? M3TV[lczKGh? M3Hl[GROW09? MUjJR|UxRTFyIN88US=> NULYT4wyOjN6NESwN|g>
SF-295 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjzNVAh|ryP NH:wfIs4OiCq MYrEUXNQ MmWxTWM2OD1zMDFOwG0> NGXYdoMzOzh2NECzPC=>
SJRH30 NUna[nNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XYblExKM7:TR?= NFTTPWU4OiCq MmDVSG1UVw>? NFrIRoNKSzVyPUGwJO69VQ>? NGDoXoczOzh2NECzPC=>
SK-BR-3 M1ja[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLVNVAh|ryP MnXMO|IhcA>? NIjHSINFVVOR M1PkcWlEPTB;MUCg{txO MnHmNlM5PDRyM{i=
SK-LMS-1 M1;5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnLPYEyOCEQvF2= NFP1bJo4OiCq NFTmNZlFVVOR NG\pVJNKSzVyPUGwJO69VQ>? NYm0OHl[OjN6NESwN|g>
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SK-N-F1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmxNEDPxE1? MUK3NkBp MV\EUXNQ MmX4TWM2OD1zMDFOwG0> M2LvcFI{QDR2MEO4
SKOV-3 M4HGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX6xNEDPxE1? MVm3NkBp M1\6d2ROW09? M4rvbGlEPTB;MUCg{txO MWCyN|g1PDB|OB?=
SK-UT-1 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTBNVAyOCEQvF2= Mkf0O|IhcA>? MnnKSG1UVw>? MX;JR|UxRTFyIN88US=> NG[xU3gzOzh2NECzPC=>
SN12C NX\oZY1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj4TY0yOCEQvF2= NFn3Z|I4OiCq M4jtNGROW09? MmSwTWM2OD1zMDFOwG0> NH7nZVczOzh2NECzPC=>
SNB-19 NEi4ZVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm5OGY6OTBizszN NWf6[GNJPzJiaB?= M4TwcWROW09? MlGwTWM2OD1zMDFOwG0> MmfYNlM5PDRyM{i=
SNU-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEns[ogyOCEQvF2= NGHqd3E4OiCq NF:0[HZFVVOR NVfGc3g2UUN3ME2xNEDPxE1? MoT1NlM5PDRyM{i=
SNU-16 NXvwOo1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHXRoYyOCEQvF2= NVjiXllxPzJiaB?= NGrRZ2ZFVVOR NGnIPXRKSzVyPUGwJO69VQ>? NUjkN4IxOjN6NESwN|g>
SNU-398 NVTyfGJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\SPJkyOCEQvF2= M163dVczKGh? Mn\sSG1UVw>? NVqyXYFtUUN3ME2xNEDPxE1? M4DQU|I{QDR2MEO4
SNU-449 MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUmxNEDPxE1? NX3uc49iPzJiaB?= NHzCTodFVVOR MoHpTWM2OD1zMDFOwG0> NFX0TGIzOzh2NECzPC=>
SR MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYmxNEDPxE1? M1rUVFczKGh? NUm3TW44TE2VTx?= M1HEcGlEPTB;MUCg{txO NIToNoIzOzh2NECzPC=>
ST486 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\1XZdmOTBizszN MW[3NkBp MoTDSG1UVw>? MYHJR|UxRTFyIN88US=> M1PQWVI{QDR2MEO4
SW579 M4jObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX:xNEDPxE1? NYLwV|dRPzJiaB?= NWrxfYJ7TE2VTx?= NYfVfVR4UUN3ME2xNEDPxE1? NGO5cHozOzh2NECzPC=>
SW684 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfrbI57OTBizszN M2PBdVczKGh? Mo\KSG1UVw>? MX\JR|UxRTFyIN88US=> NXXuWlQ5OjN6NESwN|g>
SW-780 M3nyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L0blExKM7:TR?= NE\ST4o4OiCq MknXSG1UVw>? NF;X[Y1KSzVyPUGwJO69VQ>? NELTXogzOzh2NECzPC=>
SW900 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fBc|ExKM7:TR?= NYnJNIFqPzJiaB?= M4LubmROW09? NH\CUlVKSzVyPUGwJO69VQ>? M2DwWlI{QDR2MEO4
SW1088 NHezd4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XFRlExKM7:TR?= M{LVNlczKGh? MnTuSG1UVw>? Mnz1TWM2OD1zMDFOwG0> Ml[3NlM5PDRyM{i=
SW1463 NIPVVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuxNEDPxE1? MnK2O|IhcA>? NVX0ZpZRTE2VTx?= NYfQbWlEUUN3ME2xNEDPxE1? MXOyN|g1PDB|OB?=
SW1990 NHrwe4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HLblExKM7:TR?= NH[1W5A4OiCq Ml\RSG1UVw>? NY\HOW51UUN3ME2xNEDPxE1? MVqyN|g1PDB|OB?=
T47D MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2wS3BQOTBizszN MX23NkBp MVjEUXNQ NE\vO|ZKSzVyPUGwJO69VQ>? NHHOcJozOzh2NECzPC=>
TE381.T MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;6NVExKM7:TR?= M4PQW|czKGh? NF;zeIRFVVOR NFSzeGJKSzVyPUGwJO69VQ>? MoHTNlM5PDRyM{i=
TK-10 MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTw[GFkOTBizszN M3zzcVczKGh? MmrZSG1UVw>? NG\mTHNKSzVyPUGwJO69VQ>? M2jZXFI{QDR2MEO4
U2OS Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3NfpMyOTBizszN NHL0NHk4OiCq NVfIO2pqTE2VTx?= NH;KPYxKSzVyPUGwJO69VQ>? MW[yN|g1PDB|OB?=
U251 NUXXSmF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjGXmhiOTBizszN MoH3O|IhcA>? M3vQVWROW09? MmLvTWM2OD1zMDFOwG0> NU[1cJZ{OjN6NESwN|g>
UACC-812 NWnleWpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPtc5pNOTBizszN Mn3mO|IhcA>? MnTPSG1UVw>? NWDuOGxCUUN3ME2xNEDPxE1? MX2yN|g1PDB|OB?=
YAPC MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm0bJc4OTBizszN MknNO|IhcA>? M4PGU2ROW09? NH34VmlKSzVyPUGwJO69VQ>? NYHxSoVWOjN6NESwN|g>
ZR-75-1 NH\kT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LPcFExKM7:TR?= NUXUNllsPzJiaB?= NV\PcndzTE2VTx?= M2fWfmlEPTB;MUCg{txO MUOyN|g1PDB|OB?=
A375 MkHISpVv[3Srb36gZZN{[Xl? NV\uRZJ5OS5{IN88US=> MorhOEBp M2fnWmROW09? NHix[ZFKdmirYnn0bY9vKG:oIIDoc5NxcG:{eXzheIlwdiCxZjDNSWstKEWUSzygZY5lKFN4UB?= NGHKXVgzOjN6OUS3NS=>
YUSIT1 NFWweIlHfW6ldHnvckBie3OjeR?= MYnEUXNQ MWjy[YR2[2WmIIPlcpNqfGm4aYT5JJdqfGhiSVO1NEA,KDBwNTFOwG0> MlL4NlI{QDl2N{G=
MeWo MkT1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWLEUXNQ MV;JR|UxKD1iOUi3JI5O MWWyOlAyQDV{NB?=
WiDr NELOVWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGXoVoNFVVOR MnzFTWM2OCB;IEe2JI5O NEPEOVEzPjBzOEWyOC=>
Colo-205 NG\xb2VHfW6ldHnvckBie3OjeR?= M{jJeVEh|ryP MoixOEBl NETR[o5FVVOR NEfUfWdKdmS3Y3XkJIEhcGmpaHz5JINwdXCjcnHicIUh[2:vcHHjeIlwdiCyaHXuc5R6eGV? NUXJbFQ5OjV|OEGxOVI>
RBW-1 M1;lZmZ2dmO2aX;uJIF{e2G7 NVizTGVEOSEQvF2= M4X5OmROW09? NE[xWJdPdyC{ZXT1Z5Rqd25ib3[gUYVsKDFxMjDwbI9{eGixconsZZRqd25? MYmyOFg5PTZ7MB?=
RBO-1 MUTGeY5kfGmxbjDhd5NigQ>? NULFPZVrOSEQvF2= NILER4pFVVOR NW[0NnpuUW6qaXLpeIlwdiCxZjDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? NW\Je4Z5OjR6OEW2PVA>
RBO-2 Ml:wSpVv[3Srb36gZZN{[Xl? NGPFRXEyKM7:TR?= Mn7PSG1UVw>? M12yeGlvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NIrkOmUzPDh6NU[5NC=>
RBOW M4H6NWZ2dmO2aX;uJIF{e2G7 MXqxJO69VQ>? MljMSG1UVw>? M37wSGlvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v MXKyOFg5PTZ7MB?=
M257 NHXON2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XNT|ExOCCwTR?= MoXuO|IhcA>? M2TSbWRw\XNibn;0JIlvcGmkaYSgdJJwdGmoZYLheIlwdiCxZjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= NH7SVWozOzNzN{S0Oi=>
LCP NHe0XnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLKS|FxOTByIH7N M4XXflczKGh? M1S2PGlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCOQ2CgZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMGKgcZV1[W62YYTpc44> MlvyNlM{OTd2NE[=
WM266 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jicFExOCCwTR?= MVK3NkBp M4HWeGlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCZTUK2OkBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCxSEBufXSjboTheIlwdg>? Ml7nNlM{OTd2NE[=
M257 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnQNVAxKG6P M4PybVczKGh? MlXISI9meyCwb4SgbY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIF2yOVch[2WubDDoZZJjd3W{aX7nJJdqdGRidInw[UBDWkGI NUHKNGpGOjN|MUe0OFY>
LCP NFrw[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i1Z|ExOCCwTR?= NF35Sog4OiCq NGOyTIJKdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gUGNRKGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFBTKG23dHHueIF1cW:w MXOyN|MyPzR2Nh?=
WM266 NWfWXmRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDpNVAxKG6P NGrCSm44OiCq M2\vfGlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDXUVI3PiClZXzsJIhiemKxdYLpcochSlKDRjDWOlAxTCCvdYThcpRifGmxbh?= NF7xe5IzOzNzN{S0Oi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --
NCT03340506 Recruiting Drug: dabrafenib|Drug: trametinib Melanoma|Non Small Cell Lung Cancer|Solid Tumor|Rare Cancers|High Grade Glioma Novartis Pharmaceuticals|Novartis December 28 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID