Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Cited by 104 Publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MkDLT4lv[XOnIFHzd4F6 MnrTTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFjpd{B1[WepZXSgRk1T[WZiVk[wNGUhdXW2YX70JIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMh[29vZYjwdoV{e2mwZzDDSGM{PyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBjcW:2aX75cIF1\WRvTVXLJJBzd3SnaX6gdIhwe3Cqb4L5cIF1cW:wIHL5JGFteGijU3Py[YVvKGG|c3H5JJdqfGhiSVO1NEBw\iByLkCwNFch|ryP M{fNNVI1QTByNkez
SK-MEL-28 MoT5T4lv[XOnIFHzd4F6 MlLxNUBp MXHJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP NF3KcnUzPDlyME[3Ny=>
HepG2 NFi1d5lMcW6jc3WgRZN{[Xl? MnLvTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iRWLLJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5yMESg{txO NVfjcI01OjR7MEC2O|M>
COLO205 NHjER3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX6[pZKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:yNFUh[2WubDDwdo9tcW[ncnH0bY9vKHerdHigTWM2OCCxZjCwMlAxPyEQvF2= MnLYNlQ6ODB4N{O=
HepG2 MnvESpVv[3Srb36gRZN{[Xl? MWG0OUBucW5? M1\1VGROW09? NUP4[oc4UW6qaXLpeIlwdiCxZjDBcIs2KGmwIGTHSk1j\XSjLYP0bY12dGG2ZXSgbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iU33h[FIheGixc4Doc5J6dGG2aX;uJJRz\WG2ZXSg[o9zKDR3IH3pcpMheHKrb4KgeI8hXEeILXLleIEhe3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPjBibXnud{BjgSCxZInzd4V6KGKub4Sgd4Nidm6ncjDhcoFtgXOrczD3bZRpKEmFNUCgc4YhOy55IN88US=> NWLXTY45OjR7MEC2O|M>
HFF M4W1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPvNVAh|ryP M4W4XFczKGh? NUXsbGQ1TE2VTx?= NVXBRWdRUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIHj1cYFvKEiIRjDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIFKtVoFnKHerdHigTWM2OCCxZjCzJO69VQ>? M3nqXFI{QDR2MEO4
SK-MEL-28 NYrwdZJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTxNVAyOCEQvF2= NInzXIc4OiCq NHTQdnNFVVOR Mkn3TY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> NIPL[ZAzOzh2NECzPC=>
A375P-F11 M{ewVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDoe|ZOOTBizszN NHPYZm84OiCq MVrEUXNQ M1nQUWlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCDM{e1VE1HOTFiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB5MTFOwG0> MUmyN|g1PDB|OB?=
MALME-3M NFjDbpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzXNVAh|ryP NF\PT5A4OiCq MnTMSG1UVw>? NWrj[VIzUUN3ME2xJI5O M3TpdFI{QDR2MEO4
UACC-62 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNEDPxE1? NUTYcphNPzJiaB?= MonTSG1UVw>? MknHTWM2OD1zIH7N MXuyN|g1PDB|OB?=
C32TG NELYVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Pxd|ExKM7:TR?= MWK3NkBp M4LC[2ROW09? MYjJR|UxRTFibl2= MWCyN|g1PDB|OB?=
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A375 NIHvS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm1bYhmOTBizszN M33rO|czKGh? NUS0fIVyTE2VTx?= M4jVXmlEPTB;NDDuUS=> M3faZVI{QDR2MEO4
DU-4475 M2m2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEixWo4yOCEQvF2= MmT5O|IhcA>? M4iwcGROW09? NHL3doZKSzVyPUWgcm0> NGPJXoczOzh2NECzPC=>
UACC-257 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\vPFExKM7:TR?= NG\VVXA4OiCq M1i0d2ROW09? MkXFTWM2OD14IH7N NF\MSXIzOzh2NECzPC=>
Colo 205 M3;nVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfEOYYyOCEQvF2= M4DvdFczKGh? MWrEUXNQ NVP1ZVBiUUN3ME23JI5O NVn0bGViOjN6NESwN|g>
SK-MEL-3 NXjzV|NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr3flMyOCEQvF2= MUO3NkBp MnPLSG1UVw>? M3zOfmlEPTB;NzDuUS=> NFTZTWgzOzh2NECzPC=>
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A101D M3nkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHNT|EyOCEQvF2= NGDZcpc4OiCq NF;R[m9FVVOR M1jye2lEPTB;OTDuUS=> MWeyN|g1PDB|OB?=
ES-2 NEHlTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYexNEDPxE1? MoHuO|IhcA>? MlvKSG1UVw>? M{nDVmlEPTB;NUOgcm0> MXKyN|g1PDB|OB?=
HT-29 NVXVRpdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfrRnUyOCEQvF2= M135UlczKGh? M3v2PWROW09? MY\JR|UxRTZ4IH7N M1PK[VI{QDR2MEO4
SW1417 Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVOxNEDPxE1? MknlO|IhcA>? MYPEUXNQ NY\YfG82UUN3ME2xOVghdk1? NI\xUYkzOzh2NECzPC=>
SW872 NWrVTYpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnBNVAh|ryP MVO3NkBp NFHLeW9FVVOR NIXob5NKSzVyPUO3O{BvVQ>? NFTvbJMzOzh2NECzPC=>
RKO MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjUNVAh|ryP M4nmR|czKGh? M{XTZmROW09? MYPJR|UxRTJwNUKyJO69VQ>? MYiyN|g1PDB|OB?=
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GCT NFXl[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TYU|ExKM7:TR?= MUG3NkBp M3P6fWROW09? MYPJR|UxRTFyIN88US=> M{W3WFI{QDR2MEO4
WM-115 NYTITXZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVyxNEDPxE1? MnvyO|IhcA>? M4PwfWROW09? M4XZNGlEPTB;NTDuUS=> M3Tkd|I{QDR2MEO4
YUMAC NV3oV|dQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fLNVExKM7:TR?= M{LGSlczKGh? NHPKfXBFVVOR MkLvTWM2OD13IH7N NU[0W2VjOjN6NESwN|g>
OV-90 NILCWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jS[lExKM7:TR?= MVy3NkBp NVHkepg3TE2VTx?= MUfJR|UxRTJ7IH7N MnSxNlM5PDRyM{i=
NCI-H508 NY\RSpM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PGU|ExKM7:TR?= MW[3NkBp MlL4SG1UVw>? MmXPTWM2OD1zMDFOwG0> M2rZPFI{QDR2MEO4
MDA-MB-231 NYX2b2piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXWxNEDPxE1? MUC3NkBp NF7ne5hFVVOR NGfTZYFKSzVyPUGwJO69VQ>? NVfRRXpSOjN6NESwN|g>
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SW-837 M4C4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\qXVExKM7:TR?= MYG3NkBp MmXVSG1UVw>? M3rVfWlEPTB;MUCg{txO Mk\FNlM5PDRyM{i=
UMUC-3 M1X5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfsTHlDOTBizszN NXPG[W9wPzJiaB?= NWnrfoxZTE2VTx?= MWLJR|UxRTFyIN88US=> MY[yN|g1PDB|OB?=
LS-174T NF3IcXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf0UmIyOCEQvF2= MUO3NkBp NHv5RWNFVVOR M{HRPGlEPTB;MUCg{txO Ml\QNlM5PDRyM{i=
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SHP-77 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLINVAh|ryP MkfCO|IhcA>? MWTEUXNQ NVnzNm1nUUN3ME2xNEDPxE1? NHjZOngzOzh2NECzPC=>
SW480 NFiwWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jYelExKM7:TR?= NH;lTGw4OiCq NUPORXppTE2VTx?= M1\MS2lEPTB;MUCg{txO NXXNSlBSOjN6NESwN|g>
DLD-1 M{LRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV[xNEDPxE1? MmPiO|IhcA>? NWXTSI1zTE2VTx?= NXnEc3RiUUN3ME2xNEDPxE1? MYmyN|g1PDB|OB?=
HCT-116 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfpPI9zOTBizszN M2foT|czKGh? NIjXVYpFVVOR NEfUd|dKSzVyPUGwJO69VQ>? Mom1NlM5PDRyM{i=
NCI-H747 NGLqWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUmzdJR2OTBizszN NXvRdXRoPzJiaB?= NXnqTJBwTE2VTx?= MnTaTWM2OD1zMDFOwG0> MoW3NlM5PDRyM{i=
T-84 M4rtT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTjNVAh|ryP NWPVXXBVPzJiaB?= MVXEUXNQ MYjJR|UxRTFyIN88US=> NXTmWnBoOjN6NESwN|g>
NCI-H460 M4T6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mySFExKM7:TR?= MnjoO|IhcA>? NGniTmRFVVOR NXXNNI5HUUN3ME2xNEDPxE1? MmW5NlM5PDRyM{i=
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CHP-212 M4PxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PKeFExKM7:TR?= NYHkfG5mPzJiaB?= M2nlUmROW09? MV\JR|UxRTFyIN88US=> NVvwenp2OjN6NESwN|g>
SK-N-AS M{CyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXuxNEDPxE1? MoTFO|IhcA>? NEK2[lZFVVOR MlPPTWM2OD1zMDFOwG0> MoTwNlM5PDRyM{i=
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A172 NVf3NlVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGxNEDPxE1? M4jxT|czKGh? M3nKV2ROW09? NHSxWW5KSzVyPUGwJO69VQ>? Ml3PNlM5PDRyM{i=
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A427 M4PvVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPxeVQyOCEQvF2= NHXEflk4OiCq NXq0OHl1TE2VTx?= NEXIPW5KSzVyPUGwJO69VQ>? MkS1NlM5PDRyM{i=
A431 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmxNEDPxE1? NHX3UYc4OiCq M1rL[WROW09? MVfJR|UxRTFyIN88US=> NGXtV44zOzh2NECzPC=>
A2780 NFuwUJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H6SVExKM7:TR?= NGS0UXk4OiCq M4\LTWROW09? MWjJR|UxRTFyIN88US=> NUfUN24{OjN6NESwN|g>
ARH-77 NX[2NJlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[ybHM1OTBizszN M1\TUlczKGh? MXzEUXNQ M3TOU2lEPTB;MUCg{txO NXfQNYx7OjN6NESwN|g>
Be(2)C NVv1RndUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLQflZjOTBizszN M2jnfVczKGh? Mn74SG1UVw>? NYHCd4pTUUN3ME2xNEDPxE1? MkXzNlM5PDRyM{i=
BT-20 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrHSngyOCEQvF2= M3;iNFczKGh? MY\EUXNQ MXfJR|UxRTFyIN88US=> NEGwZnkzOzh2NECzPC=>
BxPc3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLDNVAh|ryP NG[1WHU4OiCq MlTVSG1UVw>? M2GxNmlEPTB;MUCg{txO NYrCbWREOjN6NESwN|g>
C-4 I MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYSxNEDPxE1? NWPsU2lsPzJiaB?= NGfvWFhFVVOR NGLIfYdKSzVyPUGwJO69VQ>? NH3OZlIzOzh2NECzPC=>
C33A MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;NboIyOCEQvF2= MXu3NkBp NXHEfmg1TE2VTx?= NILJTYFKSzVyPUGwJO69VQ>? M1TkRlI{QDR2MEO4
CAL-27 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrhNVAh|ryP M3PSOFczKGh? MUfEUXNQ NELQe2pKSzVyPUGwJO69VQ>? MUGyN|g1PDB|OB?=
CAL-62 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYGxNEDPxE1? MXi3NkBp NH;qZm9FVVOR MnzUTWM2OD1zMDFOwG0> NGnUeJEzOzh2NECzPC=>
Calu-3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;aNVAh|ryP MX[3NkBp MWXEUXNQ M3HpfmlEPTB;MUCg{txO Ml\oNlM5PDRyM{i=
CaOV3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjqNVAh|ryP NHjOfHE4OiCq NW\WeHZuTE2VTx?= NYTsfmlFUUN3ME2xNEDPxE1? NGiyOmczOzh2NECzPC=>
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CHL-1 NUOwZYdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGflNIcyOCEQvF2= NF;0eWc4OiCq NG\kfpFFVVOR NVvtR4xDUUN3ME2xNEDPxE1? MlnFNlM5PDRyM{i=
Colo320DM M{HaOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV6xNEDPxE1? NUniN5hpPzJiaB?= NGHaUXZFVVOR NVroO3VUUUN3ME2xNEDPxE1? NEXhNXkzOzh2NECzPC=>
Colo704 Mn\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxNEDPxE1? MmfPO|IhcA>? NWW2SYxQTE2VTx?= Mnq5TWM2OD1zMDFOwG0> MmK4NlM5PDRyM{i=
COR-L23 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7EeI1lOTBizszN MluxO|IhcA>? NYXUeoF4TE2VTx?= MVvJR|UxRTFyIN88US=> MnzNNlM5PDRyM{i=
CRO-AP2 NHva[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf6[YJxOTBizszN MWe3NkBp MkjGSG1UVw>? MYPJR|UxRTFyIN88US=> NIOzfGgzOzh2NECzPC=>
Daudi M{DzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHOXWJrOTBizszN NEK2[YE4OiCq NYm4b4l7TE2VTx?= MVnJR|UxRTFyIN88US=> NF3NTI0zOzh2NECzPC=>
DOTC 24510 NUD3XXVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTxS5pVOTBizszN NHzQd|k4OiCq NIHlPHlFVVOR M{X3SmlEPTB;MUCg{txO MkK3NlM5PDRyM{i=
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EB-3 M4nzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUKxNEDPxE1? MnvwO|IhcA>? NX3mUVFTTE2VTx?= NWXVO3V{UUN3ME2xNEDPxE1? NGHVWlIzOzh2NECzPC=>
EFM-19 NWr1fFR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPKZWkyOCEQvF2= MkDiO|IhcA>? MYjEUXNQ MoXQTWM2OD1zMDFOwG0> NFfsNYQzOzh2NECzPC=>
EKVX M1XTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3ZcWo2OTBizszN NGW0dIY4OiCq NFX6UWhFVVOR MWLJR|UxRTFyIN88US=> M3XJ[VI{QDR2MEO4
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G401 NXvRUXdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom2NVAh|ryP MWm3NkBp MXHEUXNQ NFP2[IdKSzVyPUGwJO69VQ>? MUiyN|g1PDB|OB?=
HCC-70 M3XEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP3NVAh|ryP NUPabFVyPzJiaB?= MXjEUXNQ MW\JR|UxRTFyIN88US=> M123O|I{QDR2MEO4
HCC-1954 NUTrZY1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3O4PVExKM7:TR?= NH\vTpc4OiCq MnrwSG1UVw>? Mn;zTWM2OD1zMDFOwG0> NGDNS3YzOzh2NECzPC=>
Hela NFO5SYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnx[VIyOCEQvF2= NHHxS4k4OiCq MV;EUXNQ NE\SNYZKSzVyPUGwJO69VQ>? MX2yN|g1PDB|OB?=
Hep3B M2r0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrBUlgyOCEQvF2= NXfYT3JzPzJiaB?= NGi1dmNFVVOR NIDrVoZKSzVyPUGwJO69VQ>? NW\RZW1VOjN6NESwN|g>
HMCB NXfJW4g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUSxNEDPxE1? MnvBO|IhcA>? NETacGRFVVOR MnL2TWM2OD1zMDFOwG0> M4[zUlI{QDR2MEO4
HN5 NX3aWmM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYKxNEDPxE1? NIX5XHQ4OiCq MnzISG1UVw>? M4j2O2lEPTB;MUCg{txO M4nST|I{QDR2MEO4
HOS MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXTVW1VOTBizszN M4DvSFczKGh? Mom1SG1UVw>? M1\FWmlEPTB;MUCg{txO NVy1[4M2OjN6NESwN|g>
HPAF-II NYiyS5hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m3UlExKM7:TR?= MVm3NkBp MmHJSG1UVw>? M4nkeGlEPTB;MUCg{txO NInRT48zOzh2NECzPC=>
Hs746.T MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvQN|MyOCEQvF2= NHjYOpg4OiCq NHrBOVlFVVOR NUPJRmJHUUN3ME2xNEDPxE1? NFTqT48zOzh2NECzPC=>
HT NXXkV3pjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3xTIVCOTBizszN M1\XclczKGh? M1X2d2ROW09? NYPSPFl6UUN3ME2xNEDPxE1? M1TXUFI{QDR2MEO4
HT-3 MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXSRXgyOCEQvF2= M{DyWFczKGh? MmjrSG1UVw>? NVrLNXJ{UUN3ME2xNEDPxE1? MkLTNlM5PDRyM{i=
HuNS-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXyxNEDPxE1? M{ewW|czKGh? M1HTTGROW09? MYXJR|UxRTFyIN88US=> NXPuW|g6OjN6NESwN|g>
IGROV1 NF\HTHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDiS|UyOCEQvF2= M2P2Z|czKGh? NYTIVG9rTE2VTx?= MUnJR|UxRTFyIN88US=> MWGyN|g1PDB|OB?=
J82 NVvySFR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? NFvtWG84OiCq M1;FXWROW09? MUfJR|UxRTFyIN88US=> MmPsNlM5PDRyM{i=
JM1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED6dpoyOCEQvF2= NVLtbGdvPzJiaB?= M1WwN2ROW09? M17sSGlEPTB;MUCg{txO M{DOOFI{QDR2MEO4
Kato III M4XjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLQS2cyOCEQvF2= M1fIe|czKGh? NHXlbYhFVVOR MX7JR|UxRTFyIN88US=> MVOyN|g1PDB|OB?=
KHOS-240S MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3ZUIkyOCEQvF2= MoHhO|IhcA>? MoT3SG1UVw>? Mn7JTWM2OD1zMDFOwG0> MnfnNlM5PDRyM{i=
KM-12 M{jqUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH3PWcyOCEQvF2= NX;YeGM2PzJiaB?= NY\LV44zTE2VTx?= M{\IVmlEPTB;MUCg{txO NXXYSJVzOjN6NESwN|g>
KPL-1 M3fvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfUUFI6OTBizszN NIqzWHE4OiCq NHTzNpdFVVOR Mm\QTWM2OD1zMDFOwG0> MXiyN|g1PDB|OB?=
KYSE-30 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjiUFJQOTBizszN Mn74O|IhcA>? NWPZe2dnTE2VTx?= NHjtblRKSzVyPUGwJO69VQ>? NGHhU44zOzh2NECzPC=>
LNCaP MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPWNHYyOCEQvF2= MWO3NkBp MUTEUXNQ M{PJVGlEPTB;MUCg{txO NGLPPXczOzh2NECzPC=>
MCF-7 MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHLNYMyOCEQvF2= NXHBV5A{PzJiaB?= M1LIdGROW09? NXjZUXBHUUN3ME2xNEDPxE1? NY\hdGlqOjN6NESwN|g>
MC-IXC MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWOxNEDPxE1? M2rYO|czKGh? M1jrSmROW09? MWTJR|UxRTFyIN88US=> NV20PINROjN6NESwN|g>
MDA-MB-175 VII Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfIU20yOCEQvF2= NW\QeopTPzJiaB?= M1\Gc2ROW09? NY\I[HpyUUN3ME2xNEDPxE1? NWP2S2ZIOjN6NESwN|g>
MDA-MB-468 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUCxNEDPxE1? MnrEO|IhcA>? NWXFcJA2TE2VTx?= Mn\4TWM2OD1zMDFOwG0> NVPyTWFTOjN6NESwN|g>
MiaPaCa NXjYO21qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnTWWdkOTBizszN NUfoTIU6PzJiaB?= MkTPSG1UVw>? NHrOWGRKSzVyPUGwJO69VQ>? MW[yN|g1PDB|OB?=
Molt-4 NHzOUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTSSFVIOTBizszN MlzpO|IhcA>? NGPBOHVFVVOR MX\JR|UxRTFyIN88US=> M3;vflI{QDR2MEO4
NCI-ADR/RES M2LRTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVOxNEDPxE1? MmDtO|IhcA>? MUPEUXNQ NUnS[mk4UUN3ME2xNEDPxE1? NFOzNlMzOzh2NECzPC=>
NCI-H69 NETsfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV2xNEDPxE1? MormO|IhcA>? Ml7USG1UVw>? Ml\2TWM2OD1zMDFOwG0> NH34ZlgzOzh2NECzPC=>
NCI-H82 NUPaVIVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL4NVAh|ryP MXK3NkBp MUTEUXNQ NWq4PZNoUUN3ME2xNEDPxE1? M3izb|I{QDR2MEO4
NCI-N87 M{GxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PFVFExKM7:TR?= NUHCWJNIPzJiaB?= M1;1fmROW09? Ml\RTWM2OD1zMDFOwG0> NUjSdpRCOjN6NESwN|g>
NCI-H146 NVXPWmFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfCbIh[OTBizszN NU\JT21mPzJiaB?= MkO5SG1UVw>? M{TNfmlEPTB;MUCg{txO MVSyN|g1PDB|OB?=
NCI-H157 NGDpTHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrHNo8yOCEQvF2= M{P6NFczKGh? NYHob2E6TE2VTx?= NI[0S|NKSzVyPUGwJO69VQ>? M3\meFI{QDR2MEO4
NCI-H187 NYnlTXFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D5WFExKM7:TR?= NEfoR2o4OiCq NE\k[ZlFVVOR NUKwNIVVUUN3ME2xNEDPxE1? NGrVbJgzOzh2NECzPC=>
NCI-H209 NXXRO3dCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i2VFExKM7:TR?= M1PtbVczKGh? MlnMSG1UVw>? NYrEcZJ2UUN3ME2xNEDPxE1? NYG0TVZxOjN6NESwN|g>
NCI-H226 NVvXWGIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYOxNEDPxE1? MXS3NkBp M3HKPGROW09? M3zjZWlEPTB;MUCg{txO M4PhSFI{QDR2MEO4
NCI-H292 M3LEe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVviVW9WOTBizszN M3;UdFczKGh? MX;EUXNQ MmHPTWM2OD1zMDFOwG0> NUOzcolTOjN6NESwN|g>
NCI-H322 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXPNVAh|ryP MmHPO|IhcA>? MkiwSG1UVw>? M3LveWlEPTB;MUCg{txO NI\MSpozOzh2NECzPC=>
NCI-H358 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? MWq3NkBp MXjEUXNQ NFnkdVhKSzVyPUGwJO69VQ>? NEfYRXEzOzh2NECzPC=>
NCI-H520 MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHMZ5YyOCEQvF2= MmLYO|IhcA>? Mn3pSG1UVw>? M1f4UmlEPTB;MUCg{txO MX[yN|g1PDB|OB?=
NCI-H526 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELTNWIyOCEQvF2= MYm3NkBp MWTEUXNQ NXHhUpl2UUN3ME2xNEDPxE1? M2\CflI{QDR2MEO4
NCI-H630 NVv2W25jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W1OVExKM7:TR?= NVLCdnd2PzJiaB?= M{nZT2ROW09? NXy3V3d6UUN3ME2xNEDPxE1? Mn\HNlM5PDRyM{i=
NCI-H661 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnaNVAh|ryP NH\4SVU4OiCq NIrqVZFFVVOR MXnJR|UxRTFyIN88US=> M2K5OVI{QDR2MEO4
NCI-H716 NX76ZZJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:xNEDPxE1? M{jY[VczKGh? M{T4W2ROW09? MVnJR|UxRTFyIN88US=> NHjIfIQzOzh2NECzPC=>
NCI-H1563 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVexNEDPxE1? M17rTlczKGh? MYnEUXNQ NUXQdWs2UUN3ME2xNEDPxE1? MW[yN|g1PDB|OB?=
NCI-H1792 M4Lzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILweVgyOCEQvF2= MWG3NkBp NHT2ZnBFVVOR NYrMWHhXUUN3ME2xNEDPxE1? MmT1NlM5PDRyM{i=
NCI-H2030 NXHXRXJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;CNHIyOCEQvF2= NEfsc2Q4OiCq MX7EUXNQ M{PvW2lEPTB;MUCg{txO M136dlI{QDR2MEO4
NCI-H2052 M4PWeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoSzNVAh|ryP MV:3NkBp NV7JW5VPTE2VTx?= MlnITWM2OD1zMDFOwG0> NHPhSXczOzh2NECzPC=>
NCI-H2122 NGPS[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXSxNEDPxE1? NE\DR|Y4OiCq NFfF[HVFVVOR NVTvUIJvUUN3ME2xNEDPxE1? NIPnPWczOzh2NECzPC=>
NCI-H2228 NYSzVWsxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLPNVAh|ryP NGi1OVc4OiCq NEH6e2FFVVOR NU\kR4ZVUUN3ME2xNEDPxE1? NYXheW1sOjN6NESwN|g>
OE-19 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILIcZAyOCEQvF2= NYHoTGNSPzJiaB?= MoTySG1UVw>? NV7hWoN3UUN3ME2xNEDPxE1? Mlq4NlM5PDRyM{i=
OE-21 NH73do9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGxNEDPxE1? MlG3O|IhcA>? MVrEUXNQ Mnu1TWM2OD1zMDFOwG0> M2m3e|I{QDR2MEO4
OE-33 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzlNVAh|ryP NFz6UIQ4OiCq MXrEUXNQ NHnnUmdKSzVyPUGwJO69VQ>? MoLXNlM5PDRyM{i=
OVCAR-3 NVTjOo0xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;wZVExKM7:TR?= NXTP[IxlPzJiaB?= NWnUc49HTE2VTx?= M2jZcmlEPTB;MUCg{txO NI\0[pgzOzh2NECzPC=>
OVCAR-4 M33pRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV[xNEDPxE1? NFP5bHI4OiCq NXGwcHFDTE2VTx?= Ml3qTWM2OD1zMDFOwG0> Ml3YNlM5PDRyM{i=
OVCAR-5 NIixSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXexNEDPxE1? MmHLO|IhcA>? NFLaNZhFVVOR MUDJR|UxRTFyIN88US=> NEi4Rm0zOzh2NECzPC=>
P3HR-1 M2nUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fBVFExKM7:TR?= NF\qb|U4OiCq MVLEUXNQ MnLTTWM2OD1zMDFOwG0> M3u5NVI{QDR2MEO4
PC-3 NEPmWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUCxNEDPxE1? MV[3NkBp NEXZTYpFVVOR MkTyTWM2OD1zMDFOwG0> M3TpZ|I{QDR2MEO4
Raji M3n5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD1NVAh|ryP MWe3NkBp MXLEUXNQ M4Hk[mlEPTB;MUCg{txO MmD3NlM5PDRyM{i=
RD M1OzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnjNVAh|ryP NU\ncmtTPzJiaB?= NUjlPJN2TE2VTx?= M2jJdmlEPTB;MUCg{txO MoTNNlM5PDRyM{i=
RD-ES MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K1eFExKM7:TR?= M3;rU|czKGh? Mly3SG1UVw>? NFnOSJlKSzVyPUGwJO69VQ>? NYLJPJlsOjN6NESwN|g>
RL NV7IdoxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XCZ|ExKM7:TR?= MUm3NkBp MlruSG1UVw>? NWLES2hsUUN3ME2xNEDPxE1? NWqxR3VJOjN6NESwN|g>
SaOS2 M1P4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7FSZRWOTBizszN MUO3NkBp NH7ocJpFVVOR NInIRlBKSzVyPUGwJO69VQ>? NH63cFkzOzh2NECzPC=>
SCC-9 NYrvW5ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fsd|ExKM7:TR?= MWS3NkBp M2rP[mROW09? NXnhZolkUUN3ME2xNEDPxE1? NHHxSFUzOzh2NECzPC=>
SCC-12 M3zGe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXqxNEDPxE1? MmPOO|IhcA>? NGP3fIRFVVOR MnmwTWM2OD1zMDFOwG0> NEf5OXgzOzh2NECzPC=>
SCC-13 M4\VRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH6PJEyOCEQvF2= NGLYepI4OiCq MnHCSG1UVw>? MVHJR|UxRTFyIN88US=> M1nCVVI{QDR2MEO4
SCC-15 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NICxOYQyOCEQvF2= NVG1cYxpPzJiaB?= M2GydmROW09? MXLJR|UxRTFyIN88US=> MXuyN|g1PDB|OB?=
SCC-25 NEnlXllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nTcFExKM7:TR?= NIHmSHY4OiCq MXvEUXNQ MUnJR|UxRTFyIN88US=> MnfhNlM5PDRyM{i=
SCLC-3 Mly3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjHc2E2OTBizszN M{fuU|czKGh? MmW3SG1UVw>? MkHQTWM2OD1zMDFOwG0> Mn\zNlM5PDRyM{i=
SF-268 M1LTcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHSZolLOTBizszN MnrBO|IhcA>? NYTnWIlkTE2VTx?= NE[5eJFKSzVyPUGwJO69VQ>? MoK3NlM5PDRyM{i=
SF-295 NXrhdZQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfXc44yOCEQvF2= MmXPO|IhcA>? MW\EUXNQ NEXvZZVKSzVyPUGwJO69VQ>? MoP0NlM5PDRyM{i=
SJRH30 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPiPXVtOTBizszN MWi3NkBp M4DafGROW09? M1mwNGlEPTB;MUCg{txO M3TkSVI{QDR2MEO4
SK-BR-3 MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNEDPxE1? M1r2W|czKGh? M2L6TmROW09? M1rlTWlEPTB;MUCg{txO M3W1O|I{QDR2MEO4
SK-LMS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHTNYRKOTBizszN M1rHdVczKGh? MUPEUXNQ M{H3dGlEPTB;MUCg{txO MXqyN|g1PDB|OB?=
SK-N-DZ MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj2XpMyOCEQvF2= MVO3NkBp M3vRSWROW09? NWDlR2lDUUN3ME2xNEDPxE1? Ml\oNlM5PDRyM{i=
SK-N-F1 MkDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7rNVAh|ryP M3fSe|czKGh? Ml7ISG1UVw>? M{PjXGlEPTB;MUCg{txO NXTJNlZ[OjN6NESwN|g>
SKOV-3 MnjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWOxNEDPxE1? MoLoO|IhcA>? NInY[pZFVVOR M1zBV2lEPTB;MUCg{txO MV6yN|g1PDB|OB?=
SK-UT-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX5c|kyOTBizszN M3K5TFczKGh? NXq4O5FVTE2VTx?= MX\JR|UxRTFyIN88US=> MkTZNlM5PDRyM{i=
SN12C NXHOdWlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX2xNEDPxE1? M2DCNVczKGh? MmHMSG1UVw>? NU\Zb5IzUUN3ME2xNEDPxE1? NWnuVnFvOjN6NESwN|g>
SNB-19 NEfUe|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXDU3oyOCEQvF2= NUnhU3g4PzJiaB?= MVnEUXNQ NUTifll7UUN3ME2xNEDPxE1? M4TUPVI{QDR2MEO4
SNU-5 NFz6bYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUexNEDPxE1? MnPrO|IhcA>? M4KwR2ROW09? M3uwNGlEPTB;MUCg{txO M17wWFI{QDR2MEO4
SNU-16 NWTJUFZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jFcVExKM7:TR?= MVO3NkBp MVfEUXNQ MXfJR|UxRTFyIN88US=> Mne5NlM5PDRyM{i=
SNU-398 NV7LTYRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vXbVExKM7:TR?= MWW3NkBp M17oTGROW09? NE\IPJdKSzVyPUGwJO69VQ>? M4n5T|I{QDR2MEO4
SNU-449 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHNdpJyOTBizszN M{fBblczKGh? MmnWSG1UVw>? MVTJR|UxRTFyIN88US=> MnL4NlM5PDRyM{i=
SR NGDKemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H4NlExKM7:TR?= NHPnUVk4OiCq MXjEUXNQ NFjHcXNKSzVyPUGwJO69VQ>? M2HadVI{QDR2MEO4
ST486 NXjvToZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHToOJYyOCEQvF2= MofiO|IhcA>? NVXrPZJGTE2VTx?= MnPrTWM2OD1zMDFOwG0> NXPTeGNxOjN6NESwN|g>
SW579 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml34NVAh|ryP M2rzbFczKGh? NHKzSoRFVVOR NEjnPZJKSzVyPUGwJO69VQ>? MV2yN|g1PDB|OB?=
SW684 NGDiNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnm4NVAh|ryP M2\IflczKGh? NVPh[Yc6TE2VTx?= M1TpWGlEPTB;MUCg{txO Mk\LNlM5PDRyM{i=
SW-780 M1\TfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHUZlEyOTBizszN NHzkbGE4OiCq Mn;5SG1UVw>? MV7JR|UxRTFyIN88US=> NID5fZgzOzh2NECzPC=>
SW900 NVS4eFc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPYbIZbOTBizszN M3nqR|czKGh? NWj6U3Z7TE2VTx?= M{[1TGlEPTB;MUCg{txO M4X0ZVI{QDR2MEO4
SW1088 MoDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLHT|UyOCEQvF2= NXizZoY2PzJiaB?= MYXEUXNQ NH;nc3dKSzVyPUGwJO69VQ>? NHLkfWgzOzh2NECzPC=>
SW1463 NX;GXnM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXixNEDPxE1? M2L6NlczKGh? MojrSG1UVw>? NX7JeZlGUUN3ME2xNEDPxE1? NYH6b3kyOjN6NESwN|g>
SW1990 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfjNVAh|ryP NFvodnU4OiCq M37qbWROW09? MlHXTWM2OD1zMDFOwG0> MkDKNlM5PDRyM{i=
T47D M1;kfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnhNVAh|ryP M13Zb|czKGh? NHfGVolFVVOR MmHkTWM2OD1zMDFOwG0> MYmyN|g1PDB|OB?=
TE381.T NYixO4VoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESwZ5EyOCEQvF2= M2Ppe|czKGh? NXL3VVc3TE2VTx?= NFPmTm5KSzVyPUGwJO69VQ>? NHzoV|czOzh2NECzPC=>
TK-10 MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjUNVAh|ryP MVe3NkBp MlfxSG1UVw>? M2C5eGlEPTB;MUCg{txO MYeyN|g1PDB|OB?=
U2OS M3rFVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOy[VMyOCEQvF2= MXm3NkBp MoL3SG1UVw>? MV3JR|UxRTFyIN88US=> M3XVOVI{QDR2MEO4
U251 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDTVG12OTBizszN NEW0TI84OiCq MYHEUXNQ M{\Gc2lEPTB;MUCg{txO NU\HbYEyOjN6NESwN|g>
UACC-812 M3nXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzxZ2dPOTBizszN M2e4NVczKGh? NV7sblBqTE2VTx?= NWHGN2tCUUN3ME2xNEDPxE1? M2DTbFI{QDR2MEO4
YAPC NEj6WllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPINY0yOCEQvF2= M17ZPVczKGh? M1PpV2ROW09? NHzaZXJKSzVyPUGwJO69VQ>? NXPwcIJ5OjN6NESwN|g>
ZR-75-1 MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\kUlExKM7:TR?= NUXxR4RuPzJiaB?= M4rnZWROW09? NIrpTXZKSzVyPUGwJO69VQ>? NFrpco4zOzh2NECzPC=>
A375 M{XtXGZ2dmO2aX;uJIF{e2G7 NY\5dGs2OS5{IN88US=> M{\MNFQhcA>? MlfzSG1UVw>? NVfF[ml5UW6qaXLpeIlwdiCxZjDwbI9{eGixconsZZRqd25ib3[gUWVMNCCHUlusJIFv\CCVNmC= M2HKO|IzOzh7NEex
YUSIT1 M{DzUWZ2dmO2aX;uJIF{e2G7 MlztSG1UVw>? NFu4bXpz\WS3Y3XkJJNmdnOrdHn2bZR6KHerdHigTWM2OCB-IECuOUDPxE1? NHLmOGwzOjN6OUS3NS=>
MeWo NU\kOpU1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVPnS2s3TE2VTx?= MVjJR|UxKD1iOUi3JI5O NXv4V2RvOjZyMUi1NlQ>
WiDr NWK3R4oxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWHEUXNQ M{LYfmlEPTBiPTC3OkBvVQ>? MWmyOlAyQDV{NB?=
Colo-205 NV;STJlDTnWwY4Tpc44h[XO|YYm= Ml7uNUDPxE1? MXe0JIQ> NEHoVZlFVVOR M33RWWlv\HWlZXSgZUBpcWeqbImgZ49ueGG{YXLs[UBkd22yYXP0bY9vKHCqZX7veJlx\Q>? NX7hWGhyOjV|OEGxOVI>
RBW-1 MYnGeY5kfGmxbjDhd5NigQ>? MonINUDPxE1? Mme1SG1UVw>? NVnVbnhUVm9icnXkeYN1cW:wIH;mJG1mcyBzL{KgdIhwe3Cqb4L5cIF1cW:w NGL0RoszPDh6NU[5NC=>
RBO-1 M3WyNmZ2dmO2aX;uJIF{e2G7 NWLjNIVMOSEQvF2= MXXEUXNQ M3fEfWlvcGmkaYTpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> MkHNNlQ5QDV4OUC=
RBO-2 NULlfYF2TnWwY4Tpc44h[XO|YYm= MUWxJO69VQ>? NV;zfWdYTE2VTx?= MWDJcohq[mm2aX;uJI9nKCCPZXugNU8zKHCqb4PwbI9zgWyjdHnvci=> MlvZNlQ5QDV4OUC=
RBOW NFXyT4dHfW6ldHnvckBie3OjeR?= NFXLbFgyKM7:TR?= MXfEUXNQ M4PiSmlvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v MUiyOFg5PTZ7MB?=
M257 NGHOZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPLNVAxKG6P MYW3NkBp NHfKbZhFd2W|IH7veEBqdmirYnn0JJBzd2yrZnXyZZRqd25ib3[gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= NHPENmkzOzNzN{S0Oi=>
LCP NGC4OFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jwflExOCCwTR?= MWG3NkBp NH[wN2NKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v M1;kWlI{OzF5NES2
WM266 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYqxNFAhdk1? NVfPUnlZPzJiaB?= MmTsTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKFePMk[2JINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEHEJI12fGGwdHH0bY9v NITuT3YzOzNzN{S0Oi=>
M257 Ml3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNFAhdk1? M3TiUVczKGh? NIi4NlJFd2W|IH7veEBqdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= NGXjWnYzOzNzN{S0Oi=>
LCP NWjKW4ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M323e|ExOCCwTR?= M{PxdVczKGh? M1PETmlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDMR3Ah[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNHIhdXW2YX70ZZRqd25? NIfOSY0zOzNzN{S0Oi=>
WM266 M1fsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4qzfFExOCCwTR?= Ml\XO|IhcA>? NIW1PWlKdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gW20zPjZiY3XscEBp[XKkb4XybY5oKEKUQV[gWlYxOERibYX0ZY51[XSrb36= M3XzSFI{OzF5NES2

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --
NCT03340506 Recruiting Drug: dabrafenib|Drug: trametinib Melanoma|Non Small Cell Lung Cancer|Solid Tumor|Rare Cancers|High Grade Glioma Novartis Pharmaceuticals|Novartis December 28 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID