Dabrafenib (GSK2118436)

For research use only.

Catalog No.S2807

157 publications

Dabrafenib (GSK2118436) Chemical Structure

CAS No. 1195765-45-7

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Selleck's Dabrafenib (GSK2118436) has been cited by 157 publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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SK-MEL-28 NV3IZXFnU2mwYYPlJGF{e2G7 MV6xJIg> NFjpcG9KdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN NITqSIEzPDlyME[3Ny=>
HepG2 MlznT4lv[XOnIFHzd4F6 M2n2PWlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? M2PIRVI1QTByNkez
COLO205 M2rxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjvTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRMkC1JINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFch|ryP M{DybFI1QTByNkez
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HFF MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU[xNEDPxE1? M{GycFczKGh? Moe5SG1UVw>? NV;FVXBDUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIHj1cYFvKEiIRjDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIFKtVoFnKHerdHigTWM2OCCxZjCzJO69VQ>? M1;mO|I{QDR2MEO4
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UACC-62 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXOxNEDPxE1? NUDp[G02PzJiaB?= MVPEUXNQ NUDlb2tbUUN3ME2xJI5O M{DvfVI{QDR2MEO4
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MDA-MB-231 NH76OGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXexNEDPxE1? NFq1OYI4OiCq MmrnSG1UVw>? Mke5TWM2OD1zMDFOwG0> M2[0elI{QDR2MEO4
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A427 NIfYbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq4S5QyOCEQvF2= NVf2VIY1PzJiaB?= NYXoVGoyTE2VTx?= MXjJR|UxRTFyIN88US=> MWKyN|g1PDB|OB?=
A431 M1vhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\OclExKM7:TR?= MlHvO|IhcA>? MVfEUXNQ M3fHU2lEPTB;MUCg{txO Mn\WNlM5PDRyM{i=
A2780 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUexNEDPxE1? NF7Q[Jo4OiCq NETORphFVVOR NGrSRlFKSzVyPUGwJO69VQ>? M17ScVI{QDR2MEO4
ARH-77 Mkf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\5VVBnOTBizszN MXe3NkBp MonsSG1UVw>? NULTeI11UUN3ME2xNEDPxE1? MVKyN|g1PDB|OB?=
Be(2)C Ml;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vYdFExKM7:TR?= M3\zelczKGh? NVHV[plLTE2VTx?= NYH0bGc5UUN3ME2xNEDPxE1? NYrxe4ExOjN6NESwN|g>
BT-20 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjtOoEyOCEQvF2= NWG3[JVuPzJiaB?= MoPrSG1UVw>? M4rnfmlEPTB;MUCg{txO MXmyN|g1PDB|OB?=
BxPc3 M2mxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX:xNEDPxE1? MW[3NkBp NU\MN3pETE2VTx?= MYTJR|UxRTFyIN88US=> MkDLNlM5PDRyM{i=
C-4 I NH\KZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjyO4lzOTBizszN M3f5O|czKGh? M2\JVmROW09? MkXDTWM2OD1zMDFOwG0> NWjWRmVpOjN6NESwN|g>
C33A Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUSxNEDPxE1? MYK3NkBp MUfEUXNQ NX3zUoVYUUN3ME2xNEDPxE1? MVSyN|g1PDB|OB?=
CAL-27 M1TvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjqcXk1OTBizszN M2fk[VczKGh? NEDQfJdFVVOR M3zFNGlEPTB;MUCg{txO M{DBVVI{QDR2MEO4
CAL-62 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L2d|ExKM7:TR?= Mnq5O|IhcA>? M4TzemROW09? NHn2emZKSzVyPUGwJO69VQ>? NUm1TFJwOjN6NESwN|g>
Calu-3 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln3NVAh|ryP Ml7SO|IhcA>? NX\WWoFVTE2VTx?= NHLmeYRKSzVyPUGwJO69VQ>? NFPOOIYzOzh2NECzPC=>
CaOV3 M{DDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX2xNEDPxE1? NVnTW3dEPzJiaB?= NVjmcm5UTE2VTx?= NX34TodZUUN3ME2xNEDPxE1? MnvzNlM5PDRyM{i=
CGTHW1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfpNVAh|ryP MVm3NkBp NVjoNZZ{TE2VTx?= M1m3S2lEPTB;MUCg{txO NUL6XlFiOjN6NESwN|g>
CHL-1 NUD1UXhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLJT5o2OTBizszN NX;nZYxmPzJiaB?= MonDSG1UVw>? M2rxUWlEPTB;MUCg{txO MnzkNlM5PDRyM{i=
Colo320DM M4HGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{KyUlExKM7:TR?= NX7tcGpXPzJiaB?= NWi1ZnhITE2VTx?= M1zG[mlEPTB;MUCg{txO NV70UW9DOjN6NESwN|g>
Colo704 M1PET2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jDflExKM7:TR?= NUHCOpZtPzJiaB?= NETzVIFFVVOR M1PieGlEPTB;MUCg{txO MVGyN|g1PDB|OB?=
COR-L23 NFz0O2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX4ZWVCOTBizszN NHKwR5M4OiCq MX\EUXNQ MmDRTWM2OD1zMDFOwG0> NEjTVnozOzh2NECzPC=>
CRO-AP2 Mli0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXEdVcyOCEQvF2= MoPrO|IhcA>? NWnB[YNlTE2VTx?= MoLOTWM2OD1zMDFOwG0> NUfBOFNmOjN6NESwN|g>
Daudi M2Gx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXTWFMyOCEQvF2= NGfyO3M4OiCq NELGSolFVVOR NYPvXYxbUUN3ME2xNEDPxE1? M2G2dVI{QDR2MEO4
DOTC 24510 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHR[YkyOCEQvF2= MYO3NkBp Mkn6SG1UVw>? NWG1OlhPUUN3ME2xNEDPxE1? M2TxdFI{QDR2MEO4
DU-145 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? MmDzO|IhcA>? NWrzOJg5TE2VTx?= M3XPVmlEPTB;MUCg{txO MlHhNlM5PDRyM{i=
EB-3 NEfSZXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LHSFExKM7:TR?= MUW3NkBp NF3SZoRFVVOR NULkfJJQUUN3ME2xNEDPxE1? NHToNWkzOzh2NECzPC=>
EFM-19 NFjOZWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUexNEDPxE1? MmXLO|IhcA>? MmLVSG1UVw>? MVnJR|UxRTFyIN88US=> NXO2VWdYOjN6NESwN|g>
EKVX MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrqPYgyOCEQvF2= MofGO|IhcA>? M3q5d2ROW09? M{fI[2lEPTB;MUCg{txO NVu5TGlHOjN6NESwN|g>
FaDu M4T0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVmxNEDPxE1? M4LKV|czKGh? MXLEUXNQ Mn;UTWM2OD1zMDFOwG0> NGTxfoszOzh2NECzPC=>
G401 M3vQ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\xNVAh|ryP NIOxZWE4OiCq MoLvSG1UVw>? M2q3TWlEPTB;MUCg{txO M1LETlI{QDR2MEO4
HCC-70 NVrhOZRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXOxNEDPxE1? MYq3NkBp NIrLc3VFVVOR NWqxSWRlUUN3ME2xNEDPxE1? M4rKbVI{QDR2MEO4
HCC-1954 NXTLTFlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jTSVExKM7:TR?= NI\MXGI4OiCq MY\EUXNQ Mn[1TWM2OD1zMDFOwG0> M3flNFI{QDR2MEO4
Hela MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT5U3JMOTBizszN NX[wT2l{PzJiaB?= MoLTSG1UVw>? NWHQ[|AyUUN3ME2xNEDPxE1? NIrI[G8zOzh2NECzPC=>
Hep3B NYrnXlVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnQNVAh|ryP MXm3NkBp NUP5NIVXTE2VTx?= MlTvTWM2OD1zMDFOwG0> Mn;MNlM5PDRyM{i=
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HN5 M3POW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDVZml6OTBizszN M1jGdFczKGh? MXPEUXNQ M3HWUmlEPTB;MUCg{txO M{XyTFI{QDR2MEO4
HOS MknMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXINVAh|ryP MV63NkBp MkD0SG1UVw>? NF[5d4ZKSzVyPUGwJO69VQ>? Mn[3NlM5PDRyM{i=
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Hs746.T NFXlfYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK5ToNZOTBizszN NUX4XVhYPzJiaB?= MVXEUXNQ NEDMVYRKSzVyPUGwJO69VQ>? NE\rfYczOzh2NECzPC=>
HT NYfpcHQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DiRVExKM7:TR?= M1;jRlczKGh? M2TBUGROW09? NYHySYJ7UUN3ME2xNEDPxE1? MWKyN|g1PDB|OB?=
HT-3 M1rQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLLNVAh|ryP NYP3S5dSPzJiaB?= NXG1c2w1TE2VTx?= NWD3OZRSUUN3ME2xNEDPxE1? Mni0NlM5PDRyM{i=
HuNS-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHPcXBYOTBizszN NHqyO3A4OiCq NIHyV5hFVVOR MmqxTWM2OD1zMDFOwG0> NWLjRY0{OjN6NESwN|g>
IGROV1 Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[xNEDPxE1? NF\heJY4OiCq M{POZ2ROW09? M1TseWlEPTB;MUCg{txO NYS0N5h5OjN6NESwN|g>
J82 NF7v[4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PqUVExKM7:TR?= NX;ycJV3PzJiaB?= NIfjSXBFVVOR NVriSlhnUUN3ME2xNEDPxE1? M3HmblI{QDR2MEO4
JM1 NX\pZXVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? NXjmXVZUPzJiaB?= NUX2NFFoTE2VTx?= MoTFTWM2OD1zMDFOwG0> MXmyN|g1PDB|OB?=
Kato III NF7i[nVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm4NVAh|ryP M2nwblczKGh? NHXrbVVFVVOR NGqyRXNKSzVyPUGwJO69VQ>? MVGyN|g1PDB|OB?=
KHOS-240S MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrWdoQyOCEQvF2= M{DmU|czKGh? NGDzc41FVVOR MXHJR|UxRTFyIN88US=> MV2yN|g1PDB|OB?=
KM-12 NF7RcZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrGbXhlOTBizszN NWThe|ljPzJiaB?= M{D5V2ROW09? NIG4SohKSzVyPUGwJO69VQ>? NEPne4MzOzh2NECzPC=>
KPL-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fTN|ExKM7:TR?= MmLUO|IhcA>? NF22UHlFVVOR M2rIUmlEPTB;MUCg{txO M2iydFI{QDR2MEO4
KYSE-30 M4jV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3BNVAh|ryP MYK3NkBp M2rjR2ROW09? NX7QXFBJUUN3ME2xNEDPxE1? Mn7jNlM5PDRyM{i=
LNCaP Mn;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TqS|ExKM7:TR?= M2TkZ|czKGh? NUX0bJRHTE2VTx?= NE\5V2xKSzVyPUGwJO69VQ>? MYiyN|g1PDB|OB?=
MCF-7 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHraSYYyOCEQvF2= Mo\WO|IhcA>? MUnEUXNQ M37XOWlEPTB;MUCg{txO M17wUlI{QDR2MEO4
MC-IXC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmxNEDPxE1? MVS3NkBp MYPEUXNQ MknrTWM2OD1zMDFOwG0> MUGyN|g1PDB|OB?=
MDA-MB-175 VII NFLPSWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWKxNEDPxE1? NVf1WIlrPzJiaB?= M4TneGROW09? Mn\0TWM2OD1zMDFOwG0> Mlf2NlM5PDRyM{i=
MDA-MB-468 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXGxNEDPxE1? NInhW5I4OiCq NI\YRm1FVVOR NV30XpVwUUN3ME2xNEDPxE1? MmrDNlM5PDRyM{i=
MiaPaCa MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rTWFExKM7:TR?= MUC3NkBp MY\EUXNQ M2rueGlEPTB;MUCg{txO NGD0R2YzOzh2NECzPC=>
Molt-4 M2TKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3WdpNUOTBizszN M4O3d|czKGh? MVfEUXNQ NHmybndKSzVyPUGwJO69VQ>? M1LDXlI{QDR2MEO4
NCI-ADR/RES MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxNEDPxE1? M{\hUFczKGh? MXzEUXNQ MWjJR|UxRTFyIN88US=> NYXsU3FVOjN6NESwN|g>
NCI-H69 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPINVAh|ryP NH;BTVM4OiCq MVrEUXNQ M2j4c2lEPTB;MUCg{txO NF\BT|EzOzh2NECzPC=>
NCI-H82 M1H2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvXNVAh|ryP MYi3NkBp NUHEZ4tRTE2VTx?= NYPyc5dNUUN3ME2xNEDPxE1? NFP5TFYzOzh2NECzPC=>
NCI-N87 Mn7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzTO4oyOCEQvF2= MWO3NkBp M2i2RmROW09? MmH6TWM2OD1zMDFOwG0> NYrhZYlxOjN6NESwN|g>
NCI-H146 NVHQbFZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfseZEyOCEQvF2= MXi3NkBp MVXEUXNQ MYnJR|UxRTFyIN88US=> NGLndGYzOzh2NECzPC=>
NCI-H157 M1jZRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nQTlExKM7:TR?= MX[3NkBp NX\nbXJOTE2VTx?= NFW4cmZKSzVyPUGwJO69VQ>? NYfTRXVNOjN6NESwN|g>
NCI-H187 M1zOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPtNVAh|ryP NEPFbGw4OiCq M4LtZWROW09? M3rS[WlEPTB;MUCg{txO MnPZNlM5PDRyM{i=
NCI-H209 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHe3TYQyOCEQvF2= NXvaPYx7PzJiaB?= MkTDSG1UVw>? MWHJR|UxRTFyIN88US=> NF7hW|MzOzh2NECzPC=>
NCI-H226 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLyVokyOCEQvF2= MVu3NkBp NG\N[4lFVVOR NUXkbmlHUUN3ME2xNEDPxE1? MUWyN|g1PDB|OB?=
NCI-H292 M1PN[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;xV3kyOCEQvF2= NIjEbm84OiCq M3LTRmROW09? MmXWTWM2OD1zMDFOwG0> NEj3VIczOzh2NECzPC=>
NCI-H322 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDNdIxIOTBizszN MWe3NkBp M3WwOmROW09? NF3TTZZKSzVyPUGwJO69VQ>? NFfWe|AzOzh2NECzPC=>
NCI-H358 M3[0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojaNVAh|ryP Mn[yO|IhcA>? MX;EUXNQ NXvqbm1IUUN3ME2xNEDPxE1? NWT1R3c3OjN6NESwN|g>
NCI-H520 NFTpUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDPNVAh|ryP M3jPXVczKGh? M1nxWWROW09? Mkm3TWM2OD1zMDFOwG0> NG[xe3MzOzh2NECzPC=>
NCI-H526 MojsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;kOlExKM7:TR?= NE\Kb484OiCq MofvSG1UVw>? NEXX[WlKSzVyPUGwJO69VQ>? Ml7SNlM5PDRyM{i=
NCI-H630 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWCxNEDPxE1? MYK3NkBp MkmzSG1UVw>? NWTrUWZOUUN3ME2xNEDPxE1? NHLQcG0zOzh2NECzPC=>
NCI-H661 M{Xzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzrd5cyOCEQvF2= MUO3NkBp NHzkUpJFVVOR NWPveWRnUUN3ME2xNEDPxE1? MViyN|g1PDB|OB?=
NCI-H716 MkHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfpNVAh|ryP M4LCeFczKGh? MlrISG1UVw>? MknuTWM2OD1zMDFOwG0> MlLGNlM5PDRyM{i=
NCI-H1563 M3q3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHNOIc5OTBizszN M2[yelczKGh? MYfEUXNQ MWXJR|UxRTFyIN88US=> M3;lW|I{QDR2MEO4
NCI-H1792 NYTTdXc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PZOFExKM7:TR?= M3jpNVczKGh? MWjEUXNQ NH7xcHhKSzVyPUGwJO69VQ>? NFXDOogzOzh2NECzPC=>
NCI-H2030 M3qxbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHkb|h3OTBizszN NXK4RXM4PzJiaB?= NXy2[mwzTE2VTx?= M1;LWWlEPTB;MUCg{txO MnLvNlM5PDRyM{i=
NCI-H2052 NHrKfXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n2VlExKM7:TR?= MUm3NkBp Mn7aSG1UVw>? M1PXTGlEPTB;MUCg{txO M3TrZVI{QDR2MEO4
NCI-H2122 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVexNEDPxE1? NWLGXG1mPzJiaB?= NYrabW1yTE2VTx?= M1LMTWlEPTB;MUCg{txO MkfwNlM5PDRyM{i=
NCI-H2228 M4GxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLrPIwyOCEQvF2= MlHtO|IhcA>? M{OzZmROW09? NVO5b2NpUUN3ME2xNEDPxE1? MmmzNlM5PDRyM{i=
OE-19 NYT6ell2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjpUmUyOCEQvF2= MYG3NkBp M3j1WGROW09? MWXJR|UxRTFyIN88US=> Mmf3NlM5PDRyM{i=
OE-21 NYjyXHFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S2R|ExKM7:TR?= M2\Gd|czKGh? MlLXSG1UVw>? MUjJR|UxRTFyIN88US=> NEju[WwzOzh2NECzPC=>
OE-33 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL0NVAh|ryP M3rnelczKGh? NU\MT|lvTE2VTx?= MlH4TWM2OD1zMDFOwG0> M1HPZlI{QDR2MEO4
OVCAR-3 NWXwb2dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33PVlExKM7:TR?= MnrjO|IhcA>? NI[1ZYhFVVOR NGjNN3JKSzVyPUGwJO69VQ>? M{HTVFI{QDR2MEO4
OVCAR-4 MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvmNVAh|ryP M2qwVFczKGh? NU\oXGw6TE2VTx?= MoL5TWM2OD1zMDFOwG0> NGjkdJczOzh2NECzPC=>
OVCAR-5 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3npTVExKM7:TR?= NH7GUI84OiCq NVqxS4dGTE2VTx?= MWTJR|UxRTFyIN88US=> MYWyN|g1PDB|OB?=
P3HR-1 M1vtbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;n[YVHOTBizszN MnTpO|IhcA>? NV7QcGNjTE2VTx?= NXzySoJVUUN3ME2xNEDPxE1? MXuyN|g1PDB|OB?=
PC-3 NWXPeHRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3H0WFExKM7:TR?= MXy3NkBp MXzEUXNQ MXPJR|UxRTFyIN88US=> M3yyb|I{QDR2MEO4
Raji NIK1NWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\GfVExKM7:TR?= MoWwO|IhcA>? M2rrPWROW09? NGTaeFBKSzVyPUGwJO69VQ>? MXmyN|g1PDB|OB?=
RD M1\sNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n0c|ExKM7:TR?= Ml;LO|IhcA>? M2W1XmROW09? Mme1TWM2OD1zMDFOwG0> MX:yN|g1PDB|OB?=
RD-ES MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;5UJhwOTBizszN NE\Ec5M4OiCq MUTEUXNQ NYS5S|ZjUUN3ME2xNEDPxE1? NX76VWp3OjN6NESwN|g>
RL M1r2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn6NVAh|ryP MUO3NkBp NV7wXnpWTE2VTx?= NX7FVJd[UUN3ME2xNEDPxE1? NYX4PZZVOjN6NESwN|g>
SaOS2 NF;qVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnpVXJJOTBizszN MWG3NkBp NEeyclJFVVOR M{njfGlEPTB;MUCg{txO NYW3cFEzOjN6NESwN|g>
SCC-9 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPkZnYyOCEQvF2= MXO3NkBp MYnEUXNQ M3z6eGlEPTB;MUCg{txO Mn3DNlM5PDRyM{i=
SCC-12 MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLvO4FoOTBizszN NUexZ2VMPzJiaB?= MWXEUXNQ NXfYPZZFUUN3ME2xNEDPxE1? MVeyN|g1PDB|OB?=
SCC-13 M1;vTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjJSXcyOCEQvF2= NFvxTlc4OiCq NH\2XmRFVVOR MVvJR|UxRTFyIN88US=> M1;lUlI{QDR2MEO4
SCC-15 M17jemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Ltd|ExKM7:TR?= M4XyUFczKGh? MkS0SG1UVw>? M{XMemlEPTB;MUCg{txO NVTaS4Z{OjN6NESwN|g>
SCC-25 NHW4O5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD4cXBwOTBizszN NYPpVpNuPzJiaB?= NFTW[mFFVVOR MY\JR|UxRTFyIN88US=> NEDVT2IzOzh2NECzPC=>
SCLC-3 NELpOopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\yS2cyOCEQvF2= M4TnVlczKGh? NEez[45FVVOR NVLDbpd4UUN3ME2xNEDPxE1? MWKyN|g1PDB|OB?=
SF-268 NFvaZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXju[oM4OTBizszN NFTtUYk4OiCq MWXEUXNQ NUP4XYFFUUN3ME2xNEDPxE1? Mnf0NlM5PDRyM{i=
SF-295 NWWxTJpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP1em4yOCEQvF2= MUe3NkBp MVjEUXNQ NHvuSopKSzVyPUGwJO69VQ>? MWWyN|g1PDB|OB?=
SJRH30 NYfQNY54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3KwOVExKM7:TR?= NYT5R2pmPzJiaB?= MkXuSG1UVw>? MkPtTWM2OD1zMDFOwG0> NInUNmIzOzh2NECzPC=>
SK-BR-3 NWDydmRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfOV2YyOCEQvF2= MYK3NkBp M3X6XWROW09? MWnJR|UxRTFyIN88US=> MmfsNlM5PDRyM{i=
SK-LMS-1 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYqxNEDPxE1? NVHPZm1GPzJiaB?= NGTmcllFVVOR NED0dIRKSzVyPUGwJO69VQ>? M1vxNlI{QDR2MEO4
SK-N-DZ NV32TWo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi1U4wyOCEQvF2= NWHHfWt[PzJiaB?= NELUfIdFVVOR MVnJR|UxRTFyIN88US=> MYmyN|g1PDB|OB?=
SK-N-F1 Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli1NVAh|ryP M3npUFczKGh? NFjPToZFVVOR M{Drc2lEPTB;MUCg{txO MVSyN|g1PDB|OB?=
SKOV-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHXUY0yOCEQvF2= M2LOeFczKGh? NXjiOmRuTE2VTx?= M2G2NGlEPTB;MUCg{txO MXmyN|g1PDB|OB?=
SK-UT-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVSxNEDPxE1? NH\NSoY4OiCq MkjLSG1UVw>? M36z[mlEPTB;MUCg{txO NY\wTmxROjN6NESwN|g>
SN12C MnjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDRNVAh|ryP MVS3NkBp Ml\BSG1UVw>? M4r5U2lEPTB;MUCg{txO M{\NNlI{QDR2MEO4
SNB-19 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzkNVAh|ryP NV3WRmZSPzJiaB?= M4jjVWROW09? NV;iS2d5UUN3ME2xNEDPxE1? NFfzWIIzOzh2NECzPC=>
SNU-5 NV20bmw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnyzNVAh|ryP M2fUTlczKGh? NYLhXnZ4TE2VTx?= NYruPVNDUUN3ME2xNEDPxE1? NYG3eHNMOjN6NESwN|g>
SNU-16 Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXyxNEDPxE1? NIPs[JM4OiCq M3HYOmROW09? MUfJR|UxRTFyIN88US=> NXLETmR6OjN6NESwN|g>
SNU-398 MmXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG1NVAh|ryP MVW3NkBp NXn3dW1jTE2VTx?= NU\uUmFyUUN3ME2xNEDPxE1? M4fzOlI{QDR2MEO4
SNU-449 M2m1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV2xNEDPxE1? M1n4[lczKGh? M4O3UmROW09? NXf2TWI6UUN3ME2xNEDPxE1? NX[zOZVROjN6NESwN|g>
SR MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\SNFExKM7:TR?= NXHiZmZ5PzJiaB?= NIS2SJNFVVOR MW\JR|UxRTFyIN88US=> MV6yN|g1PDB|OB?=
ST486 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XjWlExKM7:TR?= MknIO|IhcA>? M4rEPGROW09? NIny[pVKSzVyPUGwJO69VQ>? MVuyN|g1PDB|OB?=
SW579 NGPpVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfMV3pWOTBizszN M1SyUVczKGh? M1;DNWROW09? M2LxOGlEPTB;MUCg{txO M2mybVI{QDR2MEO4
SW684 M4TtUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S2bFExKM7:TR?= NIHhN|Y4OiCq MUTEUXNQ M3TOWmlEPTB;MUCg{txO NVfOTo9tOjN6NESwN|g>
SW-780 NEW2NG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUOxNEDPxE1? MY[3NkBp NYi3WnJyTE2VTx?= MXPJR|UxRTFyIN88US=> NXTnTYdwOjN6NESwN|g>
SW900 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;aNVAh|ryP NX7rfZk{PzJiaB?= MYjEUXNQ M3jV[WlEPTB;MUCg{txO MlL4NlM5PDRyM{i=
SW1088 NEC4eVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuxNEDPxE1? NUfUZZZSPzJiaB?= Ml64SG1UVw>? NY\BSFVoUUN3ME2xNEDPxE1? MmDYNlM5PDRyM{i=
SW1463 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrreXAyOCEQvF2= MkH1O|IhcA>? NGfRVnBFVVOR NGXSXlVKSzVyPUGwJO69VQ>? NGiz[pczOzh2NECzPC=>
SW1990 NXHyTpR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIriVJgyOCEQvF2= M3q5eVczKGh? NX;tSZlyTE2VTx?= NFfBU4pKSzVyPUGwJO69VQ>? NV;pe2pJOjN6NESwN|g>
T47D NX3NTI1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnmNFMyOCEQvF2= MWS3NkBp MnLaSG1UVw>? M4nvcGlEPTB;MUCg{txO NGq4[XIzOzh2NECzPC=>
TE381.T NHu4XHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUSxNEDPxE1? NIfTSWY4OiCq MV;EUXNQ M2\tRWlEPTB;MUCg{txO NIDwVpAzOzh2NECzPC=>
TK-10 NIfZTo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXNTm9qOTBizszN NXu3e28xPzJiaB?= NYDOV3dwTE2VTx?= MWjJR|UxRTFyIN88US=> MkHCNlM5PDRyM{i=
U2OS MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[1cFkyOCEQvF2= MoHMO|IhcA>? NVPnVmF3TE2VTx?= NXLTRnd4UUN3ME2xNEDPxE1? NFr4WJUzOzh2NECzPC=>
U251 MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmxNEDPxE1? M3rDTlczKGh? MWTEUXNQ MVjJR|UxRTFyIN88US=> MX2yN|g1PDB|OB?=
UACC-812 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH0eoxPOTBizszN NHv4O|E4OiCq NH;3WHNFVVOR MW\JR|UxRTFyIN88US=> M4qwUFI{QDR2MEO4
YAPC MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmT2NVAh|ryP NWDXO5IxPzJiaB?= MlXwSG1UVw>? NGXHcllKSzVyPUGwJO69VQ>? MmnhNlM5PDRyM{i=
ZR-75-1 NEW1WJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXuxNEDPxE1? NIPGfHY4OiCq MVTEUXNQ M3q3bmlEPTB;MUCg{txO NEXpdmwzOzh2NECzPC=>
A375 M1O2WWZ2dmO2aX;uJIF{e2G7 NUTZO20yOS5{IN88US=> NGPmVYg1KGh? NITHV2VFVVOR M3XjR2lvcGmkaYTpc44hd2ZicHjvd5Bpd3K7bHH0bY9vKG:oIF3FT{whTVKNLDDhcoQhWz[S NFO0b48zOjN6OUS3NS=>
YUSIT1 MoWxSpVv[3Srb36gZZN{[Xl? M4HDRWROW09? MWLy[YR2[2WmIIPlcpNqfGm4aYT5JJdqfGhiSVO1NEA,KDBwNTFOwG0> M{LMbVIzOzh7NEex
MeWo MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVLnXpJGTE2VTx?= MknzTWM2OCB;IEm4O{BvVQ>? M3HxPFI3ODF6NUK0
WiDr MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFW5NYlFVVOR MXnJR|UxKD1iN{[gcm0> MWqyOlAyQDV{NB?=
Colo-205 NV\3PFhyTnWwY4Tpc44h[XO|YYm= NHnzdlgyKM7:TR?= NV7yUJpqPCCm M1jHPWROW09? NW\4eFI5UW6mdXPl[EBiKGirZ3jsfUBkd22yYYLhZoxmKGOxbYDhZ5Rqd25icHjlco91gXCn MV[yOVM5OTF3Mh?=
RBW-1 MofJSpVv[3Srb36gZZN{[Xl? NULueFFGOSEQvF2= MVzEUXNQ NY\iT4RRVm9icnXkeYN1cW:wIH;mJG1mcyBzL{KgdIhwe3Cqb4L5cIF1cW:w NE\KTpczPDh6NU[5NC=>
RBO-1 M1nkNGZ2dmO2aX;uJIF{e2G7 NIfFVY4yKM7:TR?= M4T1bGROW09? NUnwfHV1UW6qaXLpeIlwdiCxZjDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? M3\EWVI1QDh3Nkmw
RBO-2 NUXsS3BoTnWwY4Tpc44h[XO|YYm= NEXRTmQyKM7:TR?= MWLEUXNQ MnK2TY5pcWKrdHnvckBw\iBiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> M4XhVVI1QDh3Nkmw
RBOW MkTwSpVv[3Srb36gZZN{[Xl? M3faTlEh|ryP NGDNUodFVVOR NGXGellKdmirYnn0bY9vKG:oIDDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? MlvMNlQ5QDV4OUC=
M257 NGjRXWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrIZWMyODBibl2= MXO3NkBp NGP6TnVFd2W|IH7veEBqdmirYnn0JJBzd2yrZnXyZZRqd25ib3[gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= Mom2NlM{OTd2NE[=
LCP MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH5OJIyODBibl2= MlzwO|IhcA>? NWrYZlNYUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? NGrsWmszOzNzN{S0Oi=>
WM266 NUTuO5ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXoNVAxKG6P MmPuO|IhcA>? MXvJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhX01{Nk[gZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMVSgcZV1[W62YYTpc44> NIfDWYszOzNzN{S0Oi=>
M257 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTDfosxOTByIH7N MlHOO|IhcA>? NXm1fmoyTG:nczDuc5QhcW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG MWWyN|MyPzR2Nh?=
LCP NYLsfZdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjkXVdUOTByIH7N NYXJU4ZpPzJiaB?= MmrkTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? MWWyN|MyPzR2Nh?=
WM266 NGS5XXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvDdnYyODBibl2= NYHXTmJ[PzJiaB?= M3faWWlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDXUVI3PiClZXzsJIhiemKxdYLpcochSlKDRjDWOlAxTCCvdYThcpRifGmxbh?= MXeyN|MyPzR2Nh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+45% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04452877 Not yet recruiting Drug: Dabrafenib|Drug: Trametinib Carcinoma Non-Small-Cell Lung Novartis Pharmaceuticals|Novartis August 31 2020 Phase 2
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID