Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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In DMSO USD 180 In stock
USD 90 In stock
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  • BRAFi/MEKi-resistant A375DR and the parental A375 cells were treated with 2 μM vorinostat and/or the combination of 0.125 μM dabrafenib and 5 nM trametinib. Protein lysates were harvested after 72 hr. Western blot analysis was carried out for p-MEK and p-P90RSK as indicators of activation of MAPK pathway, ac-H3 as indicator for levels of acetylated histone H3 and a-tubulin as a loading control.

    Cell, 2018, 173(6):1413-1425. Dabrafenib (GSK2118436) purchased from Selleck.

    A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

  • Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NIXRU4FMcW6jc3WgRZN{[Xl? M{LTWWlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDIbZMhfGGpZ3XkJGIuWmGoIG[2NFBGKG23dHHueEBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgbY5{\WO2IHPlcIx{KGOxLXX4dJJme3OrbnegR2REOzdiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[mmxdHnufYxifGWmLV3FT{Bxem:2ZXnuJJBpd3OyaH;yfYxifGmxbjDifUBCdHCqYWPjdoVmdiCjc4PhfUB4cXSqIFnDOVAhd2ZiMD6wNFA4KM7:TR?= M3\2NVI1QTByNkez
SK-MEL-28 MUTLbY5ie2ViQYPzZZk> MkfXNUBp MVrJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP NEDRWHQzPDlyME[3Ny=>
HepG2 MofhT4lv[XOnIFHzd4F6 M1;L[mlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? NIKy[2czPDlyME[3Ny=>
COLO205 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9{MEWgZ4VtdCCycn;sbYZmemG2aX;uJJdqfGhiSVO1NEBw\iByLkCwO{DPxE1? MXKyOFkxODZ5Mx?=
HepG2 M2X5T2Z2dmO2aX;uJGF{e2G7 MVO0OUBucW5? MlzKSG1UVw>? NYj2OY1OUW6qaXLpeIlwdiCxZjDBcIs2KGmwIGTHSk1j\XSjLYP0bY12dGG2ZXSgbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iU33h[FIheGixc4Doc5J6dGG2aX;uJJRz\WG2ZXSg[o9zKDR3IH3pcpMheHKrb4KgeI8hXEeILXLleIEhe3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPjBibXnud{BjgSCxZInzd4V6KGKub4Sgd4Nidm6ncjDhcoFtgXOrczD3bZRpKEmFNUCgc4YhOy55IN88US=> MYGyOFkxODZ5Mx?=
HFF NEL2VnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M376SFExKM7:TR?= NV7FW4dsPzJiaB?= NYT2d4FPTE2VTx?= NXLK[4tuUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIHj1cYFvKEiIRjDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIFKtVoFnKHerdHigTWM2OCCxZjCzJO69VQ>? NWC3clV1OjN6NESwN|g>
SK-MEL-28 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4j2[lExKM7:TR?= NVP0SlNLPzJiaB?= MVnEUXNQ M2G3WGlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCVSz3NSWwuOjhiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB2MzFOwG0> MX[yN|g1PDB|OB?=
A375P-F11 MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PtdFExKM7:TR?= M2n3[FczKGh? NVr2RnY6TE2VTx?= MnfjTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKEF|N{XQMWYyOSClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODdzIN88US=> MU[yN|g1PDB|OB?=
MALME-3M NXfHNZlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu0NVAh|ryP M1jSWFczKGh? NYHsT|NRTE2VTx?= M{fCSWlEPTB;MTDuUS=> MnTtNlM5PDRyM{i=
UACC-62 MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DNRlExKM7:TR?= M{jjPVczKGh? MoK0SG1UVw>? NF2xc3BKSzVyPUGgcm0> NHrVNmszOzh2NECzPC=>
C32TG MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HrVVExKM7:TR?= M{HE[|czKGh? MnS1SG1UVw>? MlnXTWM2OD1zIH7N NYLrTIZEOjN6NESwN|g>
SK-MEL-1 M2\Kdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfhWlIyOCEQvF2= NVe2UYdVPzJiaB?= NHPJe5JFVVOR M37QPWlEPTB;MjDuUS=> NEH5O4QzOzh2NECzPC=>
M14 NX3Xc4ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKxNEDPxE1? MUC3NkBp NGjVZ3VFVVOR MkjRTWM2OD1{IH7N MVWyN|g1PDB|OB?=
SK-MEL-28 MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3KbYt2OTBizszN NUL4NW5TPzJiaB?= NFPVSIxFVVOR NIHWO2xKSzVyPUOgcm0> NFjETFMzOzh2NECzPC=>
A375 NHy3bFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXyc5JtOTBizszN MoXYO|IhcA>? NVfVV4tZTE2VTx?= NVzRcGJFUUN3ME20JI5O MonNNlM5PDRyM{i=
DU-4475 Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\0UlExKM7:TR?= MoXnO|IhcA>? MmjtSG1UVw>? NYD3WFlJUUN3ME21JI5O M1HMdVI{QDR2MEO4
UACC-257 M3vyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTaNVAh|ryP MVe3NkBp MULEUXNQ MWXJR|UxRTZibl2= MmK0NlM5PDRyM{i=
Colo 205 NUKzZopzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfifYwyOCEQvF2= MVi3NkBp M3zCfmROW09? M4LMUGlEPTB;NzDuUS=> NI\IcFAzOzh2NECzPC=>
SK-MEL-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnwT|YyOCEQvF2= NILBPXM4OiCq MmPYSG1UVw>? NXvVbYQ6UUN3ME23JI5O M3rnO|I{QDR2MEO4
SH-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU[xNEDPxE1? NIjvWmE4OiCq MnfJSG1UVw>? NUTjSWRwUUN3ME24JI5O NYf1O2Q5OjN6NESwN|g>
A101D MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fweVExKM7:TR?= M{DJRVczKGh? MmH6SG1UVw>? MlzRTWM2OD17IH7N NWX3WoRVOjN6NESwN|g>
ES-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXFSnlEOTBizszN NUnzZ4VSPzJiaB?= NUOwNmVjTE2VTx?= MnPHTWM2OD13MzDuUS=> Mnf0NlM5PDRyM{i=
HT-29 NH;LZnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV6xNEDPxE1? Mke0O|IhcA>? MWfEUXNQ MkPZTWM2OD14NjDuUS=> NV;PZ5hZOjN6NESwN|g>
SW1417 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT4PGMyOCEQvF2= NVSxeGZ[PzJiaB?= NGHVRoZFVVOR MlTBTWM2OD1zNUigcm0> NI\6XnAzOzh2NECzPC=>
SW872 NYjlOJhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfMPYYyOCEQvF2= MYC3NkBp MYfEUXNQ MV3JR|UxRTN5NzDuUS=> MmHJNlM5PDRyM{i=
RKO MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3flXFExKM7:TR?= NIC2TWk4OiCq NG\HR3ZFVVOR NWHxSZRQUUN3ME2yMlUzOiEQvF2= NGH2U4gzOzh2NECzPC=>
A673 M3niTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\sNVExKM7:TR?= NFjne5I4OiCq MlfESG1UVw>? NYXYdoIyUUN3ME2xNEDPxE1? MViyN|g1PDB|OB?=
GCT NF\HTmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXixZXFEOTBizszN M4m4SVczKGh? NFWyUWNFVVOR MV7JR|UxRTFyIN88US=> MVWyN|g1PDB|OB?=
WM-115 NUG5SGVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XjUFExKM7:TR?= M2fhSlczKGh? M2HpR2ROW09? NYHFcHhoUUN3ME21JI5O MYGyN|g1PDB|OB?=
YUMAC M2XQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\ucWQyOCEQvF2= MYW3NkBp Ml3TSG1UVw>? MmrTTWM2OD13IH7N NUDIRY94OjN6NESwN|g>
OV-90 Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\ENVAh|ryP NFHsOmY4OiCq Mmm0SG1UVw>? M2C5OGlEPTB;Mkmgcm0> M3XoclI{QDR2MEO4
NCI-H508 Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzVNVAh|ryP MYK3NkBp M3zIcWROW09? Mon0TWM2OD1zMDFOwG0> M{myTVI{QDR2MEO4
MDA-MB-231 M3\l[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[4b2QyOCEQvF2= M3TkZlczKGh? M3PzPWROW09? MnLzTWM2OD1zMDFOwG0> NXO2e215OjN6NESwN|g>
SW756 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjjRm5oOTBizszN NFr5Rlg4OiCq M361UmROW09? MVXJR|UxRTFyIN88US=> M2\qOFI{QDR2MEO4
SW-837 M2LSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qzclExKM7:TR?= M4fTXlczKGh? M2LKe2ROW09? NX\oeFRKUUN3ME2xNEDPxE1? MmrjNlM5PDRyM{i=
UMUC-3 MmHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWxNEDPxE1? NUnPb2tJPzJiaB?= M4HjeWROW09? NXzMcXh4UUN3ME2xNEDPxE1? MYOyN|g1PDB|OB?=
LS-174T MoLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU[xNEDPxE1? MV:3NkBp M2PidWROW09? NXizOJpMUUN3ME2xNEDPxE1? NFq0ZoUzOzh2NECzPC=>
A549 NYLxPGp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDWXWkyOCEQvF2= M3fETVczKGh? NWTBdoVpTE2VTx?= NX73U|lbUUN3ME2xNEDPxE1? MnjlNlM5PDRyM{i=
SHP-77 NHu2eoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrsVHdYOTBizszN MmDLO|IhcA>? MnfDSG1UVw>? MVXJR|UxRTFyIN88US=> M2r0UlI{QDR2MEO4
SW480 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELq[GoyOCEQvF2= M3PqRlczKGh? M1mzTGROW09? MWfJR|UxRTFyIN88US=> NIn0ZXUzOzh2NECzPC=>
DLD-1 M4TMU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVno[Y11OTBizszN NXSwZVRpPzJiaB?= MWfEUXNQ MnjOTWM2OD1zMDFOwG0> MWqyN|g1PDB|OB?=
HCT-116 NIqzOXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PoZ|ExKM7:TR?= M4nnSlczKGh? NHfvZ4tFVVOR MljLTWM2OD1zMDFOwG0> MlqwNlM5PDRyM{i=
NCI-H747 NYT3NZRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPoRlk5OTBizszN NEOx[IY4OiCq M4DiO2ROW09? MXrJR|UxRTFyIN88US=> NX\Pd2hMOjN6NESwN|g>
T-84 NYTnS|A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXSxNEDPxE1? MYS3NkBp MlK5SG1UVw>? NVHZTGpmUUN3ME2xNEDPxE1? NXXjPGV6OjN6NESwN|g>
NCI-H460 Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf1[JQxOTBizszN NUfYVmNCPzJiaB?= NH3Ke|RFVVOR NFj2eoZKSzVyPUGwJO69VQ>? NX3XcYk1OjN6NESwN|g>
Calu-6 NXXtbJhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zae|ExKM7:TR?= NWe3e5NEPzJiaB?= MVXEUXNQ MWLJR|UxRTFyIN88US=> NH\FSpQzOzh2NECzPC=>
HCC-2998 NIf1R2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPlS4kyOCEQvF2= NVnFb|RlPzJiaB?= NXv3TGR3TE2VTx?= NEXUWY9KSzVyPUGwJO69VQ>? M1f2[VI{QDR2MEO4
LS1034 NVz4UI9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rIfVExKM7:TR?= NULWUHROPzJiaB?= NXHtUGNrTE2VTx?= MkPJTWM2OD1zMDFOwG0> MkfRNlM5PDRyM{i=
CHP-212 M1m0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUexNEDPxE1? MmT5O|IhcA>? M33YcGROW09? M3nKSmlEPTB;MUCg{txO NHXpRWwzOzh2NECzPC=>
SK-N-AS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSzTJVwOTBizszN M3ewPVczKGh? MmLuSG1UVw>? M2r4VmlEPTB;MUCg{txO M3Lt[lI{QDR2MEO4
BFTC-905 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;O[VFTOTBizszN Mk\PO|IhcA>? NGXsR|BFVVOR NUT3d4poUUN3ME2xNEDPxE1? MnPUNlM5PDRyM{i=
HuT78 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLRfIYyOCEQvF2= NFvTXoE4OiCq M2O5fmROW09? NX\GXlIzUUN3ME21NkBvVQ>? Ml2zNlM5PDRyM{i=
RPMI-8226 M1n6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFKxNnAyOCEQvF2= MkD4O|IhcA>? NULpNHV2TE2VTx?= NVTjTZd4UUN3ME2yOlMhdk1? M2DsVlI{QDR2MEO4
BC-3 M3jqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nWcFExKM7:TR?= M2\JSFczKGh? M1LIU2ROW09? NHi2fmZKSzVyPUK3O{BvVQ>? MYOyN|g1PDB|OB?=
ACHN NYD6[lJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[3eWlHOTBizszN NYe5O4t1PzJiaB?= MWTEUXNQ NW[1S4t3UUN3ME2yPVQhdk1? MkHONlM5PDRyM{i=
JRT3-T35 MoDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[xNEDPxE1? M{\JcVczKGh? MWjEUXNQ MXPJR|UxRTJ7NTDuUS=> MnuzNlM5PDRyM{i=
SK-MES-1 NULT[lJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmxNEDPxE1? MYK3NkBp NUDQWW15TE2VTx?= NFe4XFVKSzVyPUOyPUBvVQ>? NWLkOWhPOjN6NESwN|g>
CESS M{OxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnWT2gyOCEQvF2= NFrobGU4OiCq NESzeXhFVVOR MUjJR|UxRTR7NzDuUS=> NU[0S5dYOjN6NESwN|g>
H4 M1HZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnRNVAh|ryP NWjadWhYPzJiaB?= NX3zc2x6TE2VTx?= M1XNUGlEPTB;NkG5JI5O MWqyN|g1PDB|OB?=
BC-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPEfHMyOCEQvF2= M2XFU|czKGh? NHO2RoRFVVOR MkfvTWM2OD15MESgcm0> M{X5bFI{QDR2MEO4
DB M1v2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y3UFExKM7:TR?= MlzhO|IhcA>? M1nVPGROW09? M{DTUGlEPTB;OEezJI5O MnO4NlM5PDRyM{i=
RPMI-6666 NGXkNYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorMNVAh|ryP NX\XNYE3PzJiaB?= NIXaO25FVVOR MX;JR|UxRTl{ODDuUS=> MWeyN|g1PDB|OB?=
MC/CAR MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXOxNEDPxE1? NITHO4E4OiCq NX7uWGxNTE2VTx?= NGnMW4NKSzVyPUGuNFAzKM7:TR?= NWe5OmllOjN6NESwN|g>
SNU-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TJXVExKM7:TR?= NEfmR244OiCq MkH2SG1UVw>? NHPKTVVKSzVyPUGuOVAyKM7:TR?= MmniNlM5PDRyM{i=
CEM/C1 M{XHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LUNlExKM7:TR?= NFm3V5k4OiCq NV7USoQ3TE2VTx?= M2\hOmlEPTB;MT63O|Mh|ryP MVOyN|g1PDB|OB?=
GDM-1 MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITHbIcyOCEQvF2= NWT4ZWhsPzJiaB?= MnflSG1UVw>? NIWyVVZKSzVyPUGuPVk4KM7:TR?= NVHqd4tCOjN6NESwN|g>
HT-1080 M2XuXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjHbY84OTBizszN MkfKO|IhcA>? M1XKbmROW09? NEPZPGlKSzVyPUKuNFA1KM7:TR?= NEDMPZQzOzh2NECzPC=>
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Colo704 NGP6SldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXqxNEDPxE1? Ml;kO|IhcA>? M1zLdGROW09? Moq3TWM2OD1zMDFOwG0> NU\lOJlMOjN6NESwN|g>
COR-L23 MojIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHobIQyOCEQvF2= M2e5WlczKGh? NH3LZpBFVVOR NVjMWmZtUUN3ME2xNEDPxE1? MUiyN|g1PDB|OB?=
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Daudi NXXJ[oRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHkVmcyOCEQvF2= MV[3NkBp NGn6WpZFVVOR NVLXSoJQUUN3ME2xNEDPxE1? M1X3PFI{QDR2MEO4
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DU-145 MnzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTaNVAh|ryP NV6zcXg5PzJiaB?= NYDiPVZSTE2VTx?= NH;TbopKSzVyPUGwJO69VQ>? M4XaXVI{QDR2MEO4
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EFM-19 M2Lu[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVqxNEDPxE1? MlPuO|IhcA>? M3POd2ROW09? NEH3WHFKSzVyPUGwJO69VQ>? M3nkS|I{QDR2MEO4
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HCC-1954 M1q1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWexNEDPxE1? NUfEVnlKPzJiaB?= M4HFTmROW09? M4HyWGlEPTB;MUCg{txO M4C0bVI{QDR2MEO4
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KYSE-30 NHTLVY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITJWmQyOCEQvF2= NWjWOo12PzJiaB?= NFfq[|lFVVOR M2nNe2lEPTB;MUCg{txO NYS0dnFKOjN6NESwN|g>
LNCaP NV;5VnM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nUNFExKM7:TR?= Mn7SO|IhcA>? NUfSN5NtTE2VTx?= NEDDWplKSzVyPUGwJO69VQ>? NVT4WWR6OjN6NESwN|g>
MCF-7 M2jtVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v5WVExKM7:TR?= M1fB[VczKGh? MlLOSG1UVw>? M{HwbWlEPTB;MUCg{txO NFPocGgzOzh2NECzPC=>
MC-IXC MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33KZVExKM7:TR?= NV7MS|VRPzJiaB?= MYLEUXNQ NF62[3pKSzVyPUGwJO69VQ>? NFTpSlMzOzh2NECzPC=>
MDA-MB-175 VII NFS1RWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTEPVgyOCEQvF2= MlXlO|IhcA>? M2f2VGROW09? MlzGTWM2OD1zMDFOwG0> NVvDT2xqOjN6NESwN|g>
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NCI-ADR/RES NYHLbnZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUWxNEDPxE1? M{XabFczKGh? MUXEUXNQ NVvw[mpKUUN3ME2xNEDPxE1? NYrFbmhXOjN6NESwN|g>
NCI-H69 NEPHTGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHCdYgyOCEQvF2= NYnnPYxOPzJiaB?= NF3NOYNFVVOR MWfJR|UxRTFyIN88US=> Mm\WNlM5PDRyM{i=
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NCI-N87 NEK2WY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXWxNEDPxE1? NV71WlNbPzJiaB?= NUjtZ5RyTE2VTx?= NFvpU|FKSzVyPUGwJO69VQ>? MYGyN|g1PDB|OB?=
NCI-H146 NF[xOYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\1b2kyOCEQvF2= M1zDS|czKGh? MXnEUXNQ NEXqR3ZKSzVyPUGwJO69VQ>? M4G0ZVI{QDR2MEO4
NCI-H157 MoD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnRXoJpOTBizszN NFe2TXE4OiCq NYXhTW9zTE2VTx?= MojmTWM2OD1zMDFOwG0> NH\uUZgzOzh2NECzPC=>
NCI-H187 NXy2S3BPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[0cHZTOTBizszN MlLMO|IhcA>? M2LreWROW09? Mlv2TWM2OD1zMDFOwG0> NETWT4EzOzh2NECzPC=>
NCI-H209 NUSyblB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jYe|ExKM7:TR?= Mme0O|IhcA>? NYnhbYQ3TE2VTx?= MVfJR|UxRTFyIN88US=> NXWzUpM6OjN6NESwN|g>
NCI-H226 MofaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjxV5oyOCEQvF2= NXHpZVAxPzJiaB?= M1zveWROW09? MVXJR|UxRTFyIN88US=> MYOyN|g1PDB|OB?=
NCI-H292 MlHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG1NVAh|ryP NULzOmxVPzJiaB?= NF;Xc4ZFVVOR NX20bHNXUUN3ME2xNEDPxE1? MXGyN|g1PDB|OB?=
NCI-H322 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHPcnMyOCEQvF2= MWG3NkBp NWHKV5lkTE2VTx?= MmHPTWM2OD1zMDFOwG0> MnK5NlM5PDRyM{i=
NCI-H358 NWWycIZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjwNVAh|ryP NY\vV4FjPzJiaB?= M4DTbWROW09? NFnab2NKSzVyPUGwJO69VQ>? M{XKXFI{QDR2MEO4
NCI-H520 NVXWcmpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO4W4lOOTBizszN MmHrO|IhcA>? NUfWVoJwTE2VTx?= Ml;ITWM2OD1zMDFOwG0> MYCyN|g1PDB|OB?=
NCI-H526 NGq3U2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW2NVAh|ryP M1fMTVczKGh? MmDMSG1UVw>? NF3VU4tKSzVyPUGwJO69VQ>? NUDqfYh3OjN6NESwN|g>
NCI-H630 NFfGSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuxNEDPxE1? NVLZOHRFPzJiaB?= NGS5bm1FVVOR NFXUUI5KSzVyPUGwJO69VQ>? MXOyN|g1PDB|OB?=
NCI-H661 M{\oT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3ydIgyOCEQvF2= NVXVN3hIPzJiaB?= MWLEUXNQ MXHJR|UxRTFyIN88US=> NXPMcIZ5OjN6NESwN|g>
NCI-H716 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVSxNEDPxE1? MlKyO|IhcA>? NUTVTG95TE2VTx?= M3jYWWlEPTB;MUCg{txO MofxNlM5PDRyM{i=
NCI-H1563 NF7kfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfXWVZ{OTBizszN NY\XSnpTPzJiaB?= MVfEUXNQ MXnJR|UxRTFyIN88US=> MmDuNlM5PDRyM{i=
NCI-H1792 M4jOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PyTlExKM7:TR?= MVy3NkBp NXLJW|RZTE2VTx?= MULJR|UxRTFyIN88US=> MofkNlM5PDRyM{i=
NCI-H2030 NVPmelBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTxNVAh|ryP M{W1[|czKGh? MkjxSG1UVw>? NInXenRKSzVyPUGwJO69VQ>? NIXvbVQzOzh2NECzPC=>
NCI-H2052 M1q4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXZZ5hbOTBizszN NGW5Omk4OiCq MUjEUXNQ M1X1RmlEPTB;MUCg{txO M3q0O|I{QDR2MEO4
NCI-H2122 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTkNVAh|ryP M1z5OlczKGh? NUTkW3dqTE2VTx?= MoD0TWM2OD1zMDFOwG0> NVT3TmZvOjN6NESwN|g>
NCI-H2228 NG\pS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHezeW4yOCEQvF2= NGjXVFg4OiCq M2iwU2ROW09? MkTaTWM2OD1zMDFOwG0> NHHYR2QzOzh2NECzPC=>
OE-19 M1fJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\YO5YyOCEQvF2= NHXNeoc4OiCq NF;WWJdFVVOR NVnPNVJSUUN3ME2xNEDPxE1? MnvzNlM5PDRyM{i=
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OVCAR-3 NHO0TY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG1N4EyOCEQvF2= MniyO|IhcA>? Mn\6SG1UVw>? M4nRWWlEPTB;MUCg{txO MorvNlM5PDRyM{i=
OVCAR-4 NELoVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\SV5puOTBizszN M{T4cVczKGh? Mm\ZSG1UVw>? MlvmTWM2OD1zMDFOwG0> Ml3NNlM5PDRyM{i=
OVCAR-5 M1fURWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fkZ|ExKM7:TR?= MY[3NkBp M1;oNGROW09? NVK0[3FIUUN3ME2xNEDPxE1? M{XjcVI{QDR2MEO4
P3HR-1 NYHBeYRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHqeGoyOTBizszN NVLubVZ3PzJiaB?= MUXEUXNQ NVruNZVkUUN3ME2xNEDPxE1? MVqyN|g1PDB|OB?=
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Raji MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVOxNEDPxE1? NGj0d5I4OiCq M3HteGROW09? NXLHcVdQUUN3ME2xNEDPxE1? NFvseZUzOzh2NECzPC=>
RD MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv5NVAh|ryP Ml\BO|IhcA>? M1;1OmROW09? NF7TR5FKSzVyPUGwJO69VQ>? NVf1RWV5OjN6NESwN|g>
RD-ES NHnyTIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF34UZMyOCEQvF2= MVS3NkBp NX\iXGl7TE2VTx?= MnfxTWM2OD1zMDFOwG0> NXmzW5gyOjN6NESwN|g>
RL NV;3NFF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[xNEDPxE1? M4XW[VczKGh? M{jwdGROW09? M2rGSGlEPTB;MUCg{txO M3u3[|I{QDR2MEO4
SaOS2 MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G0TVExKM7:TR?= NVTINIY1PzJiaB?= NIjJU|VFVVOR NFvEWYRKSzVyPUGwJO69VQ>? NGiwXVEzOzh2NECzPC=>
SCC-9 M1nHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfiWoMyOCEQvF2= MXS3NkBp NW\WcI1QTE2VTx?= MU\JR|UxRTFyIN88US=> NF\nSHgzOzh2NECzPC=>
SCC-12 M4j2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTGNVAh|ryP Mn72O|IhcA>? M{LJVWROW09? NYrLWXZwUUN3ME2xNEDPxE1? MYGyN|g1PDB|OB?=
SCC-13 M1;1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDGNVAh|ryP MWW3NkBp NH3lSINFVVOR MX;JR|UxRTFyIN88US=> MYOyN|g1PDB|OB?=
SCC-15 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXqxNEDPxE1? M1;BeVczKGh? MXXEUXNQ M1vofGlEPTB;MUCg{txO MoLWNlM5PDRyM{i=
SCC-25 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXCNVAh|ryP NUO2eYYyPzJiaB?= MmPFSG1UVw>? NHrm[mZKSzVyPUGwJO69VQ>? MYOyN|g1PDB|OB?=
SCLC-3 NHXnW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[xNEDPxE1? MYC3NkBp NE\XNHRFVVOR MmnJTWM2OD1zMDFOwG0> MUWyN|g1PDB|OB?=
SF-268 NXLVZnJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSxNEDPxE1? NYrP[VBpPzJiaB?= NEjKWIZFVVOR M33iT2lEPTB;MUCg{txO MUCyN|g1PDB|OB?=
SF-295 NIDFenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XFSFExKM7:TR?= MVi3NkBp NHLNO41FVVOR M1fpR2lEPTB;MUCg{txO M3zyeFI{QDR2MEO4
SJRH30 MlfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUexNEDPxE1? M4PBd|czKGh? NGraeXdFVVOR NIrVe4tKSzVyPUGwJO69VQ>? M3HCOVI{QDR2MEO4
SK-BR-3 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUmxNEDPxE1? MVG3NkBp NX3P[2ZUTE2VTx?= NXPldYNLUUN3ME2xNEDPxE1? MV:yN|g1PDB|OB?=
SK-LMS-1 M1fGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjMNVAh|ryP NFTTZ5U4OiCq M1mzdmROW09? M1LNVmlEPTB;MUCg{txO M1PJclI{QDR2MEO4
SK-N-DZ M4DKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zjXVExKM7:TR?= NFjjc4w4OiCq M3rDfmROW09? MlnMTWM2OD1zMDFOwG0> MXGyN|g1PDB|OB?=
SK-N-F1 NFHJSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLQT3kyOCEQvF2= MX:3NkBp MmLVSG1UVw>? M{DzSGlEPTB;MUCg{txO MX:yN|g1PDB|OB?=
SKOV-3 M4DLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDWZpYyOCEQvF2= MkfEO|IhcA>? MlvxSG1UVw>? NEjBd|JKSzVyPUGwJO69VQ>? MnjmNlM5PDRyM{i=
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SNU-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYKxNEDPxE1? NGKzUGY4OiCq MmThSG1UVw>? M3rqSmlEPTB;MUCg{txO NUDuT2hzOjN6NESwN|g>
SNU-16 NXv0bmoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nXcFExKM7:TR?= MYG3NkBp NWD5fFRSTE2VTx?= MoDrTWM2OD1zMDFOwG0> MV6yN|g1PDB|OB?=
SNU-398 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rBUFExKM7:TR?= NUnxSYF2PzJiaB?= NVWyZ49JTE2VTx?= M3\DbGlEPTB;MUCg{txO MVGyN|g1PDB|OB?=
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SR MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4npbFExKM7:TR?= Mlj2O|IhcA>? NGS0[IxFVVOR NUTBfHpUUUN3ME2xNEDPxE1? MojUNlM5PDRyM{i=
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SW579 M3zvPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\6NVAh|ryP MmLWO|IhcA>? MUjEUXNQ M4fodWlEPTB;MUCg{txO Mn3TNlM5PDRyM{i=
SW684 NUXC[nlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfxNVAh|ryP NWrRSI1XPzJiaB?= MnPOSG1UVw>? MVjJR|UxRTFyIN88US=> MoflNlM5PDRyM{i=
SW-780 MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknHNVAh|ryP NWfkOohNPzJiaB?= MkfGSG1UVw>? Mm\MTWM2OD1zMDFOwG0> MX2yN|g1PDB|OB?=
SW900 NVv6SYV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[xNEDPxE1? NGXlRpI4OiCq MorLSG1UVw>? NI\NZ4xKSzVyPUGwJO69VQ>? MoXsNlM5PDRyM{i=
SW1088 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\yfJMyOCEQvF2= NYXQXVEzPzJiaB?= MmPtSG1UVw>? M1fLOWlEPTB;MUCg{txO M{CyNFI{QDR2MEO4
SW1463 NH7sU|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXPNVAh|ryP NEfwfJA4OiCq NWn5VYJiTE2VTx?= NF\URpJKSzVyPUGwJO69VQ>? MX:yN|g1PDB|OB?=
SW1990 M{OxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;jNVAh|ryP NV7UZ45JPzJiaB?= MlnDSG1UVw>? MVrJR|UxRTFyIN88US=> NFLac5UzOzh2NECzPC=>
T47D M2XHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXYRWsyOCEQvF2= NVP5fmpnPzJiaB?= M2jsTWROW09? MlX6TWM2OD1zMDFOwG0> MX2yN|g1PDB|OB?=
TE381.T NWDUXpdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUKxNEDPxE1? MlL4O|IhcA>? M{m2TWROW09? MVPJR|UxRTFyIN88US=> M2PnXFI{QDR2MEO4
TK-10 NYnNcWZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPJPHgyOCEQvF2= M4PaVlczKGh? MnXUSG1UVw>? NX;xNIlxUUN3ME2xNEDPxE1? NWXteGJTOjN6NESwN|g>
U2OS M2jKdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofkNVAh|ryP M2D2N|czKGh? MVfEUXNQ MlPjTWM2OD1zMDFOwG0> MV:yN|g1PDB|OB?=
U251 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnNNVAh|ryP NWDxOGFjPzJiaB?= M4TmTGROW09? NIn5TnBKSzVyPUGwJO69VQ>? M2DXfFI{QDR2MEO4
UACC-812 NY\ncHNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzq[XQyOCEQvF2= M1jNWVczKGh? NF:0UVhFVVOR NWLDVmRxUUN3ME2xNEDPxE1? NYHzVllOOjN6NESwN|g>
YAPC NVnOcJN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TVfFExKM7:TR?= M{f1SFczKGh? NEjFXlNFVVOR NYC2NWE5UUN3ME2xNEDPxE1? MXyyN|g1PDB|OB?=
ZR-75-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TGOlExKM7:TR?= NGHE[IU4OiCq NXHES|FWTE2VTx?= Mk\zTWM2OD1zMDFOwG0> NYmyTXB{OjN6NESwN|g>
A375 M37ue2Z2dmO2aX;uJIF{e2G7 NVfFUINHOS5{IN88US=> MlO2OEBp NY\UWZpXTE2VTx?= MmXoTY5pcWKrdHnvckBw\iCyaH;zdIhwenmuYYTpc44hd2ZiTVXLMEBGWktuIHHu[EBUPlB? NYXPT4ZTOjJ|OEm0O|E>
YUSIT1 M2T0c2Z2dmO2aX;uJIF{e2G7 NIX6[olFVVOR MX7y[YR2[2WmIIPlcpNqfGm4aYT5JJdqfGhiSVO1NEA,KDBwNTFOwG0> MkmzNlI{QDl2N{G=
MeWo NYDlfHVpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV3rd2hbTE2VTx?= NIG3ZZdKSzVyIE2gPVg4KG6P NEDXR5YzPjBzOEWyOC=>
WiDr NELOO5NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUXEUXNQ NGH3NYdKSzVyIE2gO|Yhdk1? NULpb|dCOjZyMUi1NlQ>
Colo-205 NGDXVXNHfW6ldHnvckBie3OjeR?= M2\WdVEh|ryP NWm0W2dZPCCm M3fSNGROW09? NWDR[XVyUW6mdXPl[EBiKGirZ3jsfUBkd22yYYLhZoxmKGOxbYDhZ5Rqd25icHjlco91gXCn MVOyOVM5OTF3Mh?=
RBW-1 MXvGeY5kfGmxbjDhd5NigQ>? NHrPXJEyKM7:TR?= MXLEUXNQ M3HOSm5wKHKnZIXjeIlwdiCxZjDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? NIDxUmwzPDh6NU[5NC=>
RBO-1 NV;1[XViTnWwY4Tpc44h[XO|YYm= MXmxJO69VQ>? NIqyRoxFVVOR NHnzfoJKdmirYnn0bY9vKG:oIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NGTvNnUzPDh6NU[5NC=>
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RBOW MnXKSpVv[3Srb36gZZN{[Xl? MWKxJO69VQ>? NXLxeGdNTE2VTx?= M4\CNWlvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v MoXkNlQ5QDV4OUC=
M257 NVzFOJJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jiTlExOCCwTR?= MWi3NkBp NV;rOmtZTG:nczDuc5QhcW6qaXLpeEBxem:uaX\ldoF1cW:wIH;mJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG MUOyN|MyPzR2Nh?=
LCP MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zBPFExOCCwTR?= MonnO|IhcA>? NHrpOY5KdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v M{PhTVI{OzF5NES2
WM266 M4D6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TjRlExOCCwTR?= M3HjclczKGh? NFm1fJBKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiV12yOlYh[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNWQhdXW2YX70ZZRqd25? MnLoNlM{OTd2NE[=
M257 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPoNVAxKG6P MVO3NkBp M3;teWRw\XNibn;0JIlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= NX7kO|VrOjN|MUe0OFY>
LCP NYLDNZFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXTN2R7OTByIH7N MXy3NkBp MVLJcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v NXnCd40{OjN|MUe0OFY>
WM266 NWOycmFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHyWnAyODBibl2= NH74RXM4OiCq M2Dv[2lvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDXUVI3PiClZXzsJIhiemKxdYLpcochSlKDRjDWOlAxTCCvdYThcpRifGmxbh?= NHjvcG4zOzNzN{S0Oi=>

... Click to View More Cell Line Experimental Data

In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
8 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01153763 Completed Melanoma GlaxoSmithKline August 9 2010 Phase 2
NCT02858921 Recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis November 8 2017 Phase 2
NCT01978236 Terminated Melanoma and Brain Metastases GlaxoSmithKline April 8 2014 Phase 2
NCT01682083 Active not recruiting Melanoma Novartis Pharmaceuticals|Novartis January 8 2013 Phase 3
NCT01340833 Completed Cancer GlaxoSmithKline June 8 2011 Phase 1
NCT01723202 Active not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID