Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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Cited by 47 Publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NF;pdmFMcW6jc3WgRZN{[Xl? NEDwdIxKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygTIl{KHSjZ3fl[EBDNVKjZjDWOlAxTSCvdYThcpQh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyClbz3lfJBz\XO|aX7nJGNFSzN5IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGKrb4Tpcplt[XSnZD3NSWsheHKxdHXpckBxcG:|cHjvdplt[XSrb36gZpkhSWyyaHHTZ5Jm\W5iYYPzZZkhf2m2aDDJR|UxKG:oIECuNFAxPyEQvF2= NEDoepYzPDlyME[3Ny=>
SK-MEL-28 NYLrR5RXU2mwYYPlJGF{e2G7 MknENUBp Mn3xTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRiaX6gbJVu[W5iU1utUWVNNTJ6IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJGVTUyCyaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFA1KM7:TR?= NXHhdHlROjR7MEC2O|M>
HepG2 M2DmT2tqdmG|ZTDBd5NigQ>? NHXTN2hKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDFVmsheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwOEDPxE1? MnLVNlQ6ODB4N{O=
COLO205 M4fmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nZSWlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= NIC5VoszPDlyME[3Ny=>
HepG2 MlLaSpVv[3Srb36gRZN{[Xl? MY[0OUBucW5? Mm\jSG1UVw>? M4jSbGlvcGmkaYTpc44hd2ZiQXzrOUBqdiCWR1[tZoV1[S2|dHnteYxifGWmIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFOvYXSyJJBpd3OyaH;yfYxifGmxbjD0doVifGWmIH\vdkA1PSCvaX7zJJBzcW:{IITvJHRITi2kZYThJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFYxKG2rboOgZpkhd2S7c4PlfUBjdG:2IIPjZY5v\XJiYX7hcJl{cXNid3n0bEBKSzVyIH;mJFMvPyEQvF2= NGLLco8zPDlyME[3Ny=>
HFF MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPEW3hXOTBizszN M4\FVFczKGh? NUL2epQyTE2VTx?= M2fZUWlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCqdX3hckBJTkZiY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCELWLh[kB4cXSqIFnDOVAhd2ZiMzFOwG0> Mki3NlM5PDRyM{i=
SK-MEL-28 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfNV2FCOTBizszN MnfmO|IhcA>? MV3EUXNQ MnzJTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> NYLK[4wzOjN6NESwN|g>
A375P-F11 MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCzW5EyOCEQvF2= MnPTO|IhcA>? M4LEOGROW09? MWLJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfC2mcnn2[Y4hSTN5NWCtSlEyKGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xPzFizszN NWPXSpZ7OjN6NESwN|g>
MALME-3M NIfhfFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LUUlExKM7:TR?= MV63NkBp M362e2ROW09? NYH2O5dWUUN3ME2xJI5O MW[yN|g1PDB|OB?=
UACC-62 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrrfpAyOCEQvF2= NYPocm1iPzJiaB?= MmjrSG1UVw>? NYmzZW5kUUN3ME2xJI5O M1izR|I{QDR2MEO4
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UACC-257 NGTjWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXixNEDPxE1? NYXPTGxSPzJiaB?= NH[2TnNFVVOR MkL5TWM2OD14IH7N MkDBNlM5PDRyM{i=
Colo 205 NYfQSJVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXKxNEDPxE1? M3;Md|czKGh? MU\EUXNQ M1PpdGlEPTB;NzDuUS=> NXvlU3QyOjN6NESwN|g>
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SH-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK3OWsyOCEQvF2= MVu3NkBp NX:3epdVTE2VTx?= MU\JR|UxRThibl2= NUfCSG9GOjN6NESwN|g>
A101D MkOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITrd2oyOCEQvF2= NUT5c4p{PzJiaB?= NGqwSXVFVVOR MnrHTWM2OD17IH7N NIi0W44zOzh2NECzPC=>
ES-2 NV3FRW93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWWxNEDPxE1? M4XY[FczKGh? MVjEUXNQ MkXrTWM2OD13MzDuUS=> M1nMPVI{QDR2MEO4
HT-29 Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfvNVAh|ryP NYG3RVlwPzJiaB?= NEH1W|BFVVOR NFjIc25KSzVyPU[2JI5O MlPpNlM5PDRyM{i=
SW1417 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX2xNEDPxE1? NWG5Wm5qPzJiaB?= NV3PcJJPTE2VTx?= NGe4V4dKSzVyPUG1PEBvVQ>? NFTEeoszOzh2NECzPC=>
SW872 NYHlXoxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i0PFExKM7:TR?= MWS3NkBp MVnEUXNQ MULJR|UxRTN5NzDuUS=> M17QPVI{QDR2MEO4
RKO M{DyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXmxNEDPxE1? MYS3NkBp NFn5W|BFVVOR NYDwOIg1UUN3ME2yMlUzOiEQvF2= MmjENlM5PDRyM{i=
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GCT NWewOZh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUixNEDPxE1? M1jwUlczKGh? NFH0WJVFVVOR NXflUnVLUUN3ME2xNEDPxE1? NILHc3gzOzh2NECzPC=>
WM-115 M{jKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfENVAh|ryP M33KbFczKGh? MkjySG1UVw>? M1v5SGlEPTB;NTDuUS=> NIDzN2QzOzh2NECzPC=>
YUMAC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO5dmRFOTBizszN M37CR|czKGh? NF3zOJlFVVOR NHnLUplKSzVyPUWgcm0> Mo\SNlM5PDRyM{i=
OV-90 NUe2TYpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYexNEDPxE1? MYO3NkBp MUTEUXNQ MYfJR|UxRTJ7IH7N MYCyN|g1PDB|OB?=
NCI-H508 M1PKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVixNEDPxE1? NEH0NGU4OiCq M4fGfmROW09? NHLhOIFKSzVyPUGwJO69VQ>? M{iwb|I{QDR2MEO4
MDA-MB-231 NETXVXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\3XJJIOTBizszN NWruUVBNPzJiaB?= NUX5cm9{TE2VTx?= NWTQcYlwUUN3ME2xNEDPxE1? Mn7ENlM5PDRyM{i=
SW756 NXP3cYR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnnNVAh|ryP NG\3clY4OiCq NFPFS41FVVOR MUnJR|UxRTFyIN88US=> NUTIfXI4OjN6NESwN|g>
SW-837 NXzMeGVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrlZ|Z6OTBizszN NUC2VIZyPzJiaB?= MnS3SG1UVw>? MnP4TWM2OD1zMDFOwG0> NUW5[Gh1OjN6NESwN|g>
UMUC-3 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWmzRlF4OTBizszN MW[3NkBp M1jDdmROW09? MYHJR|UxRTFyIN88US=> MYiyN|g1PDB|OB?=
LS-174T MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PlVVExKM7:TR?= NYDwbXJ1PzJiaB?= MoXjSG1UVw>? NXnHdo5[UUN3ME2xNEDPxE1? NWfOZ|BKOjN6NESwN|g>
A549 M{jSRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j6WVExKM7:TR?= MVG3NkBp NULh[3ZJTE2VTx?= M{DidGlEPTB;MUCg{txO M{PHdVI{QDR2MEO4
SHP-77 Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzBNVAh|ryP NXrpV5NyPzJiaB?= M2exRmROW09? NYrMPVZnUUN3ME2xNEDPxE1? NGTmSnIzOzh2NECzPC=>
SW480 NHjtRmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH3VJlsOTBizszN MX:3NkBp MYfEUXNQ MWnJR|UxRTFyIN88US=> NX\vd|hrOjN6NESwN|g>
DLD-1 MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrrNVAh|ryP NIfjcGI4OiCq MX3EUXNQ MoHwTWM2OD1zMDFOwG0> NWLKfoVkOjN6NESwN|g>
HCT-116 NHLZN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW5NVAh|ryP MmS4O|IhcA>? M1TRZmROW09? MVjJR|UxRTFyIN88US=> MYWyN|g1PDB|OB?=
NCI-H747 M4roUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXsXVkyOCEQvF2= NEnsSHk4OiCq Mn7kSG1UVw>? MUXJR|UxRTFyIN88US=> NYDaUpd2OjN6NESwN|g>
T-84 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r3cVExKM7:TR?= NUPPfGc4PzJiaB?= MXPEUXNQ MYHJR|UxRTFyIN88US=> NGnZR4UzOzh2NECzPC=>
NCI-H460 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH65TYoyOCEQvF2= M4jafVczKGh? MlnISG1UVw>? M{PwWWlEPTB;MUCg{txO NVLnVHc3OjN6NESwN|g>
Calu-6 NYnLfnQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzEO2QyOCEQvF2= MmDLO|IhcA>? M3fsNmROW09? M4fRb2lEPTB;MUCg{txO M2f1XFI{QDR2MEO4
HCC-2998 NYr5Zlc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET6PJYyOCEQvF2= MUC3NkBp MYrEUXNQ MXXJR|UxRTFyIN88US=> MYSyN|g1PDB|OB?=
LS1034 M4HMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDq[npkOTBizszN MVe3NkBp M4LV[GROW09? NEHjWWNKSzVyPUGwJO69VQ>? MWWyN|g1PDB|OB?=
CHP-212 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PZXlExKM7:TR?= MV:3NkBp M2OzUWROW09? M1vncGlEPTB;MUCg{txO MUiyN|g1PDB|OB?=
SK-N-AS M3S5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVexNEDPxE1? NE\aXmo4OiCq MXnEUXNQ MYLJR|UxRTFyIN88US=> M2TUfVI{QDR2MEO4
BFTC-905 NIS3d3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHkN2VIOTBizszN M3z6XVczKGh? MYHEUXNQ MYXJR|UxRTFyIN88US=> M{DWZ|I{QDR2MEO4
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RPMI-8226 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3q2WVExKM7:TR?= M17E[lczKGh? MmrpSG1UVw>? MmXTTWM2OD1{NkOgcm0> NXjLZXBpOjN6NESwN|g>
BC-3 M3G3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH5NVAh|ryP NH:wVIY4OiCq MYrEUXNQ Mne3TWM2OD1{N{egcm0> NI[wOW4zOzh2NECzPC=>
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SK-MES-1 MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDlTVUyOCEQvF2= NXrhUVJ{PzJiaB?= NH\pSGtFVVOR M3PRb2lEPTB;M{K5JI5O NEfmZWgzOzh2NECzPC=>
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BC-1 MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknWNVAh|ryP NE\yUok4OiCq MlHXSG1UVw>? M4jtW2lEPTB;N{C0JI5O NUDsN|NyOjN6NESwN|g>
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HL-60 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLEUXYyOCEQvF2= MVm3NkBp M3rtVGROW09? M1rwNWlEPTB;Mj6xO|gh|ryP M4CzdFI{QDR2MEO4
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MES-SA MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? MYq3NkBp NXnndYhTTE2VTx?= NVW2VFBZUUN3ME22Mlk5QSEQvF2= Ml7oNlM5PDRyM{i=
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A204 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonFNVAh|ryP NHr4W4w4OiCq M33YSGROW09? MY\JR|UxRTFyIN88US=> MkK3NlM5PDRyM{i=
A427 NVL2enVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XaUFExKM7:TR?= MW[3NkBp MnXPSG1UVw>? NISwe2RKSzVyPUGwJO69VQ>? NFHvVIUzOzh2NECzPC=>
A431 NU[xNWRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLENVAh|ryP NVzxNVhsPzJiaB?= MmCzSG1UVw>? NX\jXYcyUUN3ME2xNEDPxE1? NGjFemEzOzh2NECzPC=>
A2780 NEfEdY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmxNEDPxE1? MkmzO|IhcA>? NIjUToZFVVOR NEL6W3VKSzVyPUGwJO69VQ>? M3H1bVI{QDR2MEO4
ARH-77 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rTS|ExKM7:TR?= NITrSYk4OiCq NFLWRoJFVVOR M1rzS2lEPTB;MUCg{txO M{\XR|I{QDR2MEO4
Be(2)C NXPqUowyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDiV|cyOCEQvF2= MY[3NkBp MmnISG1UVw>? MkOwTWM2OD1zMDFOwG0> NIrXU5czOzh2NECzPC=>
BT-20 M1TNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\4V2wyOTBizszN NELubIY4OiCq NETWTnlFVVOR MWPJR|UxRTFyIN88US=> MVGyN|g1PDB|OB?=
BxPc3 NIi5V|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWqxNEDPxE1? NGX6cGY4OiCq M4TkbmROW09? MoDhTWM2OD1zMDFOwG0> MYeyN|g1PDB|OB?=
C-4 I M2rMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TH[FExKM7:TR?= NGjVW2E4OiCq NWjJN3RJTE2VTx?= MmLmTWM2OD1zMDFOwG0> MUiyN|g1PDB|OB?=
C33A NHj1elhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUCxNEDPxE1? NVPWNlRyPzJiaB?= MnPKSG1UVw>? MV;JR|UxRTFyIN88US=> NYPoUYh6OjN6NESwN|g>
CAL-27 M2flWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1uxRVExKM7:TR?= Mlr2O|IhcA>? NHHTSZhFVVOR NGHhRpVKSzVyPUGwJO69VQ>? NXjJSJk{OjN6NESwN|g>
CAL-62 NXvOWGFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3kUWgyOCEQvF2= M1\peFczKGh? MlziSG1UVw>? MlHzTWM2OD1zMDFOwG0> MmHlNlM5PDRyM{i=
Calu-3 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXGxNEDPxE1? NHLZZ3Y4OiCq NHPRWGhFVVOR Mkf4TWM2OD1zMDFOwG0> Mmm4NlM5PDRyM{i=
CaOV3 M1rDT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELheFMyOCEQvF2= NYK5TGRTPzJiaB?= NViwdIpzTE2VTx?= MlHWTWM2OD1zMDFOwG0> MWiyN|g1PDB|OB?=
CGTHW1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfibo4yOCEQvF2= NVPGNJkyPzJiaB?= MmnlSG1UVw>? Mn\GTWM2OD1zMDFOwG0> NHnLcZMzOzh2NECzPC=>
CHL-1 MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV2xNEDPxE1? MUG3NkBp MmHZSG1UVw>? MmjYTWM2OD1zMDFOwG0> NYnQXnMzOjN6NESwN|g>
Colo320DM NXvsc3NMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfkNVAh|ryP NV7reoZ3PzJiaB?= NYLpdIQ{TE2VTx?= M{P6cWlEPTB;MUCg{txO NGWzUYYzOzh2NECzPC=>
Colo704 MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmxNEDPxE1? M2XO[VczKGh? M1vEfWROW09? M4H2OWlEPTB;MUCg{txO NEf0dXYzOzh2NECzPC=>
COR-L23 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmxNEDPxE1? NUPpeIhPPzJiaB?= NVG3TXVtTE2VTx?= M{fre2lEPTB;MUCg{txO MWKyN|g1PDB|OB?=
CRO-AP2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWWxNEDPxE1? MXi3NkBp MnvzSG1UVw>? MmDmTWM2OD1zMDFOwG0> MVGyN|g1PDB|OB?=
Daudi MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrHfoNzOTBizszN NVzEe2RQPzJiaB?= NEe5OXdFVVOR NWjxVYN{UUN3ME2xNEDPxE1? NF\IepozOzh2NECzPC=>
DOTC 24510 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jGXFExKM7:TR?= MW[3NkBp MVfEUXNQ NITSU2ZKSzVyPUGwJO69VQ>? M2TWflI{QDR2MEO4
DU-145 NFf6Wm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf3NVAh|ryP NX\lXoVoPzJiaB?= MUHEUXNQ MmHVTWM2OD1zMDFOwG0> MYSyN|g1PDB|OB?=
EB-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DsWVExKM7:TR?= MmfRO|IhcA>? MYTEUXNQ M4GyS2lEPTB;MUCg{txO NF;VVmMzOzh2NECzPC=>
EFM-19 NHrYfZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTafpFmOTBizszN NYLs[Fl6PzJiaB?= M3Xv[WROW09? MYrJR|UxRTFyIN88US=> NYjnTIhzOjN6NESwN|g>
EKVX MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r6NVExKM7:TR?= MoTsO|IhcA>? MWnEUXNQ NFz1UZdKSzVyPUGwJO69VQ>? NWnQdnJuOjN6NESwN|g>
FaDu NH\XbYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXqxNEDPxE1? MnfBO|IhcA>? MXfEUXNQ NUnEXnppUUN3ME2xNEDPxE1? Mon6NlM5PDRyM{i=
G401 NHnYcFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUCxNEDPxE1? NV7jZWxOPzJiaB?= M4jtVGROW09? NIrqN4JKSzVyPUGwJO69VQ>? NXPubm9DOjN6NESwN|g>
HCC-70 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1z1fFExKM7:TR?= NYPvdVVTPzJiaB?= M3j0XGROW09? NV;zNHdkUUN3ME2xNEDPxE1? M1L2RlI{QDR2MEO4
HCC-1954 M37ad2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M32xfVExKM7:TR?= NWXKendXPzJiaB?= MUXEUXNQ NI\LSZVKSzVyPUGwJO69VQ>? M2rN[VI{QDR2MEO4
Hela M1;jXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK2NVAh|ryP NHjudJI4OiCq NFTKO2dFVVOR Ml;qTWM2OD1zMDFOwG0> M2XVclI{QDR2MEO4
Hep3B MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUKxNEDPxE1? MlTDO|IhcA>? MYrEUXNQ NVjpWJZtUUN3ME2xNEDPxE1? MYiyN|g1PDB|OB?=
HMCB MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUWxNEDPxE1? M3HEclczKGh? NXnjVo8xTE2VTx?= NVrBPIZsUUN3ME2xNEDPxE1? M4T5fFI{QDR2MEO4
HN5 NGL2bXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn74NVAh|ryP NV\xUlhDPzJiaB?= MUDEUXNQ NHyyOlFKSzVyPUGwJO69VQ>? M{\RTlI{QDR2MEO4
HOS NYC2bmMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK1NVAh|ryP NWjHb3JFPzJiaB?= MVjEUXNQ NYfzc|Q3UUN3ME2xNEDPxE1? M4rHd|I{QDR2MEO4
HPAF-II MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnpVYIyOCEQvF2= M{[2OlczKGh? M2DWTmROW09? NETKNY1KSzVyPUGwJO69VQ>? MlTPNlM5PDRyM{i=
Hs746.T MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\4d3kyOCEQvF2= NIjBVZk4OiCq NFu4T41FVVOR NYnZR21{UUN3ME2xNEDPxE1? Mo\mNlM5PDRyM{i=
HT NESxUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHPNVAh|ryP MYW3NkBp MVnEUXNQ NYDI[FNVUUN3ME2xNEDPxE1? M3jSOVI{QDR2MEO4
HT-3 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXO[VEyOCEQvF2= M1rKNVczKGh? MnztSG1UVw>? M3rw[GlEPTB;MUCg{txO NYHEUJU5OjN6NESwN|g>
HuNS-1 NE\lZ|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnlfmsyOCEQvF2= Mnr6O|IhcA>? MkjrSG1UVw>? MlXQTWM2OD1zMDFOwG0> NVnoTVREOjN6NESwN|g>
IGROV1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\PPVVGOTBizszN Ml;6O|IhcA>? NVe4elVITE2VTx?= MWjJR|UxRTFyIN88US=> M3PxXlI{QDR2MEO4
J82 NFXvfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfxNVAh|ryP NHTQdIU4OiCq MYXEUXNQ NYTtcpNQUUN3ME2xNEDPxE1? NEX1eWIzOzh2NECzPC=>
JM1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrhWpEyOCEQvF2= MUm3NkBp NFvPbHBFVVOR NV3Oc2VxUUN3ME2xNEDPxE1? NVrZ[HpXOjN6NESwN|g>
Kato III MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorFNVAh|ryP NW\2Znh7PzJiaB?= NWPkXJVqTE2VTx?= M{Hmb2lEPTB;MUCg{txO Mlv6NlM5PDRyM{i=
KHOS-240S MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLlbZVmOTBizszN M4LJV|czKGh? M1XDNWROW09? NHTNc3VKSzVyPUGwJO69VQ>? NWj0WpYxOjN6NESwN|g>
KM-12 M1rmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r2VVExKM7:TR?= NX7Ob|J6PzJiaB?= MkXvSG1UVw>? MXnJR|UxRTFyIN88US=> MXmyN|g1PDB|OB?=
KPL-1 MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnoSoMyOCEQvF2= NI\3Tmk4OiCq MoTISG1UVw>? NYrtb2t[UUN3ME2xNEDPxE1? MVSyN|g1PDB|OB?=
KYSE-30 M2LId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW1fW9vOTBizszN Mnq2O|IhcA>? NIDWRmRFVVOR NET1PXlKSzVyPUGwJO69VQ>? NH7C[mczOzh2NECzPC=>
LNCaP Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqzNVAh|ryP M3X4b|czKGh? Mnq1SG1UVw>? MYTJR|UxRTFyIN88US=> NHnNSoEzOzh2NECzPC=>
MCF-7 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH2N|RoOTBizszN M{fWeVczKGh? NHW3dIVFVVOR MVnJR|UxRTFyIN88US=> NFfUV|kzOzh2NECzPC=>
MC-IXC NHLWPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrTV|BLOTBizszN MkW3O|IhcA>? M4XBR2ROW09? M4fzcWlEPTB;MUCg{txO NXfvc3NIOjN6NESwN|g>
MDA-MB-175 VII Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVuxNEDPxE1? NEPCZ4U4OiCq NELVeo5FVVOR M3zyVmlEPTB;MUCg{txO M1TMcFI{QDR2MEO4
MDA-MB-468 MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rQT|ExKM7:TR?= Mmi0O|IhcA>? NUDJdI5VTE2VTx?= MVPJR|UxRTFyIN88US=> NI\OfmYzOzh2NECzPC=>
MiaPaCa M2raS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS0NVAh|ryP Mm\NO|IhcA>? NXLFdIkzTE2VTx?= MWDJR|UxRTFyIN88US=> Ml\PNlM5PDRyM{i=
Molt-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTFcpEyOCEQvF2= MXi3NkBp MXnEUXNQ MVjJR|UxRTFyIN88US=> MmPLNlM5PDRyM{i=
NCI-ADR/RES NHLCTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH23VHEyOCEQvF2= Mo\XO|IhcA>? NX:yUlZITE2VTx?= Mof0TWM2OD1zMDFOwG0> MoHXNlM5PDRyM{i=
NCI-H69 M4\WOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3iVoEyOCEQvF2= Mn3aO|IhcA>? MWjEUXNQ MmHuTWM2OD1zMDFOwG0> NVjBblJlOjN6NESwN|g>
NCI-H82 M3y5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjVbGwyOCEQvF2= MUO3NkBp MXrEUXNQ M3PKZWlEPTB;MUCg{txO NGnleoMzOzh2NECzPC=>
NCI-N87 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLHRmN{OTBizszN M2HiN|czKGh? MWHEUXNQ MkLVTWM2OD1zMDFOwG0> Mo[0NlM5PDRyM{i=
NCI-H146 MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrwUJcyOCEQvF2= M3fINVczKGh? MnvCSG1UVw>? MmLhTWM2OD1zMDFOwG0> MVWyN|g1PDB|OB?=
NCI-H157 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYexNEDPxE1? NVzjeY92PzJiaB?= M{jzO2ROW09? M{\HT2lEPTB;MUCg{txO MWiyN|g1PDB|OB?=
NCI-H187 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTrdHlEOTBizszN MX63NkBp NUTxRppvTE2VTx?= M4LmfWlEPTB;MUCg{txO NFvyTJMzOzh2NECzPC=>
NCI-H209 NUHDc2x4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X1SVExKM7:TR?= MmnEO|IhcA>? NVzRXVJKTE2VTx?= NVXhRpRbUUN3ME2xNEDPxE1? NUHaSHlwOjN6NESwN|g>
NCI-H226 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLTNVAh|ryP MUO3NkBp NIewSo1FVVOR NV3lRpNQUUN3ME2xNEDPxE1? Mn2yNlM5PDRyM{i=
NCI-H292 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjFVJEyOCEQvF2= MX:3NkBp NHGwTGtFVVOR MWXJR|UxRTFyIN88US=> M{[3NFI{QDR2MEO4
NCI-H322 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnxT5AyOCEQvF2= MVe3NkBp MXjEUXNQ MnP1TWM2OD1zMDFOwG0> MV2yN|g1PDB|OB?=
NCI-H358 NG\MOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV6xNEDPxE1? M1;Y[lczKGh? NIjtT|RFVVOR NG\iUlRKSzVyPUGwJO69VQ>? MVKyN|g1PDB|OB?=
NCI-H520 M2K5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX3NVAh|ryP NI\JWVY4OiCq MVXEUXNQ NYLKZphJUUN3ME2xNEDPxE1? NVzvcXR1OjN6NESwN|g>
NCI-H526 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXKxNEDPxE1? MmHLO|IhcA>? NVXZ[|Y3TE2VTx?= MYTJR|UxRTFyIN88US=> NGDLfVkzOzh2NECzPC=>
NCI-H630 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHEZm5KOTBizszN Mnr2O|IhcA>? MVLEUXNQ M2rvXmlEPTB;MUCg{txO MmXHNlM5PDRyM{i=
NCI-H661 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPlcG81OTBizszN NFuyU5M4OiCq MUfEUXNQ MkHhTWM2OD1zMDFOwG0> NHXpd3AzOzh2NECzPC=>
NCI-H716 NVXIcHRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHaSJJYOTBizszN NGHidI04OiCq MnW2SG1UVw>? NGXZd25KSzVyPUGwJO69VQ>? M4PrSlI{QDR2MEO4
NCI-H1563 M3vYUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVexNEDPxE1? NXftN3V6PzJiaB?= MlS0SG1UVw>? NYDZR3oyUUN3ME2xNEDPxE1? M2Plb|I{QDR2MEO4
NCI-H1792 M4rQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi2NVAh|ryP MWm3NkBp MlvlSG1UVw>? MmfjTWM2OD1zMDFOwG0> M3nHbVI{QDR2MEO4
NCI-H2030 NEXZRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[xNEDPxE1? Mn;1O|IhcA>? MUXEUXNQ M1PO[2lEPTB;MUCg{txO M3eyTlI{QDR2MEO4
NCI-H2052 NEHr[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SxZlExKM7:TR?= MYS3NkBp MX\EUXNQ NV;XVZA1UUN3ME2xNEDPxE1? M2DVPFI{QDR2MEO4
NCI-H2122 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXyxNEDPxE1? MlTqO|IhcA>? NYrPSJdsTE2VTx?= NXXrfVg4UUN3ME2xNEDPxE1? MoP2NlM5PDRyM{i=
NCI-H2228 NIq5UGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWixNEDPxE1? NFK0fWc4OiCq Mo\0SG1UVw>? MVTJR|UxRTFyIN88US=> MkjzNlM5PDRyM{i=
OE-19 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fkcFExKM7:TR?= MmfOO|IhcA>? MoPGSG1UVw>? NHLWVldKSzVyPUGwJO69VQ>? MWGyN|g1PDB|OB?=
OE-21 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zBS|ExKM7:TR?= NHG1XJY4OiCq NVr4SI9QTE2VTx?= MYnJR|UxRTFyIN88US=> Mk\yNlM5PDRyM{i=
OE-33 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\3c|ExKM7:TR?= NFOxWJY4OiCq NFSzN3pFVVOR M3rNbGlEPTB;MUCg{txO M4T5SVI{QDR2MEO4
OVCAR-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;zNVAh|ryP MkCyO|IhcA>? NIH0[VJFVVOR MWLJR|UxRTFyIN88US=> M3PrUlI{QDR2MEO4
OVCAR-4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXE[4oxOTBizszN MYm3NkBp M4nRW2ROW09? NV2w[YFMUUN3ME2xNEDPxE1? M2fkU|I{QDR2MEO4
OVCAR-5 NYTt[|Z6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G2TVExKM7:TR?= MXm3NkBp NGXvPJdFVVOR NXTyVZdVUUN3ME2xNEDPxE1? M3GxVFI{QDR2MEO4
P3HR-1 MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYKxNEDPxE1? NYHJcHFrPzJiaB?= MWrEUXNQ NIDjdmlKSzVyPUGwJO69VQ>? NWHNT4NROjN6NESwN|g>
PC-3 NYrZN|dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:yV2hHOTBizszN MkizO|IhcA>? MX;EUXNQ NWHUUm5MUUN3ME2xNEDPxE1? NWrIVZE2OjN6NESwN|g>
Raji MkTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rDe|ExKM7:TR?= NXHRR5h3PzJiaB?= NY\2cVNsTE2VTx?= MnnDTWM2OD1zMDFOwG0> MV:yN|g1PDB|OB?=
RD NYrYb4cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHy5[ocyOCEQvF2= MYi3NkBp NH2xSXVFVVOR NVnISHhuUUN3ME2xNEDPxE1? NIXab2kzOzh2NECzPC=>
RD-ES NVHpSpJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHxW5FtOTBizszN M3jPZVczKGh? M1zabGROW09? NUfxdHFOUUN3ME2xNEDPxE1? MXmyN|g1PDB|OB?=
RL MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\PVJlNOTBizszN M1TpXFczKGh? MmXrSG1UVw>? M1rNXGlEPTB;MUCg{txO M3jLTVI{QDR2MEO4
SaOS2 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\GNVAh|ryP NHW1WXY4OiCq NV[zV4hTTE2VTx?= NF7rXVNKSzVyPUGwJO69VQ>? NVrm[Ih1OjN6NESwN|g>
SCC-9 NUnxW4x4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljXNVAh|ryP M3ntXlczKGh? NYTsRYtWTE2VTx?= NFjTPY1KSzVyPUGwJO69VQ>? MU[yN|g1PDB|OB?=
SCC-12 NH3Oe4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXToblVWOTBizszN NXzaSIpoPzJiaB?= MVLEUXNQ MXPJR|UxRTFyIN88US=> M1LCelI{QDR2MEO4
SCC-13 NFvFSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTUZotoOTBizszN NV\yT4lsPzJiaB?= NUHib442TE2VTx?= MX;JR|UxRTFyIN88US=> MkDzNlM5PDRyM{i=
SCC-15 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzPfYwyOCEQvF2= MojhO|IhcA>? MmK0SG1UVw>? MY\JR|UxRTFyIN88US=> M{jnNFI{QDR2MEO4
SCC-25 NX3GPFd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHrNVAh|ryP NX;GRnNVPzJiaB?= MYrEUXNQ M4nzb2lEPTB;MUCg{txO MXGyN|g1PDB|OB?=
SCLC-3 NVLQdVNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHnNVAh|ryP MnTrO|IhcA>? NXS2boZQTE2VTx?= NHvQOlhKSzVyPUGwJO69VQ>? NVPQ[ZdrOjN6NESwN|g>
SF-268 NWfXWJh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;mNVAh|ryP MkTqO|IhcA>? M3vFVWROW09? NGe4NHlKSzVyPUGwJO69VQ>? NIDje3EzOzh2NECzPC=>
SF-295 M2jYW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WxflExKM7:TR?= NXXTfpA6PzJiaB?= NV\HVZZbTE2VTx?= MlPoTWM2OD1zMDFOwG0> MUGyN|g1PDB|OB?=
SJRH30 NXXRSoU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Xc29XOTBizszN MV63NkBp MVfEUXNQ M2jzb2lEPTB;MUCg{txO MorVNlM5PDRyM{i=
SK-BR-3 NIKzNWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK5NVAh|ryP MojxO|IhcA>? MV3EUXNQ NWDBPG9QUUN3ME2xNEDPxE1? NHjvN4szOzh2NECzPC=>
SK-LMS-1 MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEW1OpQyOCEQvF2= NG\tdJU4OiCq MoLYSG1UVw>? M2\DdWlEPTB;MUCg{txO NFHPO5MzOzh2NECzPC=>
SK-N-DZ Mor0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XCUFExKM7:TR?= NEXLb|U4OiCq MVnEUXNQ MVvJR|UxRTFyIN88US=> NHrHb4UzOzh2NECzPC=>
SK-N-F1 NUHZTWk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\HU40yOCEQvF2= NIXXNVU4OiCq MV3EUXNQ NHPacm9KSzVyPUGwJO69VQ>? M{jvfFI{QDR2MEO4
SKOV-3 MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Pwc|ExKM7:TR?= NITDdXY4OiCq NHrjR4JFVVOR NEj2OXVKSzVyPUGwJO69VQ>? MXiyN|g1PDB|OB?=
SK-UT-1 NV7PWpl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjtUXgyOCEQvF2= NHu3UpE4OiCq NILvUYxFVVOR MmDPTWM2OD1zMDFOwG0> MljVNlM5PDRyM{i=
SN12C MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTmcYJ3OTBizszN MYG3NkBp MVTEUXNQ M{TuXGlEPTB;MUCg{txO NVv1WGVwOjN6NESwN|g>
SNB-19 NUHVd4o3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUexNEDPxE1? MVS3NkBp MX;EUXNQ M3;xe2lEPTB;MUCg{txO NGXIcIgzOzh2NECzPC=>
SNU-5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorCNVAh|ryP MVK3NkBp NY\qXG51TE2VTx?= NXnuSnVOUUN3ME2xNEDPxE1? NFm3R4szOzh2NECzPC=>
SNU-16 M{OyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;HR3pLOTBizszN M1jMWFczKGh? M{O2[WROW09? M1TCeGlEPTB;MUCg{txO NHLVfmIzOzh2NECzPC=>
SNU-398 NIfu[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moi2NVAh|ryP M1z0NVczKGh? M4LHNGROW09? NF21bI1KSzVyPUGwJO69VQ>? NUj1ZZJ2OjN6NESwN|g>
SNU-449 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfjNHUyOCEQvF2= NGGy[ow4OiCq NFHOTXVFVVOR NWHvPXFLUUN3ME2xNEDPxE1? Mn;ONlM5PDRyM{i=
SR MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32zelExKM7:TR?= MYe3NkBp M3KybmROW09? NYnsUVl5UUN3ME2xNEDPxE1? M2jpZ|I{QDR2MEO4
ST486 NV\DfXExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37TZlExKM7:TR?= NHT1eIs4OiCq Ml7vSG1UVw>? M37vW2lEPTB;MUCg{txO NVvoXGlUOjN6NESwN|g>
SW579 M{nDWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILRcYgyOCEQvF2= NXz5WWZEPzJiaB?= MkS1SG1UVw>? NFftdGxKSzVyPUGwJO69VQ>? MmHJNlM5PDRyM{i=
SW684 MmnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH62O2QyOCEQvF2= NIHsU5Y4OiCq MnPrSG1UVw>? NYrSTmZzUUN3ME2xNEDPxE1? NIfOcXEzOzh2NECzPC=>
SW-780 Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TQSFExKM7:TR?= Mn7QO|IhcA>? M{PGPWROW09? MXzJR|UxRTFyIN88US=> MXGyN|g1PDB|OB?=
SW900 NXSyU|FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrnenoyOCEQvF2= NEXl[oE4OiCq Mkj0SG1UVw>? NXzKfllPUUN3ME2xNEDPxE1? MoD5NlM5PDRyM{i=
SW1088 M{DQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\PRlExKM7:TR?= M2fZOlczKGh? MYfEUXNQ MmGyTWM2OD1zMDFOwG0> MUmyN|g1PDB|OB?=
SW1463 NVPaWVN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXixNEDPxE1? M1i4UVczKGh? MXnEUXNQ MWDJR|UxRTFyIN88US=> MVeyN|g1PDB|OB?=
SW1990 MkTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDiNpFpOTBizszN NF7wPWI4OiCq NWHkb3BUTE2VTx?= NFLPUHRKSzVyPUGwJO69VQ>? M2\hUFI{QDR2MEO4
T47D MlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjYOI0yOCEQvF2= Mm\MO|IhcA>? MV7EUXNQ NFjUZ4VKSzVyPUGwJO69VQ>? M1K4SVI{QDR2MEO4
TE381.T NVHLNoFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;SfWRjOTBizszN NHrnNFM4OiCq NEe3TppFVVOR MofyTWM2OD1zMDFOwG0> M33WZlI{QDR2MEO4
TK-10 M1rPbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi1RpREOTBizszN M{m1elczKGh? NIjHSHhFVVOR M3nYUGlEPTB;MUCg{txO MojmNlM5PDRyM{i=
U2OS NI\USotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvDVmhCOTBizszN M2\NZVczKGh? NFXWbmtFVVOR MVXJR|UxRTFyIN88US=> MlzBNlM5PDRyM{i=
U251 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLSNVAh|ryP MmjIO|IhcA>? MVnEUXNQ M3PHeWlEPTB;MUCg{txO NYTFWY1kOjN6NESwN|g>
UACC-812 MonQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[xNEDPxE1? M1LJdFczKGh? NWL5OlVNTE2VTx?= NE[ybW1KSzVyPUGwJO69VQ>? M{nUdFI{QDR2MEO4
YAPC NYj5OGJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXpNVAh|ryP M{TvOlczKGh? MX7EUXNQ M4S4SGlEPTB;MUCg{txO NE\xc20zOzh2NECzPC=>
ZR-75-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? NYK2botMPzJiaB?= M2PrSWROW09? NX3xdnFHUUN3ME2xNEDPxE1? M4XTTFI{QDR2MEO4
A375 NECz[HRHfW6ldHnvckBie3OjeR?= MlfxNU4zKM7:TR?= NFLTXHU1KGh? NXvEZZI5TE2VTx?= MYHJcohq[mm2aX;uJI9nKHCqb4PwbI9zgWyjdHnvckBw\iCPRVusJGVTUyxiYX7kJHM3WA>? NHHMflczOjN6OUS3NS=>
YUSIT1 NFLUfIxHfW6ldHnvckBie3OjeR?= M{HnNmROW09? NYSzSmFQemWmdXPl[EB{\W6|aYTpeol1gSC5aYToJGlEPTBiPjCwMlUh|ryP MYGyNlM5QTR5MR?=
MeWo M1rqR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFO5b|BFVVOR NE\aNZhKSzVyIE2gPVg4KG6P NIGzTVQzPjBzOEWyOC=>
WiDr Mm\xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoTOSG1UVw>? NHSwTWVKSzVyIE2gO|Yhdk1? Mmf6NlYxOTh3MkS=
Colo-205 M4i1UWZ2dmO2aX;uJIF{e2G7 MXSxJO69VQ>? NGfkSFM1KGR? NYDvcpV6TE2VTx?= M1:4VWlv\HWlZXSgZUBpcWeqbImgZ49ueGG{YXLs[UBkd22yYXP0bY9vKHCqZX7veJlx\Q>? MXKyOVM5OTF3Mh?=
RBW-1 Ml\WSpVv[3Srb36gZZN{[Xl? MUexJO69VQ>? MXnEUXNQ NWHLR4ZZVm9icnXkeYN1cW:wIH;mJG1mcyBzL{KgdIhwe3Cqb4L5cIF1cW:w NXTLVI01OjR6OEW2PVA>
RBO-1 NUXrepJLTnWwY4Tpc44h[XO|YYm= NXuzUFlZOSEQvF2= MoqwSG1UVw>? M4HufGlvcGmkaYTpc44hd2ZiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> MVOyOFg5PTZ7MB?=
RBO-2 MXHGeY5kfGmxbjDhd5NigQ>? MVKxJO69VQ>? NVn3TVdYTE2VTx?= MkD6TY5pcWKrdHnvckBw\iBiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> M{X4SlI1QDh3Nkmw
RBOW NXTpbXZ1TnWwY4Tpc44h[XO|YYm= NIjqUlkyKM7:TR?= MlrRSG1UVw>? MY\Jcohq[mm2aX;uJI9nKCCPZXugNU8zKHCqb4PwbI9zgWyjdHnvci=> NXjOS2E3OjR6OEW2PVA>
M257 NXfyVnA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTmdFkyODBibl2= NYD6eZhvPzJiaB?= NEjlN21Fd2W|IH7veEBqdmirYnn0JJBzd2yrZnXyZZRqd25ib3[gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= NHLiT4EzOzNzN{S0Oi=>
LCP MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\MWVExOCCwTR?= NGDKSXk4OiCq M1zaXWlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCOQ2CgZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMGKgcZV1[W62YYTpc44> MUCyN|MyPzR2Nh?=
WM266 M{Pm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1v4WlExOCCwTR?= M3raPVczKGh? MYfJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhX01{Nk[gZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMVSgcZV1[W62YYTpc44> M3LZOlI{OzF5NES2
M257 M3vUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;SNVAxKG6P MnnPO|IhcA>? NUS2O4t4TG:nczDuc5QhcW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG NGewcWwzOzNzN{S0Oi=>
LCP NX\L[lc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFiyb3gyODBibl2= MlniO|IhcA>? M1LGT2lvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDMR3Ah[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNHIhdXW2YX70ZZRqd25? M3WxU|I{OzF5NES2
WM266 NWPycnhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DJblExOCCwTR?= MXG3NkBp MkHBTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFBFKG23dHHueIF1cW:w NXXBe4JzOjN|MUe0OFY>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pMEK / pERK / ERK; 

PubMed: 31158244     


Cell lines as shown were treated with dabrafenib, over a dose range, for 1 hour. UT = untransfected.  Expression and/or phosphorylation of the indicated proteins were assessed by immunoblot.

p-S6 / p-AKT308 / p-AKT473; 

PubMed: 24735930     


Western blot analysis of phosphorylated proteins in MAPK and the PI3K-AKT pathway after 24 hours exposure to increasing concentrations of dabrafenib.

β-catenin; 

PubMed: 29167314     


HT-29 cells were treated with BRAF inhibitors Dabrafenib (2 μM), GDC-0879 (4 μM) or Vemurafenib (2 μM) for indicated times. The whole cell lysates were used for western blot with indicated antibodies.

31158244 24735930 29167314
Growth inhibition assay
IC50; 

PubMed: 24735930     


A panel of 23 BRAF(V600) mutant human melanoma cell lines was treated with serial dilutions (1-10,000 nM) of dabrafenib (A) for 72-120 hours to assess cell viability. The bars represent the average IC50 value of two or more independent experiments in duplicates and the error bars represent the SEM. 

24735930
In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
8 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059224 Recruiting Drug: Trametinib|Drug: Dabrafenib Stage IV Melanoma|Stage III Melanoma Universitair Ziekenhuis Brussel January 28 2019 Phase 2
NCT03668431 Recruiting Drug: Dabrafenib|Drug: Trametinib|Drug: PDR001 Metastatic Colorectal Cancer Massachusetts General Hospital|Novartis|Stand Up To Cancer October 15 2018 Phase 2
NCT03553329 Completed Drug: dabrafenib Unresecable Stage IIIc or IV Melanoma Poitiers University Hospital June 2 2018 --
NCT03593993 Recruiting Procedure: Surgical Cohort Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Musella Foundation May 19 2018 --
NCT03340506 Recruiting Drug: dabrafenib|Drug: trametinib Melanoma|Non Small Cell Lung Cancer|Solid Tumor|Rare Cancers|High Grade Glioma Novartis Pharmaceuticals|Novartis December 28 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID