PDE3 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1294 Cilostazol

Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Selective PDE3, IC50: 0.2 μM
S1550 Pimobendan

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.

Selective PDE3, IC50: 0.32 μM
S2484 Milrinone

Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.

Pan PDE3, IC50: 2.1 μM
S2320 Luteolin

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

Pan PDE3, Ki: 13.9 μM
S4090 Fenspiride HCl

Fenspiride is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.

Pan PDE3, pIC50: 3.44