PDE3 Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
|Selective||PDE3, IC50: 0.2 μM|
Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
|Selective||PDE3, IC50: 0.32 μM|
Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
|Pan||PDE3, IC50: 2.1 μM|
Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
|Pan||PDE3, Ki: 13.9 μM|
Fenspiride is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.
|Pan||PDE3, pIC50: 3.44|
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