PDE3 Selective Inhibitors | Activators

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S9229	Linderane	Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.	Selective
S5806	Cilostamide	Cilostamide (OPC 3689) is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively.	Selective	PDE3A, IC50: 27 nM; PDE3B, IC50: 50 nM
S1294	Cilostazol (OPC-13013)	Cilostazol (Pletal,OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.	Selective	PDE3, IC50: 0.2 μM
S1550	Pimobendan	Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.	Selective	PDE3, IC50: 0.32 μM
S5539	Olprinone	Olprinone is a phosphodiesterase III (PDE3) inhibitor with IC50 values of 0.35 mM, 150 mM and 100 mM for human cardiac PDE III, PDE I and PDE II, respectively.	Selective	PDE3, IC50: 0.35 mM
S6433	Udenafil	Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs.	Pan	PDE3, IC50: 52 nM
S2484	Milrinone	Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.	Pan	PDE3, IC50: 2.1 μM
S5836	IBMX	IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist.	Pan	PDE3, IC50: 6.5 μM
S2320	Luteolin	Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.	Pan	PDE3, Ki: 13.9 μM
S4090	Fenspiride HCl	Fenspiride(Decaspiride) is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.	Pan	PDE3, pIC50: 3.44