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Rolipram (ZK-62711)

Name: Rolipram (ZK-62711)
Brand: Selleck Chemicals
SKU: S1430
Rating: 5 (17 reviews)

Catalog No.S1430 Synonyms: SB 95952

For research use only.

The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.

CAS No. 61413-54-5

Selleck's Rolipram (ZK-62711) has been cited by 17 publications

Purity & Quality Control

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PDE Signaling Pathway Map

Biological Activity

Description

Targets

PDE4B ^[1] (Cell-free assay)	PDE4D ^[1] (Cell-free assay)
130 nM	240 nM

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Sf9 cells	MUDGeY5kfGmxbjDhd5NigQ>?	NETuTVhKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGDESVRCKGW6cILld5Nm\CCrbjDT[lkh[2WubIOsJGlEPTB;NDDuUS=>	NXflS\|c4OTFyNUK3PFU>
human PBMC	NHzNR4FHfW6ldHnvckBie3OjeR?=	NGjleHlKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTmGucHjhJJBzd2S3Y4Tpc44hcW5iaIXtZY4hWEKPQzygTWM2OD1yLkC2JO69VQ>?	M4PKeFE6ODR7M{S5
COS7 cells	NF7jXJhHfW6ldHnvckBie3OjeR?=	NGTUOVhKdmirYnn0bY9vKG:oIGDESVRDOiCneIDy[ZN{\WRiaX6gR29UPyClZXzsd{Bie3Onc4Pl[EBieyClQV3QJIh6\HKxbInzbZMtKEmFNUC9NE4yODVizszN	NUHyS2Y5OTh{MkKwPFg>
HEK293 cells	M{f2NmZ2dmO2aX;uJIF{e2G7	NIfP[FNKdmirYnn0bY9vKG:oIGDESVQh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsd{Bkd2W6cILld5NqdmdiRz3wdo91\WmwIHPveZBt\WRicnXj[ZB1d3JiYX7kJIN6[2yrYzDueYNt\W:2aXTlJIdifGWmIHnvckBkcGGwbnXsJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiRVO1NF0xNjF\|MUWg{txO	M2XRRlE6PDZ2OEi2
rat UMR106 cells	MoLuSpVv[3Srb36gZZN{[Xl?	NH\1[pNKdmirYnn0bY9vKG:oIGDESUBqdiC{YYSgWW1TOTB4IHPlcIx{KGOxLXX4dJJme3OrbnegR3JGNWy3YzDhd5Nme3OnZDDhd{BRXEhvaX7keYNm\CClQV3QJIFk[3WvdXzheIlwdiCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE43KM7:TR?=	NWDaN4VqOjJyM{CwN\|A>
human U937 cells	M3XLW2Z2dmO2aX;uJIF{e2G7	NGHuUY1KdmirYnn0bY9vKG:oIGDESVQhcW5iaIXtZY4hXTl\|NzDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44hd2ZiW{PIYYFl\W6xc3nu[UBjgSC\|Y3nueIltdGG2aX;uJINwfW62aX7nMEBKSzVyPUCuPFYh\|ryP	MnvUNVk{ODN{OUC=

Click to View More Cell Line Experimental Data

Protocol (from reference)

References

[1] MacKenzie SJ, et al. Biochem J. 2000, 347(Pt 2):571-8.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight	275.34
Formula	C₁₆H₂₁NO₃
CAS No.	61413-54-5
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

Download Rolipram (ZK-62711) SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01215552	Terminated	Drug: HT-0712	Healthy Elderly Volunteers	Dart NeuroScience LLC	September 2010	Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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