Rolipram (ZK-62711)

Catalog No.S1430 Synonyms: SB 95952

For research use only.

The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.

Rolipram (ZK-62711) Chemical Structure

CAS No. 61413-54-5

Selleck's Rolipram (ZK-62711) has been cited by 17 publications

Purity & Quality Control

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Biological Activity

Description The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.
Targets
PDE4B [1]
(Cell-free assay)
PDE4D [1]
(Cell-free assay)
130 nM 240 nM
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells MUDGeY5kfGmxbjDhd5NigQ>? NETuTVhKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGDESVRCKGW6cILld5Nm\CCrbjDT[lkh[2WubIOsJGlEPTB;NDDuUS=> NXflS|c4OTFyNUK3PFU>
human PBMC NHzNR4FHfW6ldHnvckBie3OjeR?= NGjleHlKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTmGucHjhJJBzd2S3Y4Tpc44hcW5iaIXtZY4hWEKPQzygTWM2OD1yLkC2JO69VQ>? M4PKeFE6ODR7M{S5
COS7 cells NF7jXJhHfW6ldHnvckBie3OjeR?= NGTUOVhKdmirYnn0bY9vKG:oIGDESVRDOiCneIDy[ZN{\WRiaX6gR29UPyClZXzsd{Bie3Onc4Pl[EBieyClQV3QJIh6\HKxbInzbZMtKEmFNUC9NE4yODVizszN NUHyS2Y5OTh{MkKwPFg>
HEK293 cells M{f2NmZ2dmO2aX;uJIF{e2G7 NIfP[FNKdmirYnn0bY9vKG:oIGDESVQh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bkd2W6cILld5NqdmdiRz3wdo91\WmwIHPveZBt\WRicnXj[ZB1d3JiYX7kJIN6[2yrYzDueYNt\W:2aXTlJIdifGWmIHnvckBkcGGwbnXsJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiRVO1NF0xNjF|MUWg{txO M2XRRlE6PDZ2OEi2
rat UMR106 cells MoLuSpVv[3Srb36gZZN{[Xl? NH\1[pNKdmirYnn0bY9vKG:oIGDESUBqdiC{YYSgWW1TOTB4IHPlcIx{KGOxLXX4dJJme3OrbnegR3JGNWy3YzDhd5Nme3OnZDDhd{BRXEhvaX7keYNm\CClQV3QJIFk[3WvdXzheIlwdiCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE43KM7:TR?= NWDaN4VqOjJyM{CwN|A>
human U937 cells M3XLW2Z2dmO2aX;uJIF{e2G7 NGHuUY1KdmirYnn0bY9vKG:oIGDESVQhcW5iaIXtZY4hXTl|NzDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44hd2ZiW{PIYYFl\W6xc3nu[UBjgSC|Y3nueIltdGG2aX;uJINwfW62aX7nMEBKSzVyPUCuPFYh|ryP MnvUNVk{ODN{OUC=

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 275.34
Formula

C16H21NO3

CAS No. 61413-54-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01215552 Terminated Drug: HT-0712 Healthy Elderly Volunteers Dart NeuroScience LLC September 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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