BRL-50481

Catalog No.S5837

BRL-50481 Chemical Structure

Molecular Weight(MW): 244.27

BRL-50481 is a novel and selective inhibitor of phosphodiesterase (PDE) 7 with a Ki value, derived from secondary (Dixon) plots, of 180±10 nM, being at least 200-fold selective for hrPDE7A1 over all other PDEs.

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Description BRL-50481 is a novel and selective inhibitor of phosphodiesterase (PDE) 7 with a Ki value, derived from secondary (Dixon) plots, of 180±10 nM, being at least 200-fold selective for hrPDE7A1 over all other PDEs.
Targets
PDE7 [1]
()

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: MOLT-4 T cells
  • Concentrations: 10-300 μM
  • Incubation Time: 30 min
  • Method:

    Cells are treated for 30 min with BRL 50481 (10-300 μM), rolipram (100nM-100 μM), and rolipram (10 μM) in the presence of BRL 50481 (10-300 μM). The cAMP content was then determined by immunospecific ELISA.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 49 mg/mL (200.59 mM)
Ethanol 49 mg/mL (200.59 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.27
Formula

C9H12N2O4S

CAS No. 433695-36-4
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID