• PDE1
  • PDE2
  • PDE3
  • PDE4
  • PDE5
  • PDE6
  • PDE10A
  • PDE9
  • PDE4B

PDE9 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S0039 BI-409306 BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents. Selective human PDE9A, IC50: 65 nM; rat PDE9A, IC50: 168 nM