4-Hydroxytamoxifen (Afimoxifene)

Catalog No.S7827 Synonyms: Afimoxifene

For research use only.

4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS No. 68392-35-8

Selleck's 4-Hydroxytamoxifen (Afimoxifene) has been cited by 12 Publications

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Biological Activity

Description 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.
In vitro

4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes[1]. 4-HT activates on-target modification frequency for intein-Cas9 variants [3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells NGHYdWlRem:uaX\ldoF1cW:wIHHzd4F6 NGLmbXJKdmirYnn0bY9vKG:oIHXzeJJw\2WwLYP0bY12dGG2ZXSgUWNHNTdiY3XscEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwNTDuUS=> M17sbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl3NEi4NVcoRjl3NEi4NVc9N2F-
MCF7 MoDqSpVv[3Srb36gZZN{[Xl? MlezSYZn\WO2aY\lJIRwe2ViZn;yJHs{UF1vIHXzeJJi\GmxbDDh[4FqdnO2IIDyc4xq\mW{YYTpc44hd2ZiTVPGMVch[2WubIOsJGVEPTBiPTCwMlAxODB|IN88UU4> M3Sw[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nkm2PFEoRjJ5Nkm2PFE9N2F-
MCF7 NX7HU4R5TnWwY4Tpc44h[XO|YYm= NUjsbVhDPCCqcoO= MVnJcoR2[3Srb36gc4YhTVKjbIDoZUBl\We{YXTheIlwdiCrbjDoeY1idiCPQ1[3JINmdGy|IHnuJJBp\W6xbDDy[YQh\nKnZTDSVG1KKG2nZHn1cUBkd262YXnubY5oKDVnIHPoZZJkd2GuIHTlfJRz[W5vdILlZZRm\CCIQmOgbY5kfWKjdHXkJIZweiB2IHjyd{BjgSCVUEGgZY5lKGGwdHmtSXIhemGkYnn0JI1wdm:lb3zuZYwh[W62aXLv[Jkh[mG|ZXSgbY4u[2WubDDX[ZN1\XKwIHHzd4F6NCCDY4Tpeol1gSB;IECuNFAxOSEQvF2u NIPHfoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC4OlYzPid-M{CwPFY3OjZ:L3G+
MCF7 NEf5T|ZHfW6ldHnvckBie3OjeR?= M3K1bmVn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiTVPGMVch[nKnYYP0JJR2dW:{IHPlcIx{KHW|aX7nJG1ETi15IHHzd4F6NCCHQ{WwJF0hOC5yMECxNkDPxE1w MonqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
MCF7 M1nhZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NUDJOItpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzMEBKSzVyIE2gNE4xODB3IN88UU4> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjRyNUK4Okc,OjJ2MEWyPFY9N2F-
MCF7 MWrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NH3kc41CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOsJGlEPTBiPTCwMlAxODV|NzFOwG0v NInqUWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|AyOid-Mk[0NFcxOTJ:L3G+
MCF MYTGeY5kfGmxbjDhd5NigQ>? MlPXRY51[WexbnnzeEBi[3Srdnn0fUBifCCycn;n[ZN1\XKxbnWgdoVk\XC2b4KgbY4hcHWvYX6gUWNHKGOnbHzzJIF{e2W|c3XkJIF{KGW|dILh[IlwdC2rbnT1Z4VlKHKnY3XweI9zKHKnc4DvcpNmNCCLQ{WwJF0hOC5yMEC3PVQ{KM7:TT6= NUn6e21sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NFcxOTJpPkK2OFA4ODF{PD;hQi=>
Ishikawa endometrial cells MljvSpVv[3Srb36gZZN{[Xl? NWjnNXFLSWexbnnzeEBi[3Srdnn0fUBieyCjbHvhcIlv\SCyaH;zdIhifGG|ZTDpcoR2[3Srb36gbY4hUXOqaXvhe4Eh\W6mb33leJJq[WxiY3XscJMh[2:vcHHy[YQhfG9iRUKsJGVEPTBiPTCwMlAxODhizszNMi=> NGK0U4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUO4NFIxQCd-MUWzPFAzODh:L3G+
MCF7 MnvsSpVv[3Srb36gZZN{[Xl? NGPkdnFKdmirYnn0bY9vKG:oIHXzeJJw\2WwLXnu[JVk\WRicILvcIln\XKjdHnvckBqdiCqdX3hckBOS0ZvNzDidoVie3RiY3HuZ4VzKGOnbHzzMEBKSzVyIE2gNE4xODFzNzFOwG0v NFjWc409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97MUW0PVY{Lz57MUW0PVY{RC:jPh?=
MCF7 MkG5SpVv[3Srb36gZZN{[Xl? Ml;2NlQhcHK| MVHBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQhfHKjboPjdolxfGmxbjDwdoVqdmO3YnH0[YQhd3[ncn7p[4h1KG[xbHzve4VlKGK7IHXzeJJw\2WwIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCmdXHsJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NEA:KDBwMECzJO69VS5? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ7NkO5PEc,Ojh{OU[zPVg9N2F-
Rosetta 2 DE3 MWLGeY5kfGmxbjDhd5NigQ>? MXSxJIhz M{D0TGRqe3CuYXPlcYVvfCCxZjDbN2heNWW|dILh[IlwdCCocn;tJJJm[2:vYnnuZY51KGi3bXHuJG4ufGW{bXnuZYwhUGm|LYTh[4dm\CCHUnHsdIhiKEyERDDoZZJjd3KrbnegR|M5OVNxQ{SxO3MwSzV|MGOgcZV1[W62IHX4dJJme3OnZDDpckBTd3OndIThJFIhTEV|IHPvcZBmfGWwdDDj[YxteyCjZoTldkAyKGi{IHL5JHNRSSCkaX7kbY5oKGG|c3H5MEBKSzVyIE2gNE4xODRizszNMi=> MlzOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N|k5RC:jPh?=
insect cells MUfGeY5kfGmxbjDhd5NigQ>? MUfJcohq[mm2aX;uJI9nKG[udX;ycY9v\SCHU{Kg[5Jm\W5iYnnu[Ilv\yC2bzDy[YNwdWKrbnHueEBnfWyuIHzlcod1cCCqdX3hckBGWmGucHjhJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBie3OjeTygTWM2OCB;IECuNFA3OjlizszNMi=> NHXZRVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEezOVIyPCd-Mki3N|UzOTR:L3G+
MCF-7-2a MUDGeY5kfGmxbjDhd5NigQ>? NYr0T|Z7UW6qaXLpeIlwdiCxZjDld5Rz[WSrb3ygbY5lfWOnZDDld5Rzd2enbjDy[YNmeHSxcjD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBOS0ZvNz2yZUBk\WyuczygTWM2OCB;IECuNFA4KM7:TT6= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ5MkK0PUc,OTJ4N{KyOFk9N2F-
MCF7 MlHaRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MX[yOEBpenN? NF3zOnlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IECuNFA5PSEQvF2u MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ5MkK1Okc,OTh{N{KyOVY9N2F-
MCF7 M4TscWZ2dmO2aX;uJIF{e2G7 NHHaZ|RKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDNR2YuPyCkcnXhd5QhfHWvb4KgZ4VtdHNidYPpcochVUOILUegZZN{[XluIFnDOVAhRSByLkCwPFUh|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh{NUmzOUc,OTJ6MkW5N|U9N2F-
Ishikawa cells NFTqO4RHfW6ldHnvckBie3OjeR?= Ml\OO|IhcHK| MXPBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGW|dILv[4VvKHKnY3XweI9zKGGucHjhM4JmfGFiaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGG|c3H5MEBKSzVyIE2gNE4xOSEQvF2u Ml;lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5N|EoRjJ6NEK2PVMyRC:jPh?=
insect cells MmrDSpVv[3Srb36gZZN{[Xl? M1LQ[2Rqe3CuYXPlcYVvfCCxZjDmcJVwemW|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZoV1[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhcW6|ZXP0JINmdGy|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVAhRSByLkCyJO69VS5? M3XFclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OEO1NVc3Lz5zOEizOVE4PjxxYU6=
MCF7 NFjqT5lEgXSxdH;4bYNqfHliYYPzZZk> NELPd|U2KGSjeYO= NWTBbldJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA2KGSjeYOsJGlEPTBiPTCwMlAzQTFizszNMi=> MnjRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NkS5NlgoRjJ|OE[0PVI5RC:jPh?=
GT1-7 M375SWZ2dmO2aX;uJIF{e2G7 M2\yfFIxKHSxIEK0JIhzew>? NHH6ZZRCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHnuJI1wfXOnIFfUNU04KGOnbHzzJIhiemKxcnnu[{Bj\XSjLXfhcIFkfG:|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iMUfi[ZRiNWW|dILh[IlwdCCrbnT1Z4VlKHKnc4DvcpNmKG2nYYP1doVlKGGodHXyJFIxKHSxIEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUCgQUAxNjB|M{Kg{txONg>? NGix[GY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESwNFI{QSd-Mki0NFAzOzl:L3G+
insect cells MXPGeY5kfGmxbjDhd5NigQ>? M{\mbWRqe3CuYXPlcYVvfCCxZjDmcJVwemW|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZYxxcGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJIF{e2G7LDDJR|UxKD1iMD6wOEDPxE1w NEDzPJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEizOVE4Pid-MUi4N|UyPzZ:L3G+
HEK293 M37QfGZ2dmO2aX;uJIF{e2G7 M3nqWVMxKG2rboO= MYLJcohq[mm2aX;uJI9nKEeIUD30ZYdo\WRiaIXtZY4hWEyGMjDlfJBz\XO|ZXSgbY4hcHWvYX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJBpd3OyaHH0bYR6dGK3dHHuc4wuY2R7XTDwdo9lfWO2aX;uJIFnfGW{IEOwJI1qdnNiYomgcYF{eyC|cHXjeJJwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNE4xPDRizszNMi=> NF;3TFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGzOlk4PSd-MUmxN|Y6PzV:L3G+
HEK293 MVnGeY5kfGmxbjDhd5NigQ>? NILUcpkyKGi{ MYHBcpRi\2:waYP0JIFkfGm4aYT5JIF1KHKnY3;tZolv[W62IHj1cYFvKEWUYXzwbIEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKjZHnvcE1qdmS3Y3XkJHlHWC2odYPl[EBUWkNzIHPvZYN1cX[jdH;yJJJm[3K3aYTt[Y51KG2nYYP1doVlKGGodHXyJFEhcHJiaX6gdJJme2WwY3Wgc4YhS2:nbHXueIVz[XqrbnWgTEBjgSCEUlXUJIF{e2G7LDDJR|UxKD1iMD6wO{DPxE1w NGrKVlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC3PFYxQSd-M{CwO|g3ODl:L3G+
MCF7 MlPlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NVzUUJRUPzJiaILz M3LQV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[ZN1em:pZX6gdoVk\XC2b4Kg[IVx\W6mZX70JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVA4KM7:TT6= Mm\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6M{WxO|YoRjF6OEO1NVc3RC:jPh?=
MCF7 NEfXO3ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1\je|czKGi{cx?= MmDJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSC2conwZY4h[my3ZTDhd5NigSxiR1m1NEA:KDBwMUC3JO69VS5? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd|NUiyPUc,OjN5M{W4Nlk9N2F-
MCF7 MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFvQbmY4OiCqcoO= M1T4T2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSXIu\GWyZX7k[Y51KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOTFizszNMi=> Ml;oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5N|EoRjJ6NEK2PVMyRC:jPh?=
T47D NGH2bYtEgXSxdH;4bYNqfHliYYPzZZk> MkPuOUBl[Xm| M{fJPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMh[W[2ZYKgOUBl[Xm|LDDJR|UxKD1iMD6yNUDPxE1w MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh4NEmyPEc,OjN6NkS5Nlg9N2F-
Ishikawa endometrial cells NVPQS4NSTnWwY4Tpc44h[XO|YYm= M1TWT2FvfGGpb37pd5Qh[WO2aY\peJkh[XNiaX7obYJqfGmxbjDv[kAyKG6PIEG3MYJmfGFvZYP0doFlcW:uIIP0bY12dGG2ZXSgZYxs[WyrbnWgdIhwe3CqYYThd4UhcW6mdXP0bY9vKGmwIFnzbIls[XejIHXu[I9u\XS{aXHsJINmdGy|LDDJR|UxKD1iMD61NUDPxE1w MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTN6MEKwPEc,OTV|OECyNFg9N2F-
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Assay
Methods Test Index PMID
Western blot p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 26163823
Growth inhibition assay Cell viability 26014809

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Adult Rat and Mouse Cardiac Myocytes
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 µM
  • Incubation Time: 15-45 min
  • Method:

    For sarcomere length measurements, cells are covered in Tyrode’s containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz.

  • (Only for Reference)
Animal Research:

[2]

  • Animal Models: Sprague-Dawley rats
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: oral administration
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 77 mg/mL
(198.7 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 387.51
Formula

C26H29NO2

CAS No. 68392-35-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05133674 Not yet recruiting Drug: Tamoxifen 20 mg Breast Cancer|Breast Carcinoma|Breast Tumors|Cancer of Breast|Malignant Neoplasm of Breast Karolinska University Hospital January 10 2022 Phase 2
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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