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4-Hydroxytamoxifen (Afimoxifene)

Name: 4-Hydroxytamoxifen (Afimoxifene)
Brand: Selleck Chemicals
SKU: S7827
Rating: 5 (12 reviews)

Catalog No.S7827 Synonyms: Afimoxifene

For research use only.

4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS No. 68392-35-8

Selleck's 4-Hydroxytamoxifen (Afimoxifene) has been cited by 12 Publications

1 Customer Review

Purity & Quality Control

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Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway Map

Biological Activity

Description

In vitro

4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes^[1]. 4-HT activates on-target modification frequency for intein-Cas9 variants ^[3].

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

MCF7 cells	NGHYdWlRem:uaX\ldoF1cW:wIHHzd4F6			NGLmbXJKdmirYnn0bY9vKG:oIHXzeJJw\2WwLYP0bY12dGG2ZXSgUWNHNTdiY3XscEBxem:uaX\ldoF1cW:wLDDJR\|UxRTBwNTDuUS=>	M17sbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl3NEi4NVcoRjl3NEi4NVc9N2F-
MCF7	MoDqSpVv[3Srb36gZZN{[Xl?			MlezSYZn\WO2aY\lJIRwe2ViZn;yJHs{UF1vIHXzeJJi\GmxbDDh[4FqdnO2IIDyc4xq\mW{YYTpc44hd2ZiTVPGMVch[2WubIOsJGVEPTBiPTCwMlAxODB\|IN88UU4>	M3Sw[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nkm2PFEoRjJ5Nkm2PFE9N2F-
MCF7	NX7HU4R5TnWwY4Tpc44h[XO\|YYm=		NUjsbVhDPCCqcoO=	MVnJcoR2[3Srb36gc4YhTVKjbIDoZUBl\We{YXTheIlwdiCrbjDoeY1idiCPQ1[3JINmdGy\|IHnuJJBp\W6xbDDy[YQh\nKnZTDSVG1KKG2nZHn1cUBkd262YXnubY5oKDVnIHPoZZJkd2GuIHTlfJRz[W5vdILlZZRm\CCIQmOgbY5kfWKjdHXkJIZweiB2IHjyd{BjgSCVUEGgZY5lKGGwdHmtSXIhemGkYnn0JI1wdm:lb3zuZYwh[W62aXLv[Jkh[mG\|ZXSgbY4u[2WubDDX[ZN1\XKwIHHzd4F6NCCDY4Tpeol1gSB;IECuNFAxOSEQvF2u	NIPHfoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC4OlYzPid-M{CwPFY3OjZ:L3G+
MCF7	NEf5T\|ZHfW6ldHnvckBie3OjeR?=			M3K1bmVn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiTVPGMVch[nKnYYP0JJR2dW:{IHPlcIx{KHW\|aX7nJG1ETi15IHHzd4F6NCCHQ{WwJF0hOC5yMECxNkDPxE1w	MonqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N\|UoRjF{OEK1PVM2RC:jPh?=
MCF7	M1nhZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NUDJOItpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzMEBKSzVyIE2gNE4xODB3IN88UU4>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjRyNUK4Okc,OjJ2MEWyPFY9N2F-
MCF7	MWrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NH3kc41CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOsJGlEPTBiPTCwMlAxODV\|NzFOwG0v	NInqUWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO\|AyOid-Mk[0NFcxOTJ:L3G+
MCF	MYTGeY5kfGmxbjDhd5NigQ>?			MlPXRY51[WexbnnzeEBi[3Srdnn0fUBifCCycn;n[ZN1\XKxbnWgdoVk\XC2b4KgbY4hcHWvYX6gUWNHKGOnbHzzJIF{e2W\|c3XkJIF{KGW\|dILh[IlwdC2rbnT1Z4VlKHKnY3XweI9zKHKnc4DvcpNmNCCLQ{WwJF0hOC5yMEC3PVQ{KM7:TT6=	NUn6e21sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NFcxOTJpPkK2OFA4ODF{PD;hQi=>
Ishikawa endometrial cells	MljvSpVv[3Srb36gZZN{[Xl?			NWjnNXFLSWexbnnzeEBi[3Srdnn0fUBieyCjbHvhcIlv\SCyaH;zdIhifGG\|ZTDpcoR2[3Srb36gbY4hUXOqaXvhe4Eh\W6mb33leJJq[WxiY3XscJMh[2:vcHHy[YQhfG9iRUKsJGVEPTBiPTCwMlAxODhizszNMi=>	NGK0U4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUO4NFIxQCd-MUWzPFAzODh:L3G+
MCF7	MnvsSpVv[3Srb36gZZN{[Xl?			NGPkdnFKdmirYnn0bY9vKG:oIHXzeJJw\2WwLXnu[JVk\WRicILvcIln\XKjdHnvckBqdiCqdX3hckBOS0ZvNzDidoVie3RiY3HuZ4VzKGOnbHzzMEBKSzVyIE2gNE4xODFzNzFOwG0v	NFjWc409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97MUW0PVY{Lz57MUW0PVY{RC:jPh?=
MCF7	MkG5SpVv[3Srb36gZZN{[Xl?		Ml;2NlQhcHK\|	MVHBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW\|dILv[4VvNWmwZIXj[YQhfHKjboPjdolxfGmxbjDwdoVqdmO3YnH0[YQhd3[ncn7p[4h1KG[xbHzve4VlKGK7IHXzeJJw\2WwIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCmdXHsJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NEA:KDBwMECzJO69VS5?	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ7NkO5PEc,Ojh{OU[zPVg9N2F-
Rosetta 2 DE3	MWLGeY5kfGmxbjDhd5NigQ>?		MXSxJIhz	M{D0TGRqe3CuYXPlcYVvfCCxZjDbN2heNWW\|dILh[IlwdCCocn;tJJJm[2:vYnnuZY51KGi3bXHuJG4ufGW{bXnuZYwhUGm\|LYTh[4dm\CCHUnHsdIhiKEyERDDoZZJjd3KrbnegR\|M5OVNxQ{SxO3MwSzV\|MGOgcZV1[W62IHX4dJJme3OnZDDpckBTd3OndIThJFIhTEV\|IHPvcZBmfGWwdDDj[YxteyCjZoTldkAyKGi{IHL5JHNRSSCkaX7kbY5oKGG\|c3H5MEBKSzVyIE2gNE4xODRizszNMi=>	MlzOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N\|k5RC:jPh?=
insect cells	MUfGeY5kfGmxbjDhd5NigQ>?			MUfJcohq[mm2aX;uJI9nKG[udX;ycY9v\SCHU{Kg[5Jm\W5iYnnu[Ilv\yC2bzDy[YNwdWKrbnHueEBnfWyuIHzlcod1cCCqdX3hckBGWmGucHjhJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBie3OjeTygTWM2OCB;IECuNFA3OjlizszNMi=>	NHXZRVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEezOVIyPCd-Mki3N\|UzOTR:L3G+
MCF-7-2a	MUDGeY5kfGmxbjDhd5NigQ>?			NYr0T\|Z7UW6qaXLpeIlwdiCxZjDld5Rz[WSrb3ygbY5lfWOnZDDld5Rzd2enbjDy[YNmeHSxcjD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBOS0ZvNz2yZUBk\WyuczygTWM2OCB;IECuNFA4KM7:TT6=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ5MkK0PUc,OTJ4N{KyOFk9N2F-
MCF7	MlHaRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MX[yOEBpenN?	NF3zOnlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IECuNFA5PSEQvF2u	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ5MkK1Okc,OTh{N{KyOVY9N2F-
MCF7	M4TscWZ2dmO2aX;uJIF{e2G7			NHHaZ\|RKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6\|dDDNR2YuPyCkcnXhd5QhfHWvb4KgZ4VtdHNidYPpcochVUOILUegZZN{[XluIFnDOVAhRSByLkCwPFUh\|ryPLh?=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh{NUmzOUc,OTJ6MkW5N\|U9N2F-
Ishikawa cells	NFTqO4RHfW6ldHnvckBie3OjeR?=		Ml\OO\|IhcHK\|	MXPBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGW\|dILv[4VvKHKnY3XweI9zKGGucHjhM4JmfGFiaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGG\|c3H5MEBKSzVyIE2gNE4xOSEQvF2u	Ml;lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5N\|EoRjJ6NEK2PVMyRC:jPh?=
insect cells	MmrDSpVv[3Srb36gZZN{[Xl?			M1LQ[2Rqe3CuYXPlcYVvfCCxZjDmcJVwemW\|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZoV1[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhcW6\|ZXP0JINmdGy\|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVAhRSByLkCyJO69VS5?	M3XFclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OEO1NVc3Lz5zOEizOVE4PjxxYU6=
MCF7	NFjqT5lEgXSxdH;4bYNqfHliYYPzZZk>		NELPd\|U2KGSjeYO=	NWTBbldJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA2KGSjeYOsJGlEPTBiPTCwMlAzQTFizszNMi=>	MnjRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NkS5NlgoRjJ\|OE[0PVI5RC:jPh?=
GT1-7	M375SWZ2dmO2aX;uJIF{e2G7		M2\yfFIxKHSxIEK0JIhzew>?	NHH6ZZRCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHnuJI1wfXOnIFfUNU04KGOnbHzzJIhiemKxcnnu[{Bj\XSjLXfhcIFkfG:\|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iMUfi[ZRiNWW\|dILh[IlwdCCrbnT1Z4VlKHKnc4DvcpNmKG2nYYP1doVlKGGodHXyJFIxKHSxIEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUCgQUAxNjB\|M{Kg{txONg>?	NGix[GY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESwNFI{QSd-Mki0NFAzOzl:L3G+
insect cells	MXPGeY5kfGmxbjDhd5NigQ>?			M{\mbWRqe3CuYXPlcYVvfCCxZjDmcJVwemW\|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZYxxcGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJIF{e2G7LDDJR\|UxKD1iMD6wOEDPxE1w	NEDzPJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEizOVE4Pid-MUi4N\|UyPzZ:L3G+
HEK293	M37QfGZ2dmO2aX;uJIF{e2G7		M3nqWVMxKG2rboO=	MYLJcohq[mm2aX;uJI9nKEeIUD30ZYdo\WRiaIXtZY4hWEyGMjDlfJBz\XO\|ZXSgbY4hcHWvYX6gTGVMOjl\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJJBpd3OyaHH0bYR6dGK3dHHuc4wuY2R7XTDwdo9lfWO2aX;uJIFnfGW{IEOwJI1qdnNiYomgcYF{eyC\|cHXjeJJwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNE4xPDRizszNMi=>	NF;3TFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGzOlk4PSd-MUmxN\|Y6PzV:L3G+
HEK293	MVnGeY5kfGmxbjDhd5NigQ>?		NILUcpkyKGi{	MYHBcpRi\2:waYP0JIFkfGm4aYT5JIF1KHKnY3;tZolv[W62IHj1cYFvKEWUYXzwbIEh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKjZHnvcE1qdmS3Y3XkJHlHWC2odYPl[EBUWkNzIHPvZYN1cX[jdH;yJJJm[3K3aYTt[Y51KG2nYYP1doVlKGGodHXyJFEhcHJiaX6gdJJme2WwY3Wgc4YhS2:nbHXueIVz[XqrbnWgTEBjgSCEUlXUJIF{e2G7LDDJR\|UxKD1iMD6wO{DPxE1w	NGrKVlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC3PFYxQSd-M{CwO\|g3ODl:L3G+
MCF7	MlPlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NVzUUJRUPzJiaILz	M3LQV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[ZN1em:pZX6gdoVk\XC2b4Kg[IVx\W6mZX70JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVA4KM7:TT6=	Mm\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6M{WxO\|YoRjF6OEO1NVc3RC:jPh?=
MCF7	NEfXO3ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M1\je\|czKGi{cx?=	MmDJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSC2conwZY4h[my3ZTDhd5NigSxiR1m1NEA:KDBwMUC3JO69VS5?	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd\|NUiyPUc,OjN5M{W4Nlk9N2F-
MCF7	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NFvQbmY4OiCqcoO=	M1T4T2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSXIu\GWyZX7k[Y51KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOTFizszNMi=>	Ml;oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5N\|EoRjJ6NEK2PVMyRC:jPh?=
T47D	NGH2bYtEgXSxdH;4bYNqfHliYYPzZZk>		MkPuOUBl[Xm\|	M{fJPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMh[W[2ZYKgOUBl[Xm\|LDDJR\|UxKD1iMD6yNUDPxE1w	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh4NEmyPEc,OjN6NkS5Nlg9N2F-
Ishikawa endometrial cells	NVPQS4NSTnWwY4Tpc44h[XO\|YYm=			M1TWT2FvfGGpb37pd5Qh[WO2aY\peJkh[XNiaX7obYJqfGmxbjDv[kAyKG6PIEG3MYJmfGFvZYP0doFlcW:uIIP0bY12dGG2ZXSgZYxs[WyrbnWgdIhwe3CqYYThd4UhcW6mdXP0bY9vKGmwIFnzbIls[XejIHXu[I9u\XS{aXHsJINmdGy\|LDDJR\|UxKD1iMD61NUDPxE1w	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTN6MEKwPEc,OTV\|OECyNFg9N2F-
CV1	NYDXdFFwTnWwY4Tpc44h[XO\|YYm=		NVLSPFZIPDViaILz	MXTJcpZmenOnIHHnc45qe3RiYXP0bZZqfHliYYSgS2FNPC2GTlGgZolv\GmwZzDkc41icW5vZoXz[YQhdW:3c3WgSXJT\2GvbXGgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBEXjFiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gdoVk\XC2b4KgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHHmeIVzKDR3IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGlEPTBiPTCwMlYh\|ryPLh?=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF6OUO5N{c,OjhzOEmzPVM9N2F-
CV1	MVrGeY5kfGmxbjDhd5NigQ>?		NV73TWZxPDViaILz	NYLS[nVbUW64ZYLz[UBi\2:waYP0JIFkfGm4aYT5JIF1KEeDTEStSG5CKGKrbnTpcoch\G:vYXnuMYZ2e2WmIHj1cYFvKEWUUnLleIEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCFVkGgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hemWlZYD0c5IhfHKjboPjdolxfGmxbnHsJIFkfGm4aYT5JIFnfGW{IES1JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUCgQUAxNjZ3IN88UU4>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF6OUO5N{c,OjhzOEmzPVM9N2F-
HEK293	MmjQSpVv[3Srb36gZZN{[Xl?			MVLB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHXzeJJw\2WwIILlcIF1\WRicnXj[ZB1d3JiZ3HtcYEh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGlEPTBiPTCxMlM2KM7:TT6=	NXfnU2JZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU3QDhpPkK1N\|A2Pjh6PD;hQi=>
MCF7	NETzPY9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M13sRlQ5KGi{cx?=	Mle5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHX4dJJme3Orbneg[ZN1em:pZX6gdoVk\XC2b4KgbY5kfWKjdHXkJJdqfGhiMD6wNFMhdk1ib3[g[ZN1emGmaX;sJIFv\CByLkCxJI5OKG:oIITld5Rwe3Sncn;u[UBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSCrbjDwdoV{\W6lZTDv[kA2LSCoZYThcEBjd3[rbnWgd4VzfW1uIFfJOVAhRSBzLkSxNlU1KM7:TT6=	NHjGVJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN\|I4PSd-MkG1NVMzPzV:L3G+
MCF7	NWnFU5NkSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mn3XOFghcHK\|	NYjDUpdGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIV5eHKnc4Ppcoch\XO2cn;n[Y4hemWlZYD0c5IhcW6ldXLheIVlKHerdHigNE4xPiCwTTDv[kBme3S{YXTpc4wh[W6mIECuNFchdk1ib3[geIV{fG:\|dHXyc45mKGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7IHnuJJBz\XOnbnPlJI9nKG[ndHHsJIJwfmmwZTDz[ZJ2dSCjbnSgUpVU\XK3bTygS2k2OCB;IEGuPVA2PDZizszNMi=>	MnXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyO\|UoRjJzNUGzNlc2RC:jPh?=
HeLa	MknnSpVv[3Srb36gZZN{[Xl?		M{G1PFQvPSCqcoO=	M2riXWlvcGmkaYTpc44hd2ZiRXLvcIF3cXK3czDncJlkd3C{b4TlbY4wdWG2cnn4JJBzd3SnaX6gWnA1OCCnboTyfUBqdiCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQvPSCqcoOgZoV1[S2uYXP0ZY1ie2VicnXwc5J1\XJiYYPzZZktKEmFNUCgQUAyNjl4IN88UU4>	NGTEfmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[yOFM5Pyd-Mkm2NlQ{QDd:L3G+
MDA-MB-231	M1rOU2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MYK0JIRigXN?	MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBGWiCwZXfheIl3\SCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJJRz\WG2ZXSg[ZZmenliMjDkZZl{KG[xcjC0JIRigXNibXXhd5Vz\WRiYX\0[ZIhPyCmYYnzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcoNmKGG\|c3H5MEBKSzVyIE2gNk42KM7:TT6=	MoS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7	NVPRVYl{SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kd3Kyb4LheIlwdiCxZjDbcYV1cHmuLUPIYZRpgW2rZHnu[UBqdnSxIHPlcIx2dGG{IFTORUBqdiC\|ZYL1cUBnemWnIH3l[Il2dSCrbjDpckBi[nOnbnPlJI9nKDZwMjD1[{9uVCCUTnHz[UAyNCCLQ{WwJF0hOi55IN88UU4>	NUHKeJV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NVE1PzhpPkKyOlEyPDd6PD;hQi=>
MCF7	MoLKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NX7uO4wzPzJiaILz	MkThRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Lke5JO69VS5?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh7NkewOkc,OjZ6OU[3NFY9N2F-
MCF12A	MXrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M{mzZlQ5KGi{cx?=	NXTKdYJJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBme3S{b3flckBz\WOncITvdk1l\W[rY3nlcpQhcHWvYX6gUWNHOTKDIHPlcIx{KGmwY4XiZZRm\CC5aYToJFExOCCwTTDv[kBme3S{YXTpc4wh[W6mIECuNFchdk1ib3[geIV{fG:\|dHXyc45mKGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7IHnuJJBz\XOnbnPlJI9nKG[ndHHsJIJwfmmwZTDz[ZJ2dSCjbnSgUpVU\XK3bTygS2k2OCB;IEOuNlM2QTRizszNMi=>	NGmyXmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN\|I4PSd-MkG1NVMzPzV:L3G+
MCF7	MVjDfZRwfG:6aXPpeJkh[XO\|YYm=		NUj5XpV4PCCmYYnz	MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBGWiCyb4PpeIl3\SCqdX3hckBOS0Z5IHPlcIx{KHS{ZXH0[YQh\X[ncomgNkBl[Xm\|IH\vdkA1KGSjeYOgcYVie3W{ZXSgZYZ1\XJiNzDkZZl{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOy5\|IN88UU4>	MnXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF12A	NXHWXWptSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NFTIb\|g1QCCqcoO=	MlP1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDld5Rzd2enbjDy[YNmeHSxcj3k[YZq[2mnboSgbJVu[W5iTVPGNVJCKGOnbHzzJIlv[3WkYYTl[EB4cXSqIECuNFA{KG6PIH;mJIV{fHKjZHnvcEBidmRiMD6wNUBvVSCxZjD0[ZN1d3O2ZYLvcoUh[W[2ZYKgOFghcHK\|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XliaX6gdJJme2WwY3Wgc4YhPSViZnX0ZYwh[m:4aX7lJJNmenWvLDDHTVUxKD1iMz6zNVE{OSEQvF2u	NGTGeGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN\|I4PSd-MkG1NVMzPzV:L3G+
MCF7	NX;NOpNkSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mm\QOFghcHK\|	M4D3TmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDlfJBz\XO\|aX7nJIV{fHKxZ3XuJJJm[2WydH;yJIlv[3WkYYTl[EB4cXSqIEGwNEBvVSCxZjDld5Rz[WSrb3ygZY5lKDBwMEegcm0hd2ZidHXzeI9{fGW{b37lJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJIZmfGGuIHLveolv\SC\|ZYL1cUBidmRiToXT[ZJ2dSxiR1m1NEA:KDNwNE[3N\|ch\|ryPLh?=	NFy5bWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN\|I4PSd-MkG1NVMzPzV:L3G+
MDA-MB-231	MWHDfZRwfG:6aXPpeJkh[XO\|YYm=		NYrwSZlRPCCmYYnz	NFjLPHREgXSxdH;4bYNqfHliYXfhbY5{fCCHUjDu[YdifGm4ZTDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KHS{ZXH0[YQh\X[ncomgNkBl[Xm\|IH\vdkA1KGSjeYOgcYVie3W{ZXSgdI9{fCCuYYP0JIRwe2ViYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwY3WgZZN{[XluIFnDOVAhRSB\|LkWg{txONg>?	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB5OE[wPUc,OzByN{i2NFk9N2F-
MCF12A	MlfZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M2jQPFQ5KGi{cx?=	NEX1cXhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuJJJm[2WydH;yMYRm\mmlaXXueEBpfW2jbjDNR2YyOkFiY3XscJMhcW6ldXLheIVlKHerdHigNE4xPiCwTTDv[kBme3S{YXTpc4wh[W6mIECuNFchdk1ib3[geIV{fG:\|dHXyc45mKGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7IHnuJJBz\XOnbnPlJI9nKG[ndHHsJIJwfmmwZTDz[ZJ2dSCjbnSgUpVU\XK3bTygS2k2OCB;IEOuPFkxPDVizszNMi=>	NIX4c3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN\|I4PSd-MkG1NVMzPzV:L3G+
MCF7	NWWxcHJ2S3m2b4TvfIlkcXS7IHHzd4F6		M1fUO\|Qh\GG7cx?=	M1TndWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEWUIIDvd4l1cX[nIHj1cYFvKE2FRkegZ4VtdHNidILlZZRm\CCndnXyfUAzKGSjeYOg[o9zKDRiZHH5d{Bu\WG\|dYLl[EBxd3O2IHzhd5Qh\G:\|ZTDifUBE\WyuVHn0[ZIuT2yxIHz1cYlv\XOlZX7j[UBie3OjeTygTWM2OCB;IEOuPUDPxE1w	M4PFeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5\|MEC3PFYxQTxxYU6=
MCF7	MWrGeY5kfGmxbjDhd5NigQ>?			M{jndWlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBxem:uaX\ldoF1cW:wIH;mJG1ETi15IHPlcIx{KGmwIIDy[ZNmdmOnIH;mJFEx\S14IF2gZ49v[2WwdILheIlwdiCxZjDbN2heNSCnc4TyZYRqd2xiKFWyLUwhUUN\|MDC9JFQh\|ryPLh?=	M{fXNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nkm2PFEoRjJ5Nkm2PFE9N2F-
MCF10A	NUTmZWpRS3m2b4TvfIlkcXS7IHHzd4F6		MnjUOEBl[Xm\|	NEjhbYlEgXSxdH;4bYNqfHliYXfhbY5{fCCHUjDu[YdifGm4ZTDoeY1idiCPQ1[xNGEh[2WubIOgeJJm[XSnZDDleoVzgSB{IHThfZMh\m:{IESg[IF6eyCvZXHzeZJm\CCyb4P0JIxie3RiZH;z[UBjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFQh\|ryPLh?=	NFq0No49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC3PFYxQSd-M{CwO\|g3ODl:L3G+
MCF10A	MonaR5l1d3SxeHnjbZR6KGG\|c3H5		MlmxOEBl[Xm\|	MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBGWiCwZXfheIl3\SCqdX3hckBOS0ZzMFGgZ4VtdHNidILlZZRm\CCndnXyfUAzKGSjeYOg[o9zKDRiZHH5d{Bu\WG\|dYLl[EBi\nSncjC3JIRigXNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwY3WgZZN{[XluIFnDOVAhRSB2IN88UU4>	NFvkcow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC3PFYxQSd-M{CwO\|g3ODl:L3G+
yeast cells	NGTJTXNCdnSrZYP0do9o\W6rYzDhd5NigQ>?			MmfBRY51cWW\|dILv[4VvcWNiYXP0bZZqfHliYYSg[ZN1em:pZX6gdoVk\XC2b4KgZYxxcGFiZYjwdoV{e2WmIHnuJJlm[XO2IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhOTdvYnX0ZU1me3S{YXTpc4wucW6mdXPl[EBj\XSjLXfhcIFkfG:\|aXThd4Uh[WO2aY\peJkh[nlidIfvJIh6[nKrZDDhd5NigSxiSVO1NEA:KDRwNDFOwG0v	MlTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2NEGwPFYoRjF4NESxNFg3RC:jPh?=
NCI-ADR-RES	NHvpcINCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NE\yOGw1QCCqcoO=	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHXzeJJw\2WwIILlZ4VxfG:{LXTl[olkcWWwdDDoeY1idiCQQ1mtRWRTNVKHUzDj[YxteyCrbnP1ZoF1\WRid3n0bEAxNjByMzDuUUBw\iCnc4TyZYRqd2xiYX7kJFAvODFibl2gc4YhfGW\|dH;zeIVzd26nIHHmeIVzKDR6IHjyd{BjgSC\|dXzmc5Jpd2SjbXnu[UBDKGG\|c3H5JIlvKHC{ZYPlcoNmKG:oIEWlJIZmfGGuIHLveolv\SC\|ZYL1cUwhT0l3MDC9JFQvPDZ4OESg{txONg>?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVzM{K3OUc,OjF3MUOyO\|U9N2F-
BT-20	NHTCenBHfW6ldHnvckBie3OjeR?=	Mn3HNVAh\|ryP		NHvvR\|hKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QheHKxbHnm[ZJifGmxbjDv[kBDXC1{MDDj[YxteyCrbjDwdoV{\W6lZTDv[kBVWEViYYSgNVBmNTViTTDjc45k\W62cnH0bY9vNCCLQ{OwJF0hPC56IN88UU4>	NV:ye5M5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2PVY5OSd-Mke2PVY5OTxxYU6=
Calu-1	NGPVRpZHfW6ldHnvckBie3OjeR?=		MnnXN\|AhdWmwcx?=	M3nXNWlvcGmkaYTpc44hd2ZiUFzENUBqdiCqdX3hckBE[Wy3LUGgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heGixc4DoZZRq\HmuYoX0ZY5wdC2dZEndJJBzd2S3Y4Tpc44h[W[2ZYKgN\|AhdWmwczDifUBu[XO\|IIPw[YN1em:vZYTybYMh[W6jbInzbZMtKEmFNUCgQUA1NjhizszNMi=>	NYCyRXpZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxN\|Y6PzVpPkG5NVM3QTd3PD;hQi=>
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MDA-MB-231	NYm2NHFwSW62aXPhcoNmeiCjc4PhfS=>		M1rRSlQ5KGi{cx?=	Mn7KRY51cWOjbnPldkBi\2GrboP0JIh2dWGwIFXSMZBwe2m2aY\lJG1FSS2PQj2yN\|Eh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEWuOEDPxE1w	M2eyeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUS2NVQ2Lz5{NEm0OlE1PTxxYU6=
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MCF7	NYD0PHh5SW62aXPhcoNmeiCjc4PhfS=>	NYTER3hTOjVyIITvJFUxOCCwTR?=	M{HqTVUh\GG7cx?=	MXPBcpRq[2GwY3XyJIFo[Wmwc4SgbJVu[W5iRWKtdI9{cXSrdnWgUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIV{fHKjZHnvcE1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckBifCB{NUCgeI8hPTByIH7NJIFnfGW{IEWg[IF6ew>?	M3H6bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUS2NVQ2Lz5{NEm0OlE1PTxxYU6=
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MCF7	MlWxSpVv[3Srb36gZZN{[Xl?	MUi1JJVO	Mki3NlQhcHK\|	MYfBcpRi\2:waYP0JIFkfGm4aYT5JIF1KEWUYXzwbIEhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW\|c3nvckBw\iCJUlXCNUBuWk6DIHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{NDDodpMh[nliUVnBfo9tKHKnYXflcpQh[mG\|ZXSgVnQueVCFUjDhcoFtgXOrcx?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB5OE[wPUc,OzByN{i2NFk9N2F-
MCF7	NXP5[WFSTnWwY4Tpc44h[XO\|YYm=	NXXyfY9NPSC3TR?=	NGr0WlAzPCCqcoO=	M{OwXmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3JINmdGy\|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIF3ZRmwzKG2UTlGg[ZhxemW\|c3nvckBifCB3IIXNJIFnfGW{IEK0JIhzeyCkeTDRTWF7d2xicnXh[4VvfCCkYYPl[EBTXC2zUFPSJIFv[Wy7c3nz	NInDfnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC3PFYxQSd-M{CwO\|g3ODl:L3G+
MCF7	NF2zTXhHfW6ldHnvckBie3OjeR?=	NGnDR3Y2KHWP	NGLRd2QzPCCqcoO=	M3r1VmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3JINmdGy\|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIFPDUmQyKG2UTlGg[ZhxemW\|c3nvckBifCB3IIXNJIFnfGW{IEK0JIhzeyCkeTDRTWF7d2xicnXh[4VvfCCkYYPl[EBTXC2zUFPSJIFv[Wy7c3nz	M1z0c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5\|MEC3PFYxQTxxYU6=
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MCF7	M4n2c2Z2dmO2aX;uJIF{e2G7	NYSzc5JEPSC3TR?=	M1iyc\|I1KGi{cx?=	M{SycmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3JINmdGy\|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIF3LTVY4KG2UTlGg[ZhxemW\|c3nvckBifCB3IIXNJIFnfGW{IEK0JIhzeyCkeTDRTWF7d2xicnXh[4VvfCCkYYPl[EBTXC2zUFPSJIFv[Wy7c3nz	MnvQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=

Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1	26163823
Growth inhibition assay	Cell viability	26014809

Protocol (from reference)

Cell Research: ^[1]	Cell lines: Adult Rat and Mouse Cardiac Myocytes Concentrations: 0, 0.5, 1, 3, 5, and 10 µM Incubation Time: 15-45 min Method: For sarcomere length measurements, cells are covered in Tyrode’s containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz. (Only for Reference)
Animal Research: ^[2]	Animal Models: Sprague-Dawley rats Dosages: 21 mg/kg, 54 μmol/kg Administration: oral administration (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	77 mg/mL (198.7 mM)
	Water	Insoluble
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	387.51
Formula	C₂₆H₂₉NO₂
CAS No.	68392-35-8
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3

Download 4-Hydroxytamoxifen (Afimoxifene) SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05133674	Not yet recruiting	Drug: Tamoxifen 20 mg	Breast Cancer\|Breast Carcinoma\|Breast Tumors\|Cancer of Breast\|Malignant Neoplasm of Breast	Karolinska University Hospital	January 10 2022	Phase 2
NCT03199963	Terminated	Drug: 4-OH tamoxifen\|Drug: Placebo	Mammographic Breast Density	BHR Pharma LLC	August 21 2017	Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

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