4-Hydroxytamoxifen (Afimoxifene)

For research use only.

Catalog No.S7827 Synonyms: Afimoxifene

10 publications

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS No. 68392-35-8

4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.

Selleck's 4-Hydroxytamoxifen (Afimoxifene) has been cited by 10 publications

1 Customer Review

  • CDK4/6 inhibitor resistance promotes diminished ER expression and activity. (a and b) Proliferation of MCF-7 and MR cells in the presence of different concentrations of ICI (a) or 4-hydroxytamoxifen (4-OHT) (b) was measured by the alamarBlue assay and plotted as % inhibition of proliferation against log concentration of inhibitor. Each data point represents the average value±s.d. of six replicates obtained in three independent experiments.

    Oncogene, 2016, 36(16):2255-2264. 4-Hydroxytamoxifen (Afimoxifene) purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.
In vitro

4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes[1]. 4-HT activates on-target modification frequency for intein-Cas9 variants [3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells MWPQdo9tcW[ncnH0bY9vKGG|c3H5 MmPMTY5pcWKrdHnvckBw\iCnc4Tyc4dmdi2|dHnteYxifGWmIF3DSk04KGOnbHygdJJwdGmoZYLheIlwdixiSVO1NF0xNjVibl2= MlfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTV2OEixO{c,QTV2OEixO|ww[T5?
MCF7 MY\GeY5kfGmxbjDhd5NigQ>? Mke5SYZn\WO2aY\lJIRwe2ViZn;yJHs{UF1vIHXzeJJi\GmxbDDh[4FqdnO2IIDyc4xq\mW{YYTpc44hd2ZiTVPGMVch[2WubIOsJGVEPTBiPTCwMlAxODB|IN88UU4> NH:zSVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[5OlgyLz5{N{[5OlgyRC:jPh?=
MCF7 MlLoSpVv[3Srb36gZZN{[Xl? MlfVOEBpenN? NUPnbFF{UW6mdXP0bY9vKG:oIFXSZYxxcGFiZHXndoFl[XSrb36gbY4hcHWvYX6gUWNHPyClZXzsd{BqdiCyaHXuc4whemWmIH\y[YUhWlCPSTDt[YRqfW1iY3;ueIFqdmmwZzC1KUBkcGG{Y3;hcEBl\Xi2cnHuMZRz\WG2ZXSgSmJUKGmwY4XiZZRm\CCob4KgOEBpenNiYomgV3AyKGGwZDDhcpRqNUWUIILhZoJqfCCvb37vZ49tdmGuIHHueIljd2S7IHLhd4VlKGmwLXPlcIwhX2W|dHXyckBie3OjeTygRYN1cX[rdImgQUAxNjByMEGg{txONg>? M3jyclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEi2OlI3Lz5|MEC4OlYzPjxxYU6=
MCF7 M3;lZWZ2dmO2aX;uJIF{e2G7 NXjDWoxLTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gZYdicW6|dDDNR2YuPyCkcnXhd5QhfHWvb4KgZ4VtdHNidYPpcochVUOILUegZZN{[XluIFXDOVAhRSByLkCwNFEzKM7:TT6= MkTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
MCF7 Mk\sRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MljKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|LDDJR|UxKD1iMD6wNFA2KM7:TT6= NWXvZpJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0NFUzQDZpPkKyOFA2Ojh4PD;hQi=>
MCF7 M{jCRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlWxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|LDDJR|UxKD1iMD6wNFA2OzdizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{CxNkc,OjZ2MEewNVI9N2F-
MCF NE\3OpBHfW6ldHnvckBie3OjeR?= NW[1WVhJSW62YXfvcol{fCCjY4Tpeol1gSCjdDDwdo9o\XO2ZYLvcoUhemWlZYD0c5IhcW5iaIXtZY4hVUOIIHPlcIx{KGG|c3Xzd4VlKGG|IHXzeJJi\GmxbD3pcoR2[2WmIILlZ4VxfG:{IILld5BwdnOnLDDJR|UxKD1iMD6wNFA4QTR|IN88UU4> NIW4NW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|AyOid-Mk[0NFcxOTJ:L3G+
Ishikawa endometrial cells Mn7KSpVv[3Srb36gZZN{[Xl? NXH0OG13SWexbnnzeEBi[3Srdnn0fUBieyCjbHvhcIlv\SCyaH;zdIhifGG|ZTDpcoR2[3Srb36gbY4hUXOqaXvhe4Eh\W6mb33leJJq[WxiY3XscJMh[2:vcHHy[YQhfG9iRUKsJGVEPTBiPTCwMlAxODhizszNMi=> NFG3TYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUO4NFIxQCd-MUWzPFAzODh:L3G+
MCF7 MV\GeY5kfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJI9nKGW|dILv[4VvNWmwZIXj[YQheHKxbHnm[ZJifGmxbjDpckBpfW2jbjDNR2YuPyCkcnXhd5Qh[2GwY3XyJINmdGy|LDDJR|UxKD1iMD6wNFEyPyEQvF2u M4naclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlzNUS5OlMoRjlzNUS5OlM9N2F-
MCF7 NXfNdIZKTnWwY4Tpc44h[XO|YYm= NWDlUVRzOjRiaILz NWXtT2FFSW62YXfvcol{fCCjY4Tpeol1gSCjdDDFVoFteGijIHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDld5Rzd2enbj3pcoR2[2WmIITyZY5{[3KrcITpc44heHKnaX7jeYJifGWmIH;2[ZJvcWeqdDDmc4xtd3enZDDifUBme3S{b3flckBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomg[JVidCCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlAxOyEQvF2u Mon3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N|k5RC:jPh?=
Rosetta 2 DE3 NVHZfmNITnWwY4Tpc44h[XO|YYm= NImxbmoyKGi{ NF;EUVdFcXOybHHj[Y1mdnRib3[gX|NJZS2nc4TyZYRqd2xiZoLvcUBz\WOxbXLpcoFvfCCqdX3hckBPNXSncn3pcoFtKEircz30ZYdo\WRiRWLhcJBp[SCOQlSgbIFz[m:{aX7nJGM{QDGVL1O0NVdUN0N3M{DTJI12fGGwdDDlfJBz\XO|ZXSgbY4hWm:|ZYT0ZUAzKESHMzDjc41x\XSnboSgZ4VtdHNiYX\0[ZIhOSCqcjDifUBUWEFiYnnu[Ilv\yCjc4PhfUwhUUN3MDC9JFAvODB2IN88UU4> Mm\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N|k5RC:jPh?=
insect cells NV;0OpRiTnWwY4Tpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKG[udX;ycY9v\SCHU{Kg[5Jm\W5iYnnu[Ilv\yC2bzDy[YNwdWKrbnHueEBnfWyuIHzlcod1cCCqdX3hckBGWmGucHjhJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBie3OjeTygTWM2OCB;IECuNFA3OjlizszNMi=> NWLwT2NpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3N|UzOTRpPkK4O|M2OjF2PD;hQi=>
MCF-7-2a NEfa[pVHfW6ldHnvckBie3OjeR?= MYLJcohq[mm2aX;uJI9nKGW|dILh[IlwdCCrbnT1Z4VlKGW|dILv[4VvKHKnY3XweI9zKHS{YX7zZ5JqeHSrb37hcEBi[3SrdnH0bY9vKGmwIF3DSk04NTKjIHPlcIx{NCCLQ{WwJF0hOC5yMEeg{txONg>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ5MkK0PUc,OTJ4N{KyOFk9N2F-
MCF7 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVW3TVVzOjRiaILz Mln3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSByLkCwPFUh|ryPLh?= M{HKOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkeyNlU3Lz5zOEK3NlI2PjxxYU6=
MCF7 MnjWSpVv[3Srb36gZZN{[Xl? M4rSZmlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiSVO1NEA:KDBwMEC4OUDPxE1w MnrIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
Ishikawa cells MXfGeY5kfGmxbjDhd5NigQ>? MmfYO|IhcHK| M1XsUmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiZYP0do9o\W5icnXj[ZB1d3JiYXzwbIEw[mW2YTDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WytYXzpcoUheGixc4DoZZRie2ViYYPzZZktKEmFNUCgQUAxNjBzIN88UU4> M1WyWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEK2PVMyLz5{OESyOlk{OTxxYU6=
insect cells NV;MV2NjTnWwY4Tpc44h[XO|YYm= M4jTOmRqe3CuYXPlcYVvfCCxZjDmcJVwemW|Y3XpckBt[WKnbHXkJIV{fHKjZHnvcEBnem:vIHj1cYFvKHKnY3;tZolv[W62IFXSZoV1[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhcW6|ZXP0JINmdGy|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVAhRSByLkCyJO69VS5? NHKzXJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEizOVE4Pid-MUi4N|UyPzZ:L3G+
MCF7 M2K2bWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFXLXYE2KGSjeYO= NHPJZYVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFUh\GG7czygTWM2OCB;IECuNFI6OSEQvF2u NEHwNoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i2OFkzQCd-MkO4OlQ6Ojh:L3G+
GT1-7 MV\GeY5kfGmxbjDhd5NigQ>? MlWwNlAhfG9iMkSgbJJ{ NXHKZ5lpSW62YXfvcol{fCCjY4Tpeol1gSCjdDDld5Rzd2enbjDy[YNmeHSxcjDpckBud3W|ZTDHWFEuPyClZXzsd{Bp[XKkb4Lpcoch[mW2YT3nZYxi[3Sxc3nkZZNmKHKncH;yeIVzKGenbnWgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIEG3ZoV1[S2nc4TyZYRqd2xiaX7keYNm\CC{ZYPwc45{\SCvZXHzeZJm\CCjZoTldkAzOCC2bzCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwJF0hOC5yM{OyJO69VS5? NUGxfFlrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NFAzOzlpPkK4OFAxOjN7PD;hQi=>
insect cells M2rsZ2Z2dmO2aX;uJIF{e2G7 MXrEbZNxdGGlZX3lcpQhd2ZiZnz1c5Jme2OnaX6gcIFj\WynZDDld5Rz[WSrb3yg[pJwdSCqdX3hckBz\WOxbXLpcoFvfCCHUnHsdIhiKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNiYomg[ox2d3Knc3PlcoNmKHCxbHHybZpifGmxbjDhd5NigSxiSVO1NEA:KDBwMESg{txONg>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDh|NUG3Okc,OTh6M{WxO|Y9N2F-
HEK293 NWDmSm5XTnWwY4Tpc44h[XO|YYm= M3PQTFMxKG2rboO= M3vucmlvcGmkaYTpc44hd2ZiR1\QMZRi\2enZDDoeY1idiCSTFSyJIV5eHKnc4Pl[EBqdiCqdX3hckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heGixc4DoZZRq\HmuYoX0ZY5wdC2dZEndJJBzd2S3Y4Tpc44h[W[2ZYKgN|AhdWmwczDifUBu[XO|IIPw[YN1em:vZYTybYMh[W6jbInzbZMtKEmFNUCgQUAxNjB2NDFOwG0v MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF|Nkm3OUc,OTlzM{[5O|U9N2F-
HEK293 Ml;kSpVv[3Srb36gZZN{[Xl? MYmxJIhz M16yemFvfGGpb37pd5Qh[WO2aY\peJkh[XRicnXjc41jcW6jboSgbJVu[W5iRWLhcJBp[SCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\XO2cnHkbY9tNWmwZIXj[YQhYU[SLX\1d4VlKFOUQ{GgZ49i[3SrdnH0c5IhemWlcoXpeI1mdnRibXXhd5Vz\WRiYX\0[ZIhOSCqcjDpckBxemW|ZX7j[UBw\iCFb3Xs[Y51\XKjennu[UBJKGK7IFLSSXQh[XO|YYmsJGlEPTBiPTCwMlA4KM7:TT6= MmXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{i2NFkoRjNyMEe4OlA6RC:jPh?=
MCF7 M1\SXGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MYq3NkBpenN? Mmr0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDld5Rzd2enbjDy[YNmeHSxcjDk[ZBmdmSnboSgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xNFch|ryPLh?= NEXPTFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEizOVE4Pid-MUi4N|UyPzZ:L3G+
MCF7 NE\ZNZJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3;lO|czKGi{cx?= NIL0TFhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IITyfZBidiCkbIXlJIF{e2G7LDDHTVUxKD1iMD6xNFch|ryPLh?= NH\xeII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ezOVgzQSd-MkO3N|U5Ojl:L3G+
MCF7 NIPLRoJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIPp[Xk4OiCqcoO= NVSyeYJySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBGWi2mZYDlcoRmdnRiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zMTFOwG0v NFXxRlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESyOlk{OSd-Mki0NlY6OzF:L3G+
T47D MkjNR5l1d3SxeHnjbZR6KGG|c3H5 MVy1JIRigXN? M3;YZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMh[W[2ZYKgOUBl[Xm|LDDJR|UxKD1iMD6yNUDPxE1w NYeyOYhJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OlQ6OjhpPkKzPFY1QTJ6PD;hQi=>
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 ; 

PubMed: 26163823     


LNCaP-Raf:ER cells were treated with increasing doses of 4-hydroxytamoxifen for 2 days. The bottom panel indicates densitometry of MEK1 and MEK2 signals. Data (mean ± standard error) are from two independent experiments. Pearson’s r = 0.823 for MEK1 and −0.673 for MEK2. 

26163823
Growth inhibition assay
Cell viability; 

PubMed: 26014809     


Dose-dependent effect of 4-hydroxytamoxifen on survival of T47D, MCF-7 and BT-474 cell lines after 96 h of treatment. Control samples were treated with appropriate concentrations of DMSO. Viability was assayed by MTT method.

26014809

Protocol

Cell Research:

[1]

- Collapse
  • Cell lines: Adult Rat and Mouse Cardiac Myocytes
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 µM
  • Incubation Time: 15-45 min
  • Method:

    For sarcomere length measurements, cells are covered in Tyrode’s containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: Sprague-Dawley rats
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 77 mg/mL (198.7 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 387.51
Formula

C26H29NO2

CAS No. 68392-35-8
Storage powder
in solvent
Synonyms Afimoxifene
Smiles CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID