4-Hydroxytamoxifen (Afimoxifene)

For research use only.

Catalog No.S7827 Synonyms: Afimoxifene

9 publications

4-Hydroxytamoxifen (Afimoxifene) Chemical Structure

CAS No. 68392-35-8

4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.

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Selleck's 4-Hydroxytamoxifen (Afimoxifene) has been cited by 9 publications

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  • CDK4/6 inhibitor resistance promotes diminished ER expression and activity. (a and b) Proliferation of MCF-7 and MR cells in the presence of different concentrations of ICI (a) or 4-hydroxytamoxifen (4-OHT) (b) was measured by the alamarBlue assay and plotted as % inhibition of proliferation against log concentration of inhibitor. Each data point represents the average value±s.d. of six replicates obtained in three independent experiments.

    Oncogene, 2016, 36(16):2255-2264. 4-Hydroxytamoxifen (Afimoxifene) purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.
In vitro

4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes[1]. 4-HT activates on-target modification frequency for intein-Cas9 variants [3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells NGrkR|FRem:uaX\ldoF1cW:wIHHzd4F6 MVfJcohq[mm2aX;uJI9nKGW|dILv[4VvNXO2aX31cIF1\WRiTVPGMVch[2WubDDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvPSCwTR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PTR6OEG3K|46PTR6OEG3QE9iRg>?
MCF7 M2fHNWZ2dmO2aX;uJIF{e2G7 NVn3foxQTW[oZXP0bZZmKGSxc3Wg[o9zKFt|SG2tJIV{fHKjZHnvcEBi\2GrboP0JJBzd2yrZnXyZZRqd25ib3[gUWNHNTdiY3XscJMtKEWFNUCgQUAxNjByMECzJO69VS5? MlTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4OU[4NUc,Ojd4OU[4NVww[T5?
MCF7 NEK4WGdHfW6ldHnvckBie3OjeR?= NFnhdWk1KGi{cx?= M3vpZmlv\HWldHnvckBw\iCHUnHsdIhiKGSnZ4Lh[IF1cW:wIHnuJIh2dWGwIF3DSlch[2WubIOgbY4heGinbn;sJJJm\CCocnXlJHJRVUlibXXkbZVuKGOxboThbY5qdmdiNTWgZ4hiemOxYXyg[IV5fHKjbj30doVifGWmIF\CV{BqdmO3YnH0[YQh\m:{IESgbJJ{KGK7IGPQNUBidmRiYX70bU1GWiC{YXLibZQhdW:wb3PvcI5idCCjboTpZo9lgSCkYYPl[EBqdi2lZXzsJHdme3Sncn6gZZN{[XluIFHjeIl3cXS7IE2gNE4xODBzIN88UU4> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB6Nk[yOkc,OzByOE[2NlY9N2F-
MCF7 MmLTSpVv[3Srb36gZZN{[Xl? NVO2OnpzTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gZYdicW6|dDDNR2YuPyCkcnXhd5QhfHWvb4KgZ4VtdHNidYPpcochVUOILUegZZN{[XluIFXDOVAhRSByLkCwNFEzKM7:TT6= MlXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6MkW5N|UoRjF{OEK1PVM2RC:jPh?=
MCF7 NV\yeXlESW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlywRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|LDDJR|UxKD1iMD6wNFA2KM7:TT6= M3v4V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEC1Nlg3Lz5{MkSwOVI5PjxxYU6=
MCF7 M2C3[2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWrmdVd[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzMEBKSzVyIE2gNE4xODB3M{eg{txONg>? MmfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEewNVIoRjJ4NEC3NFEzRC:jPh?=
MCF M1zIeGZ2dmO2aX;uJIF{e2G7 MVPBcpRi\2:waYP0JIFkfGm4aYT5JIF1KHC{b3fld5Rmem:wZTDy[YNmeHSxcjDpckBpfW2jbjDNR2Yh[2WubIOgZZN{\XO|ZXSgZZMh\XO2cnHkbY9tNWmwZIXj[YQhemWlZYD0c5IhemW|cH;ud4UtKEmFNUCgQUAxNjByMEe5OFMh|ryPLh?= NY[2SGdVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NFcxOTJpPkK2OFA4ODF{PD;hQi=>
Ishikawa endometrial cells Ml:wSpVv[3Srb36gZZN{[Xl? M{jWfmFod26rc4SgZYN1cX[rdImgZZMh[WytYXzpcoUheGixc4DoZZRie2ViaX7keYN1cW:wIHnuJGl{cGmtYYfhJIVv\G:vZYTybYFtKGOnbHzzJINwdXCjcnXkJJRwKEV{LDDFR|UxKD1iMD6wNFA5KM7:TT6= NV20[YZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWzPFAzODhpPkG1N|gxOjB6PD;hQi=>
MCF7 MYjGeY5kfGmxbjDhd5NigQ>? NH\nemtKdmirYnn0bY9vKG:oIHXzeJJw\2WwLXnu[JVk\WRicILvcIln\XKjdHnvckBqdiCqdX3hckBOS0ZvNzDidoVie3RiY3HuZ4VzKGOnbHzzMEBKSzVyIE2gNE4xODFzNzFOwG0v M1f5bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlzNUS5OlMoRjlzNUS5OlM9N2F-
MCF7 MWHGeY5kfGmxbjDhd5NigQ>? NVXTZXJVOjRiaILz NGDGd21CdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZYxxcGFiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHXzeJJw\2WwLXnu[JVk\WRidILhcpNkemmydHnvckBxemWrbnP1ZoF1\WRib4\ldo5q\2i2IH\vcIxwf2WmIHL5JIV{fHKxZ3XuJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDkeYFtKGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OCB;IECuNFA{KM7:TT6= M4DsSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Mkm2N|k5Lz5{OEK5OlM6QDxxYU6=
Rosetta 2 DE3 NF\yOYFHfW6ldHnvckBie3OjeR?= MmL6NUBpeg>? M4PSXmRqe3CuYXPlcYVvfCCxZjDbN2heNWW|dILh[IlwdCCocn;tJJJm[2:vYnnuZY51KGi3bXHuJG4ufGW{bXnuZYwhUGm|LYTh[4dm\CCHUnHsdIhiKEyERDDoZZJjd3KrbnegR|M5OVNxQ{SxO3MwSzV|MGOgcZV1[W62IHX4dJJme3OnZDDpckBTd3OndIThJFIhTEV|IHPvcZBmfGWwdDDj[YxteyCjZoTldkAyKGi{IHL5JHNRSSCkaX7kbY5oKGG|c3H5MEBKSzVyIE2gNE4xODRizszNMi=> NX71NoZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPVY{QThpPkK4Nlk3Ozl6PD;hQi=>
insect cells MVXGeY5kfGmxbjDhd5NigQ>? NFrtXIZKdmirYnn0bY9vKG:oIH\seY9zdW:wZTDFV|Ih\3KnZX6gZolv\GmwZzD0c{Bz\WOxbXLpcoFvfCCodXzsJIxmdme2aDDoeY1idiCHUnHsdIhiKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[nliZnz1c5Jme2OnbnPlJJBwdGG{aYrheIlwdiCjc4PhfUwhUUN3MDC9JFAvODB4Mkmg{txONg>? M3fXVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{O1NlE1Lz5{OEezOVIyPDxxYU6=
MCF-7-2a MkfBSpVv[3Srb36gZZN{[Xl? M3jqPWlvcGmkaYTpc44hd2ZiZYP0doFlcW:uIHnu[JVk\WRiZYP0do9o\W5icnXj[ZB1d3JidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25iaX6gUWNHNTdvMnGgZ4VtdHNuIFnDOVAhRSByLkCwO{DPxE1w NF7yXVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[3NlI1QSd-MUK2O|IzPDl:L3G+
MCF7 MlTvRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MY[yOEBpenN? MorHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSByLkCwPFUh|ryPLh?= M3m1NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkeyNlU3Lz5zOEK3NlI2PjxxYU6=
MCF7 MWXGeY5kfGmxbjDhd5NigQ>? M1Sxe2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IF3DSk04KGK{ZXHzeEB1fW2xcjDj[YxteyC3c3nu[{BOS0ZvNzDhd5NigSxiSVO1NEA:KDBwMEC4OUDPxE1w M1\wTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEK1PVM2Lz5zMkiyOVk{PTxxYU6=
Ishikawa cells NEXCPYhHfW6ldHnvckBie3OjeR?= NH\0SmU4OiCqcoO= M1\Fd2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiZYP0do9o\W5icnXj[ZB1d3JiYXzwbIEw[mW2YTDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WytYXzpcoUheGixc4DoZZRie2ViYYPzZZktKEmFNUCgQUAxNjBzIN88UU4> M1POWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEK2PVMyLz5{OESyOlk{OTxxYU6=
insect cells M1jq[mZ2dmO2aX;uJIF{e2G7 NIrqVoxFcXOybHHj[Y1mdnRib3[g[ox2d3Knc3PlbY4hdGGkZXzl[EBme3S{YXTpc4wh\nKxbTDoeY1idiC{ZXPvcYJqdmGwdDDFVoJmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJIF{e2G7LDDJR|UxKD1iMD6wNkDPxE1w MnrpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6M{WxO|YoRjF6OEO1NVc3RC:jPh?=
MCF7 NIf2O2REgXSxdH;4bYNqfHliYYPzZZk> M4LUNVUh\GG7cx?= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEWg[IF6eyxiSVO1NEA:KDBwMEK5NUDPxE1w NXPjRol2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OlQ6OjhpPkKzPFY1QTJ6PD;hQi=>
GT1-7 MU\GeY5kfGmxbjDhd5NigQ>? NHPKVIQzOCC2bzCyOEBpenN? MUHBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGW|dILv[4VvKHKnY3XweI9zKGmwIH3veZNmKEeWMT23JINmdGy|IHjhdoJwemmwZzDi[ZRiNWejbHHjeI9{cWSjc3WgdoVxd3K2ZYKg[4Vv\SCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hOTekZYThMYV{fHKjZHnvcEBqdmS3Y3XkJJJme3CxboPlJI1m[XO3cnXkJIFnfGW{IEKwJJRwKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTBiPTCwMlA{OzJizszNMi=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDRyMEKzPUc,Ojh2MECyN|k9N2F-
insect cells NVHiWW8zTnWwY4Tpc44h[XO|YYm= MVXEbZNxdGGlZX3lcpQhd2ZiZnz1c5Jme2OnaX6gcIFj\WynZDDld5Rz[WSrb3yg[pJwdSCqdX3hckBz\WOxbXLpcoFvfCCHUnHsdIhiKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBqdnOnY4SgZ4VtdHNiYomg[ox2d3Knc3PlcoNmKHCxbHHybZpifGmxbjDhd5NigSxiSVO1NEA:KDBwMESg{txONg>? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDh|NUG3Okc,OTh6M{WxO|Y9N2F-
HEK293 MW\GeY5kfGmxbjDhd5NigQ>? MXmzNEBucW6| MXvJcohq[mm2aX;uJI9nKEeIUD30ZYdo\WRiaIXtZY4hWEyGMjDlfJBz\XO|ZXSgbY4hcHWvYX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJBpd3OyaHH0bYR6dGK3dHHuc4wuY2R7XTDwdo9lfWO2aX;uJIFnfGW{IEOwJI1qdnNiYomgcYF{eyC|cHXjeJJwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNE4xPDRizszNMi=> NV\B[I5URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxN|Y6PzVpPkG5NVM3QTd3PD;hQi=>
HEK293 NVLaV25FTnWwY4Tpc44h[XO|YYm= NYnCVYU1OSCqch?= NX7ZNXllSW62YXfvcol{fCCjY4Tpeol1gSCjdDDy[YNwdWKrbnHueEBpfW2jbjDFVoFteGijIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCnc4TyZYRqd2xvaX7keYNm\CC\RmCt[pV{\WRiU2LDNUBkd2GldHn2ZZRweiC{ZXPyeYl1dWWwdDDt[YF{fXKnZDDh[pRmeiBzIHjyJIlvKHC{ZYPlcoNmKG:oIFPv[YxmdnSncnH6bY5mKEhiYomgRnJGXCCjc4PhfUwhUUN3MDC9JFAvODdizszNMi=> M37NOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe4OlA6Lz5|MEC3PFYxQTxxYU6=
MCF7 MmHQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVO3NkBpenN? NIj6R3BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuJJJm[2WydH;yJIRmeGWwZHXueEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlExPyEQvF2u NYD3c3NURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4N|UyPzZpPkG4PFM2OTd4PD;hQi=>
MCF7 NHnNeo5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUK3NkBpenN? NVO4b2xHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTD0dplx[W5iYnz1[UBie3OjeTygS2k2OCB;IECuNVA4KM7:TT6= NYrnS2JYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3N|U5OjlpPkKzO|M2QDJ7PD;hQi=>
MCF7 NYTXTpJVSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHzIU5o4OiCqcoO= MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFXSMYRmeGWwZHXueEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlEyKM7:TT6= MoDuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5N|EoRjJ6NEK2PVMyRC:jPh?=
T47D M3z2e2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVfUNZh4PSCmYYnz NEHufpREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFUh\GG7czygTWM2OCB;IECuNlEh|ryPLh?= NFzJdJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i2OFkzQCd-MkO4OlQ6Ojh:L3G+
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK / p-MEK / MEK1 / MEK2 / p21 / Cyclin D1 ; 

PubMed: 26163823     


LNCaP-Raf:ER cells were treated with increasing doses of 4-hydroxytamoxifen for 2 days. The bottom panel indicates densitometry of MEK1 and MEK2 signals. Data (mean ± standard error) are from two independent experiments. Pearson’s r = 0.823 for MEK1 and −0.673 for MEK2. 

26163823
Growth inhibition assay
Cell viability; 

PubMed: 26014809     


Dose-dependent effect of 4-hydroxytamoxifen on survival of T47D, MCF-7 and BT-474 cell lines after 96 h of treatment. Control samples were treated with appropriate concentrations of DMSO. Viability was assayed by MTT method.

26014809

Protocol

Cell Research:

[1]

- Collapse
  • Cell lines: Adult Rat and Mouse Cardiac Myocytes
  • Concentrations: 0, 0.5, 1, 3, 5, and 10 µM
  • Incubation Time: 15-45 min
  • Method:

    For sarcomere length measurements, cells are covered in Tyrode’s containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: Sprague-Dawley rats
  • Dosages: 21 mg/kg, 54 μmol/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 77 mg/mL (198.7 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 387.51
Formula

C26H29NO2

CAS No. 68392-35-8
Storage powder
in solvent
Synonyms Afimoxifene
Smiles CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3

In vivo Formulation Calculator (Clear solution)

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03199963 Terminated Drug: 4-OH tamoxifen|Drug: Placebo Mammographic Breast Density BHR Pharma LLC August 21 2017 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID