HomeNew ERK Inhibitors

New ERK Inhibitors

Catalog No. Product Name Information
E5898 SKLB-D18 SKLB-D18 is a first-in-class, potent, and selective inhibitor of ERK1/2 and ERK5 with an IC50's of 38.69 nM, 40.12 nM, and 59.72 nM, respectively, that also acts as an agonist of autophagy. It modulates mTOR/p70S6K and NCOA4-mediated ferroptosis, showing strong anti-tumor activity and offering a promising monotherapy strategy to overcome resistance in ERK1/2-targeted therapy for triple-negative breast cancer (TNBC).
E1959 RMC-4998 RMC-4998 is a tri-complex inhibitor that selectively targets the GTP-bound state of mutant KRASG12C, with high potency for KRASG12C-CYPA tri-complex formation with an IC50 of 28 nM. It strongly inhibits ERK signaling with an IC50 of 1–10 nM and attenuates AKT/MTOR and RAL pathways, leading to potent suppression of KRASG12C-driven tumor growth and can used in cancer research.
F1716 Phospho-ERK1/ ERK2 (Thr 202/ Thr 185) Rabbit mAb
F1152 ERK1 Rabbit mAb Mitogen-activated protein kinase 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, ERK1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, PRKM3, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, ERK2, PRKM1, PRKM2
F1555 Phospho-Erk1 (Thr 202/ Tyr 204)/ Erk2 (Thr 185/ Tyr 187) Rabbit mAb ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187),Erk1 (pT202/pY204) + Erk2 (pT185/pY187),MAP Kinase, Activated (Diphosphorylated ERK-1&2),phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)
≡ All ERK Inhibitors