New STAT Inhibitors

HomeNew STAT Inhibitors

Catalog No. Product Name Information
E6478 ML115 ML115 is a molecular probe and a highly potent, selective agonist of STAT3 with an EC50 of 2.0 nM. It can be used in research on cancer, wound healing, cardiomyopathy, and inflammatory diseases.
E6482 STAT3-IN-12 STAT3-IN-12 is a potent inhibitor of STAT3signaling, by effectively blocking IL-6-induced activation of the JAK/STAT3 pathway. STAT3-IN-12 suppresses cancer cell proliferation and migration, while promoting apoptosis and inducing cell cycle arrest.
E6446 SD-2301 SD-2301 is a potent and selective PROTAC-based STAT3 degrader that targets the VHL–cullin 2 complex, enhancing dendritic cell function and anti-tumor immunity. It synergizes with anti-PD-L1 therapy to robustly suppress tumor growth in vivo.
E5802 SD-436 SD-436 is a potent and selective PROTAC degrader of STAT3 with a DC50 of 0.5 μM. It induces complete and long-lasting tumor regression in leukemia and lymphoma xenograft models in mice.
E1990 KT-333 KT-333 is a first-in-class, potent, and selective heterobifunctional degrader of STAT3 that recruits the VHL E3 ligase for ubiquitin-proteasome-mediated degradation. It induces robust antitumor activity in preclinical models of ALK⁺ anaplastic large cell lymphoma (ALCL).
≡ All STAT Inhibitors