New Bcl-2 Inhibitors

HomeNew Bcl-2 Inhibitors

Catalog No. Product Name Information
E5962 BRD-810 BRD-810 is a potent and highly selective inhibitor of MCL1. BRD-810 targets the BH3-binding pocket of MCL1 and blocks the capturing of pro-apoptotic proteins, thereby rapidly triggering caspase activation in MCL1-dependent cells. It demonstrates potent anti-tumor effects in both hematologic malignancies and solid tumor models.
E8278 WH244 WH244 is a second-generation PROTAC that selectively degrades the anti-apoptotic proteins BCL-xL and BCL-2 with a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2.
F2528 Bcl-XL Antibody [D5E6]
E1510 Sonrotoclax Sonrotoclax(BGB-11417) is a highly potent, orally active and selective inhibitor of Bcl2. Sonrotoclax demonstrates increased potency along with in vitro and in vivo inhibitory activity against both WT Bcl-2 and the G101V mutant. Bcl-xL Sonrotoclax has effective cell killing effect against a variety of lymphoma and leukemia cell lines.
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