HomeNew Bcl-2 Inhibitors

New Bcl-2 Inhibitors

Catalog No. Product Name Information
E8278 WH244 WH244 is a second-generation PROTAC that selectively degrades the anti-apoptotic proteins BCL-xL and BCL-2 with a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2.
F2528 Bcl-XL (D5E6) Rabbit mAb
E1510 Sonrotoclax Sonrotoclax(BGB-11417) is a highly potent, orally active and selective inhibitor of Bcl2. Sonrotoclax demonstrates increased potency along with in vitro and in vivo inhibitory activity against both WT Bcl-2 and the G101V mutant. Bcl-xL Sonrotoclax has effective cell killing effect against a variety of lymphoma and leukemia cell lines.
S8550 Tapotoclax (AMG-176) Tapotoclax (AMG-176) is a potent, selective, and orally bioavailable macrocyclic inhibitor of MCL1 with a Ki of 0.13 nM. It induces a potent apoptosis in models of hematologic malignancies.
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