Fluvastatin Sodium

Catalog No.S1909 Synonyms: XU-62-320

Fluvastatin Sodium Chemical Structure

Molecular Weight(MW): 433.45

Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.

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In DMSO USD 130 In stock
USD 97 In stock
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Cited by 8 Publications

5 Customer Reviews

  • The concentration of lanosterol slightly increases (f) and that of desmosterol significantly increases (g) in the brains of fluvastatin-treated 129.Mecp2tm1.1Bird/Y mice at P70 (n = 4 mice per group; P = 0.042). *P ≤ 0.05 determined using Dunnett’s post-hoc test to compare statin- with vehicle-treated groups. All error bars represent the s.e.m.

    Nat Genet 2013 45(9), 1013-20. Fluvastatin Sodium purchased from Selleck.

    (d) Fluvastatin treatment does not significantly change serum cholesterol concentrations at 8 months of age. (e) Fluvastatin treatment ameliorates elevated lipid concentrations in 129.Mecp2tm1.1Bird/+ livers assessed at 8 months of age (*P = 0.045). One-way ANOVA was used for the data analyses . *P ≤ 0.05 determined using Dunnett’s post-hoc test to compare statin- with vehicle-treated groups. All error bars represent the s.e.m.

    Nat Genet 2013 45(9), 1013-20. Fluvastatin Sodium purchased from Selleck.

  • Mevalonate and geranylgeranyl pyrophosphate reversed fluvastatin-mediated inhibition of proliferation. YT-INDY was incubated for up to 72 hours in the presence of fluvastatin (50 uM) or the solvents in which the drugs were dissolved. The statins or vehicles were added at the start of the experiment. Some statin-treated flasks also received mevalonate (1 mM) or geranylgeranyl pyrophosphate (GGPP) (10 uM). Cell counts were performed on each flask at 24 hour intervals. Each experiment was performed three times and the data was analyzed for statistical significance by Student's t-test. Statistical significance is denoted by asterisks. *: p < 0.05, ***: p < 0.001.

    Biomark Res 2013 1(1), 33. Fluvastatin Sodium purchased from Selleck.

    C, Western blot showing that the addition of mevalonate or GGPP rescues the effect of fluvastatin on GTPase isoprenylation by blocking the appearance of unprenylated Rap1a. α-Tubulin serves as a loading control.

    Mol Cancer Ther, 2018, 17(8):1781-1792. Fluvastatin Sodium purchased from Selleck.

  • Western blot analysis of Nrf2, NQO1, and HO-1 in statin-treated VSMCs. Cells were exposed to fluvastatin and pitavastatin for 24 h at the indicated dosages.

    PLoS One, 2017, 12(5):e0178278. Fluvastatin Sodium purchased from Selleck.

Purity & Quality Control

Choose Selective HMG-CoA Reductase Inhibitors

Biological Activity

Description Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.
Features The order of magnitude of inhibition of each drug on the peroxidation was butylated hydroxytoluene > fluvastatin ≥ probucol ≥ pravastatin.
Targets
HMG-CoA reductase [1]
(Cell-free assay)
8 nM
In vitro

Fluvastatin markedly inhibits the formation of thiobarbituric acid reactive substances in iron (II)-supported peroxidation of liposomes with IC50 of 12 μM. Fluvastatin ranging from 1 μM to 100 μM inhibits peroxyl radical-mediated peroxidation of liposomes induced by water-soluble and lipid-soluble radical generators, 2,2'-azobis (2-amidinopropane) dihydro-chloride and 2,2'-azobis (2,4-dimethylvaleronitrile), respectively. [2] Fluvastatin (4 mM) and its metabolites shows superoxide anion scavenging activity in the hypoxanthine-xanthine oxidase system and a strong scavenging effect on the hydroxyl radical produced from Fenton's reaction. Fluvastatin (8 μM) and its metabolites shows protective effects on DNA damage as potent as the reference antioxidants, ascorbic acid, trolox, and probucol in CHL/IU cells. [3] Fluvastatin (100 nM) shows a dose-dependent decrease in Ang II-activated superoxide anion formation in human aortic smooth muscle cells (hASMC). [4]

In vivo Fluvastatin (10 mg/kg/day) results in a decrease in serum lipids in rabbits feed a 1.5% cholesterol containing diet. Fluvastatin (10 mg/kg/day) significantly lowers the tissue ACE in the aortae in rabbits feed a 1.5% cholesterol containing diet. Fluvastatin (10 mg/kg/day) significantly reverses the suppression of ACh-induced relaxation in rabbits feed a 1.5% cholesterol containing diet. [5]

Protocol

Animal Research:[5]
+ Expand
  • Animal Models: Male Japanese white rabbits
  • Formulation: Saline
  • Dosages: 10 mg/kg
  • Administration: Diet
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 87 mg/mL (200.71 mM)
Water 1 mg/mL (2.3 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 433.45
Formula

C24H25FNNaO4

CAS No. 93957-55-2
Storage powder
in solvent
Synonyms XU-62-320

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02115074 Active not recruiting Drug: Fluvastatine|Drug: Celebrex Glioma Centre Oscar Lambret|Anticancer Fund Belgium June 2014 Phase 1
NCT01524601 Completed Drug: Rosuvastatin Disorder Related to Renal Transplantation|Hypercholesterolemia University of Oslo School of Pharmacy|Oslo University Hospital February 2012 Phase 4
NCT00814606 Withdrawn Drug: Fluvastatin|Drug: Peginterferon alfa2a|Drug: ribavirin Hepatitis C|Hepatitis C Virus University of Chicago February 2010 Phase 2
NCT00752843 Completed Drug: mifepristone + fluvastatin Healthy Subjects Corcept Therapeutics September 2008 Phase 1
NCT00674297 Completed Drug: Fluvastatin Antiphospholipid Syndrome Hospital for Special Surgery New York|University of Texas May 2008 Phase 2
NCT00404287 Terminated Drug: Fluvastatin Aortic Valve Stenosis AORTICA Group October 1 2006 Phase 4

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HMG-CoA Reductase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID