For research use only.
Catalog No.S1909 Synonyms: XU-62-320
Molecular Weight(MW): 433.45
Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.
Selleck's Fluvastatin Sodium has been cited by 13 publications
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The concentration of lanosterol slightly increases (f) and that of desmosterol significantly increases (g) in the brains of fluvastatin-treated 129.Mecp2tm1.1Bird/Y mice at P70 (n = 4 mice per group; P = 0.042). *P ≤ 0.05 determined using Dunnett’s post-hoc test to compare statin- with vehicle-treated groups. All error bars represent the s.e.m.
Nat Genet 2013 45(9), 1013-20. Fluvastatin Sodium purchased from Selleck.
(d) Fluvastatin treatment does not significantly change serum cholesterol concentrations at 8 months of age. (e) Fluvastatin treatment ameliorates elevated lipid concentrations in 129.Mecp2tm1.1Bird/+ livers assessed at 8 months of age (*P = 0.045). One-way ANOVA was used for the data analyses . *P ≤ 0.05 determined using Dunnett’s post-hoc test to compare statin- with vehicle-treated groups. All error bars represent the s.e.m.
Nat Genet 2013 45(9), 1013-20. Fluvastatin Sodium purchased from Selleck.
Mevalonate and geranylgeranyl pyrophosphate reversed fluvastatin-mediated inhibition of proliferation. YT-INDY was incubated for up to 72 hours in the presence of fluvastatin (50 uM) or the solvents in which the drugs were dissolved. The statins or vehicles were added at the start of the experiment. Some statin-treated flasks also received mevalonate (1 mM) or geranylgeranyl pyrophosphate (GGPP) (10 uM). Cell counts were performed on each flask at 24 hour intervals. Each experiment was performed three times and the data was analyzed for statistical significance by Student's t-test. Statistical significance is denoted by asterisks. *: p < 0.05, ***: p < 0.001.
Biomark Res 2013 1(1), 33. Fluvastatin Sodium purchased from Selleck.
Purity & Quality Control
Choose Selective HMG-CoA Reductase Inhibitors
|Description||Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.|
|Features||The order of magnitude of inhibition of each drug on the peroxidation was butylated hydroxytoluene > fluvastatin ≥ probucol ≥ pravastatin.|
Fluvastatin markedly inhibits the formation of thiobarbituric acid reactive substances in iron (II)-supported peroxidation of liposomes with IC50 of 12 μM. Fluvastatin ranging from 1 μM to 100 μM inhibits peroxyl radical-mediated peroxidation of liposomes induced by water-soluble and lipid-soluble radical generators, 2,2'-azobis (2-amidinopropane) dihydro-chloride and 2,2'-azobis (2,4-dimethylvaleronitrile), respectively.  Fluvastatin (4 mM) and its metabolites shows superoxide anion scavenging activity in the hypoxanthine-xanthine oxidase system and a strong scavenging effect on the hydroxyl radical produced from Fenton's reaction. Fluvastatin (8 μM) and its metabolites shows protective effects on DNA damage as potent as the reference antioxidants, ascorbic acid, trolox, and probucol in CHL/IU cells.  Fluvastatin (100 nM) shows a dose-dependent decrease in Ang II-activated superoxide anion formation in human aortic smooth muscle cells (hASMC). 
|In vivo||Fluvastatin (10 mg/kg/day) results in a decrease in serum lipids in rabbits feed a 1.5% cholesterol containing diet. Fluvastatin (10 mg/kg/day) significantly lowers the tissue ACE in the aortae in rabbits feed a 1.5% cholesterol containing diet. Fluvastatin (10 mg/kg/day) significantly reverses the suppression of ACh-induced relaxation in rabbits feed a 1.5% cholesterol containing diet. |
-  Dansette PM, et al. Exp Toxicol Pathol, 2000, 52(2), 145-148.
-  Yamamoto A, et al. J Pharm Pharmacol, 2001, 53(2), 227-232.
-  Imaeda A, et al. Free Radic Res, 2001, 35(6), 789-801.
|In vitro||DMSO||87 mg/mL (200.71 mM)|
|Water||1 mg/mL (2.3 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02115074||Active not recruiting||Drug: Fluvastatine|Drug: Celebrex||Glioma||Centre Oscar Lambret|Anticancer Fund Belgium||June 2014||Phase 1|
|NCT01524601||Completed||Drug: Rosuvastatin||Disorder Related to Renal Transplantation|Hypercholesterolemia||University of Oslo School of Pharmacy|Oslo University Hospital||February 2012||Phase 4|
|NCT00814606||Withdrawn||Drug: Fluvastatin|Drug: Peginterferon alfa2a|Drug: ribavirin||Hepatitis C|Hepatitis C Virus||University of Chicago||February 2010||Phase 2|
|NCT00752843||Completed||Drug: mifepristone + fluvastatin||Healthy Subjects||Corcept Therapeutics||September 2008||Phase 1|
|NCT00674297||Completed||Drug: Fluvastatin||Antiphospholipid Syndrome||Hospital for Special Surgery New York|University of Texas||May 2008||Phase 2|
|NCT00404287||Terminated||Drug: Fluvastatin||Aortic Valve Stenosis||AORTICA Group||October 1 2006||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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