Pravastatin sodium

Catalog No.S3036 Synonyms: CS-514 Sodium

Pravastatin sodium Chemical Structure

Molecular Weight(MW): 446.51

Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.

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In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
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Cited by 4 Publications

1 Customer Review

  • B, Uptake of DHEAS in PC cells with 2.5 µM DHEAS and different concentrations of statins when incubated for 60 minutes. Statistical analysis was performed by comparing each condition with the DHEAS 2.5 µM and no statin state except when indicated.

    JAMA Oncol, 2015, 1(4):495-504. . Pravastatin sodium purchased from Selleck.

Purity & Quality Control

Choose Selective HMG-CoA Reductase Inhibitors

Biological Activity

Description Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
Targets
HMG-CoA reductase [1]
5.6 μM
In vitro

Pravastatin-Na at 10 μM inhibits the sterol synthesis at a level greater than 50% in PBMC. [1] Pravastatin produces relaxation of isolated aortic rings, with maximum vasorelaxations of 62.8% at 10 μM and latency of ~8 min. Pravastatin (< 10 μM) stimulates NOS activity and NO release within 10 min in cultured bovine aortic endothelial cells. L-arginine potentiates NO production in response to Pravastatin (< 10 μM) in cultured bovine aortic endothelial cells. [2] Pravastatin results in a dose-dependent inhibition of macrophage cholesterol synthesis in human monocyte derived macrophages(HMDM), mouse peritoneal macrophages (MPM) and a J-774 A.1 macrophagelike cell lines. Small concentrations of pravastatin (< 0.19 μg/mL) increases the cellular cholesterol esterification rate after incubation with LDL, but higher concentrations (< 100 μg/mL) results in an inhibition of the esterification. [3] Pravastatin (< 0.5 mM) decreases Rho/ROCK pathway activity in human colon and ileum explants, which leads to decreased CCN2 mRNA levels. Pravastatin (<1 mM) also induces CCN2 inhibition in primary human smooth muscle cells. Pravastatin (< 0.5 mM) decreases type I collagen and fibronectin mRNA levels in both human colon and ileum explants and primary human smooth muscle cells. [4]

In vivo Pravastatin (40 mg, single dose) causes a reduction in cholesterol synthesis in human monocyte derived macrophages by 62% in healthy subjects and 47% in hypercholesterolaemic patients. Pravastatin (40 mg/day, 8 weeks) results in a 55% inhibition of cholesterol synthesis and a 57% increase in LDL degradation in hypercholesterolaemic patients. [3] Pravastatin (30 mg/kg/d) results in decreased length of the dystrophic lesions by 34% and recovery of muscular structure in Male Wistar rats receiving irradiation, associated with decreased CCN2 level. [4]

Protocol

Animal Research:[4]
+ Expand
  • Animal Models: Male Wistar rats receiving irradiation for 5 weeks
  • Formulation: sterile water
  • Dosages: 30 mg/kg/day
  • Administration: Orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 89 mg/mL (199.32 mM)
Water 89 mg/mL (199.32 mM)
Ethanol 12 mg/mL (26.87 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 446.51
Formula

C23H35O7.Na

CAS No. 81131-70-6
Storage powder
in solvent
Synonyms CS-514 Sodium

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03456102 Not yet recruiting Drug: Pravastatin Tuberculosis Johns Hopkins University December 2019 Phase 2
NCT02621957 Completed Drug: GDC-0810|Drug: Pravastatin Breast Cancer Genentech Inc. December 2015 Phase 1
NCT02431013 Unknown status Drug: Simvastatin|Drug: Pravastatin|Drug: Cilostazol Dyslipidemias|Peripheral Artery Disease Ajou University School of Medicine April 2015 Phase 1
NCT02360826 Completed Drug: Pravastatin|Drug: Simvastatin Drug Distribution Children''s Mercy Hospital Kansas City|American Heart Association June 17 2014 Phase 1
NCT01958489 Completed Drug: Evacetrapib|Drug: Pravastatin Healthy Volunteers Eli Lilly and Company October 2013 Phase 1

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HMG-CoA Reductase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID