Catalog No.S3036 Synonyms: CS-514 Sodium
Molecular Weight(MW): 446.51
Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
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B, Uptake of DHEAS in PC cells with 2.5 µM DHEAS and different concentrations of statins when incubated for 60 minutes. Statistical analysis was performed by comparing each condition with the DHEAS 2.5 µM and no statin state except when indicated.
JAMA Oncol, 2015, 1(4):495-504. . Pravastatin sodium purchased from Selleck.
Purity & Quality Control
Choose Selective HMG-CoA Reductase Inhibitors
|Description||Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.|
Pravastatin-Na at 10 μM inhibits the sterol synthesis at a level greater than 50% in PBMC.  Pravastatin produces relaxation of isolated aortic rings, with maximum vasorelaxations of 62.8% at 10 μM and latency of ~8 min. Pravastatin (< 10 μM) stimulates NOS activity and NO release within 10 min in cultured bovine aortic endothelial cells. L-arginine potentiates NO production in response to Pravastatin (< 10 μM) in cultured bovine aortic endothelial cells.  Pravastatin results in a dose-dependent inhibition of macrophage cholesterol synthesis in human monocyte derived macrophages(HMDM), mouse peritoneal macrophages (MPM) and a J-774 A.1 macrophagelike cell lines. Small concentrations of pravastatin (< 0.19 μg/mL) increases the cellular cholesterol esterification rate after incubation with LDL, but higher concentrations (< 100 μg/mL) results in an inhibition of the esterification.  Pravastatin (< 0.5 mM) decreases Rho/ROCK pathway activity in human colon and ileum explants, which leads to decreased CCN2 mRNA levels. Pravastatin (<1 mM) also induces CCN2 inhibition in primary human smooth muscle cells. Pravastatin (< 0.5 mM) decreases type I collagen and fibronectin mRNA levels in both human colon and ileum explants and primary human smooth muscle cells. 
|In vivo||Pravastatin (40 mg, single dose) causes a reduction in cholesterol synthesis in human monocyte derived macrophages by 62% in healthy subjects and 47% in hypercholesterolaemic patients. Pravastatin (40 mg/day, 8 weeks) results in a 55% inhibition of cholesterol synthesis and a 57% increase in LDL degradation in hypercholesterolaemic patients.  Pravastatin (30 mg/kg/d) results in decreased length of the dystrophic lesions by 34% and recovery of muscular structure in Male Wistar rats receiving irradiation, associated with decreased CCN2 level. |
-  Kurakata S, et al. Immunopharmacology, 1996, 34(1), 51-61.
-  Kaesemeyer WH, et al. J Am Coll Cardiol, 1999, 33(1), 234-241.
-  Keidar S, et al. Br J Clin Pharmacol, 1994, 38(6), 513-519.
|In vitro||DMSO||89 mg/mL (199.32 mM)|
|Water||89 mg/mL (199.32 mM)|
|Ethanol||12 mg/mL (26.87 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03456102||Not yet recruiting||Drug: Pravastatin||Tuberculosis||Johns Hopkins University||December 2019||Phase 2|
|NCT02621957||Completed||Drug: GDC-0810|Drug: Pravastatin||Breast Cancer||Genentech Inc.||December 2015||Phase 1|
|NCT02431013||Unknown status||Drug: Simvastatin|Drug: Pravastatin|Drug: Cilostazol||Dyslipidemias|Peripheral Artery Disease||Ajou University School of Medicine||April 2015||Phase 1|
|NCT02360826||Completed||Drug: Pravastatin|Drug: Simvastatin||Drug Distribution||Children''s Mercy Hospital Kansas City|American Heart Association||June 17 2014||Phase 1|
|NCT01958489||Completed||Drug: Evacetrapib|Drug: Pravastatin||Healthy Volunteers||Eli Lilly and Company||October 2013||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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