Home Cytoskeletal Signaling Kinesin inhibitor GW406108X For research use only.

GW406108X

Synonyms: GW108X

GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.

GW406108X Chemical Structure

GW406108X Chemical Structure

CAS: 1644443-92-4

Purity & Quality Control

Batch: S695301 DMSO] 80 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 98.36%
98.36

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Biological Activity

Description GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
Targets
ULK1 [2]
(Cell-free assay)		 Kif15 [1]
(in the ATPase assay)
6.37(pIC50) 0.82 μM

Chemical Information & Solubility

Molecular Weight 400.21 Formula

C20H11Cl2NO4
CAS No. 1644443-92-4 SDF --
Smiles OC1=C(Cl)C=C(C=C1Cl)/C=C/2C(=O)NC3=C2C=C(C=C3)C(=O)C4=CC=CO4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 80 mg/mL ( (199.89 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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