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Liver X Receptor

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S2630 GW3965 Hydrochloride GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively.
Small, 2025, 21(20):e2307097
Int J Chron Obstruct Pulmon Dis, 2025, 20:411-423
Sci Rep, 2024, 14(1):30786
Verified customer review of GW3965 Hydrochloride
S7076 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of 20nM for LXRα and 5 μM for FXR, respectively. This compound is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. It significantly suppresses cell proliferation and induces apoptosis.
J Clin Invest, 2025, 135(10)e186478
J Exp Med, 2025, 222(3)e20230647
Neurobiol Dis, 2025, 215:107094
Verified customer review of T0901317
S8390 LXR-623 (WAY-252623) LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.
Acta Neuropathol Commun, 2022, 10(1):40
Cancers (Basel), 2022, 14(16)3873
EMBO Mol Med, 2019, 11(10):e10769
E1142 GSK2033 GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα and LXRβ, respectively.
J Exp Med, 2025, 222(3)e20230647
J Lipid Res, 2025, 66(5):100795
bioRxiv, 2023, 10.1101/2023.05.11.540294
S7934 SR9243 SR9243 is a potent and selective LXR inverse agonist.
Front Immunol, 2021, 12:732102
FEBS Lett, 2016, 590(11):1614-29
S8689 Abequolixron (RGX-104) Abequolixron (RGX-104) is an orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
Theranostics, 2025, 15(12):5572-5591
S6427 AZ876 AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively.
J Clin Invest, 2019, 129(3):1129-1151
E7041 Desmosterol Desmosterol is the immediate unsaturated precursor of cholesterol and the final biosynthetic intermediate in the Bloch pathway and a key activator of liver X receptors(LXR) while inhibiting SREBP to regulate lipid homeostasis. Its reduction promotes mitochondrial ROS production in macrophages and activates the NLRP3 inflammasome exhibiting potential for research in inflammation, metabolism, and cardiovascular diseases.
E0099 GSK3987 GSK3987 is an agonist of pan LXRα/β with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. This compound increases the expression of ABCA1 and SREBP-1c and induces cellular cholesterol efflux and triglyceride accumulation.