Liver X Receptor

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Isoform-selective Inhibitors

Liver X Receptor Products

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Catalog No. Product Name Information Product Use Citations Product Validations
A5313 LXR alpha Rabbit Recombinant mAb LXR alpha Rabbit Recombinant mAb detects endogenous level of total LXR alpha.
J Virol, 2021, 95(6)e01938-20
S2630 GW3965 HCl GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively.
Nat Immunol, 2021, 10.1038/s41590-021-01047-4
J Med Chem, 2021, 64(14):9943-9959
ACS Chem Biol, 2021, 16(1):136-149
S6427 AZ876 AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively.
J Clin Invest, 2019, 129(3):1129-1151
S7076 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.
Front Cardiovasc Med, 2021, 8:746989
Hepatology, 2020, 10.1002/hep.31594
Cell Mol Immunol, 2020, 10.1038/s41423-020-00546-y
S7934 SR9243 SR9243 is a potent and selective LXR inverse agonist.
Front Immunol, 2021, 12:732102
FEBS Lett, 2016, 590(11):1614-29
S8390 LXR-623 (WAY-252623) LXR-623 (WAY-252623) is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.
EMBO Mol Med, 2019, 11(10):e10769
Cancers (Basel), 2019, 11(6)
S8689 RGX-104 RGX-104 is a orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
A5313 LXR alpha Rabbit Recombinant mAb LXR alpha Rabbit Recombinant mAb detects endogenous level of total LXR alpha.
J Virol, 2021, 95(6)e01938-20
S2630 GW3965 HCl GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively.
Nat Immunol, 2021, 10.1038/s41590-021-01047-4
J Med Chem, 2021, 64(14):9943-9959
ACS Chem Biol, 2021, 16(1):136-149
S6427 AZ876 AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively.
J Clin Invest, 2019, 129(3):1129-1151
S7076 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.
Front Cardiovasc Med, 2021, 8:746989
Hepatology, 2020, 10.1002/hep.31594
Cell Mol Immunol, 2020, 10.1038/s41423-020-00546-y
S7934 SR9243 SR9243 is a potent and selective LXR inverse agonist.
Front Immunol, 2021, 12:732102
FEBS Lett, 2016, 590(11):1614-29
S8390 LXR-623 (WAY-252623) LXR-623 (WAY-252623) is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.
EMBO Mol Med, 2019, 11(10):e10769
Cancers (Basel), 2019, 11(6)
S8689 RGX-104 RGX-104 is a orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene.