ROR

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Isoform-selective Inhibitors

ROR Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S3483 TMP778 TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay.
S0094 SR 0987 SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.
S2654 Neoruscogenin Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).
S2969 SR3335 SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.
S5775 SR1078 SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.
Cell Death Dis, 2021, 12(3):247
S6610 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ.
S6724 SR1001 SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.
S7076 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.
Front Cardiovasc Med, 2021, 8:746989
Hepatology, 2020, 10.1002/hep.31594
Cell Mol Immunol, 2020, 10.1038/s41423-020-00546-y
S8860 Cintirorgon (LYC-55716) Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.
S3483 TMP778 TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay.
S0094 SR 0987 SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.
S2654 Neoruscogenin Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).
S2969 SR3335 SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.
S5775 SR1078 SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.
Cell Death Dis, 2021, 12(3):247
S6610 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ.
S6724 SR1001 SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.
S7076 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.
Front Cardiovasc Med, 2021, 8:746989
Hepatology, 2020, 10.1002/hep.31594
Cell Mol Immunol, 2020, 10.1038/s41423-020-00546-y
S8860 Cintirorgon (LYC-55716) Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.