ROR
Inhibitory Selectivity
Isoform-specific Inhibitors
ROR Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3483New |
TMP778TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay. |
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| S7076 |
T0901317T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis. |
(C) Cells were pretreated with DMSO or T0901317 (5 μM), then incubated with 100 mg/L ox-LDL for 6 h. |
|
| S6610 |
GSK2981278GSK2981278 is a highly potent and selective inverse agonist for RORγ. |
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| S5775 |
SR1078SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist. |
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| S0094 |
SR 0987SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer. |
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| S2969New |
SR3335SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM. |
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| S8860 |
Cintirorgon (LYC-55716)Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ. |
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| S6724 |
SR1001SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively. |
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| S2654 |
NeoruscogeninNeoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1). |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3483New |
TMP778TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7076 |
T0901317T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis. |
(C) Cells were pretreated with DMSO or T0901317 (5 μM), then incubated with 100 mg/L ox-LDL for 6 h. |
|
| S6610 |
GSK2981278GSK2981278 is a highly potent and selective inverse agonist for RORγ. |
||
| S5775 |
SR1078SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist. |
||
| S0094 |
SR 0987SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer. |
||
| S2969New |
SR3335SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM. |
||
| S8860 |
Cintirorgon (LYC-55716)Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ. |
||
| S6724 |
SR1001SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively. |
||
| S2654 |
NeoruscogeninNeoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1). |
