ROR

All (6) ROR Agonists (6)

Catalog No.	Information	Product Use Citations	Product Validations
S7076	T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.	J Cell Mol Med, 2020, 24(6):3384-3398 Nat Commun, 2019, 11;10(1):4621 Neoplasia, 2019, 22(1):1-9	(C) Cells were pretreated with DMSO or T0901317 (5 μM), then incubated with 100 mg/L ox-LDL for 6 h.
S6610^New	GSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ.
S5775	SR1078 SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.
S8860^New	Cintirorgon (LYC-55716) Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.
S6724^New	SR1001 SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.
S2654^New	Neoruscogenin Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).

Catalog No.	Information	Product Use Citations	Product Validations
S7076	T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.	J Cell Mol Med, 2020, 24(6):3384-3398 Nat Commun, 2019, 11;10(1):4621 Neoplasia, 2019, 22(1):1-9	(C) Cells were pretreated with DMSO or T0901317 (5 μM), then incubated with 100 mg/L ox-LDL for 6 h.
S6610^New	GSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ.
S5775	SR1078 SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.
S8860^New	Cintirorgon (LYC-55716) Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.
S6724^New	SR1001 SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.
S2654^New	Neoruscogenin Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).