ROR

Inhibitory Selectivity

ROR Products

Catalog No. Information Product Use Citations Product Validations
S7076

T0901317

T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.

S6610

GSK2981278

GSK2981278 is a highly potent and selective inverse agonist for RORγ.

S5775

SR1078

SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.

S0094New

SR 0987

SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.

S8860

Cintirorgon (LYC-55716)

Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.

S2654New

Neoruscogenin

Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).

S6724

SR1001

SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.

Catalog No. Information Product Use Citations Product Validations
S7076

T0901317

T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.

S6610

GSK2981278

GSK2981278 is a highly potent and selective inverse agonist for RORγ.

S5775

SR1078

SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.

S0094New

SR 0987

SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.

S8860

Cintirorgon (LYC-55716)

Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.

S2654New

Neoruscogenin

Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).

S6724

SR1001

SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.