IRE1

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7272 4μ8C <1 mg/mL 19 mg/mL <1 mg/mL
S7771 STF-083010 <1 mg/mL 63 mg/mL <1 mg/mL
S8286 MKC-3946 <1 mg/mL 38 mg/mL 3 mg/mL
S8658 kira6 <1 mg/mL 60 mg/mL 60 mg/mL
Catalog No. Information Product Use Citations Product Validations
S7272

4μ8C

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.

S7771

STF-083010

STF-083010 is a specific IRE1α endonuclease inhibitor without affecting its kinase activity.

S8286

MKC-3946

MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.

S8658New

kira6

kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization.

Tags: IRE1 inhibitor | IRE1 modulator | IRE1 stress