Propranolol HCl

Catalog No.S4076 Batch:S407602

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Technical Data

Formula

C16H21NO2.HCl

Molecular Weight 295.8 CAS No. 318-98-9
Solubility (25°C)* In vitro DMSO 59 mg/mL (199.45 mM)
Water 59 mg/mL (199.45 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor.
Targets
β-adrenergic receptor [1]
12 nM
In vitro

Propranolol, a non-selective β1 and β2 adrenergic blocker, has no effect on the proliferation of neonatal mouse cardiac fibroblasts (NMCFs).[2]

In vivo

Propranolol, an anti-arrhythmic drugs, consistently reduces the heart rates of adult mice by approximately 10%-20%, whereas isoproterenol has the opposite effect.[2]

Protocol (from reference)

Cell Assay:

[2]

  • Cell lines

    neonatal mice cardiomyocytes (NMCMs)

  • Concentrations

    10, 20, 40, 50, and 100 μM

  • Incubation Time

    6, 12, 18, and 24 h

  • Method

    In vitro, the neonatal mice cardiomyocytes (NMCMs) are treated with different drugs of different concentration, including isoproterenol (0, 1, 2.5, 5, 10, 20, and 50 μM); amiodarone (0, 1, 2.5, 5, 10, 20, and 50 μM); metoprolol (0, 10, 20, 30, 50, 100, 150, and 200 μM); propranolol (0, 10, 20, 40, 50, and 100 μM); lidocaine (0, 1, 2.5, 5, 10, 20, and 50 μM); verapamil(0, 1, 2.5, 5, 10, 20, and 50 μM);ivabradine (0, 1, 2, 3, 5, 10, and 20 μM). And the concentrations of drugs that promote CMs proliferation most significantly are chosen for subsequent experiments, including isoproterenol (10 μM), amiodarone (5 μM), metoprolol (20 μM), propranolol (20 μM), lidocaine (5 μM), verapamil (2.5 μM), ivabradine (3 μM) for NMCMs, NMCFs, and hPSC-CM.

Animal Study:

[2]

  • Animal Models

    1-day-old neonatal mice; 12-week-old adult mice

  • Dosages

    10 mg/kg/d

  • Administration

    s.c.; ALZET Osmotic Pumps

Selleck's Propranolol HCl has been cited by 14 publications

Multiple cancer cell types release LIF and Gal3 to hijack neural signals [ Cell Res, 2024, 10.1038/s41422-024-00946-z] PubMed: 38467743
Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline [ Sci Rep, 2024, 14(1):4178] PubMed: 38378892
Ketone bodies promote stroke recovery via GAT-1-dependent cortical network remodeling [ Cell Reports, 2023, 42(4)] PubMed: None
Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma [ EBioMedicine, 2022, 82:104149] PubMed: 35816899
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch [ Cell Rep, 2022, 38(10):110468] PubMed: 35263588
KCNQ1-deficient and KCNQ1-mutant human embryonic stem cell-derived cardiomyocytes for modeling QT prolongation [ Stem Cell Res Ther, 2022, 13(1):287] PubMed: 35765105
Targeting the β2 -adrenergic receptor increases chemosensitivity in multiple myeloma by induction of apoptosis and modulating cancer cell metabolism [ J Pathol, 2022, 10.1002/path.6020] PubMed: 36245401
Targeting ADRB2 enhances sensitivity of non-small cell lung cancer to VEGFR2 tyrosine kinase inhibitors [ Cell Death Discov, 2022, 8(1):36] PubMed: 35075132
LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy [ Front Endocrinol (Lausanne), 2022, 13:895360] PubMed: 35813614
LPIN1 Induces Gefitinib Resistance in EGFR Inhibitor-Resistant Non-Small Cell Lung Cancer Cells [ Cancers (Basel), 2022, 14(9)2222] PubMed: 35565351

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.