For research use only.
CAS No. 16676-29-2
Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
Selleck's Naltrexone HCl has been cited by 4 publications
2 Customer Reviews
The sex difference in epidermal melanocytes after tranexamic acid treatment following naltrexone treatment. Naltrexone was injected intraperitoneally into the mice throughout the experimental period. Five days after the final UVB irradiation of the eye, the number of Dopa-positive melanocytes in the epidermal sheets prepared from the ear was determined. The values are presented as the means±SD derived from six animals (biological replicates; *P < 0.05).
Photodermatol Photoimmunol Photomed, 2016, 32(3):136-45.. Naltrexone HCl purchased from Selleck.
Purity & Quality Control
Choose Selective Opioid Receptor Inhibitors
|Description||Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.|
|In vivo||Naltrexone (0.32 mg/kg) reduces ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%) in rhesus monkeys. Naltrexone (0.1 mg/kg) reduces ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake.  Naltrexone (1-3 mg/kg) potently and dose-dependently inhibits reinstatement of ethanol-seeking produced by non-contingent deliveries of the liquid dipper filled with 8% ethanol.  Naltrexone elicits optimal enhancement of morphine's antinociceptive potency in mice when co-administered (i.p.) at about 100 ng/kg together with morphine (3 mg/kg).  Naltrexone (10 ng/kg i.p.) augments the antinociception produced by an acute submaximal dose of intrathecal (5 mg) or systemic (7.5 mg/kg i.p.) morphine in the tail-flick test in rats. Naltrexone combined with Morphine inhibits the decline in morphine antinociception and prevented the loss of morphine potency in rats.  Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels.  Naltrexone completely prevents the reduction in anogenital distance in prenatally stressed (PS) males and restores the growth rate of both sexes. Naltrexone also decreases the anxiety of PS rats in the plus-maze, increases the opioid component of exploration to control levels, but increases anxiety in control males. |
-  Williams KL, et al. Psychopharmacology (Berl), 1998, 139(1-2), 53-61.
-  Bienkowski P, et al. Eur J Pharmacol, 1999, 374(3), 321-327.
-  Shen KF, et al. Brain Res, 1997, 757(2), 176-190.
|In vitro||DMSO||14 mg/mL (37.05 mM)|
|Water||14 mg/mL (37.05 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04391764||Not yet recruiting||Drug: Naltrexone|Drug: Placebo oral tablet||Liver Cirrhosis||Institute of Liver and Biliary Sciences India||August 5 2020||Not Applicable|
|NCT03678792||Withdrawn||Drug: Buprenorphine/naloxone|Drug: Morphine|Drug: Tramadol||Opioid-Related Disorders|Opioid Withdrawal||University of Alabama at Birmingham||November 15 2019||Phase 3|
|NCT03810495||Active not recruiting||Drug: naltrexone implant||Opioid Use Disorder||Go Medical Industries Pty Ltd|National Institute on Drug Abuse (NIDA)|New York State Psychiatric Institute|Columbia University|Clinilabs Inc.||April 11 2019||Phase 1|
|NCT03879460||Completed||Drug: Naltrexone Hydrochloride||Opioid Intoxication||Timothy Smith|Canadian Department of National Defense||March 18 2019||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.