Naltrexone HCl

For research use only.

Catalog No.S2103

4 publications

Naltrexone HCl Chemical Structure

CAS No. 16676-29-2

Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 127 In stock
EUR 58 In stock
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Selleck's Naltrexone HCl has been cited by 4 publications

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  • The sex difference in epidermal melanocytes after tranexamic acid treatment following naltrexone treatment. Naltrexone was injected intraperitoneally into the mice throughout the experimental period. Five days after the final UVB irradiation of the eye, the number of Dopa-positive melanocytes in the epidermal sheets prepared from the ear was determined. The values are presented as the means±SD derived from six animals (biological replicates; *P < 0.05).

    Photodermatol Photoimmunol Photomed, 2016, 32(3):136-45.. Naltrexone HCl purchased from Selleck.

    (b) plasma IL-6 and (c) plasma tumornecrosis factor (TNF)-a concentrations in the colon carcinomamodel. The values represent the mean±SD derived from sixanimals. *P < 0.05

    Photodermatol Photoimmunol Photomed, 2017, 33(2):84-91. Naltrexone HCl purchased from Selleck.

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Biological Activity

Description Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
opioid receptor [1]
8 nM
In vivo Naltrexone (0.32 mg/kg) reduces ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%) in rhesus monkeys. Naltrexone (0.1 mg/kg) reduces ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. [1] Naltrexone (1-3 mg/kg) potently and dose-dependently inhibits reinstatement of ethanol-seeking produced by non-contingent deliveries of the liquid dipper filled with 8% ethanol. [2] Naltrexone elicits optimal enhancement of morphine's antinociceptive potency in mice when co-administered (i.p.) at about 100 ng/kg together with morphine (3 mg/kg). [3] Naltrexone (10 ng/kg i.p.) augments the antinociception produced by an acute submaximal dose of intrathecal (5 mg) or systemic (7.5 mg/kg i.p.) morphine in the tail-flick test in rats. Naltrexone combined with Morphine inhibits the decline in morphine antinociception and prevented the loss of morphine potency in rats. [4] Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels. [5] Naltrexone completely prevents the reduction in anogenital distance in prenatally stressed (PS) males and restores the growth rate of both sexes. Naltrexone also decreases the anxiety of PS rats in the plus-maze, increases the opioid component of exploration to control levels, but increases anxiety in control males. [6]


Solubility (25°C)

In vitro DMSO 14 mg/mL (37.05 mM)
Water 14 mg/mL (37.05 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 377.86


CAS No. 16676-29-2
Storage powder
in solvent
Synonyms N/A
Smiles C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04391764 Not yet recruiting Drug: Naltrexone|Drug: Placebo oral tablet Liver Cirrhosis Institute of Liver and Biliary Sciences India August 5 2020 Not Applicable
NCT03678792 Withdrawn Drug: Buprenorphine/naloxone|Drug: Morphine|Drug: Tramadol Opioid-Related Disorders|Opioid Withdrawal University of Alabama at Birmingham November 15 2019 Phase 3
NCT03810495 Active not recruiting Drug: naltrexone implant Opioid Use Disorder Go Medical Industries Pty Ltd|National Institute on Drug Abuse (NIDA)|New York State Psychiatric Institute|Columbia University|Clinilabs Inc. April 11 2019 Phase 1
NCT03879460 Completed Drug: Naltrexone Hydrochloride Opioid Intoxication Timothy Smith|Canadian Department of National Defense March 18 2019 Phase 1

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Opioid Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID