Naltrexone HCl

Catalog No.S2103

Naltrexone HCl Chemical Structure

Molecular Weight(MW): 377.86

Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
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2 Customer Reviews

  • (b) plasma IL-6 and (c) plasma tumornecrosis factor (TNF)-a concentrations in the colon carcinomamodel. The values represent the mean±SD derived from sixanimals. *P < 0.05

    Photodermatol Photoimmunol Photomed, 2017, 33(2):84-91. Naltrexone HCl purchased from Selleck.

    The sex difference in epidermal melanocytes after tranexamic acid treatment following naltrexone treatment. Naltrexone was injected intraperitoneally into the mice throughout the experimental period. Five days after the final UVB irradiation of the eye, the number of Dopa-positive melanocytes in the epidermal sheets prepared from the ear was determined. The values are presented as the means±SD derived from six animals (biological replicates; *P < 0.05).

    Photodermatol Photoimmunol Photomed, 2016, 32(3):136-45.. Naltrexone HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Opioid Receptor Inhibitors

Biological Activity

Description Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
Targets
opioid receptor [1]
8 nM
In vivo Naltrexone (0.32 mg/kg) reduces ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%) in rhesus monkeys. Naltrexone (0.1 mg/kg) reduces ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. [1] Naltrexone (1-3 mg/kg) potently and dose-dependently inhibits reinstatement of ethanol-seeking produced by non-contingent deliveries of the liquid dipper filled with 8% ethanol. [2] Naltrexone elicits optimal enhancement of morphine's antinociceptive potency in mice when co-administered (i.p.) at about 100 ng/kg together with morphine (3 mg/kg). [3] Naltrexone (10 ng/kg i.p.) augments the antinociception produced by an acute submaximal dose of intrathecal (5 mg) or systemic (7.5 mg/kg i.p.) morphine in the tail-flick test in rats. Naltrexone combined with Morphine inhibits the decline in morphine antinociception and prevented the loss of morphine potency in rats. [4] Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels. [5] Naltrexone completely prevents the reduction in anogenital distance in prenatally stressed (PS) males and restores the growth rate of both sexes. Naltrexone also decreases the anxiety of PS rats in the plus-maze, increases the opioid component of exploration to control levels, but increases anxiety in control males. [6]

Protocol

Solubility (25°C)

In vitro DMSO 14 mg/mL (37.05 mM)
Water 14 mg/mL (37.05 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 377.86
Formula

C20H23NO4.HCl

CAS No. 16676-29-2
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03275350 Recruiting Opioid-use Disorder|Hiv Oregon Health and Science University|National Institute on Drug Abuse (NIDA)|Johns Hopkins University|University of Kentucky|Whitman-Walker Health|Jackson Health System|Florida Department of Health|Tarzana Treatment Centers|Ruth M. Rothstein CORE Center February 5 2018 Phase 2|Phase 3
NCT00831272 Completed Alcohol Dependence David Oslin|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|University of Pennsylvania January 5 2009 Phase 4
NCT03660475 Recruiting Dry Eye Disease Eugene B. McLaurin M.D. F.A.C.S.|Total Eye Care PA July 31 2018 Phase 2
NCT03482479 Not yet recruiting Eosinophilic Granulomatosis With Polyangiitis (EGPA)|Churg-Strauss Syndrome (CSS)|Giant Cell Arteritis|Granulomatosis With Polyangiitis|Microscopic Polyangiitis|Polyarteritis Nodosa|Takayasu Arteritis University of Pennsylvania December 30 2018 Phase 2
NCT03278886 Recruiting HIV Infection|Alcohol Use|Pain Boston Medical Center|National Institute on Alcohol Abuse and Alcoholism (NIAAA) July 3 2018 Phase 1|Phase 2
NCT03581630 Completed Breast Cancer|Obesity|Overweight Gangnam Severance Hospital July 29 2017 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Opioid Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID