Naltrexone HCl

Catalog No.S2103

For research use only.

Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.

Naltrexone HCl Chemical Structure

CAS No. 16676-29-2

Selleck's Naltrexone HCl has been cited by 7 Publications

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Purity & Quality Control

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Biological Activity

Description Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
Targets
opioid receptor [1]
8 nM
In vivo Naltrexone (0.32 mg/kg) reduces ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%) in rhesus monkeys. Naltrexone (0.1 mg/kg) reduces ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. [1] Naltrexone (1-3 mg/kg) potently and dose-dependently inhibits reinstatement of ethanol-seeking produced by non-contingent deliveries of the liquid dipper filled with 8% ethanol. [2] Naltrexone elicits optimal enhancement of morphine's antinociceptive potency in mice when co-administered (i.p.) at about 100 ng/kg together with morphine (3 mg/kg). [3] Naltrexone (10 ng/kg i.p.) augments the antinociception produced by an acute submaximal dose of intrathecal (5 mg) or systemic (7.5 mg/kg i.p.) morphine in the tail-flick test in rats. Naltrexone combined with Morphine inhibits the decline in morphine antinociception and prevented the loss of morphine potency in rats. [4] Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels. [5] Naltrexone completely prevents the reduction in anogenital distance in prenatally stressed (PS) males and restores the growth rate of both sexes. Naltrexone also decreases the anxiety of PS rats in the plus-maze, increases the opioid component of exploration to control levels, but increases anxiety in control males. [6]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 14 mg/mL
(37.05 mM)
Water 14 mg/mL
(37.05 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 377.86
Formula

C20H23NO4.HCl

CAS No. 16676-29-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05011266 Not yet recruiting Drug: Buprenorphine/naloxone|Drug: Placebo Opioid-use Disorder New York State Psychiatric Institute|National Institute on Drug Abuse (NIDA) March 1 2022 Phase 2|Phase 3
NCT05087771 Not yet recruiting Drug: injectable naltrexone|Drug: oral naltrexone Alcohol Use Disorder University of Colorado Denver January 2022 Phase 4
NCT05002946 Not yet recruiting Drug: SP-104|Drug: Naltrexone Hydrochloride 50Mg Oral Tablet Healthy Scilex Pharmaceuticals Inc. January 6 2022 Phase 1
NCT04828694 Not yet recruiting Drug: BICX104|Drug: Vivitrol Opioid-use Disorder BioCorRx Pharmaceuticals Inc.|National Institute on Drug Abuse (NIDA) July 2021 Phase 1
NCT04902625 Not yet recruiting Drug: Naltrexone-Bupropion Combination Obesity Morbid|Bariatric Surgery Candidate|Medication Persistence Zuyderland Medisch Centrum|Nederlandse Obesitas Kliniek June 2021 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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