Ethynodiol diacetate

For research use only.

Catalog No.S3160 Synonyms: 8080 CB

Ethynodiol diacetate Chemical Structure

Molecular Weight(MW): 384.51

Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.
Progesterone receptor [1]
In vitro

Nordihydroguaiaretic acid (NDGA) (< 1.5 μM) decreases the percentage of sister chronnatid exchanges (SCEs) in human lymphocyte culture treated with ethynodiol diacetate (150 μg/mL). Since the NDGA treatment, in the presence of S9 mix, reduce the genotoxic damage by ethynodiol diacetate, the reduction may be due to the inhibition of cytochrome P450s which prevents the metabolic activation of ethynodiol diacetate or NDGA may act as a free radical scavenger. [1] Ethynodiol diacetate (150 μg/mL) increases sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) frequencies and inhibits lymphocyte proliferation in the presence of S9 mix in human lymphocyte. [2]

In vivo Ethynodiol diacetate (6 mg/kg b.w. daily) significantly increases the amounts of excreted 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in urine in female rats. Significant increase in the weights of pituitary, liver and kidneys are noted in rats treated with ethynodiol diacetate (6 mg/kg b.w. daily). [3] Norgestrel (75 μg/day) and ethynodiol diacetate (150 μg/day), co-administered with ethinyl estradiol (7.5 μg/day), lowers the plasma concentrations of HDL cholesterol in cynomolgus monkeys. [4]


Solubility (25°C)

In vitro DMSO 77 mg/mL (200.25 mM)
Water 77 mg/mL (200.25 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 384.51


CAS No. 297-76-7
Storage powder
in solvent
Synonyms 8080 CB

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID