research use only

Ethisterone Estrogen/progestogen Receptor agonist

Name: Ethisterone
Brand: Selleck Chemicals
SKU: S2611
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S2611

Ethisterone(17α-Ethynyltestosterone) is a progestogen hormone being considered to treat prostate cancer.

Chemical Structure

Molecular Weight: 312.45

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Quality Control

Batch: Purity: 99.32%

99.32

Related Targets	Adrenergic Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE RAAS Progesterone Receptor Opioid Receptor PGES THR
Other Estrogen/progestogen Receptor Inhibitors	Elacestrant (RAD1901) Dihydrochloride MPP dihydrochloride Cholesterol Endoxifen HCl G15 Chrysin Licochalcone A AZD9496 PHTPP Liquiritigenin

Solubility

In vitro
Batch:

DMSO : 0.05 mg/mL (0.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	312.45	Formula	C₂₁H₂₈O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	434-03-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	17α-Ethynyltestosterone			Smiles	CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C#C)O)C

Mechanism of Action

Targets/IC₅₀/Ki	progestogen Receptor
In vivo	Ethisterone (dose range: 40 μg-5 mg/day × 6) stimulates weight gain but has a rather weak effect on the sulphate pools and incorporation rates in mice. This compound results in rapid increases in labeling indexes and scleroblast population began simultaneously in the central portion in the posterior margin of the joint plate in adult females of the medaka, Oryzias latipes, and the population becomes approximately ten times that in the control fish on the fifth day.
References	[1] https://pubmed.ncbi.nlm.nih.gov/5108603/ [2] http://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.1976.00279.x/abstract

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Handling Instructions

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