E6446 dihydrochloride

For research use only.

Catalog No.S6719

E6446 dihydrochloride Chemical Structure

CAS No. 1345675-25-3

E6446 dihydrochloride is a specific Toll-like receptor 9 inhibitor.

Purity & Quality Control

Choose Selective TLR Inhibitors

Biological Activity

Description E6446 dihydrochloride is a specific Toll-like receptor 9 inhibitor.
TLR9 [1]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 M4nLVGZ2dmO2aX;uJIF{e2G7 MV[yOEBpenN? NIrUT2xCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHj1cYFvKFSOUkmg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFPwS2IucW6mdXPl[EBPTi2tYYDwZWIh[WO2aY\heIlwdiCjZoTldkAzPCCqcoOgZpkhe3CnY4Tyc5Bpd3SxbXX0dpkh[mG|ZXSgV2VCWCC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTBwMEG1{txO MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR|N{[yPUc,Ojh2M{e2Nlk9N2F-
plasmacytoid dendritic cells Mnn6SpVv[3Srb36gZZN{[Xl? M4O1dlE5KGi{cx?= NVTLZ3Z6SW62YXfvcol{fCCjY4Tpeol1gSCjdDDUUHI6KGmwIHj1cYFvKHCuYYPtZYN6fG:rZDDk[Y5lemm2aXOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCFcFfBMYlv\HWlZXSgTWZPNWGucHjhJJBzd2S3Y4Tpc44h[W[2ZYKgNVghcHK|IHL5JGVNUVODLDDJR|UxRDBwMEZOwG0> NW[yUJlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|c3OjlpPkK4OFM4PjJ7PD;hQi=>
HEK293 MkiySpVv[3Srb36gZZN{[Xl? MnHrNlQhcHK| NE\4ZYlCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHj1cYFvKFSOUkeg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFPMNlY1NWmwZIXj[YQhVkZva3HwdIFDKGGldHn2ZZRqd25iYX\0[ZIhOjRiaILzJIJ6KHOyZXP0do9xcG:2b33leJJ6KGKjc3XkJHNGSVBicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1zLkm5{txO NXHPS2s2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|c3OjlpPkK4OFM4PjJ7PD;hQi=>

... Click to View More Cell Line Experimental Data

In vivo

E6446 is orally bioavailable (20%) and has high volumes of distribution in mice (95.9 l/kg)[1].


Animal Research:


- Collapse
  • Animal Models: MRL/lpr mice
  • Dosages: 20 or 60 mg/kg
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL (191.38 mM)
DMSO 3 mg/mL (5.74 mM)
Ethanol '2 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 522.51


CAS No. 1345675-25-3
Storage powder
in solvent
Synonyms N/A

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy E6446 dihydrochloride | E6446 dihydrochloride supplier | purchase E6446 dihydrochloride | E6446 dihydrochloride cost | E6446 dihydrochloride manufacturer | order E6446 dihydrochloride | E6446 dihydrochloride distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID