Dimethyl Fumarate

For research use only. Not for use in humans.

Catalog No.S2586

1 publication

Dimethyl Fumarate Chemical Structure

Molecular Weight(MW): 144.13

Dimethyl fumarate is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 140 In stock
USD 97 In stock
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Selleck's Dimethyl Fumarate has been cited by 1 publication

1 Customer Review

  • DMF enhances proteasome inhibitor toxicity in tumor cells. (A) GBM5/6/12/14 cells were treated with DMF (5 μM), velcade (10 nM) or the drug combination. Cells were isolated 24 h after treatment and viability determined by trypan blue exclusion assay (n = 3, +/− SEM) *P < 0.05 greater than DMF alone.

    Cancer Biol Ther, 2014, 15(12):1646-57.. Dimethyl Fumarate purchased from Selleck.

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Biological Activity

Description Dimethyl fumarate is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.
In vitro

Dimethyl fumarate causes short-lived oxidative stress, which leads to increased levels and nuclear localization of the transcription factor nuclear factor erythroid 2-related factor 2 and a subsequent increase in glutathione synthesis and recycling in neuronal cells. [1] Dimethyl fumarate inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl fumarate impairs nuclear factor κB (NF-κB) signaling via reduced p65 nuclear translocalization and phosphorylation. Dimethyl fumarate inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling. [2] Dimethyl fumarate inhibits TNF-alpha-induced nuclear entry of NF-kappaB in rat heart endothelial cells (RHEC). [3] Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and neurotoxin release. Dimethyl fumarate attenuates CCL2-induced monocyte chemotaxis, suggesting that Dimethyl fumarate could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators. [4]

Methods Test Index PMID
Western blot
NRF2 / IRP2 / FBXL5 / FTH1 / FTL ; 

PubMed: 28289076     

Western blots of HEK293 cells treated with increasing concentrations of DMF show dysregulated iron signaling, as indicated by simultaneously high protein levels of IRP2, FBXL5, FTL, and FTH1. ACTB was used as a loading control.

In vivo Dimethyl fumarate inhibits nuclear entry of NF-kappaB in RHEC and reduces myocardial infarct size after ischemia and reperfusion in rats in vivo. [3] Dimethyl fumarate oral administration is shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice. [5]


Solubility (25°C)

In vitro DMSO 29 mg/mL (201.2 mM)
Ethanol 10 mg/mL (69.38 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 144.13


CAS No. 624-49-7
Storage powder
in solvent
Synonyms N/A
Smiles COC(=O)\C=C\C(=O)OC

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03526224 Active not recruiting Drug: Dimethyl Fumarate|Drug: Teriflunomide Tecfidera|Teriflunomide University at Buffalo June 4 2018 --
NCT02969304 Completed Drug: dimethyl fumarate Multiple Sclerosis Biogen December 30 2016 --
NCT02461069 Completed Drug: Dimethyl fumarate Multiple Sclerosis Relapsing-Remitting University Hospital Muenster|Biogen May 6 2015 Phase 4
NCT02736279 Recruiting Drug: Dimethyl fumarate Multiple Sclerosis Virginia Simnad|Biogen|EvergreenHealth May 2015 --
NCT03092544 Active not recruiting Drug: dimethyl fumarate Multiple Sclerosis Multiple Sclerosis Center of Northeastern New York|Icahn School of Medicine at Mount Sinai|Biogen February 2015 Phase 4
NCT02125604 Completed Drug: dimethyl fumarate Relapsing-Remitting Multiple Sclerosis Biogen June 2014 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID