Xylazine HCl

Catalog No.S2516 Batch:S251601

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Technical Data

Formula

C12H16N2S.HCl

Molecular Weight 256.79 CAS No. 23076-35-9
Solubility (25°C)* In vitro DMSO 44 mg/mL (171.34 mM)
Ethanol 44 mg/mL (171.34 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Xylazine(BAY 1470 hydrochloride) is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.
Targets
α2-adrenergic receptor [1]
In vivo

Xylazine dose-dependently inhibits norepinephrine release and lipolysis in beagle dogs. Xylazine also tends to decrease epinephrine levels dose-dependently. [1] Xylazine hydrochloride dose- and time-dependently reduces amount of minimum alveolar concentration (MAC) in horse.  Xylazine hydrochloride dose- and time-dependently increases blood glucose concentration in horse. [2] Xylazine induces variable bilateral caudal analgesia extending from coccyx to S3, with minimal sedation, ataxia, and cardiovascular and respiratory depression in standing mares. Xylazine significantly decreases heart and respiratory rates, systolic, diastolic, and mean arterial blood pressure, PCV, hemoglobin concentration, arterial oxygen content, and oxygen transport. [3] Xylazine results in significantly decreased heart rate, increased incidence of atrioventricular block, and decreased cardiac output and cardiac index in horse. [4] Xylazine induces sedation and selective (S3 to Co) analgesia for at least 2 hours in cows. Xylazine significantly decreases heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration, and significantly increases PaCO2, base excess, and bicarbonate concentration in cows. [5] Xylazine severely depresses the N3 field (-75%) and completely abolishes the climbing fiber field (-100%) in the nonanesthetized, decerebrated rat. Xylazine- ketamine injections also severely depresses the N3 field (-75%) and nearly completely abolishes theclimbing fiber field (-90%) in the nonanesthetized, decerebrated rat.[6]

Protocol (from reference)

Selleck's Xylazine HCl has been cited by 8 publications

Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI [ Cell Death Dis, 2023, 14(5):318] PubMed: 37169762
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization [ Eur J Pharmacol, 2021, 911:174522] PubMed: 34560076
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis [ Fitoterapia, 2021, 152:104922] PubMed: 33984439
Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice [ STAR Protoc, 2021, 2(4):100915] PubMed: 34755118
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis. [ Cell Host Microbe, 2018, 24(1):97-108] PubMed: 29937272
Evidence of altered depression and dementia‐related proteins in the brains of young rats after ovariectomy [Fang YY, et al. J Neurochem, 2018, 146(6):703-721] PubMed: 29939407
Experimental observation of human bone marrow mesenchymal stem cell transplantation into rabbit intervertebral discs [Tao H, et al. Biomed Rep, 2016, 5(3):357-360] PubMed: 27588177
CTA Combined with CT Perfusion for Assessing the Efficacy of Anti-angiogenic Therapy in Rabbit VX2 Tumors. [Wang H, et al. Acad Radiol, 2012, 19(3):358-65] PubMed: 22310524

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.