Toremifene Citrate

Catalog No.S1776 Synonyms: NSC 613680

Toremifene Citrate Chemical Structure

Molecular Weight(MW): 598.08

Toremifene Citrate is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 227 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

1 Customer Review

  • D: Marginal degradation of MGMT in MCF7 cells treated with toremifene, a SERM. MGMT: O6-methylguanine DNA-methyltransferase; C: control.

    J Biomed Res, 2016, 30(5): 393-410.. Toremifene Citrate purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Toremifene Citrate is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.
Targets
Estrogen receptor [1]
In vitro

Toremifene (7.5 mM) causes approximately 60% of the cells to exhibit morphologic characteristics typical of cells undergoing programmed death, or apoptosis in human breast cancer cells. Toremifene (5-10 mM) results in elevated levels of TRPM-2 and TGF beta 1 mRNAs in in vitro or in vivo grown tumor cells. Toremifene causes growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to undergo apoptosis and by inhibiting other cells from entering mitosis. [1] Toremifene induces a dose-dependent level of adducts that is lower than that observed for TAM. Toremifene significantly enhances endogenous DNA adduct formation. [2] Toremifene affects the cell turnover by inhibiting mitotic activity and modifying abundant spontaneous apoptosis in DMBA-induced rat mammary carcinoma. [3]

In vivo Toremifene, at the highest tested dose, increases the incidence of hepatocellular carcinomas in the DEN-initiated groups to a level one-third that observed with Tamoxifen administration to DEN-initiated rats. Toremifene increases the incidence of hypernephromas in previously DEN-initiated rats. [4] Toremifene results in aneuploidy in 50% of the cells examined and compared with the 85% level induced by Tamoxifen in female Sprague-Dawley rats. [5]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (167.2 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 598.08
Formula

C32H36ClNO8

CAS No. 89778-27-8
Storage powder
in solvent
Synonyms NSC 613680

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00003865 Withdrawn Ovarian Cancer George Washington University July 22 1999 Phase 2
NCT03351062 Recruiting Breast Cancer Female Chinese Anti-Cancer Association|Fudan University|Henan Cancer Hospital|First Hospital of Jilin University|Southwest Hospital China|First Hospital of China Medical University|Guangdong Provincial People''s Hospital|Harbin Medical University|First Affiliated Hospital of Chongqing Medical University|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Jiangsu Provincial People''s Hospital|Cancer Institute and Hospital Chinese Academy of Medical Sciences|Zhejiang Cancer Hospital|Tianjin Medical University Cancer Institute and Hospital|Union hospital of Fujian Medical University|Hebei Tumor Hospital|Hunan Cancer Hospital|Affiliated Hospital of Qinghai University|Wuhan TongJi Hospital|Hainan People''s Hospital|The Third Affiliated Hospital of Kunming Medical College.|The Third Affiliated Hospital of Nanchang University November 2017 Phase 3
NCT02506790 Recruiting Breast Cancer Petrov Research Institute of Oncology July 2015 Phase 2
NCT02344940 Active not recruiting Breast Cancer Shanghai Jiao Tong University School of Medicine December 2014 Phase 4
NCT02132390 Not yet recruiting Breast Cancer|Chemotherapy Induced Amenorrhea|Ovarian Function Suppression Peking Union Medical College Hospital May 2014 Phase 3
NCT02132000 Recruiting Breast Cancer Patients in Premenopausal|Estrogen and/or Progesterone Receptor Positive Fengxi Su|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University April 2014 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Estrogen/progestogen Receptor Signaling Pathway Map

Related Estrogen/progestogen Receptor Products

Tags: buy Toremifene Citrate | Toremifene Citrate ic50 | Toremifene Citrate price | Toremifene Citrate cost | Toremifene Citrate solubility dmso | Toremifene Citrate purchase | Toremifene Citrate manufacturer | Toremifene Citrate research buy | Toremifene Citrate order | Toremifene Citrate mouse | Toremifene Citrate chemical structure | Toremifene Citrate mw | Toremifene Citrate molecular weight | Toremifene Citrate datasheet | Toremifene Citrate supplier | Toremifene Citrate in vitro | Toremifene Citrate cell line | Toremifene Citrate concentration | Toremifene Citrate nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID