Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Progesterone (NSC 9704)

Progesterone (NSC 9704)

Catalog No.S1705 Synonyms: NSC 64377, Pregn-4-ene-3,20-dione

For research use only.

Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione) is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

Progesterone (NSC 9704) Chemical Structure

CAS No. 57-83-0

Selleck's Progesterone (NSC 9704) has been cited by 8 Publications

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Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway Map

Biological Activity

Description Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione) is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.
Targets
progestogen Receptor [1]
In vitro

Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. [1] Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. [2] Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human T47D cells MYfGeY5kfGmxbjDhd5NigQ>? NFjRS4czOCCq MVzBZ5RqfmG2aX;uJI9nKHC{b3fld5Rmem:wZTDy[YNmeHSxcjDpckBpfW2jbjDUOFdFKGOnbHzzJIFnfGW{IEKwJIhzeyCkeTDQVmUufGGpZ3XkJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjFibl2= NV62dYRKOTl6NkOwPFM>
CV-1 cells MX7GeY5kfGmxbjDhd5NigQ>? MWfF[oZm[3SrdnWgZ49v[2WwdILheIlwdiCob4KgbIFt\i2vYYjpcYFtKGGldHn2ZZRqd25ib3[gbJVu[W5icILv[4V{fGW{b37lJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCFVj2xJINmdGy|LDDFR|UxRTFwNTDuUS=> MlX5PVY3Pzl4OB?=
HEK293 cells NVfYdYpYTnWwY4Tpc44h[XO|YYm= M{flUmFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHJIWiCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2yJI5O NG[wZ5ozPTNyNU[4PC=>
SF-12 cells M17OS2Z2dmO2aX;uJIF{e2G7 M4CxUWRqe3CuYXPlcYVvfCCxZjDETHQh\nKxbTDoeY1idiCjbnTyc4dmdiC{ZXPldJRweiCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhW0ZvMUKgZ4VtdHNuIFvpQVkvPSCwTR?= Mo\xNVI6PTRyNkK=
CHO cells MW\GeY5kfGmxbjDhd5NigQ>? NETxTVFC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHRIWjViZYjwdoV{e2WmIHnuJGNJVyClZXzsd{BjgSCudXPp[oVz[XOnIHHzd4F6NCCHQ{WwQVIvPzdizszN NUPCS2d[OTh|MEeyPVQ>
human K562/R7 cells M2L2R2Z2dmO2aX;uJIF{e2G7 MmDJNUDPxE1? M{fvelczKGh? M2e4TXBwfGWwdHnheIlwdiCxZjDkc5hwenWkaXPpck1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLYLld4l{fGGwdDDoeY1idiCNNU[yM3I4KGOnbHzzJIF{e2W|c3XkJIF{KGSxeH;yeYJq[2mwIFnDOVAh[XRiMTD1UUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUGwMlYh|ryP MVKyOVY{PDB2MR?=
A2780 cells MnLTSpVv[3Srb36gZZN{[Xl? NWnESW5JUW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKGGmcnnhcZlkcW5vcnXzbZN1[W62IFGyO|gxKGOnbHzzJIJ6KEixZXPod5QhOzN|NEKgZZN{[XluIFnDOVA:PDdwOE[zJO69VQ>? MV:xPFY4QDR7NR?=
HeLa cells M4nGUWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1XDXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBFVkFicnXwcIlk[XSrb36gZpkhcW2jZ3nu[{BidmGueYPpdy=> MkWzNVgxPjZyNUW=
Click to View More Cell Line Experimental Data
In vivo Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. [4] Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

 DMSO 22 mg/mL
(69.96 mM)
Water Insoluble
Ethanol ''63 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.46
Formula

C21H30O2
CAS No. 57-83-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05109676 Recruiting Other: Questionnaire IVF University Hospital Toulouse January 2022 Not Applicable
NCT04939064 Recruiting -- Normal Endometrial Physiology Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) January 18 2022 --
NCT04499131 Recruiting Drug: Progesterone|Other: Artificial Cycle (no intervention) Infertility Female|ENDOMETRIAL RECEPTIVITY Instituto Valenciano de Infertilidad IVI VALENCIA December 9 2021 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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