Progesterone

Catalog No.S1705

Progesterone Chemical Structure

Molecular Weight(MW): 314.46

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

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In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 397 In stock
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Cited by 2 Publications

2 Customer Reviews

  • Metformin alleviated EP-induced decidualization of endometrial stromal cells. (A–D) Endometrial stromal cells were treated with or without estradiol (10 nM) and progesterone (1 μM) in the absence or presence of metformin (1 mM) for 10 days or 14 days. Then, mRNA levels of IGFBP-1 and prolactin in endometrial stromal cells were examined by RT-qPCR assay (A and B). Secreted protein levels of IGFBP-1 and prolactin into media were tested by matching ELISA kits (C and D). #* P < 0.05.

    Biomed Pharmacother, 2019, 109:1578-1585. Progesterone purchased from Selleck.

    SPOP inhibits progesterone-induced S phase entry and Erk1/2 activation. (A) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for 24 hr. The cell cycle percentages was determined by PI staining and FACS; (B) T47D cells were transfected with control siRNAs or SPOP-specific siRNAs. After 48 hr, cells were treated and analyzed as in (A); (C) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for indicated times. Cell lysates were prepared for WB analyses; (D) T47D cells were transfected with control or SPOP-specific siRNA. After 48 hr, cells were treated and analyzed as in (C).

    Am J Cancer Res, 2015, 5(10): 3210-3220.. Progesterone purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.
Targets
progestogen Receptor [1]
In vitro

Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. [1] Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. [2] Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human T47D cells NXPVNW5yTnWwY4Tpc44h[XO|YYm= MnniNlAhcA>? MUfBZ5RqfmG2aX;uJI9nKHC{b3fld5Rmem:wZTDy[YNmeHSxcjDpckBpfW2jbjDUOFdFKGOnbHzzJIFnfGW{IEKwJIhzeyCkeTDQVmUufGGpZ3XkJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjFibl2= MXqxPVg3OzB6Mx?=
CV-1 cells M1zs[2Z2dmO2aX;uJIF{e2G7 Mmf0SYZn\WO2aY\lJINwdmOnboTyZZRqd25iZn;yJIhidGZvbXH4bY1idCCjY4TpeoF1cW:wIH;mJIh2dWGwIIDyc4dme3Sncn;u[UBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ2[tNUBk\WyuczygSWM2OD1zLkWgcm0> MYi5OlY4QTZ6
HEK293 cells NVS3[|ExTnWwY4Tpc44h[XO|YYm= MYrB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDSS3Ih\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MjDuUS=> M3vtUFI2OzB3Nki4
SF-12 cells MVTGeY5kfGmxbjDhd5NigQ>? MljoSIl{eGyjY3Xt[Y51KG:oIFTIWEBnem:vIHj1cYFvKGGwZILv[4VvKHKnY3XweI9zKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{BUTi1zMjDj[YxteyxiS3m9PU42KG6P NWjuUYtqOTJ7NUSwOlI>
CHO cells MljHSpVv[3Srb36gZZN{[Xl? MYjB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGTHVlUh\XiycnXzd4VlKGmwIFPIU{Bk\WyuczDifUBtfWOrZnXyZZNmKGG|c3H5MEBGSzVyPUKuO|ch|ryP MVyxPFMxPzJ7NB?=
human K562/R7 cells MXjGeY5kfGmxbjDhd5NigQ>? MUCxJO69VQ>? MoPqO|IhcA>? MXvQc5RmdnSrYYTpc44hd2ZiZH;4c5J2[mmlaX6tbY5lfWOnZDDjfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUzV4Mj;SO{Bk\WyuczDhd5Nme3OnZDDhd{Bld3ixcoXibYNqdiCLQ{WwJIF1KDFidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMD62JO69VQ>? MmPqNlU3OzRyNEG=
A2780 cells NVrHNVluTnWwY4Tpc44h[XO|YYm= MlLmTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJIFlemmjbYnjbY4uemW|aYP0ZY51KEF{N{iwJINmdGy|IHL5JGhw\WOqc4SgN|M{PDJiYYPzZZktKEmFNUC9OFcvQDZ|IN88US=> NICzTGwyQDZ5OES5OS=>
HeLa cells NInmfYhEgXSxdH;4bYNqfHliYYPzZZk> NYrofI9JS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKESQQTDy[ZBtcWOjdHnvckBjgSCrbXHnbY5oKGGwYXz5d4l{ NILPSYsyQDB4NkC1OS=>

... Click to View More Cell Line Experimental Data

In vivo Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. [4] Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. [5]

Protocol

Solubility (25°C)

In vitro Ethanol 63 mg/mL (200.34 mM)
DMSO 22 mg/mL (69.96 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.46
Formula

C21H30O2

CAS No. 57-83-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03489473 Not yet recruiting Diagnostic Test: 18F-FES PET CT scan Endometrial Cancer Radboud University|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|University Medical Center Groningen|Haukeland University Hospital January 1 2020 --
NCT03756480 Not yet recruiting -- Endometriosis|Endometrial Diseases Johns Hopkins University|National Institutes of Health (NIH) November 2019 --
NCT02653911 Not yet recruiting Other: Acupuncture|Other: Sham-acupuncture group Polycystic Ovary Syndrome Guang''anmen Hospital of China Academy of Chinese Medical Sciences October 2019 Not Applicable
NCT04081701 Recruiting Diagnostic Test: Ga68-DOTATATE-PET/MRI CNS Tumors|Meningioma|Esthesioneuroblastoma|Hemangioblastoma|Medulloblastoma|Paraganglioma|Pituitary Adenoma Weill Medical College of Cornell University|Novartis Pharmaceuticals September 4 2019 --
NCT03680053 Not yet recruiting Drug: Duphaston|Drug: Cetrorelix Infertility|ART ShangHai Ji Ai Genetics & IVF Institute September 2019 Not Applicable

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID