Progesterone

Catalog No.S1705

Progesterone Chemical Structure

Molecular Weight(MW): 314.46

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 397 In stock
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Cited by 2 Publications

2 Customer Reviews

  • Metformin alleviated EP-induced decidualization of endometrial stromal cells. (A–D) Endometrial stromal cells were treated with or without estradiol (10 nM) and progesterone (1 μM) in the absence or presence of metformin (1 mM) for 10 days or 14 days. Then, mRNA levels of IGFBP-1 and prolactin in endometrial stromal cells were examined by RT-qPCR assay (A and B). Secreted protein levels of IGFBP-1 and prolactin into media were tested by matching ELISA kits (C and D). #* P < 0.05.

    Biomed Pharmacother, 2019, 109:1578-1585. Progesterone purchased from Selleck.

    SPOP inhibits progesterone-induced S phase entry and Erk1/2 activation. (A) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for 24 hr. The cell cycle percentages was determined by PI staining and FACS; (B) T47D cells were transfected with control siRNAs or SPOP-specific siRNAs. After 48 hr, cells were treated and analyzed as in (A); (C) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for indicated times. Cell lysates were prepared for WB analyses; (D) T47D cells were transfected with control or SPOP-specific siRNA. After 48 hr, cells were treated and analyzed as in (C).

    Am J Cancer Res, 2015, 5(10): 3210-3220.. Progesterone purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.
Targets
progestogen Receptor [1]
In vitro

Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. [1] Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. [2] Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human T47D cells NFnsSINHfW6ldHnvckBie3OjeR?= NGDKNIUzOCCq NVfiSFZXSWO2aY\heIlwdiCxZjDwdo9o\XO2ZYLvcoUhemWlZYD0c5IhcW5iaIXtZY4hXDR5RDDj[YxteyCjZoTldkAzOCCqcoOgZpkhWFKHLYTh[4dm\CCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6xJI5O M2LhNFE6QDZ|MEiz
CV-1 cells NYnrVVU1TnWwY4Tpc44h[XO|YYm= M3X3[2Vn\mWldHn2[UBkd26lZX70doF1cW:wIH\vdkBp[WyoLX3hfIlu[WxiYXP0bZZifGmxbjDv[kBpfW2jbjDwdo9o\XO2ZYLvcoUhemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPWMVEh[2WubIOsJGVEPTB;MT61JI5O NWftNZJoQTZ4N{m2PC=>
HEK293 cells NGTkc5JHfW6ldHnvckBie3OjeR?= Mn35RYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVmdTKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUKgcm0> M3TmTlI2OzB3Nki4
SF-12 cells M2TndGZ2dmO2aX;uJIF{e2G7 NUPXXY9[TGm|cHzhZ4Vu\W62IH;mJGRJXCCocn;tJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCVRj2xNkBk\WyuczygT4k:QS53IH7N NXTjRXB5OTJ7NUSwOlI>
CHO cells Mn:2SpVv[3Srb36gZZN{[Xl? NUfoRllqSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVT1J3IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nlibIXjbYZmemG|ZTDhd5NigSxiRVO1NF0zNjd5IN88US=> Mlu5NVg{ODd{OUS=
human K562/R7 cells NVrPNJU3TnWwY4Tpc44h[XO|YYm= NF\oRnEyKM7:TR?= M4P3TVczKGh? Ml\pVI91\W62aXH0bY9vKG:oIHTvfI9zfWKrY3nuMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IHj1cYFvKEt3NkKvVlch[2WubIOgZZN{\XO|ZXSgZZMh\G:6b4L1ZolkcW5iSVO1NEBifCBzIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUCuOkDPxE1? NGHqU24zPTZ|NEC0NS=>
A2780 cells NGrzTY1HfW6ldHnvckBie3OjeR?= M4PMPGlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBi\HKrYX35Z4lvNXKnc3nzeIFvfCCDMke4NEBk\WyuczDifUBJd2WlaIP0JFM{OzR{IHHzd4F6NCCLQ{WwQVQ4Njh4MzFOwG0> MkXvNVg3Pzh2OUW=
HeLa cells M37a[mN6fG:2b4jpZ4l1gSCjc4PhfS=> NGrCblNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhTE6DIILldIxq[2G2aX;uJIJ6KGmvYXfpcoch[W6jbInzbZM> MXOxPFA3PjB3NR?=

... Click to View More Cell Line Experimental Data

In vivo Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. [4] Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. [5]

Protocol

Solubility (25°C)

In vitro Ethanol 63 mg/mL (200.34 mM)
DMSO 22 mg/mL (69.96 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.46
Formula

C21H30O2

CAS No. 57-83-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03740568 Recruiting Infertility|Progesterone|Frozen Embryo Transfer|Euploid Embryo Transfer|Pregnancy Outcome|Artificial Cycle|Ongoing Pregnancy Institut Universitari Dexeus|Fundación Santiago Dexeus Font|Dexeus Clinic Woman December 2019 Not Applicable
NCT03740568 Recruiting Infertility|Progesterone|Frozen Embryo Transfer|Euploid Embryo Transfer|Pregnancy Outcome|Artificial Cycle|Ongoing Pregnancy Institut Universitari Dexeus|Fundación Santiago Dexeus Font|Dexeus Clinic Woman December 2019 Not Applicable
NCT03637062 Not yet recruiting High Risk Pregnancy QH Medical Technology Ltd. December 1 2019 Not Applicable
NCT03637062 Not yet recruiting High Risk Pregnancy QH Medical Technology Ltd. December 1 2019 Not Applicable
NCT03540225 Not yet recruiting Premature Birth|Twin Pregnancy Chiu Yee Liona Poon|Chinese University of Hong Kong June 2019 Phase 3
NCT03540225 Not yet recruiting Premature Birth|Twin Pregnancy Chiu Yee Liona Poon|Chinese University of Hong Kong June 2019 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID