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Progesterone (NSC 9704)

Name: Progesterone (NSC 9704)
Brand: Selleck Chemicals
SKU: S1705
Rating: 5 (9 reviews)

Catalog No.S1705 Synonyms: NSC 64377, Pregn-4-ene-3,20-dione

For research use only.

Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione) is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

Progesterone (NSC 9704) Chemical Structure

CAS No. 57-83-0

Selleck's Progesterone (NSC 9704) has been cited by 9 Publications

2 Customer Reviews

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Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway Map

Biological Activity

Description

Targets

progestogen Receptor ^[1]

In vitro

Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. ^[1] Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. ^[2] Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

human T47D cells	M1PBOGZ2dmO2aX;uJIF{e2G7		MV6yNEBp	Mnn1RYN1cX[jdHnvckBw\iCycn;n[ZN1\XKxbnWgdoVk\XC2b4KgbY4hcHWvYX6gWFQ4TCClZXzsd{Bi\nSncjCyNEBpenNiYomgVHJGNXSjZ3fl[EBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5zIH7N	Mnq2NVk5PjNyOEO=
CV-1 cells	MlS4SpVv[3Srb36gZZN{[Xl?			NGnGXoZG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDmc5IhcGGuZj3tZZhqdWGuIHHjeIl3[XSrb36gc4YhcHWvYX6gdJJw\2W\|dHXyc45mKHKnY3XweI9zKGW6cILld5Nm\CCrbjDDWk0yKGOnbHzzMEBGSzVyPUGuOUBvVQ>?	NEnyR4Y6PjZ5OU[4
HEK293 cells	NV3ycWNVTnWwY4Tpc44h[XO\|YYm=			MojORYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVmdTKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[nlibIXjbYZmemG\|ZTDy[ZBwenSncjDn[Y5mKGG\|c3H5MEBGSzVyPUKgcm0>	M4PHcVI2OzB3Nki4
SF-12 cells	NHr2RXdHfW6ldHnvckBie3OjeR?=			M1jqWGRqe3CuYXPlcYVvfCCxZjDETHQh\nKxbTDoeY1idiCjbnTyc4dmdiC{ZXPldJRweiCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhW0ZvMUKgZ4VtdHNuIFvpQVkvPSCwTR?=	M2K0ZVEzQTV2ME[y
CHO cells	NXTWS25UTnWwY4Tpc44h[XO\|YYm=			MkjCRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDUS3I2KGW6cILld5Nm\CCrbjDDTG8h[2WubIOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhTUN3ME2yMlc4KM7:TR?=	MYSxPFMxPzJ7NB?=
human K562/R7 cells	NWPmbGVSTnWwY4Tpc44h[XO\|YYm=	M1fNTFEh\|ryP	NV\IXndLPzJiaB?=	NXXYd\|VmWG:2ZX70bYF1cW:wIH;mJIRwgG:{dXLpZ4lvNWmwZIXj[YQh[3m2b4TvfIlkcXS7IHHnZYlve3RiZH;4c5J2[mmlaX6tdoV{cXO2YX70JIh2dWGwIFu1OlIwWjdiY3XscJMh[XO\|ZYPz[YQh[XNiZH;4c5J2[mmlaX6gTWM2OCCjdDCxJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVAvPiEQvF2=	NHvCSHozPTZ\|NEC0NS=>
A2780 cells	M3TxfGZ2dmO2aX;uJIF{e2G7			MWHJcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gZYRzcWGveXPpck1z\XOrc4ThcpQhSTJ5OECgZ4VtdHNiYomgTI9m[2i\|dDCzN\|M1OiCjc4PhfUwhUUN3ME20O{45PjNizszN	MWCxPFY4QDR7NR?=
HeLa cells	MUPDfZRwfG:6aXPpeJkh[XO\|YYm=			NH3xfWxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhTE6DIILldIxq[2G2aX;uJIJ6KGmvYXfpcoch[W6jbInzbZM>	MYixPFA3PjB3NR?=

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In vivo

Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. ^[4] Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. ^[5]

Protocol (from reference)

References

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Solubility (25°C)

In vitro

Chemical Information

Molecular Weight	314.46
Formula	C₂₁H₃₀O₂
CAS No.	57-83-0
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Download Progesterone (NSC 9704) SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04922424	Not yet recruiting	Drug: Atorvastatin\|Other: placebo	Hypertension\|Hyperlipidemias	Yale University	September 30 2022	Phase 1
NCT04814940	Not yet recruiting	Other: MENOPUR Cohort	Infertility Female	Ferring Pharmaceuticals	September 1 2022	--
NCT04989972	Withdrawn	Drug: PSIL428\|Dietary Supplement: Oyster mushroom	Anxiety and Depression	Wake Network Inc.\|Professor Roger Gibson Section of Psychiatry Faculty of Medical Sciences UWI	September 15 2022	Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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