For research use only.
CAS No. 57-83-0
Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.
Selleck's Progesterone has been cited by 7 publications
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Metformin alleviated EP-induced decidualization of endometrial stromal cells. (A–D) Endometrial stromal cells were treated with or without estradiol (10 nM) and progesterone (1 μM) in the absence or presence of metformin (1 mM) for 10 days or 14 days. Then, mRNA levels of IGFBP-1 and prolactin in endometrial stromal cells were examined by RT-qPCR assay (A and B). Secreted protein levels of IGFBP-1 and prolactin into media were tested by matching ELISA kits (C and D). #* P < 0.05.
Biomed Pharmacother, 2019, 109:1578-1585. Progesterone purchased from Selleck.
SPOP inhibits progesterone-induced S phase entry and Erk1/2 activation. (A) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for 24 hr. The cell cycle percentages was determined by PI staining and FACS; (B) T47D cells were transfected with control siRNAs or SPOP-specific siRNAs. After 48 hr, cells were treated and analyzed as in (A); (C) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for indicated times. Cell lysates were prepared for WB analyses; (D) T47D cells were transfected with control or SPOP-specific siRNA. After 48 hr, cells were treated and analyzed as in (C).
Am J Cancer Res, 2015, 5(10): 3210-3220.. Progesterone purchased from Selleck.
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|Description||Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.|
Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required.  Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers.  Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). 
|In vivo||Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen.  Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. |
-  Owen GI, et al. J Biol Chem,?998, 273(17), 10696-10701.
-  Joshi PA, et al. Nature,?010, 465(7299), 803-807.
-  Bitran D, et al. Pharmacol Biochem Behav,?993, 45(2), 423-428.
|In vitro||Ethanol||63 mg/mL (200.34 mM)|
|DMSO||22 mg/mL (69.96 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04642391||Not yet recruiting||Drug: Cosyntropin||Cirrhosis|Adrenal Insufficiency||University of Virginia||July 1 2021||--|
|NCT04298541||Not yet recruiting||Drug: Ga-68- DOTATATE|Drug: Ga-68-DOTATOC||Meningioma||Weill Medical College of Cornell University|Cornell University||January 31 2021||Phase 2|
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