Progesterone

For research use only.

Catalog No.S1705

5 publications

Progesterone Chemical Structure

Molecular Weight(MW): 314.46

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 397 In stock
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Selleck's Progesterone has been cited by 5 publications

2 Customer Reviews

  • Metformin alleviated EP-induced decidualization of endometrial stromal cells. (A–D) Endometrial stromal cells were treated with or without estradiol (10 nM) and progesterone (1 μM) in the absence or presence of metformin (1 mM) for 10 days or 14 days. Then, mRNA levels of IGFBP-1 and prolactin in endometrial stromal cells were examined by RT-qPCR assay (A and B). Secreted protein levels of IGFBP-1 and prolactin into media were tested by matching ELISA kits (C and D). #* P < 0.05.

    Biomed Pharmacother, 2019, 109:1578-1585. Progesterone purchased from Selleck.

    SPOP inhibits progesterone-induced S phase entry and Erk1/2 activation. (A) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for 24 hr. The cell cycle percentages was determined by PI staining and FACS; (B) T47D cells were transfected with control siRNAs or SPOP-specific siRNAs. After 48 hr, cells were treated and analyzed as in (A); (C) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for indicated times. Cell lysates were prepared for WB analyses; (D) T47D cells were transfected with control or SPOP-specific siRNA. After 48 hr, cells were treated and analyzed as in (C).

    Am J Cancer Res, 2015, 5(10): 3210-3220.. Progesterone purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.
Targets
progestogen Receptor [1]
In vitro

Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. [1] Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. [2] Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human T47D cells MlTPSpVv[3Srb36gZZN{[Xl? NHvuPWYzOCCq MmrrRYN1cX[jdHnvckBw\iCycn;n[ZN1\XKxbnWgdoVk\XC2b4KgbY4hcHWvYX6gWFQ4TCClZXzsd{Bi\nSncjCyNEBpenNiYomgVHJGNXSjZ3fl[EBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5zIH7N MYexPVg3OzB6Mx?=
CV-1 cells NE\G[IVHfW6ldHnvckBie3OjeR?= MlHsSYZn\WO2aY\lJINwdmOnboTyZZRqd25iZn;yJIhidGZvbXH4bY1idCCjY4TpeoF1cW:wIH;mJIh2dWGwIIDyc4dme3Sncn;u[UBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ2[tNUBk\WyuczygSWM2OD1zLkWgcm0> M1TUeFk3Pjd7Nki=
HEK293 cells M2jyXWZ2dmO2aX;uJIF{e2G7 MknsRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVmdTKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUKgcm0> NYDWenFSOjV|MEW2PFg>
SF-12 cells NGGzSXZHfW6ldHnvckBie3OjeR?= NW\pNFU6TGm|cHzhZ4Vu\W62IH;mJGRJXCCocn;tJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCVRj2xNkBk\WyuczygT4k:QS53IH7N NHi0WFUyOjl3NEC2Ni=>
CHO cells NYTBPIVXTnWwY4Tpc44h[XO|YYm= NFjjfmRC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHRIWjViZYjwdoV{e2WmIHnuJGNJVyClZXzsd{BjgSCudXPp[oVz[XOnIHHzd4F6NCCHQ{WwQVIvPzdizszN M4HNd|E5OzB5Mkm0
human K562/R7 cells NVPjVZNnTnWwY4Tpc44h[XO|YYm= M4PSOlEh|ryP MXe3NkBp NGfhW2tRd3SnboTpZZRqd25ib3[g[I95d3K3YnnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgbJVu[W5iS{W2Nk9TPyClZXzsd{Bie3Onc4Pl[EBieyCmb4jvdpVjcWOrbjDJR|UxKGG2IEGgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNE43KM7:TR?= NInLcoQzPTZ|NEC0NS=>
A2780 cells NFfaVldHfW6ldHnvckBie3OjeR?= NUXDNXNxUW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKGGmcnnhcZlkcW5vcnXzbZN1[W62IFGyO|gxKGOnbHzzJIJ6KEixZXPod5QhOzN|NEKgZZN{[XluIFnDOVA:PDdwOE[zJO69VQ>? MVexPFY4QDR7NR?=
HeLa cells MXHDfZRwfG:6aXPpeJkh[XO|YYm= MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gSG5CKHKncHzpZ4F1cW:wIHL5JIlu[WerbnegZY5idHm|aYO= NGnTdIwyQDB4NkC1OS=>

... Click to View More Cell Line Experimental Data

In vivo Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. [4] Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. [5]

Protocol

Solubility (25°C)

In vitro Ethanol 63 mg/mL (200.34 mM)
DMSO 22 mg/mL (69.96 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.46
Formula

C21H30O2

CAS No. 57-83-0
Storage powder
in solvent
Synonyms N/A
Smiles CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03680053 Not yet recruiting Drug: Duphaston|Drug: Cetrorelix Infertility|ART ShangHai Ji Ai Genetics & IVF Institute September 2020 Not Applicable
NCT03756480 Not yet recruiting -- Endometriosis|Endometrial Diseases Johns Hopkins University|National Institutes of Health (NIH)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) June 2020 --
NCT04133077 Not yet recruiting Biological: blood samples collection Breast Cancer Female Centre Jean Perrin June 1 2020 Not Applicable
NCT04298541 Not yet recruiting Drug: Ga-68- DOTATATE|Drug: Ga-68-DOTATOC Meningioma Weill Medical College of Cornell University|Cornell University April 2020 Phase 2
NCT04290520 Not yet recruiting Other: bioassay Infertility|IVF Centre Hospitalier Universitaire de Nīmes March 1 2020 --

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID