Catalog No.S8457 Synonyms: UK-371804 HCl
Molecular Weight(MW): 422.29
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
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Choose Selective Serine Protease Inhibitors
|Description||UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).|
In Vitro, UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM).
|In vivo||In Vivo, in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters.|
|In vitro||DMSO||30 mg/mL warmed (71.04 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02036255||Completed||Patency|Infection||Universitair Ziekenhuis Brussel||May 2015||Phase 3|
|NCT02165891||Recruiting||Empyema Pleural||Queen Fabiola Children''s University Hospital||February 2015||Phase 3|
|NCT02125617||Terminated||Prostatic Neoplasms||Kristoffer Staal Rohrberg|Janssen-Cilag Ltd.|Rigshospitalet Denmark||January 2014||--|
|NCT01638585||Terminated||Diabetic Foot|Critical Limb Ischemia||GWT-TUD GmbH||June 2011||Phase 3|
|NCT02770560||Completed||Kidney Failure Chronic|Vascular Access Devices||Universitair Ziekenhuis Brussel||May 2010||--|
|NCT01134237||Unknown status||Retained Hemothorax||National Taiwan University Hospital||May 2010||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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