UK-371804 HCl
For research use only.
Catalog No.S8457
1 publication
CAS No. 256476-36-5
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
Selleck's UK-371804 HCl has been cited by 1 publication
Purity & Quality Control
Choose Selective Serine Protease Inhibitors
Biological Activity
| Description | UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). | ||
|---|---|---|---|
| Targets |
|
||
| In vitro |
In Vitro, UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM)[1]. |
||
| In vivo | In Vivo, in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters[1]. |
Protocol
| Animal Research:[1] |
- Collapse
|
|---|
Solubility (25°C)
| In vitro | DMSO | 30 mg/mL warmed (71.04 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 422.29 |
|---|---|
| Formula | C14H16ClN5O4S.HCl |
| CAS No. | 256476-36-5 |
| Storage |
powder in solvent |
| Synonyms | N/A |
| Smiles | CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl.Cl |
In vivo Formulation Calculator (Clear solution)
| Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) | ||||||||||
| Dosage | mg/kg |  |
Average weight of animals | g | |
Dosing volume per animal | ul | |
Number of animals | |
| Step 2: Enter the in vivo formulation () | ||||||||||
| % DMSO % % Tween 80 % ddH2O | ||||||||||
| CalculateReset | ||||||||||
Calculation results:
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT04588220 | Active not recruiting | Other: Obstetric ultrasound and fetal-maternal assessment | Preterm Premature Rupture of Membranes | Cengiz Gokcek Women''s and Children''s Hospital | October 7 2020 | -- |
| NCT04688879 | Completed | Procedure: intra-arterial urokinase thrombolysis | Arterial Occlusion Mesenteric Artery Superior | Chang Gung Memorial Hospital | March 1 2020 | -- |
| NCT03769337 | Unknown status | Diagnostic Test: serum biomarkers | Prosthetic Joint Infections | Istituto Ortopedico Galeazzi | September 1 2018 | -- |
| NCT02036255 | Completed | Drug: Taurolidine Urokinase|Drug: Taurolidine Heparin | Patency|Infection | Universitair Ziekenhuis Brussel | May 2015 | Phase 3 |
| NCT01638585 | Terminated | Drug: urokinase | Diabetic Foot|Critical Limb Ischemia | GWT-TUD GmbH | June 2011 | Phase 3 |
| NCT02770560 | Completed | Device: Urokinase locking solution | Kidney Failure Chronic|Vascular Access Devices | Universitair Ziekenhuis Brussel | May 2010 | -- |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.
