UK-371804 HCl
For research use only. Not for use in humans.
Catalog No.S8457 Synonyms: UK-371804 HCl
Molecular Weight(MW): 422.29
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
Purity & Quality Control
Choose Selective Serine Protease Inhibitors
Biological Activity
| Description | UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). | ||
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| Targets |
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| In vitro |
In Vitro, UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM)[1]. |
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| In vivo | In Vivo, in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters[1]. |
Protocol
| Animal Research:[1] |
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Solubility (25°C)
| In vitro | DMSO | 30 mg/mL warmed (71.04 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 422.29 |
|---|---|
| Formula | C14H16ClN5O4S.HCl |
| CAS No. | 256476-36-5 |
| Storage | powder |
| in solvent | |
| Synonyms | UK-371804 HCl |
| Smiles | Cl.CC(C)(N[S](=O)(=O)C1=CC2=C(C=C1)C(=CN=C2NC(N)=N)Cl)C(O)=O |
Bio Calculators
Molarity Calculator
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT03769337 | Recruiting | Diagnostic Test: serum biomarkers | Prosthetic Joint Infections | Istituto Ortopedico Galeazzi | September 1 2018 | -- |
| NCT03051165 | Terminated | Device: Hypoglossal Nerve Stimulation Treatment Withdrawal | Obstructive Sleep Apnea | Emory University | November 21 2016 | Not Applicable |
| NCT03052192 | Recruiting | -- | Aging|Polypharmacy|Malnutrition|Inflammation|Emergency Service Hospital | Hvidovre University Hospital|Clinical Research Centre|Lundbeck Foundation|Region Hovedstaden | November 2016 | -- |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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