For research use only.

Catalog No.S7378

5 publications

AEBSF HCl Chemical Structure

Molecular Weight(MW): 239.69

AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.

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Choose Selective Serine Protease Inhibitors

Biological Activity

Description AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
Features Broad spectrum, irreversible serine protease inhibitor.
serine protease [1]
In vitro

AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. [1] AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. [2] AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern. [4]

In vivo AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. [3] AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model. [4]


Animal Research:[3]
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  • Animal Models: Mice infected by a lethal T. Gondii
  • Dosages: ~76.8 mg/kg daily
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 47 mg/mL (196.08 mM)
Ethanol 47 mg/mL (196.08 mM)
Water 20 mg/mL (83.44 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 239.69


CAS No. 30827-99-7
Storage powder
in solvent
Synonyms N/A
Smiles Cl.NCCC1=CC=C(C=C1)[S](F)(=O)=O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID