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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8969 Molnupiravir (EIDD-2801) Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19.
Antioxidants (Basel), 2025, 14(8)945
Biomed Res, 2025, 46(2):37-50
Antiviral Res, 2024, 225:105840
S9866 Nirmatrelvir (PF-07321332)

Nirmatrelvir (PF-07321332) is an reversible covalent inhibitor of SARS-CoV-2 main protease (Mpro, also referred to as 3CL protease) with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme.
Antioxidants (Basel), 2025, 14(8)945
Commun Biol, 2025, 8(1):1061
Sci Rep, 2025, 15(1):11307
S0833 EIDD-1931 (NHC) EIDD-1931 (NHC) is an active metabolite of EIDD-2801, a promising COVID-19 inhibitor. This compound has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs with average IC50 of 0.15 μM, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir.
Microbiol Spectr, 2025, 13(4):e0269224
Nucleic Acids Res, 2023, 10.1093/nar/gkad1002
NPJ Digit Med, 2022, 5(1):83
S9963 Paquinimod (ABR-215757) Paquinimod (ABR 25757), a specific inhibitor of S100A8/A9, could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice.
Redox Biol, 2025, 81:103532
J Inflamm Res, 2025, 18:14941-14959
Cell Rep, 2024, 43(11):114900
E1131 Ensitrelvir fumarate S-217622 (Ensitrelvir fumarate) is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor with IC50 of 13 nM.
Emerg Microbes Infect, 2025, 14(1):2552716
E1900 Simnotrelvir Simnotrelvir(SIM0417, SARS-CoV-2-IN-41) is an inhibitor of coronavirus main proteinase (3CLpro) (SARS-CoV-2 3CLpro) with an IC50 of 24 nM. It has a potential anti-SARS-CoV-2 activity.
E7079 Ensitrelvir Ensitrelvir (S-217622) is an oral, non-covalent, non-peptidic inhibitor of the SARS-CoV-2 3CL protease, with an IC50 of 13 nM. It also exhibits antiviral activity in vitro and is a potential oral agent for treating COVID-19.
S0793 ML188 ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with IC50 of 1.5 μM. This compound has antiviral activity.
S0875 XP-59 XP-59 is a potent inhibitor of the SARS-CoV Mpro, with a Ki of 0.1 μM.
E1112 GS-621763 GS-621763, an orally bioavailable prodrug of GS-441524, shows a dose-dependent antiviral effect on SARS-CoV-2 reporter virus expressing nanoluciferase (SARS-CoV-2 nLUC) replication with an EC50 of 2.8 μM, also inhibits reporter SARS-CoV-2 expressing firefly luciferase (SARS-CoV-2 Fluc) replication with EC50 of 0.125 μM.