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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8969 Molnupiravir (EIDD-2801) Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19.
Antioxidants (Basel), 2025, 14(8)945
Biomed Res, 2025, 46(2):37-50
Antiviral Res, 2024, 225:105840
S9866 Nirmatrelvir (PF-07321332)

Nirmatrelvir (PF-07321332) is an reversible covalent inhibitor of SARS-CoV-2 main protease (Mpro, also referred to as 3CL protease) with an ki of 3.11 nM. It binds directly to the catalytic cysteine (Cys145) residue of the enzyme.
Antioxidants (Basel), 2025, 14(8)945
Commun Biol, 2025, 8(1):1061
Sci Rep, 2025, 15(1):11307
S0833 EIDD-1931 (NHC) EIDD-1931 (NHC) is an active metabolite of EIDD-2801, a promising COVID-19 inhibitor. This compound has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs with average IC50 of 0.15 μM, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir.
Microbiol Spectr, 2025, 13(4):e0269224
Nucleic Acids Res, 2023, 10.1093/nar/gkad1002
NPJ Digit Med, 2022, 5(1):83
S9963 Paquinimod (ABR-215757) Paquinimod (ABR 25757), a specific inhibitor of S100A8/A9, could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice.
Redox Biol, 2025, 81:103532
J Inflamm Res, 2025, 18:14941-14959
Cell Rep, 2024, 43(11):114900
E1131 Ensitrelvir fumarate S-217622 (Ensitrelvir fumarate) is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor with IC50 of 13 nM.
Emerging Microbes & Infections, 2025, 2552716
Emerg Microbes Infect, 2025, 14(1):2552716
E1900 Simnotrelvir Simnotrelvir(SIM0417, SARS-CoV-2-IN-41) is an inhibitor of coronavirus main proteinase (3CLpro) (SARS-CoV-2 3CLpro) with an IC50 of 24 nM. It has a potential anti-SARS-CoV-2 activity.
E7079 Ensitrelvir Ensitrelvir (S-217622) is an oral, non-covalent, non-peptidic inhibitor of the SARS-CoV-2 3CL protease, with an IC50 of 13 nM. It also exhibits antiviral activity in vitro and is a potential oral agent for treating COVID-19.
S0793 ML188 ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with IC50 of 1.5 μM. This compound has antiviral activity.
S0875 XP-59 XP-59 is a potent inhibitor of the SARS-CoV Mpro, with a Ki of 0.1 μM.
E1112 GS-621763 GS-621763, an orally bioavailable prodrug of GS-441524, shows a dose-dependent antiviral effect on SARS-CoV-2 reporter virus expressing nanoluciferase (SARS-CoV-2 nLUC) replication with an EC50 of 2.8 μM, also inhibits reporter SARS-CoV-2 expressing firefly luciferase (SARS-CoV-2 Fluc) replication with EC50 of 0.125 μM.