Levonorgestrel

Licensed by Pfizer Catalog No.S1727 Synonyms: D-Norgestrel

For research use only.

Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.

Levonorgestrel  Chemical Structure

CAS No. 797-63-7

Selleck's Levonorgestrel has been cited by 2 Publications

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Biological Activity

Description Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.
Targets
Progesterone receptor [1]
In vitro

Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. [1] Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. [2] Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects [3]

In vivo Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. [4] Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus). [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 312.45
Formula

C21H28O2

CAS No. 797-63-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05058872 Recruiting Drug: Levonorgestrel/ethinyl estradiol|Drug: Placebo Oral Hormonal Contraceptive Use|Neural Activity|Mood|Hedonic Function University of Colorado Denver September 20 2021 Phase 4
NCT04663568 Recruiting Device: Levonorgestrel-releasing intrauterine system Tubal Ligation Assiut University December 1 2020 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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