Hexestrol
Catalog No.S2473 Synonyms: Bibenzyl
Molecular Weight(MW): 270.37
Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
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Choose Selective Estrogen/progestogen Receptor Inhibitors
Biological Activity
| Description | Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. | ||||
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| Features | Much higher ERβ binding selectivity than Erα. | ||||
| Targets |
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| In vitro |
Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6] |
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| In vivo | Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7] |
Protocol
| Animal Research:[7] |
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Solubility (25°C)
| In vitro | DMSO | 42 mg/mL (155.34 mM) |
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| Ethanol | 42 mg/mL (155.34 mM) | |
| Water | Insoluble | |
| In vivo | Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% propylene glycol, 5% Tween 80, 65% D5W For best results, use promptly after mixing. |
30 mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 270.37 |
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| Formula | C18H22O2 |
| CAS No. | 84-16-2 |
| Storage | powder |
| in solvent | |
| Synonyms | Bibenzyl |
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