Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Hexestrol For research use only.

Hexestrol

Synonyms: Bibenzyl

Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

Hexestrol Chemical Structure

Hexestrol Chemical Structure

CAS No. 84-16-2

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Hexestrol Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Features Much higher ERβ binding selectivity than Erα.
Targets
ERα [1] ERβ [1]
0.07 nM(EC50) 0.175 nM(EC50)
In vitro
In vitro Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6]
In Vivo
In vivo Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7]
Animal Research Animal Models adult mice aged 90-120 days
Dosages 3 mg/kg and 6 mg/kg
Administration administered intraperitoneally once daily for 30 days

Chemical Information & Solubility

Molecular Weight 270.37 Formula

C18H22O2
CAS No. 84-16-2 SDF Download Hexestrol SDF
Smiles CCC(C1=CC=C(C=C1)O)C(CC)C2=CC=C(C=C2)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 54 mg/mL ( (199.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 54 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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