For research use only.

Catalog No.S2473 Synonyms: Bibenzyl

Hexestrol Chemical Structure

CAS No. 84-16-2

Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

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Biological Activity

Description Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Features Much higher ERβ binding selectivity than Erα.
ERα [1] ERβ [1]
0.07 nM(EC50) 0.175 nM(EC50)
In vitro

Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6]

In vivo Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7]


Animal Research:[7]
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  • Animal Models: adult mice aged 90-120 days
  • Dosages: 3 mg/kg and 6 mg/kg
  • Administration: administered intraperitoneally once daily for 30 days
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (155.34 mM)
Ethanol 42 mg/mL (155.34 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 270.37


CAS No. 84-16-2
Storage powder
in solvent
Synonyms Bibenzyl
Smiles CCC(C1=CC=C(C=C1)O)C(CC)C2=CC=C(C=C2)O

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% DMSO % % Tween 80 % ddH2O

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